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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
MS-GF+
 
Resource Report
Resource Website
100+ mentions
MS-GF+ (RRID:SCR_015646) software resource Software that performs peptide identification by scoring MS/MS spectra against peptides derived from a protein sequence database. protein idenitification, peptide sequence, ms, ms spectrum, proteomic, bio.tools, FASEB list is listed by: Debian
is listed by: bio.tools
has parent organization: Pacific Northwest National Laboratory
NCRR RR018522;
NCRR 1-P41-RR024851;
NIAID ;
W.R. Wiley Environmental Molecular Science Laboratory
PMID:25358478 Free, Available for download, Acknowledgment requested biotools:ms-gf https://github.com/sangtaekim/msgfplus, https://bio.tools/ms-gf SCR_015646 MSGF+, MSGFPlus 2026-07-25 12:08:11 155
CharProtDB: Characterized Protein Database
 
Resource Report
Resource Website
CharProtDB: Characterized Protein Database (RRID:SCR_005872) CharProtDB database, data or information resource The Characterized Protein Database, CharProtDB, is designed and being developed as a resource of expertly curated, experimentally characterized proteins described in published literature. For each protein record in CharProtDB, storage of several data types is supported. It includes functional annotation (several instances of protein names and gene symbols) taxonomic classification, literature links, specific Gene Ontology (GO) terms and GO evidence codes, EC (Enzyme Commisssion) and TC (Transport Classification) numbers and protein sequence. Additionally, each protein record is associated with cross links to all public accessions in major protein databases as ��synonymous accessions��. Each of the above data types can be linked to as many literature references as possible. Every CharProtDB entry requires minimum data types to be furnished. They are protein name, GO terms and supporting reference(s) associated to GO evidence codes. Annotating using the GO system is of importance for several reasons; the GO system captures defined concepts (the GO terms) with unique ids, which can be attached to specific genes and the three controlled vocabularies of the GO allow for the capture of much more annotation information than is traditionally captured in protein common names, including, for example, not just the function of the protein, but its location as well. GO evidence codes implemented in CharProtDB directly correlate with the GO consortium definitions of experimental codes. CharProtDB tools link characterization data from multiple input streams through synonymous accessions or direct sequence identity. CharProtDB can represent multiple characterizations of the same protein, with proper attribution and links to database sources. Users can use a variety of search terms including protein name, gene symbol, EC number, organism name, accessions or any text to search the database. Following the search, a display page lists all the proteins that match the search term. Click on the protein name to view more detailed annotated information for each protein. Additionally, each protein record can be annotated. protein, annotation, functional annotation, taxonomic classification, literature, gene ontology, evidence code, enzyme commission, transport classification, protein sequence, bio.tools is listed by: Debian
is listed by: bio.tools
is related to: Gene Ontology
has parent organization: J. Craig Venter Institute
NHGRI R01 HG004881;
NIAID contract HHSN266200100038C
PMID:22140108 biotools:charprotdb, nlx_149421 https://bio.tools/charprotdb SCR_005872 Characterized Protein Database 2026-07-25 12:11:41 0
Database of Antimicrobial Activity and Structure of Peptides
 
Resource Report
Resource Website
10+ mentions
Database of Antimicrobial Activity and Structure of Peptides (RRID:SCR_016600) DBAASP database, data or information resource Collection of manually curated data regarding structure and antimicrobial activity of natural and synthetic peptides. Provides the information and analytical resources to develop antimicrobial compounds with the high therapeutic index. data, collection, structure, antimicrobial, activity, natural, synthetic, peptide, sequence NIAID G2102;
Shota Rustaveli National Science Foundation FR397718014;
International Science and Technology Center
PMID:26578581
PMID:27060142
Free, Freely available SCR_016600 DataBase of Antimicrobial Activity and Structure of Peptides, Database of Antimicrobial Activity and Structure of Peptides 2026-07-25 12:12:11 42
ImmGen
 
Resource Report
Resource Website
100+ mentions
ImmGen (RRID:SCR_021792) database, data or information resource Project combines immunology and computational biology laboratories in effort to establish complete road map of gene-expression and regulatory networks in all immune cells. Project will generate, with rigorously standardized conditions, complete compendium of genome-wide data sets showing expression of protein-coding genes for all defined cell populations of mouse immune system. gene expression, regulatory networks, all immune cells, protein coding genes, mouse immune system NIAID R24 AI072073 PMID:18800157
PMID:32978299
Free, Freely available SCR_021792 Immunological Genome Project 2026-07-25 12:12:16 258
ApiDB CryptoDB
 
Resource Report
Resource Website
10+ mentions
ApiDB CryptoDB (RRID:SCR_013455) ApiDB CryptoDB database, data or information resource An integrated genomic and functional genomic database for the parasite Cryptosporidium. CryptoDB integrates whole genome sequence and annotation along with experimental data and environmental isolate sequences provided by community researchers. The database includes supplemental bioinformatics analyses and a web interface for data-mining. Organisms included in CryptoDB are Cryptosporidium parvum, Cryptosporidium hominis, Cryptosporidium muris and environmental isolate sequences from numerous species. CryptoDB is allied with the databases PlasmoDB and ToxoDB via ApiDB, an NIH/NIAID-funded Bioinformatics Resource Center. Tools include: * BLAST: Identify Sequence Similarities * Sequence Retrieval: Retrieve Specific Sequences using IDs and coordinates * PubMed and Entrez: View the Latest Cryptosporidium Pubmed and Entrez Results * Genome Browser: View Sequences and Features in the genome browser * CryptoCyc: Explore Automatically Defined Metabolic Pathways * Searches via Web Services: Web service access to our data cryptosporidium parvum, cryptosporidium, cryptosporidium genome, cryptosporidium orf, cryptosporidium sage tag alignments, cryptosporidium snp, genomic sequence, dna motif, snp, est, orf, data set, bio.tools uses: SynView
is listed by: 3DVC
is listed by: Debian
is listed by: bio.tools
has parent organization: Eukaryotic Pathogen Database Resources
NIAID contract HHSN266200400037C PMID:16381902 nif-0000-02698, biotools:cryptodb, r3d100012265 https://bio.tools/cryptodb http://cryptodb.org/ SCR_013455 CryptoDB, Cryptosporidium Genomics Resource 2026-07-25 12:12:07 25
Cytokine Registry
 
Resource Report
Resource Website
1+ mentions
Cytokine Registry (RRID:SCR_014368) database, data or information resource A registry of cytokines, chemokines, and receptors generated for the purpose of collecting, integrating, and mapping between entity names and synonyms from several resources. These resources include MeSH, the Protein Ontology, EntrezGene, HGNC, MGI, UniProt and others. cytokine, registry, innate immune system, chemokine, receptor uses: UniProt
uses: MeSH
uses: Plant Ontology
uses: Mouse Genome Informatics (MGI)
uses: HGNC
uses: Entrez Gene
is affiliated with: The Immunology Database and Analysis Portal (ImmPort)
has parent organization: University of California at San Francisco; California; USA
NIAID ;
NIH ;
Department of Health and Human Services
Acknowledgement required, Registry file is available for download SCR_014368 ImmPort Cytokine Registry 2026-07-25 12:12:09 1
EPIMHC
 
Resource Report
Resource Website
1+ mentions
EPIMHC (RRID:SCR_016279) database, data or information resource Database of naturally processed MHC-restricted peptide ligands and epitopes for customized computational vaccinology. mhc, peptide, ligand, eiptope, vaccine, vaccinology, virology, t cell, immunogenic, molecule, virus NIAID AI50900;
NIAID AI43649;
Molecular Immunology Foundation
PMID:15657103 Freely available, The research community can contribute to this resource SCR_016279 EPIMHC Database 2026-07-25 12:12:12 4
Human Immunology Project Consortium
 
Resource Report
Resource Website
10+ mentions
Human Immunology Project Consortium (RRID:SCR_001491) HIPC organization portal, consortium, portal, data or information resource Consortium established to capitalize on recent advances in immune profiling methods in order to create a novel public resource that characterizes diverse states of the human immune system following infection; prior to and following vaccination against an infectious disease; or prior to and following treatment with an immune adjuvant that targets a known innate immune receptor(s). Through this program, well-characterized human cohorts are studied using a variety of modern analytic tools, including multiplex transcriptional, cytokine, and proteomic assays; multiparameter phenotyping of leukocyte subsets; assessment of leukocyte functional status; and multiple computational methods. Centralized research resources and a comprehensive, centralized database will be constructed for use by the greater scientific community. The information gained from the program will provide a comprehensive understanding of the human immune system and its regulation, and will reveal novel associations between components of the immune system and other biological systems, identify novel immune mediators and pathways, establish predictors of vaccine safety in different populations, and enable the rapid evaluation of different vaccine formulations and administration regimens in human populations. immune profiling, immune system, infection, vaccine, infectious disease, immune adjuvant, immune receptor, multiplex assay, phenotyping, systems biology, mass spectrometry, regulation, mediator, pathway, database, leukocyte, transcriptome, proteome is parent organization of: ImmuneSpace Infection, Vaccination, Treatment with immune adjuvant NIAID Free, Freely available SciRes_000173 SCR_001491 immune profiling, immuneprofiling.org 2026-07-26 09:02:59 17
Tree-Based Pipeline Optimization Tool
 
Resource Report
Resource Website
1+ mentions
Tree-Based Pipeline Optimization Tool (RRID:SCR_017531) TPOT software resource, software toolkit Software Python package to automate building of ML pipelines by combining flexible expression tree representation of pipelines with stochastic search algorithms such as genetic programming. Automated, machine, learning, optimize, pipeline, genetic, programming NIAID R01 AI117694 Free, Available for download, Freely available SCR_017532 https://epistasislab.github.io/tpot/, https://github.com/EpistasisLab/tpot SCR_017531 Tree based Pipeline Optimization Tool 2026-07-25 12:13:05 1
MassQL
 
Resource Report
Resource Website
1+ mentions
MassQL (RRID:SCR_025106) software resource, source code Software application for universal searching of Mass Spectrometry data. Open source MS query language for flexible and mass spectrometer manufacturer-independent mining of MS data. Implements common MS terminology to build consensus vocabulary to search for MS patterns in single mass spectrometry run. Enables set of mass spectrometry patterns to be queried directly from raw data. Mass Spectrometry data searching, mass spectrometry data, mining of MS data, common MS terminology, mass spectrometry patterns, raw data query, NIGMS R01 GM125943;
NIGMS R01 GM107550;
NIGMS R35 GM128690;
NIAID R21 AI156669;
NIAID R15 AI137996;
NSF ;
Burroughs Wellcome Fund ;
University of Michigan ;
National Research Foundation of Korea ;
German Research Foundation ;
Swedish Research Council ;
Ministry of Innovative Development of the Republic of Uzbekistan ;
German Ministry for Education and Research ;
Horizon 2020 programme of the European Union ;
Czech Science Foundation ;
U.S. Department of Energy Joint Genome Institute ;
National Cancer Center Research and Development Fund ;
AMED Japan Program for Infectious Diseases Research and Infrastructure ;
Novo Nordisk Foundation ;
Denmark ;
Betty and Gordon Moore Foundation
DOI:10.1101/2022.08.06.503000 Free, Available for download, Freely available https://pypi.org/project/massql/ SCR_025106 Mass Spec Query Language 2026-07-25 12:14:51 1
IBEX Knowledge Base
 
Resource Report
Resource Website
1+ mentions
IBEX Knowledge Base (RRID:SCR_025296) knowledge base Open, global repository as central resource for reagents, protocols, panels, publications, software, and datasets. In addition to IBEX, we support standard, single cycle multiplexed imaging (Multiplexed 2D imaging), volume imaging of cleared tissues with clearing enhanced 3D (Ce3D), highly multiplexed 3D imaging (Ce3D-IBEX), and extension of the IBEX dye inactivation protocol to the Leica Cell DIVE (Cell DIVE-IBEX). Committed to sharing knowledge related to multiplexed imaging. Antibody validation community knowledgebase. Antibody, validation, multiplexed imaging, NCI ;
NIAID ;
Schroeder Allergy and Immunology Research Institute ;
McMaster University ;
CA ;
Chan Zuckerberg Initiative ;
Wellcome Trust
Free, Freely available https://zenodo.org/records/7693279 SCR_025296 Iterative Bleaching Extends Multiplexity (IBEX) Knowledge-Base 2026-07-25 12:14:56 3
Sparse Inverse Covariance Estimation for Ecological Association Inference
 
Resource Report
Resource Website
10+ mentions
Sparse Inverse Covariance Estimation for Ecological Association Inference (RRID:SCR_022646) SPIEC-EASI software resource, software toolkit Software R package estimates inverse covariance matrix from sequencing data.Statistical method for inference of microbial ecological networks from amplicon sequencing datasets. inverse covariance matrix estimation, sequencing data, microbial ecological networks inference, amplicon sequencing datasets microbial ecological networks, NIAID T32AI007180;
NIDDK R01 DK103358;
NIGMS RO1 GM63270;
Simons Foundation
PMID:25950956 Free, Available for download, Freely available SCR_022646 SParse InversE Covariance Estimation for Ecological Association Inference 2026-07-25 12:13:09 12
SingleR
 
Resource Report
Resource Website
100+ mentions
SingleR (RRID:SCR_023120) software resource, software toolkit Software R package for unbiased cell type recognition of scRNA-seq data. Performs unbiased cell type recognition from single-cell RNA sequencing data, by leveraging reference transcriptomic datasets of pure cell types to infer cell of origin of each single cell independently. unbiased cell type recognition, scRNA-seq data, reference transcriptomic datasets, pure cell types, infer cell of origin UCSF Marcus Award ;
NHLBI HL131560;
UCSF Nina Ireland Program award ;
NHLBI HL139897;
NIAID
PMID:30643263 Free, Available for download, Freely available https://github.com/dviraran/SingleR, https://github.com/LTLA/SingleR SCR_023120 Single-cell RNA-seq cell types Recognition 2026-07-25 12:13:10 321
DADA2
 
Resource Report
Resource Website
500+ mentions
DADA2 (RRID:SCR_023519) software resource, software toolkit Open source software R package for modeling and correcting Illumina sequenced amplicon errors. Fast and accurate sample inference from amplicon data with single nucleotide resolution. modeling and correcting amplicon errors, Illumina sequenced amplicon errors, amplicon errors, sample inference, amplicon data, single nucleotide resolution is used by: ImmuMicrobiome
is related to: dadasnake
has parent organization: Stanford University; Stanford; California
NSF ;
NIAID R01AI112401;
Samarth Foundation
PMID:27214047 Free, Available for download, Freely available https://bioconductor.org/packages/dada2/ SCR_023519 2026-07-25 12:13:12 960
ATHLATES
 
Resource Report
Resource Website
1+ mentions
ATHLATES (RRID:SCR_023689) software resource, software toolkit Software package for determining HLA genotypes for individuals from Illumina exome sequencing data. Program applies assembly, allele identification and allelic pair inference to short read sequences, and applies it to data from Illumina platforms. Illumina, HLA genotypes determination, Illumina exome sequencing data, allele identification, allelic pair inference, short read sequence, Washington University School of Medicine ;
NIAID ;
National Institutes of Health ;
Department of Health and Human Services
PMID:23748956 Free, Available for download, Freely available SCR_023689 2026-07-25 12:13:13 3
drug perturbation Gene Set Enrichment Analysis
 
Resource Report
Resource Website
1+ mentions
drug perturbation Gene Set Enrichment Analysis (RRID:SCR_025351) dpGSEA software resource, source code Software tool to detect phenotypically relevant drug targets through unique transcriptomic enrichment that emphasizes biological directionality of drug-derived gene sets. Exploratory tool to screen for possible drug targeting molecules. detect phenotypically relevant drug targets, drug-derived gene sets, transcriptomic enrichment, NHLBI T32HL007567;
NIAID P30AI036219
DOI:10.1186/s12859-020-03929-0 Free, Available for download, Freely available SCR_025351 2026-07-25 12:14:57 1
Mixed effects association testing for single cells
 
Resource Report
Resource Website
1+ mentions
Mixed effects association testing for single cells (RRID:SCR_025632) MASC software resource, source code Software tool for testing whether specified covariate influences membership of single cells in any of multiple cellular subsets while accounting for technical confounds and biological variation. specified covariate, influences membership, single cells, multiple cellular subsets, accounting for technical confounds and biological variation, NIAMSD UH2AR067677;
NIAID U19AI111224;
NIAMSD 1R01AR063759;
NIAMSD R01 AR064850;
Doris Duke Charitable Foundation ;
NIAMSD T32 AR007530;
William Docken Inflammatory Autoimmune Disease Fund ;
Ruth L. Kirschstein National Research Service Award ;
Rheumatology Research Foundation Tobe and Stephen Malawista
PMID:30333237 SCR_025632 , Mixed-effects modeling of Associations of Single Cells, Mixed-effects Association testing for Single Cells 2026-07-25 12:15:05 2
Dynamic Regulatory Events Miner
 
Resource Report
Resource Website
1+ mentions
Dynamic Regulatory Events Miner (RRID:SCR_003080) DREM software application, software resource, data processing software The Dynamic Regulatory Events Miner (DREM) allows one to model, analyze, and visualize transcriptional gene regulation dynamics. The method of DREM takes as input time series gene expression data and static transcription factor-gene interaction data (e.g. ChIP-chip data), and produces as output a dynamic regulatory map. The dynamic regulatory map highlights major bifurcation events in the time series expression data and transcription factors potentially responsible for them. DREM 2.0 was released and supports a number of new features including: * new static binding data for mouse, human, D. melanogaster, A. thaliana * a new and more flexible implementation of the IOHMM supports dynamic binding data for each time point or as a mix of static/dynamic TF input * expression levels of TFs can be used to improve the models learned by DREM * the motif finder DECOD can be used in conjuction with DREM and help find DNA motifs for unannotated splits * new features for the visualization of expressed TFs, dragging boxes in the model view, and switching between representations transcription, gene regulation, dynamics, time series, gene expression, static, dynamic, transcription factor-gene interaction, chip-chip, transcription factor, regulatory network, hidden markov model, systems biology, gene regulatory network, times series expression data, dynamic network, chip-seq has parent organization: Carnegie Mellon University; Pennsylvania; USA NIH ;
NIGMS 1RO1 GM085022;
NIAID DNO1 AI-5001;
NSF 0448453
PMID:22897824 Free, Available for download, Freely available nif-0000-30478 SCR_003080 Dynamic Regulatory Events Miner (DREM) 2026-07-26 09:03:21 5
Short Time-series Expression Miner (STEM)
 
Resource Report
Resource Website
50+ mentions
Short Time-series Expression Miner (STEM) (RRID:SCR_005016) STEM software application, software resource, data processing software The Short Time-series Expression Miner (STEM) is a Java program for clustering, comparing, and visualizing short time series gene expression data from microarray experiments (~8 time points or fewer). STEM allows researchers to identify significant temporal expression profiles and the genes associated with these profiles and to compare the behavior of these genes across multiple conditions. STEM is fully integrated with the Gene Ontology (GO) database supporting GO category gene enrichment analyses for sets of genes having the same temporal expression pattern. STEM also supports the ability to easily determine and visualize the behavior of genes belonging to a given GO category or user defined gene set, identifying which temporal expression profiles were enriched for these genes. (Note: While STEM is designed primarily to analyze data from short time course experiments it can be used to analyze data from any small set of experiments which can naturally be ordered sequentially including dose response experiments.) Platform: Windows compatible, Mac OS X compatible, Linux compatible, Unix compatible statistical analysis, term enrichment, visualization, cluster, compare, short time series, gene expression, microarray, expression profile, gene, gene ontology, gene enrichment analyses, FASEB list is listed by: Gene Ontology Tools
is related to: Gene Ontology
has parent organization: Carnegie Mellon University; Pennsylvania; USA
NIAID NO1 AI-5001;
NSF 0448453
PMID:16597342
PMID:15961453
Open unspecified license - Free for academic use nlx_97053 SCR_005016 Short Time-series Expression Miner 2026-07-26 09:03:50 81
DICOMConvert
 
Resource Report
Resource Website
DICOMConvert (RRID:SCR_014100) software application, software resource, standalone software A DICOM image converter based on the ITK IO mechanism for reading and writing images. The formats currently supported by the converter are DICOM to: Analyze (*.hdr); MetaImage (*.mhd); Nrrd (*.nhdr, *.nrrd). standalone software, dicom, image converter is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
has parent organization: National Institutes of Health
Center for Infectious Disease Imaging ;
NIAID ;
NIBIB
Available for download SCR_014100 Dicom Converter 2026-07-26 09:06:02 0

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