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Cancer Research UK Cambridge Institute Pre-Clinical Genome Editing Core Facility (RRID:SCR_028661)Copy Citation Copied
URL: https://www.cruk.cam.ac.uk/core-facilities/pre-clinical-genome-editing/
Proper Citation: Cancer Research UK Cambridge Institute Pre-Clinical Genome Editing Core Facility (RRID:SCR_028661)
Description: Core facility provides genome editing services in vitro and in vivo for translational cancer research. Services span functional genomics (CRISPR screens across cells, organoids and patient-derived xenograft models, integrated with single-cell RNA sequencing), transgenics (embryo manipulation, pronuclear injection, electroporation, cryopreservation, and import/export of genetically modified models), and multimodal pre-clinical trials run through a dedicated Small Animal Hospital using genetically engineered, xenograft and orthotopic models. Offers experimental design consultation to match editing technologies to each research question.
Resource Type: core facility, service resource, access service resource
Keywords: ABRF, genome editing services, in vitro, in vivo, translational cancer research, functional genomics, CRISPR screens, cells, organoids, patient-derived xenograft models, single-cell RNA sequencing,
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