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Maturation-dependent response of the piglet brain to scaled cortical impact.

AC Duhaime | SS Margulies | SR Durham | MM O'Rourke | JA Golden | S Marwaha | R Raghupathi
Journal of neurosurgery | 2000 Sep

The goal of this study was to investigate the relationship between maturational stage and the brain's response to mechanical trauma in a gyrencephalic model of focal brain injury. Age-dependent differences in injury response might explain certain unique clinical syndromes seen in infants and young children and would determine whether specific therapies might be particularly effective or even counterproductive at different ages.

Pubmed ID: 10969944

TBI Model

  • Other
  • Focal contusion injury

    • Animal Information

  • Species: pig
  • Strain: Yorkshire
  • Age (weeks): 4 - 17
  • Weight (grams): No weight reported

    • Assessments

    Histology, Hematoxylin and Eosin

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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