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Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury and hemorrhage.

RM Boudreau | M Johnson | R Veile | LA Friend | H Goetzman | TA Pritts | CC Caldwell | AT Makley | MD Goodman
The Journal of surgical research | 2017 Jul

Posttraumatic coagulopathy and inflammation can exacerbate secondary cerebral damage after traumatic brain injury (TBI). Tranexamic acid (TXA) has been shown clinically to reduce mortality in hemorrhaging and head-injured trauma patients and has the potential to mitigate secondary brain injury with its reported antifibrinolytic and antiinflammatory properties. We hypothesized that TXA would improve posttraumatic coagulation and inflammation in a murine model of TBI alone and in a combined injury model of TBI and hemorrhage (TBI/H).

Pubmed ID: 28688660

TBI Model

  • Weight-drop model

    • Animal Information

  • Species: mouse
  • Strain: C57BL/6
  • Age (weeks): 8 - 10
  • Weight (grams): No weight reported

    • Assessments

    Enzyme-linked immunosorbent assay (ELISA), Rotational thromboelastometry, Splenic cytology

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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