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Androgen is responsible for enhanced susceptibility of melatonin against traumatic brain injury in females.

SS Li | LL Xie | ZZ Li | YJ Fan | MM Qi | YG Xi
Neuroscience letters | 2021 May 01

Numerous publications have demonstrated that melatonin administration is associated with mortality reduction and improvement in neurological outcomes after traumatic brain injury (TBI). However, there are significant sex differences in several diseases associated with melatonin. We aimed to determine whether androgen was responsible for enhanced susceptibility of melatonin against TBI in females, as well as potential molecular mechanisms.

Pubmed ID: 33766734

TBI Model

  • Weight-drop model
  • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): No age reported
  • Weight (grams): 300 - 350
  • Assessments

    Immunofluorescence, open field test, TUNEL staining, Western blot

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available
  • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available