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URL: http://www.wormbase.org/db/get?name=WBStrain00040706
Proper Citation: RRID:WB-STRAIN:WBStrain00040706
Description: Caenorhabditis elegans with name mrt-1(yp2) I. from WB.
Species: Caenorhabditis elegans
Synonyms: mrt-1(yp2) I.
Notes: yp2 mutation perturbs the MRT-1 DNA-binding domain. Mortal germline. Progressive telomere shortening due to telomerase dysfunction. Hypersensitive to DNA interstrand crosslinking agents. This strain will becomce sterile after propagating 10-20 generations. mrt-1 mutants can be rejuvenated by outcrossing. Reference: Meier B, et al. EMBO J. 2009 Nov 18;28(22):3549-63.|"yp2 mutation perturbs the MRT-1 DNA-binding domain. Mortal germline. Progressive telomere shortening due to telomerase dysfunction. Hypersensitive to DNA interstrand crosslinking agents. This strain will become sterile after propagating 10-20 generations. mrt-1 mutants can be rejuvenated by outcrossing. Reference: Meier B, et al. EMBO J. 2009 Nov 18;28(22):3549-63."
Affected Gene: WBGene00045237(mrt-1)
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Source: Integrated Animals
Source Database: WormBase (WB)
