Searching across hundreds of databases

Our searching services are busy right now. Please try again later

  • Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut-brain axis.

H Li | J Sun | J Du | F Wang | R Fang | C Yu | J Xiong | W Chen | Z Lu | J Liu
Neurogastroenterology and motility | 2018 May

Traumatic brain injury (TBI) is a common occurrence following gastrointestinal dysfunction. Recently, more and more attentions are being focused on gut microbiota in brain and behavior. Glucagon-like peptide-1 (GLP-1) is considered as a mediator that links the gut-brain axis. The aim of this study was to explore the neuroprotective effects of Clostridium butyricum (Cb) on brain damage in a mouse model of TBI.

Pubmed ID: 29193450

TBI Model

  • Weight-drop model
  • Modified Weight-drop model

    • Animal Information

  • Species: mouse
  • Strain: C57BL/6
  • Age (weeks): 6 - 8
  • Weight (grams): 18 - 22

    • Assessments

    Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence staining, TUNEL staining, Western blot, Immunofluorescence, modified Neurological Severity Score (mNSS)

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

    Recent News Entries

    Contact Us

    Department of Neurosciences, School of Medicine

    University of California, San Diego





    About SciCrunch | Privacy Policy | Terms of Service

    SciCrunch