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Single low-dose lipopolysaccharide preconditioning: neuroprotective against axonal injury and modulates glial cells.

RC Turner | ZJ Naser | BP Lucke-Wold | AF Logsdon | RL Vangilder | RR Matsumoto | JD Huber | CL Rosen
Neuroimmunology and neuroinflammation | 2017 Jan

Over 7 million traumatic brain injuries (TBI) are reported each year in the United States. However, treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly understood. Lipopolysaccharide (LPS) administration before controlled cortical impact can contribute to neuroprotection. However, the underlying mechanisms and whether LPS preconditioning confers neuroprotection against closed-head injuries remains unclear.

Pubmed ID: 28164149

TBI Model

  • Other
  • Impact acceleration injury

    • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): 13 - 17
  • Weight (grams): No weight reported

    • Assessments

    Fluoro-Jade B staining (FJB), Histology, Locomotor behavior, Immunohistochemistry (IHC)

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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