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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=288084580
Proper Citation: RRID:RGD_288084580
Description: Rattus norvegicus with name F344-Txn1m1Kyo from RGD.
Species: Rattus norvegicus
Notes: This mutation Phe54Leu is an autosomal dominant mutation that appeared in a stock of F344/NSlc rats that had been mutagenized with N-ethyl-N-nitrosourea (ENU). Rats heterozygous for Txn1 (Txn1 /+) exhibited running seizures only in its juvenile stage. The rat called Adem rat, exhibited age dependent mitochondrial cytopathy (Adem). The rats were backcrossed for more than ten generations on the F344/NSlc inbred background to ensure other mutations induced by ENU was reduced. The causative gene was identified as a missense substitution (c. 160 T > C, p. Phe54Leu) in exon 3 of Txn1.
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)