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Modafinil attenuates the neuroinflammatory response after experimental traumatic brain injury.

Y Ozturk | I Bozkurt | Y Guvenc | U Kepoglu | M Cingirt | O Gulbahar | T Ozcerezci | S Senturk | ME Yaman
Journal of neurosurgical sciences | 2023 Aug

Modafinil has been proven to exert anti-inflammatory, anti-oxidative and neuroprotective effects on numerous neurological disorders. However, its effects after traumatic brain injury (TBI) have not been yet explored. The aim of this study was to explore if Modafinil can attenuate the neuroinflammatory phase of TBI and clarify the possible underlying mechanisms.

Pubmed ID: 34545730

TBI Model

  • Weight-drop model

    • Animal Information

  • Species: rat
  • Strain: Wistar Albino
  • Age (weeks): No age reported
  • Weight (grams): No weight reported

    • Assessments

    Garcia Test

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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