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Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway.

J Fang | H Wang | J Zhou | W Dai | Y Zhu | Y Zhou | X Wang | M Zhou
Drug design, development and therapy | 2018

The neuroprotective effects of Baicalin have been confirmed in several central nervous system (CNS) diseases. However, its possible effect on traumatic brain injury (TBI) model is still not clear. The present study is aimed to investigate the role and the underling mechanisms of 7-D-glucuronic acid-5,6-dihydroxyflavone (Baicalin) on TBI model.

Pubmed ID: 30127597

TBI Model

  • Weight-drop model
  • Modified Weight-drop model

    • Animal Information

  • Species: mouse
  • Strain: ICR
  • Age (weeks): 6 - 8
  • Weight (grams): 28 - 32

    • Assessments

    Brain water content, Immunofluorescence, Malondialdehyde level, Neurological Severity Score (NSS), qRT-PCR, TUNEL staining, Western blot, glutathione peroxidase, superoxide dismutase

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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