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URL: http://www.wormbase.org/db/get?name=WBStrain00000276
Proper Citation: RRID:WB-STRAIN:WBStrain00000276
Description: Caenorhabditis elegans with name me8 X. from WB.
Species: Caenorhabditis elegans
Synonyms: me8 X.
Notes: Homozygotes produce 10-15% XO male self progeny; nondisjuction is correlated with an increased frequency of achiasmate X chromosomes in oocyte nuclei, and an unaltered distribution of X chromosome crossovers. Heterozygotes produce 1-2% male self-progeny. Homozygotes (and XO hemizygotes) are slower growing than WT; reduced male mating efficiency. me8 disrupts the function of the cis-acting X chromosome meiotic pairing center. Molecular studies show that the me8 chromosome carries a terminal deletion that removes >70 kb from the left end of the X chromosome, including the endogenous telomere; further, a segment of chromosome V has been translocated to the left end of X, and a new telomere has been added de novo to the end of the translocated segment.
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Source: Integrated Animals
Source Database: WormBase (WB)
