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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00034402
Source Database: WormBase (WB)
Affected Genes: WBGene00003172(mec-8)|WBGene00004895(smu-1)|WBGene00006787(unc-52)
Genomic Alteration: WBGene00003172(mec-8), WBGene00004895(smu-1), WBGene00006787(unc-52)
Availability: available
Source References: EMPTY
Synonyms: mec-8(u218) smu-1(mn602) I; unc-52(e669su250ts) II.
Alternate IDs: WB-STRAIN:SP2123, CGC_SP2123
Notes: Made_by: R Herman|"Temperature sensitive mec-8 allele, mechanosensory abnormal at 25 C. Reference: Spike CA, et al. Mol Cell Biol. 2001 Aug;21(15):4985-95."
Proper citation: RRID:WB-STRAIN:WBStrain00034402 Copy
http://www.wormbase.org/db/get?name=WBStrain00034490
Source Database: WormBase (WB)
Availability: available
Source References: EMPTY
Synonyms: ncIs17.
Alternate IDs: WB-STRAIN:ST66, CGC_ST66
Notes: Mutagen:Gamma rays|"ncIs17 contains [hsp-16.2::eGFP + pBluscript]. Superficially wild-type."
Proper citation: RRID:WB-STRAIN:WBStrain00034490 Copy
http://www.wormbase.org/db/get?name=WBStrain00034492
Source Database: WormBase (WB)
Availability: unknown
Source References: EMPTY
Synonyms: EMPTY
Alternate IDs: WB-STRAIN:ST205
Notes: EMPTY
Proper citation: RRID:WB-STRAIN:WBStrain00034492 Copy
http://www.wormbase.org/db/get?name=WBStrain00034450
Source Database: WormBase (WB)
Affected Genes: WBGene00004027(pie-1)
Genomic Alteration: WBGene00004027(pie-1)
Availability: unknown
Source References: EMPTY
Synonyms: EMPTY
Alternate IDs: WB-STRAIN:SS629
Notes: EMPTY
Proper citation: RRID:WB-STRAIN:WBStrain00034450 Copy
http://www.wormbase.org/db/get?name=WBStrain00034451
Source Database: WormBase (WB)
Affected Genes: WBGene00002059(ife-1)
Genomic Alteration: WBGene00002059(ife-1)
Availability: available
Source References: EMPTY
Synonyms: ife-1(bn127) III.
Alternate IDs: WB-STRAIN:SS712, CGC_SS712
Notes: Made_by: Dunkelbarger/Strome|"Mutagen:UV/TMP"|"Temperature sensitive sterility. Should be cultured at 15C or 20C. At 25C, spermatocytes fail in cytokinesis and accumulate as multinucleate cells unable to mature to spermatids. Milder defect in oogenesis is not temperature sensitive. Oocyte production is slowed, but appear relatively normal and are fertile. Inefficient translation of several maternal mRNAs (mex-1, oma-1, pos-1, and pal-1). Eukaryotic translation initiation factor 4E (eIF4E) gene (isoform 1, germ cell specific, P granule associated; F53A2.6). Homozygous 590 bp deletion starts at nt 191 in exon 1 and extends through exon 2 and into the 3' UTR to nt 780. The deletion removes over 70% of the coding region for IFE-1, including the helices and sheets that make up the mRNA platform and a Trp residue essential for m7GTP cap binding, suggesting it is a null mutation. Deletion breakpoint determined by sequencing by SS is: aagtggcctcaacgcgttgt"
Proper citation: RRID:WB-STRAIN:WBStrain00034451 Copy
http://www.wormbase.org/db/get?name=WBStrain00034452
Source Database: WormBase (WB)
Affected Genes: WBGene00003993(pgl-2)
Genomic Alteration: WBGene00003993(pgl-2)
Availability: available
Source References: EMPTY
Synonyms: pgl-2(bn123) III.
Alternate IDs: WB-STRAIN:SS727, CGC_SS727
Notes: Fertile at all temperatures.|"Mutagen:UV/TMP"
Proper citation: RRID:WB-STRAIN:WBStrain00034452 Copy
http://www.wormbase.org/db/get?name=WBStrain00034454
Source Database: WormBase (WB)
Affected Genes: WBGene00003992(pgl-1)|WBGene00003993(pgl-2)|WBGene00006761(unc-24)
Genomic Alteration: WBGene00003992(pgl-1), WBGene00003993(pgl-2), WBGene00006761(unc-24)
Availability: available
Source References: EMPTY
Synonyms: pgl-2(bn123) III; pgl-1(bn101) unc-24(e138) IV.
Alternate IDs: WB-STRAIN:SS730, CGC_SS730
Notes: Mutagen:UV/TMP|"Unc. Maintain at 15C. Sterile at higher temperatures."
Proper citation: RRID:WB-STRAIN:WBStrain00034454 Copy
http://www.wormbase.org/db/get?name=WBStrain00034455
Source Database: WormBase (WB)
Affected Genes: WBGene00001073(dpy-11)|WBGene00003993(pgl-2)|WBGene00003994(pgl-3)
Genomic Alteration: WBGene00001073(dpy-11), WBGene00003993(pgl-2), WBGene00003994(pgl-3)
Availability: available
Source References: EMPTY
Synonyms: pgl-2(bn123) III; pgl-3(bn104) dpy-11(e224) V.
Alternate IDs: WB-STRAIN:SS731, CGC_SS731
Notes: Dpy. Fertile at all temperatures.|"Mutagen:UV/TMP"
Proper citation: RRID:WB-STRAIN:WBStrain00034455 Copy
http://www.wormbase.org/db/get?name=WBStrain00034456
Source Database: WormBase (WB)
Affected Genes: WBGene00001073(dpy-11)|WBGene00003992(pgl-1)|WBGene00003993(pgl-2)|WBGene00003994(pgl-3)|WBGene00006761(unc-24)
Genomic Alteration: WBGene00001073(dpy-11), WBGene00003992(pgl-1), WBGene00003993(pgl-2), WBGene00003994(pgl-3), WBGene00006761(unc-24)
Availability: available
Source References: EMPTY
Synonyms: pgl-2(bn123) III; pgl-1(bn101) unc-24(e138) IV; pgl-3(bn104) dpy-11(e224) V.
Alternate IDs: WB-STRAIN:SS733, CGC_SS733
Notes: Dpy. Unc. Mostly sterile at all temperatures, but a small fraction are fertile at low temperatures. Maintain at 15C.|"Mutagen:UV/TMP"
Proper citation: RRID:WB-STRAIN:WBStrain00034456 Copy
http://www.wormbase.org/db/get?name=WBStrain00034457
Source Database: WormBase (WB)
Affected Genes: WBGene00001072(dpy-10)|WBGene00002229(klp-19)
Genomic Alteration: WBGene00001072(dpy-10), WBGene00002229(klp-19)
Availability: available
Source References: PMID:36617680
Synonyms: klp-19(bn126)/mT1 [dpy-10(e128)] III.
Alternate IDs: WB-STRAIN:SS746, CGC_SS746
Notes: Heterozygotes are WT and segregate WT, Dpys (mT1 homozygotes) and L1 lethals (bn126 homozygotes). klp-19 deletion is 435 bases between TTCACAGTGTTCGTGGAGAA and GCAAGGAATCGCGCCGGCT. klp-19 deletion is lethal over hT2.|"Mutagen:UV/TMP"|"Supplementary_genotype klp-19(bn126)mT1[dpy-10(e128)] III."
Proper citation: RRID:WB-STRAIN:WBStrain00034457 Copy
http://www.wormbase.org/db/get?name=WBStrain00034469
Source Database: WormBase (WB)
Affected Genes: WBGene00001148(eat-20)
Genomic Alteration: WBGene00001148(eat-20)
Availability: available
Source References: PMID:10655217
Synonyms: eat-20(nc4)
Alternate IDs: WB-STRAIN:ST6, CGC_ST6
Notes: Starved appearance: shorter body length, pale intestine, reduced pharyngeal pumping, smaller brood size and extended egg-laing period.
Proper citation: RRID:WB-STRAIN:WBStrain00034469 Copy
http://www.wormbase.org/db/get?name=WBStrain00034461
Source Database: WormBase (WB)
Affected Genes: WBGene00003405(mre-11)
Genomic Alteration: WBGene00003405(mre-11)
Availability: available
Source References: EMPTY
Synonyms: mre-11(iow1)/nT1[qIs51] (IV;V).
Alternate IDs: WB-STRAIN:SSM2, CGC_SSM2
Notes: Heterozygotes are wild-type with pharyngeal GFP signal, and segregate wild-type GFP, arrested nT1[qIs51] aneuploids, and non-GFP iow1 homozygotes (viable; see note below). Homozygous nT1[qIs51] inviable. Pick wild-type GFP and check for correct segregation of progeny to maintain. iow1 is a separation-of-function allele of mre-11. Homozygotes develop into adults wild-type in appearance, but laying dead eggs due to defects in meiotic DSB repair: mre-11(iow1) worms form meiotic DSBs but are impaired in their resection. Pick GFP+ to maintain (mre-11(iow1)/nT1[qIs51]) and GFP- to obtain homozygous mre-11(iow1) worms for analysis. Reference: Yin Y & Smolikove S. Mol Cell Biol. 2013 Jul;33(14):2732-47. doi: 10.1128/MCB.00055-13. Epub 2013 May 13. Erratum in: Mol Cell Biol. 2015 Jul;35(14):2568. PubMed PMID: 23671188; PubMed Central PMCID: PMC3700128.|"Mutagen:UV/TMP"
Proper citation: RRID:WB-STRAIN:WBStrain00034461 Copy
http://www.wormbase.org/db/get?name=WBStrain00034463
Source Database: WormBase (WB)
Affected Genes: WBGene00009731(exo-1)
Genomic Alteration: WBGene00009731(exo-1)
Availability: available
Source References: PMID:36176234
Synonyms: exo-1(tm1842) III.
Alternate IDs: WB-STRAIN:SSM72, CGC_SSM72
Notes: Reference: Yin Y & Smolikove S. Mol Cell Biol. 2013 Jul;33(14):2732-47.|"Supplementary_genotype exo-1(tm1842)"
Proper citation: RRID:WB-STRAIN:WBStrain00034463 Copy
http://www.wormbase.org/db/get?name=WBStrain00034464
Source Database: WormBase (WB)
Affected Genes: WBGene00004297(rad-51)
Genomic Alteration: WBGene00004297(rad-51)
Availability: available
Source References: EMPTY
Synonyms: rad-51(iow53[GFP::rad-51]) IV/nT1[qIs51] (IV;V).
Alternate IDs: WB-STRAIN:SSM264, CGC_SSM264
Notes: Heterozygotes are wild-type with pharyngeal-expressed GFP, and segregate wild-type GFP+(pharynx) heterozygotes, arrested nT1[qIs51] homozygotes, and viable non-GFP(pharynx) rad-51(iow53[GFP::rad-51]) homozygotes. Balancer is prone to breaking down. If a population contains a mix of bright and dim GFP animals, pick dim GFP and check for correct segregation of progeny to maintain. iow53 inserted a GFP tag at the N-terminus of the endogenous rad-51 locus, but the tagged protein is not fully functional. non-GFP(pharynx) rad-51(iow53[GFP::rad-51]) homozygotes form GFP foci in the germline that are mostly spo-11 dependent, and GFP::rad-51 homozygotes have defects in unloading RAD-51. Created by CRISPR using pDD282, therefore may also contain 3XFLAG. Reference: Koury E, et al. Nucleic Acids Res. 2018 Jan 25;46(2):748-764.|"Made_by: Matthew Wheat and Emily Koury"
Proper citation: RRID:WB-STRAIN:WBStrain00034464 Copy
http://www.wormbase.org/db/get?name=WBStrain00034466
Source Database: WormBase (WB)
Affected Genes: WBGene00006706(ubc-9)
Genomic Alteration: WBGene00006706(ubc-9)
Availability: available
Source References: EMPTY
Synonyms: ubc-9(iow31[3xFLAG::ubc-9]) IV/nT1[qIs51] (IV;V)
Alternate IDs: WB-STRAIN:SSM291, CGC_SSM291
Notes: Heterozygotes are wild type with pharyngeal-expressed GFP, and segregate wild type GFP+ heterozygotes, arrested nT1[qIs51] homozygotes, and viable non-GFP ubc-9(iow31[3xFLAG::ubc-9]) homozygotes. ubc-9(iow31[3xFLAG::ubc-9]) homozygotes produce 100% dead embryos, but cytologically they have normal germline (examined by DAPI and RAD-51 staining), suggesting that 3xFLAG::ubc-9 is functional in the gonad but not in the non-maternally rescued embryo. Maintain the strain by picking GFP+ worms. 3XFLAG bas added by CRISPR/Cas9. Synonymous point mutation where included in the repair template (positions 30, 33 and 36 of coding sequence). Reference: Reichman R, et al. Genetics. 2018 Apr;208(4):1421-1441.|"Made_by: Rachel Reichman"|"No longer available from the CGC"
Proper citation: RRID:WB-STRAIN:WBStrain00034466 Copy
http://www.wormbase.org/db/get?name=WBStrain00034436
Source Database: WormBase (WB)
Affected Genes: WBGene00001072(dpy-10)|WBGene00003220(mes-2)|WBGene00006744(unc-4)|WBGene00006787(unc-52)
Genomic Alteration: WBGene00001072(dpy-10), WBGene00003220(mes-2), WBGene00006744(unc-4), WBGene00006787(unc-52)
Availability: available
Source References: PMID:1783292, PMID:37818613
Synonyms: mes-2(bn11) unc-4(e120)/mnC1 [dpy-10(e128) unc-52(e444)] II.
Alternate IDs: WB-STRAIN:SS186, CGC_SS186
Notes: Heterozygotes are WT and segregate WT, DpyUnc and Uncs which give sterile progeny (maternal effect sterile: the progeny from mutant mothers are sterile). The mutation is a strict mel, fully penetrant, and fully expressed. Sterility is due to a failure in germ-cell proliferation.|"Supplementary_genotype mes-2(bn11); unc-4(e120)/mnC1[dpy-10(e128) unc-52(e444)] II"
Proper citation: RRID:WB-STRAIN:WBStrain00034436 Copy
http://www.wormbase.org/db/get?name=WBStrain00034437
Source Database: WormBase (WB)
Affected Genes: WBGene00003221(mes-3)
Genomic Alteration: WBGene00003221(mes-3)
Availability: available
Source References: PMID:1783292
Synonyms: mes-3(bn21) I.
Alternate IDs: WB-STRAIN:SS222, CGC_SS222
Notes: Strict maternal effect sterile at 25C. TSP during embryogenesis. The progeny of homozygous mothers, raised at the restrictive temperature, are sterile. Sterile worms have dramatic reduction in number of germ cells (10-100 fold less than WT).
Proper citation: RRID:WB-STRAIN:WBStrain00034437 Copy
http://www.wormbase.org/db/get?name=WBStrain00034438
Source Database: WormBase (WB)
Affected Genes: WBGene00001864(him-5)|WBGene00006752(unc-13)
Genomic Alteration: WBGene00001864(him-5), WBGene00006752(unc-13)
Availability: available
Source References: EMPTY
Synonyms: unc-13(e51) I; him-5(e1490) V; nDp4 (I;V)/+.
Alternate IDs: WB-STRAIN:SS230, CGC_SS230
Notes: Animals with the Duplication are WT. Animals which have lost the Duplication are Unc. Throws males.
Proper citation: RRID:WB-STRAIN:WBStrain00034438 Copy
http://www.wormbase.org/db/get?name=WBStrain00034439
Source Database: WormBase (WB)
Affected Genes: WBGene00001067(dpy-5)|WBGene00003221(mes-3)
Genomic Alteration: WBGene00001067(dpy-5), WBGene00003221(mes-3)
Availability: available
Source References: PMID:1783292
Synonyms: mes-3(bn35) dpy-5(e61) I; sDp2 (I;f).
Alternate IDs: WB-STRAIN:SS262, CGC_SS262
Notes: Animals with the Duplication have a WT phenotype. Animals which have lost the Duplication are Dpy and give sterile Dpy progeny. Strict maternal effect sterile. Sterile worms have a dramatic reduction in number of germs cells (10-100 fold less than WT). See also WBPaper00002343.
Proper citation: RRID:WB-STRAIN:WBStrain00034439 Copy
http://www.wormbase.org/db/get?name=WBStrain00034431
Source Database: WormBase (WB)
Affected Genes: WBGene00001803(lite-1)|WBGene00004010(pha-1)
Genomic Alteration: WBGene00001803(lite-1), WBGene00004010(pha-1)
Availability: available
Source References: EMPTY
Synonyms: pha-1(e2123) III; lite-1(ce314) X; sraEx329.
Alternate IDs: WB-STRAIN:SRS329, CGC_SRS329
Notes: sraEx329 [odr-2(18)p::chop-2(H134R)::TagRFP + odr-2(18)p::mKO + pBX(pha-1(+))]. Maintain at 25C. This transgenic line expresses mKO and TagRFP in SMB in the head, and has little response to blue light in the absence of ATR. In the presence of ATR asymmetrical stimulation of SMB causes the worm to turn in the same direction the head was bent when SMB was excited. Reference: Kocabas A, et al. Nature. 2012 Sep 23. doi: 10.1038/nature11431.
Proper citation: RRID:WB-STRAIN:WBStrain00034431 Copy
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