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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
Multivariate Analysis of Transcript Splicing
 
Resource Report
Resource Website
100+ mentions
Multivariate Analysis of Transcript Splicing (RRID:SCR_013049) MATS software application, software resource, data analysis software, data processing software Software tool to detect differential alternative splicing events from RNA-Seq data. Calculates P value and false discovery rate that difference in isoform ratio of gene between two conditions exceeds given user defined threshold. Can automatically detect and analyze alternative splicing events corresponding to all major types of alternative splicing patterns. Handles replicate RNA-Seq data from both paired and unpaired study design. Differential alternative splicing events, splicing events calculation, RNA-Seq data, gene isoform ratio, alternative splicing patterns, patterns detection, patterns analysis, replicate RNA-Seq data is listed by: OMICtools
is listed by: SourceForge
has parent organization: Childrens Hospital of Philadelphia - Research Institute; Pennsylvania; USA
Free, Available for download, Freely available OMICS_01336, SCR_020941 SCR_013049 RNAseq MATS, RMATS, rMATS, MATS, RNA MATS 2026-07-28 09:43:10 192
Probalign
 
Resource Report
Resource Website
10+ mentions
Probalign (RRID:SCR_013332) Probalign software application, software resource, data processing software, alignment software, image analysis software THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software that uses partition function posterior probability estimates to compute maximum expected accuracy multiple sequence alignments. Computes maximal expected accuracy multiple sequence alignments from partition function posterior probabilities.Produces accurate alignments on long and heterogeneous length datasets containing protein repeats. is used by: eProbalign
is listed by: OMICtools
is listed by: Debian
has parent organization: New Jersey Institute of Technology; New Jersey; USA
PMID:16954142
DOI:10.1093/bioinformatics/btl472
THIS RESOURCE IS NO LONGER IN SERVICE OMICS_00985 https://sources.debian.org/src/probalign/ SCR_013332 Probalign: multiple sequence alignment using partition function posterior probabilities 2026-07-28 09:43:15 16
AcroMine
 
Resource Report
Resource Website
AcroMine (RRID:SCR_013196) service resource, software resource, data access protocol, web service An acronym dictionary which can be used to find distinct expanded forms of acronyms from MEDLINE. This freely available service can be used through your browser or by integrating it with your applications using the ReSTful service. Acromine identifies abbreviation definitions by assuming a word sequence co-occurring frequently with a parenthetical expression to be a potential expanded form. Applied to the whole MEDLINE (9,635,599 abstracts), the implemented system extracted 68,007 abbreviation candidates and recognized 467,402 expanded forms. The current Acromine achieves 99% precision and 82-95% recall on our evaluation corpus that roughly emulates the whole MEDLINE. acronym, abbreviation, disambiguation, computational linguistics, text mining is listed by: FORCE11
is listed by: OMICtools
has parent organization: University of Manchester; Manchester; United Kingdom
JISC ;
BBSRC ;
EPSRC
PMID:20360059
PMID:17050571
Free, Public OMICS_01169, nif-0000-10215 SCR_013196 Acromine 2026-07-28 09:43:11 0
Cufflinks
 
Resource Report
Resource Website
5000+ mentions
Cufflinks (RRID:SCR_014597) software application, data analysis software, sequence analysis software, software resource, data processing software Software tool for transcriptome assembly and differential expression analysis for RNA-Seq. Includes script called cuffmerge that can be used to merge together several Cufflinks assemblies. It also handles running Cuffcompare as well as automatically filtering a number of transfrags that are likely to be artifacts. If the researcher has a reference GTF file, the researcher can provide it to the script to more effectively merge novel isoforms and maximize overall assembly quality. transcriptome, rna-seq, rna seq, cuffmerge, cufflink, cuffcompare, transfrags, artifacts, gtf file, transcriptome assembly, expression analysis, bio.tools, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
is listed by: SoftCite
works with: GeneScissors
is hosted by: GitHub
DOI:10.1038/nbt.1621 Acknowledgement requested, Source code available on GitHub biotools:cufflinks, OMICS_01304, SCR_013307 https://github.com/cole-trapnell-lab/cufflinks, https://bio.tools/cufflinks, https://sources.debian.org/src/cufflinks/ SCR_014597 2026-07-28 09:43:54 8838
Prokka
 
Resource Report
Resource Website
1000+ mentions
Prokka (RRID:SCR_014732) software application, data analysis software, sequence analysis software, software resource, data processing software THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software tool for the rapid annotation of prokaryotic genomes. It produces GFF3, GBK and SQN files that are ready for editing in Sequin and ultimately submitted to Genbank/DDJB/ENA. A typical 4 Mbp genome can be fully annotated in less than 10 minutes on a quad-core computer, and scales well to 32 core SMP systems., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. annotation, prokaryote, genome, prokaryotic genome, sequence analysis software, annotation software, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
DOI:10.1093/bioinformatics/btu153 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_04220, biotools:prokka https://bio.tools/prokka, https://sources.debian.org/src/prokka/, https://sources.debian.org/src/prokka/ SCR_014732 2026-07-28 09:43:55 4876
Qvalue
 
Resource Report
Resource Website
10+ mentions
Qvalue (RRID:SCR_001073) software application, software resource, data analysis software, data processing software R package that takes a list of p-values resulting from the simultaneous testing of hypotheses and estimates their q-values. It is designed to measure the proportion of false positives when a test is significant. The software is capable of generating plots for visualization. It can be applied to problems in genomics, brain imaging, astrophysics, and data mining. p value, false positive, null hypothesis, genomics, brain imaging, astrophysics, data mining, r, visualization is listed by: OMICtools
is hosted by: Bioconductor
Free, Available for download, Freely available OMICS_00624 https://github.com/jdstorey/qvalue SCR_001073 2026-07-28 09:40:11 31
ToppCluster
 
Resource Report
Resource Website
100+ mentions
ToppCluster (RRID:SCR_001503) ToppCluster service resource, resource, data analysis service, production service resource, analysis service resource A tool for performing multi-cluster gene functional enrichment analyses on large scale data (microarray experiments with many time-points, cell-types, tissue-types, etc.). It facilitates co-analysis of multiple gene lists and yields as output a rich functional map showing the shared and list-specific functional features. The output can be visualized in tabular, heatmap or network formats using built-in options as well as third-party software. It uses the hypergeometric test to obtain functional enrichment achieved via the gene list enrichment analysis option available in ToppGene. term enrichment, gene, analysis, gene enrichment analysis, connectivity, heatmap, ortholog, microarray, function, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: GenitoUrinary Development Molecular Anatomy Project
is related to: ToppGene Suite
NIDDK 1U01DK70219;
NIDDK P30DK078392;
NCRR U54 RR025216;
NIDCR U01DE020049
PMID:20484371 Free OMICS_02225, nlx_152801, biotools:toppcluster https://bio.tools/toppcluster SCR_001503 ToppCluster: A multiple gene list feature analyzer for the dissection of biological systems 2026-07-28 09:40:12 144
StatAlign
 
Resource Report
Resource Website
1+ mentions
StatAlign (RRID:SCR_001892) software application, data analysis software, sequence analysis software, software resource, data processing software Software package for Bayesian analysis of protein, DNA and RNA sequences. It utilizes multiple alignments, phylogenetic trees and evolutionary parameters to quantify uncertainty in these analyses. It is written in Java. software package, bayesian, protein, dna, rna, sequencing, java, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB)
PMID:23335014 Free, Available for download, Freely available biotools:StatAlign, OMICS_03743 https://bio.tools/StatAlign SCR_001892 StatAlign 2.0 2026-07-28 09:40:27 1
GRS
 
Resource Report
Resource Website
1+ mentions
GRS (RRID:SCR_001008) software application, data analysis software, software resource, data management software, data processing software A compression tool for efficient storage of Genome Re-Sequencing data. GRS processes genome sequence data without use of reference SNPs and other variants. It can also automatically rebuild the individual genome sequence data using the reference genome sequence. data analysis software, data management software, compression tool, data compression, storage, genome, resequencing is listed by: OMICtools THIS RESOURCE IS NO LONGER IN SERVICE OMICS_00960 SCR_001008 2026-07-28 09:40:10 2
FACTA+.
 
Resource Report
Resource Website
1+ mentions
FACTA+. (RRID:SCR_001767) FACTA+ service resource, software resource, data access protocol, web service Text mining tool to discover associations between biomedical concepts from MEDLINE articles. Use the service from your browser or via a Web Service. The whole MEDLINE corpus containing more than 20 million articles is indexed with an efficient text search engine, and it allows you to navigate such associations and their textual evidence in a highly interactive manner - the system accepts arbitrary query terms and displays relevant concepts immediately. A broad range of important biomedical concepts are covered by the combination of a machine learning-based term recognizer and large-scale dictionaries for genes, proteins, diseases, and chemical compounds. There is also a FACTA+ visualization service that can be found here: http://www.nactem.ac.uk/facta-visualizer/ text mining, gene, protein, disease, symptom, drug, enzyme, compound, biomedical, association, machine learning, chemical, text-mining software, bio.tools is listed by: OMICtools
is listed by: FORCE11
is listed by: bio.tools
is listed by: Debian
is related to: MEDLINE
has parent organization: National Centre for Text Mining
JISC PMID:18772154 Free, Freely available biotools:facta_plus, nif-0000-10272, OMICS_01181 http://refine1-nactem.mc.man.ac.uk/facta/, https://bio.tools/facta_plus SCR_001767 Finding Associated Concepts with Text Analysis 2026-07-28 09:40:16 2
NTAP
 
Resource Report
Resource Website
10+ mentions
NTAP (RRID:SCR_001488) NTAP software application, software resource, data analysis software, data processing software THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 23,2022. Software for tiling array data analysis to survey the genome-wide binding sites of transcription factor HY5 in Arabidopsis and the genome-wide histone modifications/DNA methylation level in rice. It was developed in the process of generating NimbleGen analysis. Written in R and Perl. software, tiling array, data analysis, rice, arabidopsis, hy5, transcription factor, genome is listed by: OMICtools
has parent organization: Peking University; Beijing; China
PMID:19468055 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_00808 SCR_001488 NimbleGen Tiling array Analysis Package, NimbleGen Tilingarray Analysis Package 2026-07-28 09:40:12 10
FusionCatcher
 
Resource Report
Resource Website
1+ mentions
FusionCatcher (RRID:SCR_000060) software application, data analysis software, sequence analysis software, software resource, data processing software Software that searches for novel/known fusion genes, translocations, and chimeras in RNA-seq data (paired-end reads from Illumina NGS platforms like Solexa and HiSeq) from diseased samples. fusion gene, known fusion gene, translocation, chimera, rna-seq data, hiseq, solexa, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
DOI:10.1101/011650 Free, Available for download, Freely available biotools:fusioncatcher, OMICS_01348 https://github.com/ndaniel/fusioncatcher/blob/master/doc/manual.md, https://bio.tools/fusioncatcher http://code.google.com/p/fusioncatcher/ SCR_000060 2026-07-28 09:39:56 7
Dissect
 
Resource Report
Resource Website
Dissect (RRID:SCR_000058) Dissect software application, software resource, data processing software, alignment software, image analysis software THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. Software transcriptome-to-genome alignment tool, which can identify and characterize transcriptomic events such as duplications, inversions, rearrangements and fusions. Structural events containing transcripts, transcriptome-to-genome alignment, identify and characterize transcriptomic events, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
has parent organization: Simon Fraser University; British Columbia; Canada
PMID:22689759 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01346, biotools:dissect https://bio.tools/dissect SCR_000058 Dissect: DIScovery of Structural Events Containing Transcripts, DIScovery of Structural Events Containing Transcripts 2026-07-28 09:39:55 0
RAVEN
 
Resource Report
Resource Website
100+ mentions
RAVEN (RRID:SCR_001937) RAVEN service resource, data or information resource, data analysis service, database, production service resource, analysis service resource Tool to search for putative regulatory genetic variation in your favorite gene. Single nucleotide polymorphisms (SNPs) (from dbSNP and user defined) are analyzed for overlap with potential transcription factor binding sites (TFBS) and phylogenetic footprinting using UCSC phastCons scores from multiple alignments of 8 vertebrate genomes., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. transcription factor binding site, phylogenetic footprint, regulatory sequence variation, genetic variation, in silico, regulatory sequence, FASEB list uses: Embassy-domsearch
is listed by: OMICtools
has parent organization: University of British Columbia; British Columbia; Canada
PMID:18208319 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01932 SCR_001937 Regulatory analysis of Variation in Enhancers, RAVEN - Regulatory analysis of Variation in ENhancers 2026-07-28 09:40:28 127
cpnDB: A Chaperonin Database
 
Resource Report
Resource Website
1+ mentions
cpnDB: A Chaperonin Database (RRID:SCR_002263) cpnDB service resource, data or information resource, data analysis service, database, production service resource, analysis service resource A curated collection of chaperonin sequence data collected from public databases or generated by a network of collaborators exploiting the cpn60 target in clinical, phylogenetic and microbial ecology studies. The database contains all available sequences for both group I and group II chaperonins. Users can search the database by Chaperonin type, group (I or II), BLAST, or other options, and can also enter and analyze FASTA sequences. chaperonin sequence, microbial ecology, phylogenetics, chaperonin, plastid, mitochondria, cytoplasm, sequence, blast, fasta, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
Canadian Biotechnology Strategy ;
National Research Council Genomics and Health Initiative
PMID:15289485 Free, Freely available biotools:cpndb, OMICS_01511, nif-0000-02694 https://bio.tools/cpndb http://www.cpndb.ca/cpnDB/home.php SCR_002263 2026-07-28 09:40:23 3
Pathosystems Resource Integration Center
 
Resource Report
Resource Website
1000+ mentions
Pathosystems Resource Integration Center (RRID:SCR_004154) PATRIC service resource, data or information resource, data analysis service, database, production service resource, analysis service resource, bioinformatics resource center A Bioinformatics Resource Center bacterial bioinformatics database and analysis resource that provides researchers with an online resource that stores and integrates a variety of data types (e.g. genomics, transcriptomics, protein-protein interactions (PPIs), three-dimensional protein structures and sequence typing data) and associated metadata. Datatypes are summarized for individual genomes and across taxonomic levels. All genomes, currently more than 10 000, are consistently annotated using RAST, the Rapid Annotations using Subsystems Technology. Summaries of different data types are also provided for individual genes, where comparisons of different annotations are available, and also include available transcriptomic data. PATRIC provides a variety of ways for researchers to find data of interest and a private workspace where they can store both genomic and gene associations, and their own private data. Both private and public data can be analyzed together using a suite of tools to perform comparative genomic or transcriptomic analysis. PATRIC also includes integrated information related to disease and PPIs. The PATRIC project includes three primary collaborators: the University of Chicago, the University of Manchester, and New City Media. The University of Chicago is providing genome annotations and a PATRIC end-user genome annotation service using their Rapid Annotation using Subsystem Technology (RAST) system. The National Centre for Text Mining (NaCTeM) at the University of Manchester is providing literature-based text mining capability and service. New City Media is providing assistance in website interface development. An FTP server and download tool are available. genomics, genome, transcriptomics, protein-protein interaction, sequence typing, proteobacteria, brucella, rickettsia, coxiella, coronavirus, calicivirus, lyssavirus, virus, hepatitis a, hepatitis e, pathway, proteome, metabolic pathway, drug, vaccine, diagnostics, FASEB list is listed by: OMICtools
has parent organization: Virginia Polytechnic Institute and State University; Virginia; USA
NIAID PMID:24225323
PMID:17142235
Free, Public, Acknowledgement requested r3d100010142, OMICS_01658, nlx_17476 http://patricbrc.vbi.vt.edu/portal/portal/patric/Home, https://doi.org/10.17616/R3WS3X http://patric.vbi.vt.edu/ SCR_004154 PathoSystems Resource Integration Center, PATRIC, Pathosystems Resource Integration Center 2026-07-28 09:40:53 1083
RegulonDB
 
Resource Report
Resource Website
100+ mentions
RegulonDB (RRID:SCR_003499) RegulonDB data or information resource, database Database on transcriptional regulation in Escherichia coli K-12 containing knowledge manually curated from original scientific publications, complemented with high throughput datasets and comprehensive computational predictions. Graphic and text-integrated environment with friendly navigation where regulatory information is always at hand. They provide integrated views to understand as well as organized knowledge in computable form. Users may submit data to make it publicly available. transcription, gene regulation, operon, bacteria, evolutionary conservation, regulatory phrase, transcriptional regulation, transcriptional regulatory network, bio.tools, FASEB list is listed by: OMICtools
is listed by: 3DVC
is listed by: bio.tools
is listed by: Debian
has parent organization: National Autonomous University of Mexico; Mexico City; Mexico
NIGMS GM071962;
NIGMS GM077678;
Consejo Nacional de Ciencia y Tecnologia 103686;
Consejo Nacional de Ciencia y Tecnologia 179997;
Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica IN210810;
Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica IN209312
PMID:23203884 nif-0000-03399, OMICS_01868, biotools:regulondb https://bio.tools/regulondb SCR_003499 2026-07-28 09:40:48 148
Gene Weaver
 
Resource Report
Resource Website
10+ mentions
Gene Weaver (RRID:SCR_003009) analysis service resource, service resource, data or information resource, data repository, data analysis service, database, production service resource, storage service resource Freely accessible phenotype-centered database with integrated analysis and visualization tools. It combines diverse data sets from multiple species and experiment types, and allows data sharing across collaborative groups or to public users. It was conceived of as a tool for the integration of biological functions based on the molecular processes that subserved them. From these data, an empirically derived ontology may one day be inferred. Users have found the system valuable for a wide range of applications in the arena of functional genomic data integration. phenotype, microarray, gene, genome, functional genomics, process, pathway, function, gene set, genomic data integration, analysis, visualization is used by: NIF Data Federation
is used by: Integrated Datasets
is listed by: OMICtools
is related to: Integrated Manually Extracted Annotation
has parent organization: Jackson Laboratory
Integrative Neuroscience Initiative on Alcoholism ;
NIAAA U01 AA13499;
NIAAA U24 AA13513;
NIAAA R01 AA18776
PMID:22080549
PMID:19733230
Free, Freely available r3d100012464, OMICS_02232, nif-0000-00517 http://ontologicaldiscovery.org/, https://doi.org/10.17616/R3248T SCR_003009 GeneWeaver, GeneWeaver - A system for the integration of functional genomics experiments, Ontological Discovery Environment, GeneWeaver.org 2026-07-28 09:40:34 34
YLoc
 
Resource Report
Resource Website
10+ mentions
YLoc (RRID:SCR_002464) YLoc service resource, data analysis service, data access protocol, software resource, production service resource, web service, analysis service resource An interpretable web server for predicting subcellular localization. In addition to the predicted location, YLoc gives a reasoning why this prediction was made and which biological properties of the protein sequence lead to this prediction. Moreover, a confidence estimate helps users to rate predictions as trustworthy. YLoc+ is able to predict the location of multiple-targeted proteins with high accuracy. The YLoc webserver is also accessible via SOAP. subcellular localization, protein is listed by: OMICtools
has parent organization: University of Tubingen; Tubingen; Germany
PMID:20507917
PMID:20299325
Acknowledgement requested OMICS_01638 SCR_002464 Yloc - Interpretable Subcellular Localization Prediction 2026-07-28 09:40:26 36
ngLOC
 
Resource Report
Resource Website
10+ mentions
ngLOC (RRID:SCR_003150) ngLOC service resource, data analysis service, software resource, production service resource, analysis service resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 5, 2023.An n-gram-based Bayesian classifier that predicts subcellular localization of proteins both in prokaryotes and eukaryotes. The downloadable version of this software with source code is freely available for academic use under the GNU General Public License. subcellular localization, protein, eukaryote, prokaryote, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
PMID:22780965
PMID:17472741
THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01629, biotools:ngloc https://bio.tools/ngloc SCR_003150 ngLOC - A Bayesian method for predicting protein subcellular localization 2026-07-28 09:40:44 22

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