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Organism Name
RRID:RGD_288084580 RRID Copied  
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RRID:RGD_288084580
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Organism Information

URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=288084580

Proper Citation: RRID:RGD_288084580

Description: Rattus norvegicus with name F344-Txn1m1Kyo from RGD.

Species: Rattus norvegicus

Notes: This mutation Phe54Leu is an autosomal dominant mutation that appeared in a stock of F344/NSlc rats that had been mutagenized with N-ethyl-N-nitrosourea (ENU). Rats heterozygous for Txn1 (Txn1 /+) exhibited running seizures only in its juvenile stage. The rat called Adem rat, exhibited age dependent mitochondrial cytopathy (Adem). The rats were backcrossed for more than ten generations on the F344/NSlc inbred background to ensure other mutations induced by ENU was reduced. The causative gene was identified as a missense substitution (c. 160 T > C, p. Phe54Leu) in exon 3 of Txn1.

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Ratings and Alerts

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Data and Source Information

Source: Integrated Animals

Source Database: Rat Genome Database (RGD)