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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00040703
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001851(hif-1)
Genomic Alteration: WBGene00001851(hif-1)
Availability: available
References:
Synonyms: hif-1(ia4) V; yakEx125.
Alternate IDs: WB-STRAIN:XZ2084, CGC_XZ2084
Notes: yakEx125 [rab-3p::hif-1(cDNA) + myo-2p::mCherry]. Pick animals with red pharynx to maintain. HIF-1 expressed from pan-neuronal-specific promoter in hif-1 mutant background for tissue-specific rescuing experiments. yakEx125 does not rescue lethality in hif-1 mutant animals exposed to 50ppm hydrogen sulfide. Reference: Topalidou I & and Miller DL. bioRxiv 174581; doi: https:
Proper citation: RRID:WB-STRAIN:WBStrain00040703 Copy
http://www.wormbase.org/db/get?name=WBStrain00040706
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00045237(mrt-1)
Genomic Alteration: WBGene00045237(mrt-1)
Availability: available
References:
Synonyms: mrt-1(yp2) I.
Alternate IDs: WB-STRAIN:YA1039, CGC_YA1039
Notes: yp2 mutation perturbs the MRT-1 DNA-binding domain. Mortal germline. Progressive telomere shortening due to telomerase dysfunction. Hypersensitive to DNA interstrand crosslinking agents. This strain will becomce sterile after propagating 10-20 generations. mrt-1 mutants can be rejuvenated by outcrossing. Reference: Meier B, et al. EMBO J. 2009 Nov 18;28(22):3549-63.|"yp2 mutation perturbs the MRT-1 DNA-binding domain. Mortal germline. Progressive telomere shortening due to telomerase dysfunction. Hypersensitive to DNA interstrand crosslinking agents. This strain will become sterile after propagating 10-20 generations. mrt-1 mutants can be rejuvenated by outcrossing. Reference: Meier B, et al. EMBO J. 2009 Nov 18;28(22):3549-63."
Proper citation: RRID:WB-STRAIN:WBStrain00040706 Copy
http://www.wormbase.org/db/get?name=WBStrain00040780
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000426(ced-12)
Genomic Alteration: WBGene00000426(ced-12)
Availability: available
References:
Synonyms: ced-12(bz187) I.
Alternate IDs: WB-STRAIN:ZB547, CGC_ZB547
Notes: Induces persistence of programmed cell death corpses and necrotic cell death corpses.
Proper citation: RRID:WB-STRAIN:WBStrain00040780 Copy
http://www.wormbase.org/db/get?name=WBStrain00040781
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000802(crt-1)
Genomic Alteration: WBGene00000802(crt-1)
Availability: available
References:
Synonyms: crt-1(bz29) V.
Alternate IDs: WB-STRAIN:ZB1028, CGC_ZB1028
Notes: Probably null calreticulin. W28 amber. Slow growth (one day developmental delay). Nearly sterile if raised at 25C. Suppresses mec-4(d)-induced neurodegeneration. Bent-head.
Proper citation: RRID:WB-STRAIN:WBStrain00040781 Copy
http://www.wormbase.org/db/get?name=WBStrain00040788
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001623(glt-5)
Genomic Alteration: WBGene00001623(glt-5)
Availability: available
References:
Synonyms: glt-5(bz70) II.
Alternate IDs: WB-STRAIN:ZB1099, CGC_ZB1099
Notes: Reference: Mano et al. (2007) J Biol Chem 282(47):34412-9.
Proper citation: RRID:WB-STRAIN:WBStrain00040788 Copy
http://www.wormbase.org/db/get?name=WBStrain00040787
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001622(glt-4)
Genomic Alteration: WBGene00001622(glt-4)
Availability: available
References:
Synonyms: glt-4(bz69) II.
Alternate IDs: WB-STRAIN:ZB1098, CGC_ZB1098
Notes: Reference: Mano et al. (2007) J Biol Chem 282(47):34412-9.
Proper citation: RRID:WB-STRAIN:WBStrain00040787 Copy
http://www.wormbase.org/db/get?name=WBStrain00040702
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001851(hif-1)
Genomic Alteration: WBGene00001851(hif-1)
Availability: available
References:
Synonyms: hif-1(ia4) V; yakEx145.
Alternate IDs: WB-STRAIN:XZ2083, CGC_XZ2083
Notes: yakEx145 [unc-47p::hif-1(cDNA) + myo-2p::mCherry]. Pick animals with red pharynx to maintain. HIF-1 expressed from GABA-ergic neuron-specific promoter in hif-1 mutant background for tissue-specific rescuing experiments. yakEx145 does not rescue lethality in hif-1 mutant animals exposed to 50ppm hydrogen sulfide. Reference: Topalidou I & and Miller DL. bioRxiv 174581; doi: https:
Proper citation: RRID:WB-STRAIN:WBStrain00040702 Copy
http://www.wormbase.org/db/get?name=WBStrain00040784
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000802(crt-1)
Genomic Alteration: WBGene00000802(crt-1)
Availability: available
References:
Synonyms: crt-1(bz50) V.
Alternate IDs: WB-STRAIN:ZB1031, CGC_ZB1031
Notes: Point mutation in G102E. No easily detected phenotype, selected for suppression of mec-4(d)-induced degeneration caused by ectopic expression of mec-4(u231) in the ventral nerve cord. Bent-head.
Proper citation: RRID:WB-STRAIN:WBStrain00040784 Copy
http://www.wormbase.org/db/get?name=WBStrain00040783
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000802(crt-1)
Genomic Alteration: WBGene00000802(crt-1)
Availability: available
References:
Synonyms: crt-1(bz31) V.
Alternate IDs: WB-STRAIN:ZB1030, CGC_ZB1030
Notes: Point mutation C133Y. No easily detected phenotype, selected for suppression of mec-4(d)-induced degeneration caused by ectopic expression of mec-4(d)-induced neurodegeneration. Bent-head.
Proper citation: RRID:WB-STRAIN:WBStrain00040783 Copy
http://www.wormbase.org/db/get?name=WBStrain00040786
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001621(glt-3)
Genomic Alteration: WBGene00001621(glt-3)
Availability: unknown
References:
Synonyms: glt-3(bz34) IV.
Alternate IDs: WB-STRAIN:ZB1096
Notes: EMPTY
Proper citation: RRID:WB-STRAIN:WBStrain00040786 Copy
http://www.wormbase.org/db/get?name=WBStrain00040879
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00017641(csr-1)
Genomic Alteration: WBGene00017641(csr-1)
Availability: available
References:
Synonyms: csr-1(fj54) IV/nT1 [qIs51] (IV;V).
Alternate IDs: WB-STRAIN:ZT3, CGC_ZT3
Notes: Heterozygotes are wild-type with pharyngeal GFP signal, and segregate WT GFP, arrested nT1[qIs51] aneuploids, and non-GFP csr-1(fj54) homozygotes (sterile, but some animals lay a small number of dead eggs). Homozygous nT1[qIs51] inviable. Pick WT GFP and check for correct segregation of progeny to maintain. The fj54 mutation deletes a 524 bp region including half of the second exon, the third exon, and almost all of the fourth exon, causing a frame shift to stop the translation of both PAZ and Piwi domains. The deletion can be checked by PCR with the following primers: AAGAAATACCAATGCGGAGGCA and TTCACGGCTCTTTGCAGTTTCA.|"Made_by: Moriguchi/Tabara"|"Mutagen:UV/TMP"
Proper citation: RRID:WB-STRAIN:WBStrain00040879 Copy
http://www.wormbase.org/db/get?name=WBStrain00040875
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00004319(rbr-2)
Genomic Alteration: WBGene00004319(rbr-2)
Availability: available
References:
Synonyms: rbr-2(tm1231) IV.
Alternate IDs: WB-STRAIN:ZR1, CGC_ZR1
Notes: 648 bp deletion (confirmed). About 80% of animals show defects in vulval development (Muv or Vul).
Proper citation: RRID:WB-STRAIN:WBStrain00040875 Copy
http://www.wormbase.org/db/get?name=WBStrain00040878
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000254(bli-4)|WBGene00008400(drh-3)
Genomic Alteration: WBGene00000254(bli-4), WBGene00008400(drh-3)
Availability: available
References:
Synonyms: drh-3(fj52) I/hT2 [bli-4(e937) let-?(q782) qIs48] (I;III).
Alternate IDs: WB-STRAIN:ZT2, CGC_ZT2
Notes: Heterozygotes are WT. drh-3 homozygotes are sterile. the fj52 mutation deletes a 405 bp region including the promoter, the first exon and half of the second exon. The deletion can be checked by PCR with the following primers: TTTATTGATTCCGCCGTTGCTC and TGCAGCTCCAGCCACTCTATCA. The fj52 mutation was isolated from a deletion mutant libray of the K. Nishiwaki group. Homozygous hT2[bli-4 let-? qIs48] inviable.|"Made_by: Moriguchi/Kuroki"|"Mutagen:UV/TMP"
Proper citation: RRID:WB-STRAIN:WBStrain00040878 Copy
http://www.wormbase.org/db/get?name=WBStrain00040877
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00003473(mtl-1)|WBGene00003474(mtl-2)
Genomic Alteration: WBGene00003473(mtl-1), WBGene00003474(mtl-2)
Availability: unknown
References:
Synonyms: mtl-1(tm1770) mtl-2(gk125) V.
Alternate IDs: WB-STRAIN:ZS1
Notes: This strain is described as zs1. It should be ZS1
Proper citation: RRID:WB-STRAIN:WBStrain00040877 Copy
http://www.wormbase.org/db/get?name=WBStrain00040871
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000898(daf-2)
Genomic Alteration: WBGene00000898(daf-2)
Availability: available
References:
Synonyms: daf-2(m596) III; hpEx2905.
Alternate IDs: WB-STRAIN:ZM9028, CGC_ZM9028
Notes: hpEx2905 [myo-2p::RFP + myo-3p::daf-2]. Pick RFP+ to maintain. Maintain at 15C. Temperature sensitive dauer constitutive. [NOTE: (07-14-2015) The genotype of this strain was incorrectly reported as daf-2(e1370), but is in fact daf-2(m596).] References: Hung W, et al. EMBO J. 2013 Jun 12;32(12):1745-60. Hung W, et al. Development. 2014 Apr;141(8):1767-79.
Proper citation: RRID:WB-STRAIN:WBStrain00040871 Copy
http://www.wormbase.org/db/get?name=WBStrain00040806
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00006575(tir-1)
Genomic Alteration: WBGene00006575(tir-1)
Availability: available
References:
Synonyms: tir-1(qd4) III.
Alternate IDs: WB-STRAIN:ZD101, CGC_ZD101
Notes: Enhanced pathogen susceptibility. Egg laying in response to food is defective. Reference: Shivers RP et al., (2009) Cell Host Microbe 6:321-30.
Proper citation: RRID:WB-STRAIN:WBStrain00040806 Copy
http://www.wormbase.org/db/get?name=WBStrain00040809
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00004758(sek-1)
Genomic Alteration: WBGene00004758(sek-1)
Availability: available
References:
Synonyms: sek-1(km4) X; qdEx11.
Alternate IDs: WB-STRAIN:ZD260, CGC_ZD260
Notes: no longer available from the CGC.|"qdEx11 [osm-5p::sek-1(cDNA)::GFP::unc-54-3' UTR + myo-2p::mStrawberry::unc-54-3' UTR]. Array rescues sek-1 in ciliated sensory neurons. References: Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30."
Proper citation: RRID:WB-STRAIN:WBStrain00040809 Copy
http://www.wormbase.org/db/get?name=WBStrain00040808
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00004758(sek-1)
Genomic Alteration: WBGene00004758(sek-1)
Availability: available
References:
Synonyms: sek-1(km4) X; qdEx8.
Alternate IDs: WB-STRAIN:ZD202, CGC_ZD202
Notes: qdEx8 [unc-119p::sek-1(cDNA)::GFP::unc-54-3' UTR + myo-2p::mStrawberry::unc-54-3' UTR]. Array rescues sek-1 in neurons. References: Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30.
Proper citation: RRID:WB-STRAIN:WBStrain00040808 Copy
http://www.wormbase.org/db/get?name=WBStrain00040802
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00021316(Y32H12A.8)
Genomic Alteration: WBGene00021316(Y32H12A.8)
Availability: available
References:
Synonyms: Y32H12A.8(tm419) III.
Alternate IDs: WB-STRAIN:ZB2774, CGC_ZB2774
Notes: Made_by:
Proper citation: RRID:WB-STRAIN:WBStrain00040802 Copy
http://www.wormbase.org/db/get?name=WBStrain00040881
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: available
References:
Synonyms: zwIs106.
Alternate IDs: WB-STRAIN:ZW127, CGC_ZW127
Notes: zwIs106 contains [unc-9p::GFP + lin-15(+)]. Superficially wild-type. Maintain under normal conditions. Described in Altun et al. Dev Dyn 238:1936-50 (2009).
Proper citation: RRID:WB-STRAIN:WBStrain00040881 Copy
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