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Combined [(18)F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice.

I Israel | A Ohsiek | E Al-Momani | C Albert-Weissenberger | C Stetter | S Mencl | AK Buck | C Kleinschnitz | S Samnick | AL Sirén
Journal of neuroinflammation | 2016 Jun 07

Traumatic brain injury (TBI) is a major cause of death and disability. Neuroinflammation contributes to acute damage after TBI and modulates long-term evolution of degenerative and regenerative responses to injury. The aim of the present study was to evaluate the relationship of microglia activation to trauma severity, brain energy metabolism, and cellular reactions to injury in a mouse closed head injury model using combined in vivo PET imaging, ex vivo autoradiography, and immunohistochemistry.

Pubmed ID: 27266706

TBI Model

  • Other
  • Closed head injury

    • Animal Information

  • Species: mouse
  • Strain: C57BL/6N
  • Age (weeks): 10 - 15
  • Weight (grams): No weight reported

    • Assessments

    Autoradiography, Immunohistochemistry (IHC), Neurological Severity Score (NSS), hematoxylin and eosin, μPET

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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