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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00034624
Source Database: WormBase (WB)
Affected Genes: WBGene00007062(ebp-3)|WBGene00012156(ebp-2)|WBGene00013344(ebp-1)
Genomic Alteration: WBGene00007062(ebp-3), WBGene00012156(ebp-2), WBGene00013344(ebp-1)
Availability: available
Source References: EMPTY
Synonyms: ebp-2(he278) II; ebp-1 & Y59A8B.25 & ebp-3(he279) V.
Alternate IDs: WB-STRAIN:SV1877, CGC_SV1877
Notes: he278 is a CRISPR-induced deletion of ebp-2. he279 is a deletion removing ebp-1, Y59A8B.25 & ebp-3. Low penetrance of pleiotropic phenotypes among adults, including low frequency of dumpy, sterile and/or uncoordinated animals and nonviable larvae that explode through the vulva. Some adults develop irregularities that seem to represent epidermal bulges. Reference: Schmidt et al., J Cell Biol. 2017 Sep 4; 216(9): 27772793. doi: 10.1083/jcb.201607038
Proper citation: RRID:WB-STRAIN:WBStrain00034624 Copy
http://www.wormbase.org/db/get?name=WBStrain00034625
Source Database: WormBase (WB)
Availability: available
Source References: EMPTY
Synonyms: flvEx4.
Alternate IDs: WB-STRAIN:SWF5, CGC_SWF5
Notes: flvEx4 [rig-3p::wArchon1::GFP + sra-6::ChR2-GFP + elt-2p::nGFP]. Pick GFP+ to maintain. Voltage-sensor protein wArchon1 transgene injected into N2 background. Reference: Piatkevich KD, et al. Nature Chemical Biology. 2018. doi:10.1038/s41589-018-0004-9.|"Made_by: Steven Flavell"
Proper citation: RRID:WB-STRAIN:WBStrain00034625 Copy
http://www.wormbase.org/db/get?name=WBStrain00034629
Source Database: WormBase (WB)
Affected Genes: WBGene00004178(prg-1)|WBGene00006759(unc-22)
Genomic Alteration: WBGene00004178(prg-1), WBGene00006759(unc-22)
Availability: available
Source References: PMID:31839537
Synonyms: prg-1(n4357) I.
Alternate IDs: WB-STRAIN:SX158, CGC_SX158
Notes: 21U RNA expression abnormal. Temperature sensitive sterility. Transposon silencing abnormal. Superficially WT. Deletion breakpoints: GTTTTCTTTCCTTGGAGAGGT|"Mutagen:EMS/Tc3"|"Twitching due to transposon insertion in unc-22."|"Twitching due to transposon insertion in unc-22. [(07/16/2018) NOTE: A user has reported their PCR and sequence analysis suggest this strain contains does not still contain Tc3, but retains loss unc-22 function, apparently due to imprecise excision.]"
Proper citation: RRID:WB-STRAIN:WBStrain00034629 Copy
http://www.wormbase.org/db/get?name=WBStrain00034620
Source Database: WormBase (WB)
Affected Genes: WBGene00004203(swsn-1)|WBGene00006843(unc-119)
Genomic Alteration: WBGene00004203(swsn-1), WBGene00006843(unc-119)
Availability: available
Source References: PMID:32494730
Synonyms: unc-119(ed3) III; heIs105 IV; swsn-1(os22) heSi164 V; heSi141 X.
Alternate IDs: WB-STRAIN:SV1578, CGC_SV1578
Notes: heIs105 [rps-27::loxP::NLS::mCherry::let858 UTR::loxP::NLS::GFP::let-858 UTR + unc-119(+)] IV. heSi164 [rps-27::loxN::NLS::mCherry::let858 UTR::swsn-1p::swsn-1::unc-54 UTR::loxN::NLS::GFP::let-858 UTR + unc-119(+)] V. heSi141 [hlh-8(short)::FLAG::CRE::tbb-2 + unc-119(+)] X. Maintain the line at 15C and shift to 25C for mutant analysis. Expression of CRE recombinase in the mesoblast lineage driven by the hlh-8 promoter. heSi164 carries a swsn-1 rescue construct which ensures rescue of the temperature-sensitive swsn-1(os22) mutation. Upon expression of CRE (in this case in the mesoblast lineage) the swsn-1 gene will be excised, creating a mesoblast specific mutant of swsn-1. This recombination event can be visualized by a switch from red to green in those mesoblast cells in which swsn-1 was lost. The animals are healthy at 15C, but embryonic lethal and larval arrested at 23-25C. swsn-1(os22) causes mild overproliferation in the mesoblast lineage. The swsn-1 rescuing transgene is unable to rescue germline development of swsn-1(os22) mutants. Reference: Ruijtenberg S & van den Heuvel S. Cell. 2015 Jul 16;162(2):300-13.
Proper citation: RRID:WB-STRAIN:WBStrain00034620 Copy
http://www.wormbase.org/db/get?name=WBStrain00034678
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV. gtIs67.
Alternate IDs: WB-STRAIN:TG1756, CGC_TG1756
Notes: gtIs67 [pie-1p::GFP(lap)::sld-5 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034678 Copy
http://www.wormbase.org/db/get?name=WBStrain00034670
Source Database: WormBase (WB)
Affected Genes: WBGene00006643(tsp-17)
Genomic Alteration: WBGene00006643(tsp-17)
Availability: available
Source References: EMPTY
Synonyms: vtIs1 V; tsp-17(gt1681) X.
Alternate IDs: WB-STRAIN:TG1681, CGC_TG1681
Notes: vtIs1 [dat-1p::GFP + rol-6] V. Rollers. Reference: Masoudi N, et al. PLoS Genet. 2014 Dec 4;10(12):e1004767.
Proper citation: RRID:WB-STRAIN:WBStrain00034670 Copy
http://www.wormbase.org/db/get?name=WBStrain00034671
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs60.
Alternate IDs: WB-STRAIN:TG1749, CGC_TG1749
Notes: gtIs60 [pie-1p::GFP(lap)::orc-1 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034671 Copy
http://www.wormbase.org/db/get?name=WBStrain00034673
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs62.
Alternate IDs: WB-STRAIN:TG1751, CGC_TG1751
Notes: gtIs62 [pie-1p::GFP(lap)::cdc-6 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034673 Copy
http://www.wormbase.org/db/get?name=WBStrain00034675
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs64.
Alternate IDs: WB-STRAIN:TG1753, CGC_TG1753
Notes: gtIs64 [pie-1p::GFP(lap)::mcm-3 + unc-119(+)]. ltIs37 [(pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034675 Copy
http://www.wormbase.org/db/get?name=WBStrain00034676
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs65.
Alternate IDs: WB-STRAIN:TG1754, CGC_TG1754
Notes: gtIs65 [pie-1p::GFP(lap)::cdc-45 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034676 Copy
http://www.wormbase.org/db/get?name=WBStrain00034677
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs66.
Alternate IDs: WB-STRAIN:TG1755, CGC_TG1755
Notes: gtIs66 [pie-1p::GFP(lap)::div-1 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034677 Copy
http://www.wormbase.org/db/get?name=WBStrain00034680
Source Database: WormBase (WB)
Affected Genes: WBGene00018909(slx-1)
Genomic Alteration: WBGene00018909(slx-1)
Availability: available
Source References: PMID:36176234
Synonyms: slx-1(tm2644) I.
Alternate IDs: WB-STRAIN:TG1868, CGC_TG1868
Notes: Reference: Agostinho A, et al. PLos Genetics 2013.|"Supplementary_genotype slx-1(tm2644)"
Proper citation: RRID:WB-STRAIN:WBStrain00034680 Copy
http://www.wormbase.org/db/get?name=WBStrain00034602
Source Database: WormBase (WB)
Affected Genes: WBGene00000870(cyd-1)|WBGene00001072(dpy-10)|WBGene00004394(rol-1)|WBGene00006787(unc-52)
Genomic Alteration: WBGene00000870(cyd-1), WBGene00001072(dpy-10), WBGene00004394(rol-1), WBGene00006787(unc-52)
Availability: available
Source References: EMPTY
Synonyms: rol-1(e91) cyd-1(he112)/mnC1 [dpy-10(e28) unc-52(e444)] II.
Alternate IDs: WB-STRAIN:SV314, CGC_SV314
Notes: Heterozygotes are WT and segregate WT, DpyUncs, and rol-1 cyd-1 homozygotes which are thin, sterile, uncoordinated animals. rol-1 is largely suppressed by cyd-1. No postembryoinc cell divisions take place in cyd-1.
Proper citation: RRID:WB-STRAIN:WBStrain00034602 Copy
http://www.wormbase.org/db/get?name=WBStrain00034603
Source Database: WormBase (WB)
Affected Genes: WBGene00000383(cdc-14)
Genomic Alteration: WBGene00000383(cdc-14)
Availability: available
Source References: EMPTY
Synonyms: cdc-14(he118) II.
Alternate IDs: WB-STRAIN:SV327, CGC_SV327
Notes: Extra cell divisions within several cell lineages.|"Made_by: R.M. Saito"
Proper citation: RRID:WB-STRAIN:WBStrain00034603 Copy
http://www.wormbase.org/db/get?name=WBStrain00034605
Source Database: WormBase (WB)
Affected Genes: WBGene00003056(lon-2)|WBGene00006749(unc-9)
Genomic Alteration: WBGene00003056(lon-2), WBGene00006749(unc-9)
Availability: available
Source References: EMPTY
Synonyms: heDf1 maIs103/lon-2(e678) unc-9(e101) X.
Alternate IDs: WB-STRAIN:SV411, CGC_SV411
Notes: maIs103[rnr::GFP unc-36(+)] X. The heDf1 deletion includes cdk-4. Heterozygotes produce 1/4 thin, sterile, uncoordinated animals that fail to undergo postembryonic somatic cell divisions. heDf1 mutants are of L1 size, smaller than cdk-4 mutants. lon-2 and unc-9 do not exactly balance heDf1, but unc-9 is pretty close. It should also be possible to follow the heterozygotes by looking at the GFP. Despite trying, unable to separate the maIs integration from heDf1 or the other cdk-4 alleles. By maintaining animals with GFP (visible especially in early animals and in eggs) you should be able to maintain heDf1. rnr::GFP is expressed during S-phase in heterozygous animals. rnr::GFP expression is not detected in heDf1 animals. maIs103 is tightly linked to heDf1. Maintain by picking several single animals and scoring for 1/4 mutant progeny.
Proper citation: RRID:WB-STRAIN:WBStrain00034605 Copy
http://www.wormbase.org/db/get?name=WBStrain00034606
Source Database: WormBase (WB)
Affected Genes: WBGene00000383(cdc-14)
Genomic Alteration: WBGene00000383(cdc-14)
Availability: available
Source References: EMPTY
Synonyms: cdc-14(he141) II.
Alternate IDs: WB-STRAIN:SV557, CGC_SV557
Notes: Extra cell divisions within several cell lineages.|"Made_by: R.M. Saito"
Proper citation: RRID:WB-STRAIN:WBStrain00034606 Copy
http://www.wormbase.org/db/get?name=WBStrain00034681
Source Database: WormBase (WB)
Affected Genes: WBGene00016602(mus-81)|WBGene00018909(slx-1)
Genomic Alteration: WBGene00016602(mus-81), WBGene00018909(slx-1)
Availability: available
Source References: EMPTY
Synonyms: mus-81(tm1937) slx-1(tm2644) I.
Alternate IDs: WB-STRAIN:TG1878, CGC_TG1878
Notes: Reference: Agostinho A, et al. PLos Genetics 2013.
Proper citation: RRID:WB-STRAIN:WBStrain00034681 Copy
http://www.wormbase.org/db/get?name=WBStrain00034682
Source Database: WormBase (WB)
Affected Genes: WBGene00000254(bli-4)|WBGene00008140(xpf-1)|WBGene00016602(mus-81)
Genomic Alteration: WBGene00000254(bli-4), WBGene00008140(xpf-1), WBGene00016602(mus-81)
Availability: available
Source References: EMPTY
Synonyms: mus-81(tm1937) I/hT2 [bli-4(e937) let-?(q782) qIs48] (I;III); xpf-1(tm2842) II.
Alternate IDs: WB-STRAIN:TG1890, CGC_TG1890
Notes: Segregates WT GFP+ heterozygotes, non-GFP mus-81; xpf-1 double homozygotes, very rare GFP+ homozygous hT2, and dead eggs. Maintain by picking wild-type GFP+ to retain balanced strain: 15-25% of mus-81; xpf-1 double homozygotes are viable. unc-119(ed3) has likely been lost through outcrossing, but could still be present in the background. Reference: Agostinho A, et al. PLos Genetics 2013.
Proper citation: RRID:WB-STRAIN:WBStrain00034682 Copy
http://www.wormbase.org/db/get?name=WBStrain00034683
Source Database: WormBase (WB)
Affected Genes: WBGene00000254(bli-4)|WBGene00008140(xpf-1)|WBGene00018909(slx-1)
Genomic Alteration: WBGene00000254(bli-4), WBGene00008140(xpf-1), WBGene00018909(slx-1)
Availability: available
Source References: EMPTY
Synonyms: slx-1(tm2644) I/hT2 [bli-4(e937) let-?(q782) qIs48] (I;III); xpf-1(tm2842) II.
Alternate IDs: WB-STRAIN:TG1891, CGC_TG1891
Notes: Segregates WT GFP+ heterozygotes, non-GFP slx-1; xpf-1 double homozygotes, very rare GFP+ homozygous hT2, and dead eggs. Maintain by picking wild-type GFP+ to retain balanced strain: 15-25% of slx-1 xpf-1 double homozygotes are viable. Reference: Agostinho A, et al. PLos Genetics 2013.
Proper citation: RRID:WB-STRAIN:WBStrain00034683 Copy
http://www.wormbase.org/db/get?name=WBStrain00034684
Source Database: WormBase (WB)
Affected Genes: WBGene00000254(bli-4)|WBGene00001865(him-6)|WBGene00018909(slx-1)
Genomic Alteration: WBGene00000254(bli-4), WBGene00001865(him-6), WBGene00018909(slx-1)
Availability: unknown
Source References: EMPTY
Synonyms: slx-1(tm2644) I/hT2 [bli-4(e937) let-?(q782) qIs48] (I;III); him-6(ok412) IV.
Alternate IDs: WB-STRAIN:TG1975
Notes: Him. Heterozygotes are WT. Segregates WT GFP+ heterozygotes, non-GFP slx-1 homozygotes, very rare GFP+ homozygous hT2, and dead eggs. Maintain by picking wild-type GFP+ to retain balanced strain: 15-25% of slx-1(tm2644) homozygotes are viable. Reference: Agostinho A, et al. PLos Genetics 2013.
Proper citation: RRID:WB-STRAIN:WBStrain00034684 Copy
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