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Proper Citation: RRID:MGI:5517354
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: decreased mature B cell number, increased IgG3 level, decreased follicular B cell number, abnormal B cell physiology, increased IgM level, increased T cell proliferation, abnormal T cell morphology, abnormal T cell physiology, abnormal B cell activation, abnormal B cell differentiation, abnormal T cell differentiation, abnormal lung morphology, abnormal salivary gland morphology, abnormal thymus morphology, autoimmune response, abnormal B cell morphology, decreased B cell apoptosis, increased anti-double stranded DNA antibody level, increased anti-insulin autoantibody level, increased double-positive T cell number, enlarged spleen, glomerulonephritis, immune system phenotype, increased B cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased germinal center B cell number, increased inflammatory response, increased interleukin-2 secretion, increased physiological sensitivity to xenobiotic, increased regulatory T cell number, increased spleen germinal center size, increased transitional stage T1 B cell number, premature death, spleen hyperplasia, thymus hyperplasia, vasculitis, increased IgG1 level, increased IgE level, increased B cell proliferation
Affected Gene: Ptpn22
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No rating or validation information has been found for Ptpn22tm1.1Draw/Ptpn22tm1.1Draw.
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
