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Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway.

J Yuan | D Wang | Y Liu | X Chen | H Zhang | F Shen | X Liu | J Fu
The Journal of surgical research | 2018 Aug

Several studies have recently found that oxidative stress plays a pivotal role in the pathogenesis of traumatic brain injury (TBI) and may represent a target in TBI treatment. Hydrogen-rich water was recently shown to exert neuroprotective effects in various neurological diseases through its antioxidant properties. However, the mechanisms underlying its effects in TBI are not clearly understood. The purpose of our study was to evaluate the neuroprotective role of hydrogen-rich water in rats with TBI and to elucidate the possible mechanisms underlying its effects.

Pubmed ID: 29907217

TBI Model

  • Weight-drop model
  • Feeney's Weight-drop method
  • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): No age reported
  • Weight (grams): 250 - 300
  • Assessments

    GPx, CAT, MDA level, Immunohistochemistry (IHC), RT-PCR, Western blot, modified Neurological Severity Score (mNSS)

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available
  • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available