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URL: http://www.wormbase.org/db/get?name=WBStrain00007654
Proper Citation: RRID:WB-STRAIN:WBStrain00007654
Description: Caenorhabditis elegans with name sec-5(pk2357)/dpy-10(e128) II. from WB.
Species: Caenorhabditis elegans
Synonyms: sec-5(pk2357)/dpy-10(e128) II.
Notes: Heterozygotes segregate wild-type heterozygotes, Dpy, and sec-5 homozygotes (scrawny, small broods, abnormal gut appearance) sec-5 is homozygous maternal-effect lethal; M+Z- animals produce a few dead L1-L2 stage larvae with Vab defects. Based upon phenotype, pk2357 is a strong loss-of-function, but likely not a null allele; molecular lesion produces a premature stop at position 389. Reference: Frische EW, et al. EMBO J. 2007 Dec 12;26(24):5083-92. [NOTE: This strain was previously described as carrying pk2358, but pk2357 is the correct allele. Both pk2357 and pk2358 cause the same nonsense (amber) change.]
Affected Gene: WBGene00001072(dpy-10)|WBGene00004752(sec-5)
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Source: Integrated Animals
Source Database: WormBase (WB)
