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It is a Company Limited by Guarantee comprising golf handicapping experts from all the Golf Unions and Associations that administer golf in Great Britain and Ireland. A golf handicap allows players of all levels of golfing ability to compete against each other on a fair and equal basis. Thus a handicap system is effectively essential to the popularity and prosperity of the game of Amateur Golf. The System developed and refined by the Council of National Golf Unions (CONGU) provides a player with a golf handicap that reflects their playing ability relative to that of all other players handicapped by the CONGU Handicapping System. In 2004 CONGU incorporated Ladies golf handicaps within the system and this effectively completed the objective of providing a golf handicap that allowed players of all levels of ability to compete on an equal basis at Club, District, Provincial, National and International levels. What CONGU does? Develop and maintain a Golf Handicapping System that provides CONGU Handicaps for all players of the Clubs affiliated to the National Unions and Associations. Also to assist and support these Organisations, and their Affiliated Clubs, in administering golf handicaps on a day-to-day basis. Why CONGU does it? To promote the development of golf at Affiliated Clubs by providing a Handicapping System which produces golf handicaps that allow amateur players, male and female, of significantly varying abilities to compete against each other on as equitable a basis as possible. Keywords: Golf, Handicap, Popularity, Player, Devlopment, Handicapping, Organization,

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• SciCrunch
• 14 years ago - by Anonymous

Portal for Macromolecular X-Ray Crystallography to produce and support an integrated suite of programs that allows researchers to determine macromolecular structures by X-ray crystallography, and other biophysical techniques. Used in the education and training of scientists in experimental structural biology for determination and analysis of protein structure.

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• SciCrunch
• 17 years ago - by Anonymous

This portal allows for the detection of regions of genomic sequences that are rich in the CpG pattern is important because such regions are resistant to methylation and tend to be associated with genes which are frequently switched on. Regions rich in the CpG pattern are known as CpG islands. The function of the program cpgplot is to plot CpG rich areas, and cpgreport to report all CpG rich regions. The nuclear genomes of vertebrates are mosaics of isochores, very long stretches of DNA that are homogeneous in base composition and are compositionally correlated with the coding sequences that they embed. Isochores can be partitioned in a small number of families that cover a range of GC levels. Program isochore plots GC content over a sequence. Sponsors: This resource is supported by European Bioinformatics Institute. Keywords: Software, Plotting, Pattern, CpG, Gene, Function, Isochore, DNA, Genome, Homogeneous, Coding, Sequence, Family, Sequencing,

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• SciCrunch
• 17 years ago - by Anonymous

Welcome to CPAN, where you you will find All Things Perl. CPAN is the Comprehensive Perl Archive Network, a large collection of Perl software and documentation. You can begin exploring from either http://www.cpan.org/, http://www.perl.com/CPAN/ or any of the mirrors listed at http://www.cpan.org/SITES.html. Note that CPAN is also the name of a Perl module, CPAN.pm, which is used to download and install Perl software from the CPAN archive. This FAQ covers only a little about the CPAN module and you may find the documentation for it by using perldoc CPAN via the command line or on the web at http://search.cpan.org/dist/CPAN/lib/CPAN.pm. Sponsors: CPAN works with the generosity and cooperation of hundreds of developers, over 100 participating mirrors, funet.fi donating the network bandwidth, storage space and computing power, volunteers who help keep everything together and users whose interest in Perl keep the archive alive and growing. Keywords: Comprehension, Perl, Archive, Software, Documentation,

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• SciCrunch
• 17 years ago - by Anonymous

Company offers Data Curation, Data Governance and Models, Bioinformatics Analysis, Workflows and Pipelines, Knowledge Mining, Target Profiles, Building Databases with content, Business Analyst services to clients in Pharmaceutical and Biotech companies, Foundations, Government and Hospitals.

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• SciCrunch
• 13 years ago - by Anonymous

Knowledge management system designed to handle neurobiological information at different levels of organization of vertebrate nervous system. Database and repository for information about neural circuitry, storing and analyzing data concerned with nomenclature, taxonomy, axonal connections, and neuronal cell types. Handles data and metadata collated from original literature, or inserted by scientists that is associated to four levels of organization of vertebrate nervous system. Data about expressed molecules, neuron types and classes, brain regions, and networks of brain regions.

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• SciCrunch
• 15 years ago - by Anonymous

This form allows you to assemble a set of contiguous sequences (contigs) with the CAP3 program. The CAP3 program has a capability to clip 5'' and 3'' low-quality regions of reads. It uses base quality values in computation of overlaps between reads, construction of multiple sequence alignments of reads, and generation of consensus sequences. The program also uses forward-reverse constraints to correct assembly errors and link contigs. Results of CAP3 on four BAC data sets are presented. The performance of CAP3 was compared with that of PHRAP on a number of BAC data sets. PHRAP often produces longer contigs than CAP3 whereas CAP3 often produces fewer errors in consensus sequences than PHRAP. It is easier to construct scaffolds with CAP3 than with PHRAP on low-pass data with forward-reverse constraints. Sponsors: This project was supported by NIH Grant R01HG01502-02 from NHGRI. Keywords: CAP3, Program, Form, Computation, DNA, Dataset, Database, Program,, THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 17 years ago - by Anonymous

CASP is a tool to image analysis in comet assay. CASP has been developed to work with either color, or gray-scale images of fluorescence-stained comets saved in TIF format. In its present version CASP does not control a video or CCD camera. Comets stained with silver (dark cells on white background) must be converted into negative images in order to be analysed correctly. An unlimited number of images can be marked, CASP will load them successively into a image view window (see screenshot). Only comets oriented from left (head) to right (tail) can be analysed correctly. The user can adjust various thresholds of sensitivity and save the adjustments for future use. A measurement frame is drawn on the screen and its size adjusted. The adjustments are frozen to prevent accidental modification. The frame is moved onto a cell and measurement is activated. An intensity profile shows up on a profile window together with selected result values (right window on figure 1) and the result can be saved. In addition to such parameter as head radius, tail length etc, the program calculates the tail moment (TM) and the Olive tail moment (OTM). If several cells are present on the same picture, the user can proceed with the measurement of another cell on the same picture or can load a new picture. The saved results can be visualized during the working session in a spreadsheet in view results window. When measurements are terminated, the results can be exported into a text file and imported into a commercial spreadsheet calculation program. CASP is optimized for a 600x800 resolution. Sponsors: This work has been supported by the University of Wroclaw. Keywords: Comet, Assay, Software, Laboratory, Camera, Negative, Cell, Analysis, Image,

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• SciCrunch
• 17 years ago - by Anonymous

The primary goal of the CardioGenomics PGA is to begin to link genes to structure, function, dysfunction and structural abnormalities of the cardiovascular system caused by clinically relevant genetic and environmental stimuli. The principal biological theme to be pursued is how the transcriptional network of the cardiovascular system responds to genetic and environmental stresses to maintain normal function and structure, and how this network is altered in disease. This PGA will generate a high quality, comprehensive data set for the functional genomics of structural and functional adaptation of the cardiovascular system by integrating expression data from animal models and human tissue samples, mutation screening of candidate genes in patients, and DNA polymorphisms in a well characterized general population. Such a data set will serve as a benchmark for future basic, clinical, and pharmacogenomic studies. Training and education are also a key focus of the CardioGenomics PGA. In addition to ongoing journal clubs and seminars, the PGA will be sponsoring symposia at major conferences, and developing workshops related to the areas of focus of this PGA. Information regarding upcoming events can be found in the Events section of this site, and information about training and education opportunities sponsored by CardioGenomics can be found on the Teaching and Education page. The CardioGenomics project came to a close in 2005. This server, cardiogenomics.med.harvard.edu, remains online in order to continue to distribute data that was generated by investigators under the auspices of the CardioGenomics Program for Genomic Applications (PGA). :Sponsors: This resource is supported by The National Heart, Lung and Blood Institute (NHLBI) of the NIH., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 14 years ago - by Anonymous

Candrive''s aim is to improve the health, safety and quality-of-life of Canada''s older drivers. Candrive''s vision is to establish a national multi-disciplinary collaborative approach to identify, analyze and examine the issues pertaining to the safe operation of vehicles by older persons. One of the goals of the Candrive research program is to find a way to extend the length of time that older drivers can drive. Candrive will examine both the effectiveness of retraining programs and the use of customized or restricted licensing for older drivers who might automatically have had their licence revoked. Unfortunately, even if such measures prove useful, there will still be a small minority of older drivers who are no longer safe to drive. By identifying this minority as early as possible, the program will help protect the reputation, public image and rights of the majority of older drivers who represent the safest and most experienced drivers on the road. Sponsors: This resource is supported by a Team Grant from the Canadian Institutes of Health Research (CIHR). Candrive also receives support from the Ottawa Hospital Research Institute. Keywords: Health, Safety, Analysis, Vehicle, Driver,

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• SciCrunch
• 17 years ago - by Anonymous

A working guide to the rapidly developing world of Next-Generation DNA sequencing, with an emphasis on bioinformatics.

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• SciCrunch
• 13 years ago - by Anonymous

COLELMS calculates LMS values, smoothed LMS, and growth reference centiles based in smoothed LMS values. df value is set to when calculating smoothed LMS values. You are responsible for setting an appropriate df for your data. This is version 0.2 of the software. Sponsors: This resource is supported by Boston College. Keywords: Software, LMS, Calculation, Growth, Data, Stata, Module,

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• SciCrunch
• 16 years ago - by Anonymous

This web site contains information relevant to nomenclature of the avian brain. Its current purpose is to serve as a communication means by which scientists can become more knowledgeable about the avian brain, exchange ideas, and formulate proposals for changing the existing nomenclature. Sponsors: This resource is supported by the Duke University Medical Center. Keywords: Avian, Brain, Rearch, Research, Nomenclature, Atlas,

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• SciCrunch
• 17 years ago - by Anonymous

This portal shows you the current research projects happening with in the Cancer Genomics Project. Sponsors: This project is supported by Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agenecy. Keywords: Research, Cancer, Genomics, Genetic, Gne, Project,

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• SciCrunch
• 17 years ago - by Anonymous

This is a database of faces and non-faces, that has been used extensively at the Center for Biological and Computational Learning at MIT. It is freely available for research use. CBCL FACE DATABASE #1: :- Includes complete Readme File :- 19 x 19 Grayscale PGM format images :- Training set: 2,429 faces, 4,548 non-faces :- Test set: 472 faces, 23,573 non-faces :- 27 Megabytes compressed : 110 Megabytes uncompressed :- tar / gz format compression Sponsors: This database is supported by the MIT Center for Biological and Compulational Learning. Keywords: Download, Database, Face, Non-face, Biological, Comuptaitonal, Research,

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• SciCrunch
• 17 years ago - by Anonymous

The California Institute for Regenerative Medicine is accelerating the development of new therapies for chronic disease and injury by funding stem cell research programs throughout California. T he mission of CIRM is to support and advance stem cell research and regenerative medicine under the highest ethical and medical standards for the discovery and development of cures, therapies, diagnostics and research technologies to relieve human suffering from chronic disease and injury. CIRM was established in 2004 after Californians passed Proposition 71, the California Stem Cell Research and Cures Initiative. The statewide ballot measure, which provided 3 billion in funding for stem cell research at California universities and research institutions, called for the establishment of a new state agency to make grants and provide loans for stem cell research, research facilities and other vital research opportunities. CIRM funds stem cell research at for-profit and not-for-profit institutions throughout California. Grants are awarded as part of Requests for Applications (RFAs). Applications for these RFAs are reviewed by a panel of experts, which makes recommendations to the Governing Board. The board then votes on grants to fund for each RFA. Keywords: Regenerative, Medicine, Development, Therapy, Chronic, Disease, Ilness, Stem cell, Research, Meidcal, Discovery, Cure, Therapy, Diagnostic, Technology, Human, Grant, Funding,

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• SciCrunch
• 17 years ago - by Anonymous

Software tool for carrying out power calculations for large genetic association studies, including two stage genome wide association studies.

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• SciCrunch
• 17 years ago - by Anonymous

This web site has been created to provide a centralized source for CS2 and related vector information. It will be updated (on an irregular basis) with additional information, including new vector designs. CS2 vector: pCS2 is a multipurpose expression vector. Although originally designed for expressing proteins in Xenopus embryos from either injected RNA or DNA, pCS2 is also useful for high-level transient expression in a wide variety of mammalian and avian cells. It is also functional in zebrafish embryos (as DNA or RNA), and it can be used for in vitro transcription/translation (using, for example, the Promega TnT system). A number of derivatives of CS2 have been constructed that allow fusions to epitope tags and other marker proteins, as well as nuclear localization signals or the gal4 DNA binding and activation domains. In almost all cases, the same reading frames are used for the fusion vectors, to facilitate moving genes between multiple CS2 derivatives. pCS2 features: pCS2 contains a strong enhancer/promoter (simian CMV IE94) followed by a polylinker and the SV40 late polyadenlyation site. An SP6 promoter is present in the 5'' untranslated region of the mRNA from the sCMV promoter, allowing in vitro RNA synthesis of sequences cloned into the polylinker. A T7 promoter in reverse orientation between the polylinker and the SV40 polyA site for probe synthesis, as well as a second polylinker after the SV40 polyA site to provide several possible sites to linearize the vector for SP6 RNA transcription. The vector backbone is from pBluescript II KS and includes the amp resistance gene and an f1 origin for producing single stranded DNA. :Sponsors: This resource is supported by the University of Michigan. : Keywords: Vector, Resource, Expression, Protein, Xenopus, Embryo, RNA, DNA, Transient, Zebrafish, Domain, mRNA, Synthesis, Promoter,

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• SciCrunch
• 17 years ago - by Anonymous

Conversion Software Registry (CSR) has been designed for collecting information about software packages that are capable of file format conversions. The work is motivated by a community need for finding file format conversions inaccessible via current search engines and by the specific need to support systems that could actually perform conversions, such as the NCSA Polyglot. In addition, the value of CSR is in complementing the existing file format registries and introducing software quality information obtained by content-based comparisons of files before and after conversions. The contribution of this work is in the CSR data model design that includes file format extension based conversion, as well as software scripts, software quality measures and test file specific information for evaluating software quality. The CSR system serves as the source of information and a test bed for the system that can execute the conversions automatically by using the third party software, for example, NCSA Polyglot. The CSR system is a database with a web-based interface that provides services related to a) finding a conversion path between formats b) uploading information about the 3rd party software packages and file extensions, c) uploading files for testing, and finally d) uploading scripts in operating system (OS) specific scripting languages (Windows AutoHotKey, AppleScript and Perl) for automated conversions according to the idea of imposed code reuse used by NCSA Polyglot. In order to provide file format conversion services, CSR have included the following components into CSR related to software capable of conversions: input and output file formats (extensions), scripts operating on the software, validated files to be used for information loss measurements, as well as quantitative measures of the information loss for conversions. The CSR focuses: on software and finding the format conversion paths described by a number of software packages and unique input and output formats. The formats themselves are represented by extensions. While not always unique, extensions are often the only accessible information when the 3rd party software is installed (often listed under the File/Open menu in most packages). The CSR also contains information about the software, operating system, software interface and scripts to execute the software. The scripts are important for the automating conversions with the 3rd party software and can be implemented using AutoHotkey scripts (Windows), AppleScript (Mac) or one of a variety of scripting languages for Unix. The information loss due to file format conversions is measured externally by different techniques within the NCSA object-to-object comparison framework called Versus. The comparison is relevant to the software domain, for example for 3D applications surface area or spin images are used and the loss (0-100 range with 100 representing no loss) for a particular software-conversion pair is stored in the database. The information loss also represents edge weights to Input/Output (I/O) Graph, a simple workflow used for finding the shortest conversion path. The CSR is written as a web service. It consists of three main components: Query, Add, Edit. In the Query mode users can a) view list of all software packages with their conversion options, b) select subsets of software in the I/O-Graph, c) search the database by conversions, software, extensions, MIME and PUID. The I/O-Graph contains all information about installed applications and the conversions they allow. The JAVA applet front end is part of the CSR web visualization interface. Section Add allows users to add new software packages with their conversion capabilities and upload the software scripts to automate them. The last section, Edit is designed for adding detailed information about the software, extensions and for uploading the test files. CSR requires users to login for adding and editing. The web fields are auto completed to help search. Sponsors: This research was partially supported by a National Archive and Records Administration (NARA) supplement to NSF PACI cooperative agreement CA #SCI-9619019. Keywords: Software, Registry, Information, Conversion, Database, Tool

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• SciCrunch
• 17 years ago - by Anonymous

This is a trial for a large randomised placebo controlled trial among trauma patients with, or at risk of, significant haemorrhage, of the effects of antifibrinolytic treatment on death and transfusion requirement. Sponsors: This resource is supported by UK NIHR Health Technology Assessment programme, Pfizer, BUPA Foundation, and J P Moulton Charitable Foundation. Keyowrds: Trial, Placebo, Drug, Trauma, Haemorrhage, Antifibrinolytic, Treatment, Death, Transfusion,

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• SciCrunch
• 17 years ago - by Anonymous