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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=404976869
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2024-03-18)
References:
Synonyms:
Alternate IDs: 404976869
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Tlr4 gene of Crl:SD rat embryos. The resulting mutation is a 14-bp deletion in exon 2; rn7:chr5:80,151,447-80,151,460. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_404976869 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=124715482
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 124715482
Notes: Generated by pronuclear injection of a CRISPR plasmid expressing Cas9 and single-guide RNA targeting the sequence CACTCAGCTTGTTCATGTCCTGG (protospacer adjacent motif underlined) into one-cell SS (SS/JrHsdMcwi) rat embryos. This model harbors a 6-bp deletion (mRatBN7.2 chr2:174,841,367-174,841,372) including the p52SHC initiation codon. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_124715482 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632518356
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 632518356
Notes: DBH-Cre knock-in (KI) rats, developed on the Sprague
Dawley (SD) rat background, were generated using the CRISPR/Cas9
system. In this knock-in model, a gene cassette encod-
ing 2A peptide, fused to Cre recombinase was introduced to
replace the TAA stop codon in exon 12 of the rat Dbh gene. Additionally, a
synonymous mutation p. T616= (ACG to ACA) was incorporated to pre-
vent gRNA binding and recutting of the sequence following
homology-directed repair. The gRNA targeting the rat DBH gene
(gRNA-B1: 5′-TTACTCAGTGTCTGCCTCCGTGG-3′), the donor vector con-
taining the “P2A-Cre” cassette, and a synonymous mutation p. T616=
(ACG to ACA), along with Cas9 mRNA, were co-injected into fertilized rat embryos. F0 founders. DBH-Cre KI rats were bred with wild-type SD rats (Guangdong Vital River Laboratory Animal Technology Co., Ltd.,
China). Shenzhen Institute of Advanced Technolog, Shenzhen, China
Proper citation: RRID:RGD_632518356 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=152985692
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2022-06-08)
References:
Synonyms:
Alternate IDs: 152985692
Notes: CRISPR/Cas9 mutagenesis was used to knockout Cd247 in the WAG/RijCmcr (WAG) strain. A single guide RNA (sgRNA) targeting the Cd247 exon 2 sequence GATGGAATCCTCTTCATCTACGG (protospacer adjacent motif in bold) was injected along with SpCas9 protein into one-cell WAG embryos. A founder offspring harboring a 17-bp frame-shift indel mutation deleting GAATCCTCTTCATCTAC (rn6.0 chr13:84,064,185-84,064,201) was identified and confirmed by Sanger sequencing. The frameshift mutation is predicted to cause a premature truncation of the normal 165 amino acid protein coding sequence after only 37 amino acids, lacking most of the transmembrane and the entirety of the external cellular protein domains. Contact MCW rat distribution at [email protected].
Proper citation: RRID:RGD_152985692 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=631721277
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 631721277
Notes: The mutant rats were generated using CRISPR/Cas9 technology to target upstream of exon 11 or downstream of exon 21 of rat Shank3. The resulting mutant carried approximately 26 kb deletions with the removal of the Shank3 exon 11–21 [email protected] at Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
Proper citation: RRID:RGD_631721277 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=152998995
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2022-07-15)
References:
Synonyms:
Alternate IDs: 152998995
Notes: This model was generated at the Medical College of Wisconsin by CRISPR/Cas9 in Crl:SD strain. The resulting mutation is a 16-bp deletion in the third exon of Ager. rn6.0:chr20:4,150,397-4,150,412. contact MCW Rat Distribution at [email protected]
Proper citation: RRID:RGD_152998995 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629142769
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 629142769
Notes: The is the wild type litter mate for the Dmd mutant: CD-Dmdem1Gene (RGD:629142768), Genethon; 1, bis rue de l’internationale23
91000 Evry, France
Proper citation: RRID:RGD_629142769 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629142768
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 629142768
Notes: The model was generated using a single guide RNA-Cas9 targeted to exon 45 of the rat Dmd gene on a Sprague-Dawley (CD®(SD), Crl:CD(SD)) background. One male founder with a 606 bp deletion encompassing Dmd exon 45 and spanning from 207 bp into the 3’ region of intron 44 to 223 bp into the 5’ region of intron 45,including exon 45, was selected for phenotyping. The heterozygous/hemizygous Dmd knock-out lines were used for breeding. Genethon; 1, bis rue de l’internationale23
91000 Evry, France
Proper citation: RRID:RGD_629142768 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=617301241
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2025-07-28)
References:
Synonyms:
Alternate IDs: 617301241
Notes: Crl:SD embryos were injected with CRISPR-Cas9 using guide RNA targeting the sequence AGGTCATGGATCTTCCAGCC. A 4-bp deletion in exon 2 (rn7: chr5:126,730,986-126,730,989) resulted. Dr. Noreen Rossi, Contact Email: [email protected]
Proper citation: RRID:RGD_617301241 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=616390066
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 616390066
Notes: To generate the 5p15.2 deletion in the rat, two CRISPR gRNAs were designed at syntenic loci in the rat genome: ATGTCGATGTCTTGTTAGGGTGG at Chr.2:83120000 (RGSC 6.0/rn6) and GCTGAGATGGCTTTCAGAAATGG at Chr.2:84800000 (RGSC 6.0/rn6), which induced ≈1.68 Mb chromosomal deletion. The Biocytogen Transgenic and Gene Targeting core injected 50 ng uL−1 of each gRNAs and 100 ng uL−1 Cas9 RNA into single‐cell SD rat zygotes. Embryos were cultured overnight and transferred to pseudopregnant females. PCR was used to screen for the deletion. PCR was performed using genomic ear or tail DNA, and the following primer pair: Proximal Forward‐TTGCTCAGCTGTTAAGGGAAACTAT and Distal Reverse‐TCATCAAAATGCACCAAAAGTGCAA (these primers generate ≈485 bp product). PCR primers were used to detect the breakpoint on the undeleted 5p15.2 interval (wild‐type allele): Proximal Forward‐TTGCTCAGCTGTTAAGGGAAACTAT and Proximal Reverse‐GGAGTAAGTCAACTGACTAGGGGACA (these primers generate ≈618 bp product).
Proper citation: RRID:RGD_616390066 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=617301243
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2025-07-28)
References:
Synonyms:
Alternate IDs: 617301243
Notes: Crl:SD embryos were injected with CRISPR-Cas9 using guide RNA targeting the sequence GAATACATTCAGAAGCGCTT. A 29-bp deletion in exon 5 (rn7: chr10:46,393,272-46,393,300) resulted. Dr. Noreen Rossi, Contact Email: [email protected]
Proper citation: RRID:RGD_617301243 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626170601
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2025-09-02)
References:
Synonyms:
Alternate IDs: 626170601
Notes: In collaboration with Horizon Discovery, we generated a CRISPR/Cas9-mediated deletion of a 1065bp region spanning Grin2a exon 8 (which encodes key pore forming domains of GluN2A) in Long Evans (LE) embryos, generating a KO allele. Simons Initiative for the Developing Brain (SIDB), Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH8 9XD, UK. Contact SIDB Scientific Officer for enquiries on rat distribution ([email protected]).
Proper citation: RRID:RGD_626170601 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629116668
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2025-12-09)
References:
Synonyms:
Alternate IDs: 629116668
Notes: The knock-in rat line was engineered to express the iCRE recombinase under the SLC6A9 locus. It was generated in SD background and maintain in this background for many generations. Rat Resource and Research Center
Proper citation: RRID:RGD_629116668 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626168268
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryorecovery (as of 2025-08-29)
References:
Synonyms:
Alternate IDs: 626168268
Notes: Deletion of the genetic interval Sult1a1-Spn of Sprague Dawley rat: we targeted an extended sequence of the whole locus from one allele and the CRISPR/Cas9 system allowed us to remove the region encompassing 28 genes, orthologous to human. European Mouse Mutant Archive(EMMA)
Proper citation: RRID:RGD_626168268 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629142772
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2025-12-30)
References:
Synonyms:
Alternate IDs: 629142772
Notes: Cas9 and sgRNA targeting the sequence GCTTTGCAACTTGTGCAGCA were injected into SS embryos to mutate a CTCF binding site within the first intron of Golt1a. a 3-bp deletion rn6 chr13:50,545,341-50,545,343 resulted. Custom Rats at Medical College of Wisconsin, Email: [email protected]
Proper citation: RRID:RGD_629142772 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629142773
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2025-12-30)
References:
Synonyms:
Alternate IDs: 629142773
Notes: Cas9 and sgRNA targeting the sequence GGGCATCTTCTGCCACCTAC were injected into SS embryos to mutate a CTCF binding site within the first intron of Ren. An 11-bp deletion rn6 chr13:50,509,649-50,509,659 resulted. Custom Rats at Medical College of Wisconsin, Email: [email protected]
Proper citation: RRID:RGD_629142773 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626469804
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo (as of 2025-09-17)
References:
Synonyms:
Alternate IDs: 626469804
Notes: This is a Tbx21 knockout rat created using ZFN technology targeting exon 1 coding sequences 378-412. The resulting mutation is a 22-bp deletion (392-413). Inotiv
Proper citation: RRID:RGD_626469804 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632517841
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2026-01-28)
References:
Synonyms:
Alternate IDs: 632517841
Notes: CRISPR/Cas9-mediated knock-in of an IRES-Cre cassette into the 3' UTR of the endogenous Oxtr gene. The line is maintained in the heterozygous state and preserves normal Oxtr expression. Availability Contact Email: [email protected],Central Institute of Mental Health
Proper citation: RRID:RGD_632517841 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=617148292
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2025-07-07)
References:
Synonyms:
Alternate IDs: 617148292
Notes: Four single guide RNAs and SpCas9 targeting sequences ATGAAGTGCCTAGCTTCATT, GAAGCTAGGCACTTCATCTA, ATTCATAATGGGACACTCGA, and CCCAGCCTCAGATTCATAAT flanking a chromosome 2 region distal to Npr3 were targeted in SS/JrHsdMcwi embryos. A 29,508 bp deletion in chromosome 2 (rn6: chr2:61,845,176-61,874,684) resulted, along with an insertion of 3 nucleotides (TGG). Please contact: [email protected]
Proper citation: RRID:RGD_617148292 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626419677
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo (as of 2025-09-05)
References:
Synonyms:
Alternate IDs: 626419677
Notes: Gnal knockout rats were generated by CRISPR/Cas9 technology. Exon1 of rat Gnal splicing variant 2 was targeted, resulting in a deletion of 1 base pair that corresponds to position 44 downstream of the translation start point ATG of the Gnal splicing variant 2. CRISPR technology details: self-synthesized Cas9 mRNA using px 330 vector, applying T7 transcription kit followed by Poly-Adenylation and Capping. No sequencing performed, whether Cas9 has been inserted into the rat genome is unknown. Homozygous:
Approximately 25% body weight reduction; Smaller body size; Hyperactivity; Better rotarod performance than wild-type littermates.Heterozygous:
No body weight change; No body size change; Hypo-activity; Worse rotarod performance than wild-type littermates. European Mouse Mutant Archive(EMMA)
Proper citation: RRID:RGD_626419677 Copy
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