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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00030465
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
References:
Synonyms: unc-119(tm4063) III; wgIs740.
Alternate IDs: WB-STRAIN:OP740, CGC_OP740
Notes: Made_by: Waterston Lab|"Modern strain"|"wgIs740 [lin-32::TY1::EGFP::3xFLAG + unc-119(+)]. TY1::EGFP::3xFLAG tag inserted in frame at C-terminus of coding sequence by recombineering. Expression of transgene confirmed by GFP. References: Sarov M, et al. Nat Methods (2006) 10:839-44. Zhong, M, et al. PLoS Genet (2010) 6(2):e1000848. Strain was constructed as part of the Regulatory Element Project, part of modENCODE (URL: www.modencode.org)."
Proper citation: RRID:WB-STRAIN:WBStrain00030465 Copy
http://www.wormbase.org/db/get?name=WBStrain00030551
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00006606(tra-3)
Genomic Alteration: WBGene00006606(tra-3)
Availability: available
References:
Synonyms: tra-3(e1107) IV; ccIs56 V.
Alternate IDs: WB-STRAIN:PD56, CGC_PD56
Notes: ccIs56 [sup-7(st5) +unc-54::lacZ] V. Non-nuclear unc-54::lacZ fusion expressed in nuclei and cytoplasm of body wall muscles.
Proper citation: RRID:WB-STRAIN:WBStrain00030551 Copy
http://www.wormbase.org/db/get?name=WBStrain00030552
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00006789(unc-54)
Genomic Alteration: WBGene00006789(unc-54)
Availability: available
References:
Synonyms: unc-54(e190) I; ccIs126.
Alternate IDs: WB-STRAIN:PD126, CGC_PD126
Notes: ccIs126 [myo-2p::lacZ + unc-54(+)]. lacZ expression in pharyngeal and body wall muscles. Superficially wild-type, but gives some paralyzed animals.
Proper citation: RRID:WB-STRAIN:WBStrain00030552 Copy
http://www.wormbase.org/db/get?name=WBStrain00030557
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: available
References:
Synonyms: ccTi1594 umnIs7 III.
Alternate IDs: WB-STRAIN:PD2218, CGC_PD2218
Notes: ccTi1594 [mex-5p::GFP::gpr-1::smu-1 3'UTR + Cbr-unc-119(+), III: 680195] III. umnIs7 [myo-2p::GFP + NeoR, III:9421936] III. GFP expression in germline and GFP expression in pharynx. High penetrance of non-Mendelian inheritance. Neomycin resistant. The GPR-1 overexpression transgene consistently confers a high penetrance of non-Mendelian inheritance; fluorescent markers allow tracking of Mendelian and non-Mendelian events. The genomic location of ccTi1594 is with respect to the WEBcel235 assembly.|"Supplementary_genotype ccTi1594 [mex-5p::GFP::gpr-1::smu-1 3'UTR + Cbr-unc-119(+), III: 680195] III. umnIs7 [myo-2p::GFP + NeoR, III:9421936] III"
Proper citation: RRID:WB-STRAIN:WBStrain00030557 Copy
http://www.wormbase.org/db/get?name=WBStrain00030558
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: available
References:
Synonyms: ccTi1594 umnIs27 III.
Alternate IDs: WB-STRAIN:PD2220, CGC_PD2220
Notes: ccTi1594 [mex-5p::GFP::gpr-1::smu-1 3'UTR + Cbr-unc-119(+), III: 680195] III. umnIs27 [myo-2::GFP + NeoR, III: 8856215 (intergenic)] III. GFP expression in germline and GFP expression in pharynx. High penetrance of non-Mendelian inheritance. Neomycin resistant. The GPR-1 overexpression transgene consistently confers a high penetrance of non-Mendelian inheritance; fluorescent markers allow tracking of Mendelian and non-Mendelian events. The genomic location of ccTi1594 is with respect to the WEBcel235 assembly.
Proper citation: RRID:WB-STRAIN:WBStrain00030558 Copy
http://www.wormbase.org/db/get?name=WBStrain00030555
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
References:
Synonyms: ccTi1594 unc-119(ed3) III.
Alternate IDs: WB-STRAIN:PD1594, CGC_PD1594
Notes: ccTi1594 [mex-5p::GFP::gpr-1::smu-1 3'UTR + Cbr-unc-119(+), III: 680195] III. GFP expression in germline. Transgene rescues unc-119(ed3). Improved GPR-1 over-expression transgene appears to be stably expressed in the germline at a wide range of temperatures and does not require special handling. (unlike other GPR-1 overexpressing transgenes previously described in the literature). The GPR-1 overexpression transgene consistently confers a high penetrance of non-Mendelian inheritance. Neomycin resistant. The genomic location of ccTi1594 is with respect to the WEBcel235 assembly.|"Made_by: Christian Froekjaer Jensen"
Proper citation: RRID:WB-STRAIN:WBStrain00030555 Copy
http://www.wormbase.org/db/get?name=WBStrain00030556
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
References:
Synonyms: ccTi1594 unc-119(ed3) III; hjSi20 IV.
Alternate IDs: WB-STRAIN:PD2217, CGC_PD2217
Notes: ccTi1594 [mex-5p::GFP::gpr-1::smu-1 3'UTR + Cbr-unc-119(+), III: 680195] III. hjSi20 [myo-2p::mCherry::unc-54 3'UTR] IV. GFP expression in germline. mCherry expression in pharynx. The ccTi1594 transgene rescues unc-119(ed3). High penetrance of non-Mendelian inheritance. The GPR-1 overexpression transgene consistently confers a high penetrance of non-Mendelian inheritance; fluorescent markers allow tracking of Mendelian and non-Mendelian events. The genomic location of ccTi1594 is with respect to the WEBcel235 assembly.
Proper citation: RRID:WB-STRAIN:WBStrain00030556 Copy
http://www.wormbase.org/db/get?name=WBStrain00030553
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: unknown
References:
Synonyms: EMPTY
Alternate IDs: WB-STRAIN:PD1074
Notes: A defined and recently cloned population of animals derived from the original Bristol variant of C. elegans originally obtained by Brenner from E. Dougherty with no known history of mutagenesis. Brenners original population, called N2, was used as the basis for the vast majority of laboratory strains in use currently. No early frozen stock of the unmutagenized N2 population currently exists, but later stocks were available from several laboratories. PD1074 is a clonal population founded by picking a single worm of one such stock, VC3510. VC3510 in turn derives from a subpopulation of N2 described in the literature as VC2010. PD1074 is intended to be used as a wild type reference strain with the closely matched genome assembly of Yoshimura et al (ref) available on Wormbase as VC2010-1.0. (ENA study accession PRJEB28388; assembly accession GCA_900538205). We note that PD1074 is expected to be largely similar to most lab N2 strains, but that as a clonal isolate derived from N2, there will be some loci that will vary compared to any other particular N2 isolate. One such example is a partial deletion of the alh-2 locus in PD1074. Additional loci that were found to vary between the prior N2 reference genome (WormBase release WS264) and the VC2010-1.0 assembly are detailed in supplemental table 8 in Yoshimura et al (ref).|"A defined and recently cloned population of animals derived from the original Bristol variant of C. elegans originally obtained by Brenner from E. Dougherty with no known history of mutagenesis. Brenners original population, called N2, was used as the basis for the vast majority of laboratory strains in use currently. No early frozen stock of the unmutagenized N2 population currently exists, but later stocks were available from several laboratories. PD1074 is a clonal population founded by picking a single worm of one such stock, VC3510. VC3510 in turn derives from a subpopulation of N2 described in the literature as VC2010. PD1074 is intended to be used as a wild type reference strain with the closely matched genome assembly of Yoshimura, et al. (Genome Res. 2019 Jun;29(6):1009-1022) available on Wormbase as VC2010-1.0. (ENA study accession PRJEB28388; assembly accession GCA_900538205). We note that PD1074 is expected to be largely similar to most lab N2 strains, but that as a clonal isolate derived from N2, there will be some loci that will vary compared to any other particular N2 isolate. One such example is a partial deletion of the alh-2 locus in PD1074. Additional loci that were found to vary between the prior N2 reference genome (WormBase release WS264) and the VC2010-1.0 assembly are detailed in supplemental table 8 in Yoshimura, et al, (2019)."|"Added Wild_Isolate tag as genotype info suggesting that they were sampled from the wild."|"Made_by: Karen Artiles & Mark Edgley"|"no longer available from the CGC."|"Supplementary_genotype"|"WBStrain provided so WBPaper00061243 paper added based on AFP_Strain data."|"WBStrain provided so WBPaper00061573 paper added based on AFP_Strain data."
Proper citation: RRID:WB-STRAIN:WBStrain00030553 Copy
http://www.wormbase.org/db/get?name=WBStrain00030562
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00008502(skih-2)|WBGene00011280(pelo-1)
Genomic Alteration: WBGene00008502(skih-2), WBGene00011280(pelo-1)
Availability: available
References:
Synonyms: pelo-1(cc2849) III; skih-2(cc2854) IV.
Alternate IDs: WB-STRAIN:PD2860, CGC_PD2860
Notes: Made_by: Joshua Arribere|"Temperature-sensitive. Weakly fertile at 16C; sterile at 23C. Incomplete de-repression of nonstop mRNAs. Reference: Arribere, JA and Fire, AZ. Nonsense-mediated decay triggers SKI/pelota-dependent decay in a metazoan."
Proper citation: RRID:WB-STRAIN:WBStrain00030562 Copy
http://www.wormbase.org/db/get?name=WBStrain00030561
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00006789(unc-54)
Genomic Alteration: WBGene00006789(unc-54)
Availability: available
References:
Synonyms: unc-54(cc2859[unc-54::GFP::TAA::NSUTR]) I.
Alternate IDs: WB-STRAIN:PD2859, CGC_PD2859
Notes: Endogenous unc-54::GFP made by CRISPR. Exhibits green thick muscle filaments in the body wall muscle. Weakly Unc. Reference: Arribere JA, Cenik ES, Jain N, Hess GT, Lee CH, Bassik MC, Fire AZ. Translation readthrough mitigation. Nature. 2016 Jun 30;534(7609):719-23. Epub 2016 Jun 1.|"Made_by: Joshua Arribere"
Proper citation: RRID:WB-STRAIN:WBStrain00030561 Copy
http://www.wormbase.org/db/get?name=WBStrain00030568
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00004010(pha-1)|WBGene00006789(unc-54)
Genomic Alteration: WBGene00004010(pha-1), WBGene00006789(unc-54)
Availability: unknown
References:
Synonyms: EMPTY
Alternate IDs: WB-STRAIN:PD3852
Notes: EMPTY
Proper citation: RRID:WB-STRAIN:WBStrain00030568 Copy
http://www.wormbase.org/db/get?name=WBStrain00030566
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: unknown
References:
Synonyms: rrf-3(pk1426);him-8(e1489)
Alternate IDs: WB-STRAIN:PD3330
Notes: EMPTY
Proper citation: RRID:WB-STRAIN:WBStrain00030566 Copy
http://www.wormbase.org/db/get?name=WBStrain00030600
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001072(dpy-10)|WBGene00002955(let-856)|WBGene00006744(unc-4)|WBGene00006787(unc-52)
Genomic Alteration: WBGene00001072(dpy-10), WBGene00002955(let-856), WBGene00006744(unc-4), WBGene00006787(unc-52)
Availability: available
References:
Synonyms: let-856(cc514) unc-4(e120)/mnC1 [dpy-10(e128) unc-52(e444)] II.
Alternate IDs: WB-STRAIN:PD7227, CGC_PD7227
Notes: Heterozygotes are WT and segregate WT, paralyzed Dpys and Unc-4s which arrest as larval lethals.
Proper citation: RRID:WB-STRAIN:WBStrain00030600 Copy
http://www.wormbase.org/db/get?name=WBStrain00030530
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00022727(prkl-1)
Genomic Alteration: WBGene00022727(prkl-1)
Availability: available
References:
Synonyms: prkl-1(zy11) IV.
Alternate IDs: WB-STRAIN:OU100, CGC_OU100
Notes: Reference: Sanchez-Alvarez L, et al. PLoS Genet. 2011 Sep;7(9):e1002257.
Proper citation: RRID:WB-STRAIN:WBStrain00030530 Copy
http://www.wormbase.org/db/get?name=WBStrain00030538
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00016201(tdo-2)
Genomic Alteration: WBGene00016201(tdo-2)
Availability: available
References:
Synonyms: tdo-2(zg216) III.
Alternate IDs: WB-STRAIN:OW715, CGC_OW715
Notes: Crispr/Cas9 engineered deletion mutant removes 28 basepairs in tdo-2 coding region. Reference: Michels H, et al. Sci Rep. 2016 Dec 20;6:39199.|"Made_by: H. Michels"
Proper citation: RRID:WB-STRAIN:WBStrain00030538 Copy
http://www.wormbase.org/db/get?name=WBStrain00030535
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00015802(kynu-1)
Genomic Alteration: WBGene00015802(kynu-1)
Availability: available
References:
Synonyms: kynu-1(tm4924) X.
Alternate IDs: WB-STRAIN:OW454, CGC_OW454
Notes: C15H9.7. Homozygous viable. Reference: van der Goot AT, et al. Proc. Natl. Acad. Sci. U.S.A. 2012 109(37) 14912-7.|"Made_by: A. van der Goot"
Proper citation: RRID:WB-STRAIN:WBStrain00030535 Copy
http://www.wormbase.org/db/get?name=WBStrain00030536
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00017051(afmd-1)
Genomic Alteration: WBGene00017051(afmd-1)
Availability: available
References:
Synonyms: afmd-1(tm4547) IV.
Alternate IDs: WB-STRAIN:OW477, CGC_OW477
Notes: D2024.2. Homozygous viable. Reference: van der Goot AT, et al. Proc. Natl. Acad. Sci. U.S.A. 2012 109(37) 14912-7.|"Made_by: R. Seinstra"
Proper citation: RRID:WB-STRAIN:WBStrain00030536 Copy
http://www.wormbase.org/db/get?name=WBStrain00030533
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001709(grk-2)
Genomic Alteration: WBGene00001709(grk-2)
Availability: available
References:
Synonyms: grk-2(gk268) III; pkIs2386 IV.
Alternate IDs: WB-STRAIN:OW15, CGC_OW15
Notes: pkIs2386 [unc-54p::alpha-synnuclein::YFP + unc-119(+)].
Proper citation: RRID:WB-STRAIN:WBStrain00030533 Copy
http://www.wormbase.org/db/get?name=WBStrain00030531
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: available
References:
Synonyms: zyIs1.
Alternate IDs: WB-STRAIN:OU247, CGC_OU247
Notes: zyIs1 [lin-11::RFP + rol-6(su1006)]. Roller. Reference: Sanchez-Alvarez L, et al. PLoS Genet. 2011 Sep;7(9):e1002257.
Proper citation: RRID:WB-STRAIN:WBStrain00030531 Copy
http://www.wormbase.org/db/get?name=WBStrain00030539
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00016201(tdo-2)
Genomic Alteration: WBGene00016201(tdo-2)
Availability: available
References:
Synonyms: tdo-2(zg217) III.
Alternate IDs: WB-STRAIN:OW716, CGC_OW716
Notes: Crispr/Cas9 engineered deletion mutant removes 14 basepairs in tdo-2 coding region. Reference: Michels H, et al. Sci Rep. 2016 Dec 20;6:39199.|"Made_by: H. Michels"
Proper citation: RRID:WB-STRAIN:WBStrain00030539 Copy
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