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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695031
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_14695031, 14695031, RRRC_845, RRRC_0845, RRRC_00845
Notes: This strain was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 6.0kb 5' and 1.8kb 3' homology arms and a FRT-CAG-Pac-FRT cassette. The FRT-CAG-Pac-FRT cassette is inserted into the intron between Il2rg 4th and 5th exon. No genomic sequence is deleted. Chimeras were formed by microinjecting into F344 blastocysts. Founder animals were mated with SD rats to produce this strain. Rat Resource and Research Center
Proper citation: RRID:RRRC_00845 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695030
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_14695030, 14695030, RRRC_846, RRRC_0846, RRRC_00846
Notes: This strain was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 5.8kb 5' and 1.7kb 3' homology arms. A G843D point mutation is introduced into the Pex1 gene. The 12th and 13th exons are flanked with two loxP sites. A FRT-CAG-Pac-FRT cassette is inserted into the intron between Pex1 13th and 14th exon. This strain mimics the Peroxisomal Disorders. Heterozygote does not show any abnormalities. Rat Resource and Research Center
Proper citation: RRID:RRRC_00846 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=598973845
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_598973845, 598973845, RRRC_932, RRRC_0932, RRRC_00932
Notes: The targeted mutation in the rat GFAP gene was based on the severity and frequency of the R239H mutation in human disease. The CRISPR/Cas9 system was used to mediated knockin of point mutation (R237H) to Sprague-Dawley embryos. The current background srain is Crl:CD (SD). This mutant strain serves as a model for Alexander disease. knockins have post-weaning failure to thrive and ~10% mortality by 12 weeks, but afterwards are viable and can breed . The strain is now deposited at Rat Resource and Research Center
Proper citation: RRID:RRRC_00932 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150526809
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_150526809, 150526809, RRRC_940, RRRC_0940, RRRC_00940
Notes: This spontaneous mutant strain was originally derived from King Holtzman background and now maintained in Sprague Dawley background. A single nucleotide mutation was identified in the androgen receptor gene. The tfm males are sterile so the mutation is carried via females who breed normally. Rat Resource and Research Center
Proper citation: RRID:RRRC_00940 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150521608
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_150521608, 150521608, RRRC_881, RRRC_0881, RRRC_00881
Notes: CRISPR/Cas9 system was used to introduce an
inversion coupled with small deletions in the exon 2 at both the sgRNA1 (11 bp) and sgRNA2 sites (3 bp) in the rat Lrp5 gene of Crl:SD embryos. Rat Resource and Research Center
Proper citation: RRID:RRRC_00881 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=13208223
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_13208223, 13208223, RRRC_924, RRRC_0924, RRRC_00924
Notes: The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. Rat Resource and Research Center
Proper citation: RRID:RRRC_00924 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=405100723
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2025-08-29)
Alternate IDs: RGD_405100723, 405100723, RRRC_1022, RRRC_01022
Notes: The CRISPR/Case9 knock-in of CAG-LSL-Ghsr (LSL: loxp-Stop-Loxp) to the ROSA 26 locus of LE rats has cre recombinase-dependent expression of rat Ghsr under the control of CAG promoter. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. Rat Resource and Research Center
Proper citation: RRID:RRRC_01022 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695002
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_14695002, 14695002, RRRC_850, RRRC_0850, RRRC_00850
Notes: The CRISPR/Cas9 genome editing system was used to generate L1cam mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 4 of the rat L1cam created a 1bp-insertion (206_207insT) in exon 4. No protein expression was detected in the brain. Rat Resource and Research Center
Proper citation: RRID:RRRC_00850 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695003
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_14695003, 14695003, RRRC_851, RRRC_0851, RRRC_00851
Notes: The CRISPR/Cas9 genome editing system was used to generate L1cam mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 4 of the rat L1cam created a 300 bp-deletion(c.205_505del) in exon 4. No protein expression was detected in the brain. Rat Resource and Research Center
Proper citation: RRID:RRRC_00851 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695085
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_14695085, 14695085, RRRC_731, RRRC_0731, RRRC_00731
Notes: The use of zinc finger nuclease technology (ZFN) to knockin a luciferase reporter directly downstream of MuRF1 (Trim63) coding sequences in rats,leaving endogenous MuRF1 gene expression intact and bicistro-nically linking it to the inserted reporter through a hepatitis CIRES (HCV-IRES). The resulting knockin rat line, MuRF1-hiLUCs, has reporter characteristics that are fully reflective ofendogenous MuRF1 gene expression, can be used as a universalbiomarker of skeletal muscle atrophyin vivo, and has abioluminescent readout compatible with whole animal imagingmodalities. Rat Resource and Research Center
Proper citation: RRID:RRRC_00731 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14694998
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_14694998, 14694998, RRRC_853, RRRC_0853, RRRC_00853
Notes: This mutant strain was generated by injecting TALEN targeting rat Sdhb into NTac:SD embryo. The resulting mutant is a 4 bp-deletion in Sdhb. Rat Resource and Research Center
Proper citation: RRID:RRRC_00853 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695000
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_14695000, 14695000, RRRC_855, RRRC_0855, RRRC_00855
Notes: This mutant strain was generated by injecting TALEN targeting rat Sdhb into NTac:SD embryo. The resulting mutant is a 15 bp-deletion in Sdhb. Rat Resource and Research Center
Proper citation: RRID:RRRC_00855 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=617212698
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Live Animals (as of 2025-07-16)
Alternate IDs: RGD_617212698, 617212698, RRRC_1035, RRRC_01035
Notes: The rat Abca4 gene (Gene ID: 310836; GenBank accession number: NM_001107721.1) is located on rat chromosome 2. Exon 2 to exon 8 were selected as the target site for CRISPR/Cas9 modification on Sprague Dawley embryos. Rat Resource and Research Center
Proper citation: RRID:RRRC_01035 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11081142
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_11081142, 11081142, RRRC_741, RRRC_0741, RRRC_00741
Notes: Crispr/Cas9 targeting of Exon 3 of rat Pgr gene resulting in a deletion of Exon3 Rat Resource and Research Center
Proper citation: RRID:RRRC_00741 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=598092487
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Live Animals (as of 2025-03-18)
Alternate IDs: RGD_598092487, 598092487, RRRC_1038, RRRC_01038
Notes: A targeted 16 bp deletion was made in Exon 3 of the rat Cftr gene using CRISPR-Cas9 technology. Rat Resource and Research Center
Proper citation: RRID:RRRC_01038 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11081151
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_11081151, 11081151, RRRC_744, RRRC_0744, RRRC_00744
Notes: CRISPR/Cas9 induced 29 base pair deletion in exon 1 Rat Resource and Research Center
Proper citation: RRID:RRRC_00744 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11040561
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Cryopreserved Sperm; Cryorecovery
Alternate IDs: RGD_11040561, 11040561, RRRC_745, RRRC_0745, RRRC_00745
Notes: CRISPR/Cas9 system was used to generate this mutant; this induced 89 base pair deletion in exon 1 of the Htr7 gene. Rat Resource and Research Center
Proper citation: RRID:RRRC_00745 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150521610
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_150521610, 150521610, RRRC_867, RRRC_0867, RRRC_00867
Notes: CRISPR/Cas9 system was used to introduce a 18-bp deletion of exon 2 in the rat Lrp5 gene of Crl:SD embryos. Rat Resource and Research Center
Proper citation: RRID:RRRC_00867 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=626469555
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Live Animals (as of 2025-09-15)
Alternate IDs: RGD_626469555, 626469555, RRRC_1048, RRRC_01048
Notes: Crispr/Cas9 mediated 103 bp deletion within Exon 1 of the Phlda2 gene Rat Resource and Research Center
Proper citation: RRID:RRRC_01048 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=626189121
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Live Animals (as of 2025-09-03)
Alternate IDs: RGD_626189121, 626189121, RRRC_1055, RRRC_01055
Notes: Embryos from “SD-Foxn1rnuTg(Rho-S334X)3LavRrrc (RGD: 626189117)”, citation ID:RRID:RRRC_00539, were injected with the plasmid gene construct floxed TdTomato created by Envigo, coupled to the universal CAG promoter Rat Resource and Research Center
Proper citation: RRID:RRRC_01055 Copy
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