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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.bioconductor.org/packages/release/bioc/html/flowFP.html
A Bioconductor software package for fingerprint generation of flow cytometry data, used to facilitate the application of machine learning and datamining tools for flow cytometry.
Proper citation: flowFP (RRID:SCR_001537) Copy
http://cran.r-project.org/web/packages/MCMC.qpcr/
Software package that implements generalized linear mixed model analysis of qRT-PCR data based on lognormal-Poisson model fitted using MCMC. Control genes are not required but can be incorporated as Bayesian priors or, when template abundances correlate with conditions, as trackers of global effects (common to all genes). Also implemented are the lognormal model for higher-abundance data and a classic model involving multi-gene normalization on a by-sample basis. Several plotting functions are included to extract and visualize results.
Proper citation: MCMC.qpcr (RRID:SCR_001721) Copy
http://www-personal.umich.edu/~jianghui/rseqdiff/
An R package that can detect differential gene and isoform expressions from RNA-seq data of multiple biological conditions. The approach considers three cases for each gene: 1) no differential expression, 2) differential expression without differential splicing and 3) differential splicing.
Proper citation: rSeqDiff (RRID:SCR_001683) Copy
https://cran.r-project.org/src/contrib/Archive/QuasiSeq/
Software package to apply the QL, QLShrink and QLSpline methods to quasi-Poisson or quasi-negative binomial models for identifying differentially expressed genes in RNA-seq data.
Proper citation: QuasiSeq (RRID:SCR_001715) Copy
A computer algorithm to predict aggregation nucleating regions in proteins as well the effect of mutations and environmental conditions on the aggregation propensity of these regions.
Proper citation: TANGO (RRID:SCR_001770) Copy
http://bioinformatics.dreamhosters.com/?page_id=113#Genomic_Protein_Sequence_Analysis
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 10th,2023. An M software package for Clustering 16S rRNA sequences into operational taxonomic units (OTUs). The download link contain the package and some benchmark data sets.
Proper citation: MSClust (RRID:SCR_001773) Copy
http://cufflinks.cbcb.umd.edu/
Software that estimates expression at transcript-level resolution and controls for variability evident across replicate libraries.
Proper citation: Cuffdiff (RRID:SCR_001647) Copy
http://sourceforge.net/projects/pennseq/
Software for isoform-specific gene expression quantification in RNA-Seq by modeling non-uniform read distribution. Instead of making parametric assumptions, they give adequate weight to the underlying data by the use of a non-parametric approach. The rationale is that regardless what factors lead to non-uniformity, whether it is due to hexamer priming bias, local sequence bias, positional bias, RNA degradation, mapping bias or other unknown reasons, the probability that a fragment is sampled from a particular region will be reflected in the aligned data. This empirical approach thus maximally reflects the true underlying non-uniform read distribution.
Proper citation: PennSeq (RRID:SCR_001763) Copy
http://www.bioconductor.org/packages/release/bioc/html/SLqPCR.html
Software functions for analysis of real-time quantitative PCR data at SIRS-Lab GmbH.
Proper citation: SLqPCR (RRID:SCR_001669) Copy
https://github.com/shka/R-SAMstrt
Software package that provides the significance analysis of sequencing data with spike-in normalization. The statistical backgrounds and the benefits depend on SAMseq of the samr package.
Proper citation: SAMstrt (RRID:SCR_001780) Copy
http://ccb.jhu.edu/software/ASprofile/
A suite of programs for extracting, quantifying and comparing alternative splicing (AS) events from RNA-seq data.
Proper citation: ASprofile (RRID:SCR_001833) Copy
http://www.genome.duke.edu/labs/ohler/research/NASTIseq/
Software for integrated detection of natural antisense transcripts using strand-specific RNA sequencing data.
Proper citation: NASTIseq (RRID:SCR_001797) Copy
http://www.bioconductor.org/packages/release/bioc/html/OrderedList.html
An R / bioconductor package for detecting similarity in ordered gene lists. Thereby, either simple lists can be compared or gene expression data can be used to deduce the lists. Significance of similarities is evaluated by shuffling lists or by resampling in microarray data, respectively.
Proper citation: OrderedList (RRID:SCR_001834) Copy
Software environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
Proper citation: R Project for Statistical Computing (RRID:SCR_001905) Copy
https://github.com/benedictpaten/pecan
A Java consistency based multiple sequence alignment software program.
Proper citation: Pecan (RRID:SCR_001909) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowClust.html
A Bioconductor software package for automated gating of flow cytometry data that implements a robust model-based clustering approach based on multivariate t mixture models with the Box-Cox transformation.
Proper citation: flowClust (RRID:SCR_001807) Copy
http://www.nesys.uio.no/Atlas3D/
A splice alignment software tool of RNA-Seq reads mapping.
Proper citation: HSA (RRID:SCR_001809) Copy
http://www.bioconductor.org/packages/release/bioc/html/COMPASS.html
Software for combinatorial polyfunctionality analysis of single cells. It is a statistical framework that enables unbiased analysis of antigen-specific T-cell subsets. It uses a Bayesian hierarchical framework to model all observed cell-subsets and select the most likely to be antigen-specific while regularizing the small cell counts that often arise in multi-parameter space. The model provides a posterior probability of specificity for each cell subset and each sample, which can be used to profile a subject's immune response to external stimuli such as infection or vaccination.
Proper citation: COMPASS (RRID:SCR_001801) Copy
http://www.agcol.arizona.edu/software/tcw/
Software package for assembling, annotating, querying, and comparing transcript and expression level data that consists of two parts: * singleTCW (sTCW): Single transcript sets or assemblies; annotation; differential expression (EdgeR, DEGSeq, DESeq, GoSeq) * multiTCW (mTCW): Comparison of multiple transcript sets; ortholog grouping (e.g., OrthoMCL) It has been tested on Linux and uses Java, mySQL and optionally R.
Proper citation: TCW (RRID:SCR_001875) Copy
https://www.bioinformatics.babraham.ac.uk/projects/seqmonk/
Software tool to visualize and analyse high throughput mapped sequence data.
Proper citation: SeqMonk (RRID:SCR_001913) Copy
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