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A cell repository containing cells and DNA for studies of aging and the degenerative processes associated with it. Scientists use the highly-characterized, viable, and contaminant-free cell cultures from this collection for research on such diseases as Alzheimer's disease, progeria, Parkinson's disease, Werner syndrome, and Cockayne syndrome. The collections of the Repository include DNA and cell cultures from individuals with premature aging disorders, as well as DNA from individuals of advanced age from the the Baltimore Longitudinal Study of Aging at the Gerontology Research Center and other Longevity Collections. The Repository also includes samples from an Adolescent Study of Obesity, Apparently Healthy Controls, Animal Models of Aging, and both human and animal differentiated cell types. The cells in this resource have been collected over the past three decades using strict diagnostic criteria and banked under the highest quality standards of cell culture. Scientists can use the highly-characterized, viable, and contaminant-free cell cultures from this collection for genetic and cell biology research.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on April 26, 2011. Information for depositors Investigators who are willing to share mice with the PD research community through this resource should send an email to PDMice_at_ninds.nih.gov describing the mouse. The submission will be reviewed by the PD Models Repository Oversight Committee and, if accepted, a copy of the MTA will be sent by return email. NINDS is most interested in distributing mice that have been characterized in a peer-reviewed publication, but other models will certainly be considered. The email should describe the following: The protocol for identification from tail DNA. The health report of the mice to be shipped (the report has to be less than 2 months old). Information about the strain and any special needs for care and breeding. Information about any publications involving the mice Certification that mice are not encumbered by continuing intellectual property or other rights to any research, data or discovery utilizing the animals. Information for consumers Investigators desiring to study the mice available through the repository should send a request via email to PDMice_at_ninds.nih.gov. Requests will be reviewed by the PD Models Repository Oversight Committee and priority will be determined on a first come, first served basis; two breeding pairs will typically be shipped to any single requester. As detailed in the MTA, mice are not available for commercial research, including but not limited to drug screening. Neither the creator nor UCLA have a role in the governance of the Repository, and specifically, cannot impose conditions upon availability or distribution. It is anticipated that until the Repository is in a mode of steady state production, requests will be collected and mice distributed as supply allows. The email requesting mice should include: A brief description of the protocol Either a copy of the IACUC approval letter or numberNINDS/UCLA Repository for Parkinson's Disease Mouse Models: One of the most immediate and important benefits of discoveries regarding the genetic or environmental causes of Parkinson's disease (PD) is the subsequent development of animal models wherein therapeutic and/or preventative interventions may be studied. The widespread availability of such models is critically important to making progress against a disorder that affects more than 500,000 Americans at any given time. The National Institute of Neurological Disorders and Stroke (NINDS) fully recognizes the burden placed on investigators by the financial and logistical realities of distributing high demand research resources. Some investigators have deposited their mice with national distribution facilities but many mouse models are not available through such resources. Developing means to facilitate greater sharing of mouse models of PD is one of the goals developed by the PD research community at the July 2002 summit meeting convened by the NIH Director. Accordingly, as part of the effort to accelerate PD research, NINDS and the University of California at Los Angeles (UCLA) created a resource that will distribute transgenic mouse models of human PD that are not yet available through national commercial resources. Investigators who are willing to share mice with the PD research community can simply arrange with NINDS to have the mice deposited at UCLA and investigators desiring to study the mice may arrange with NINDS to obtain two breeding pairs. The process will use Material Transfer Agreements created specifically for this arrangement.

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• SciCrunch
• 17 years ago - by Anonymous

Repository of mouse vectors, ES cells, mice, embryos, and sperm generated by NIH KOMP Mutagenesis Project. In addition, KOMP Repository offers services in support of KOMP products, including ES cell microinjection, vector cloning, post-insertional modification of cloned ES cells, cryopreservation, assisted reproduction techniques (IVF, ICSI) and mouse breeding, pathology services, phenotyping services, etc. KOMP Repository is final component of more than $50 million trans-NIH initiative to increase availability of genetically altered mice and related materials. The University of California, Davis (UC Davis) and Children''s Hospital Oakland Research Institute (CHORI) in Oakland, Calif., are collaborating to preserve, protect, and make available about 8,500 types of knockout mice and related products available to research community. Products are generated by two KOMP mutagenesis teams (CSD consortium and Regeneron Inc). All KOMP products generated by CSD consortium and Regeneron are available through KOMP Repository. Notice as of December 19, 2019: Materials from KOMP Repository have been deposited into MMRRC, including all mouse models and mouse embryonic stem cell lines. Eventually www.komp.org will be sunsetting, and IMSR will remove KOMP Repository listings, since they were double listed in MMRRC. MMRRC will contain the most accurate and up to date resource models.

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• SciCrunch
• 17 years ago - by Anonymous

Colonies of barrier-raised, Specific Pathogen-Free (SPF) rodents under contractual arrangement with commercial vendors, specifically for use in aging research. They are not available for use as a general source of adult animals for unrelated areas of research. Animals from the NIA aged rodent colonies are available to investigators at academic and non-profit research institutions under the terms described on the Eligibility Criteria page. Orders must be submitted through the online rodent ordering system (ROS) (http://arc.niapublications.org/acb/stores/1/). Available strains: * Inbred Rats: Fischer 344 (F344), Brown Norway (BN) * Hybrid Rats: F344xBN F1 (F344BN); * Inbred Mice: BALB/cBy, CBA, C57BL/6, DBA/2 * Hybrid Mice: CB6F1 (BALB/cBy x C57BL/6), B6D2F1 (C57BL/6 x DBA/2) * Caloric Restricted Rats: F344 (males only), F344BN F1 (males only) * Caloric Restricted Mice: C57BL/6; B6D2F1 (males only)

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• SciCrunch
• 15 years ago - by Anonymous

A free software using a sliding-window approach to identify differentially methylated regions (DMR) from whole-genome bisulfite sequencing.

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• SciCrunch
• 13 years ago - by Anonymous

An R package that specifically focuses on statistical and population genetics methods. The motivation behind the package is to produce an easy to use interface to many of the commonly used methods and models used in statistical and population genetics and an alternative interface for some of the methodology produced by our group. (entry from Genetic Analysis Software)

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• SciCrunch
• 14 years ago - by Anonymous

National genetics data repository facilitating access to genotypic and phenotypic data for Alzheimer's disease (AD). Data include GWAS, whole genome (WGS) and whole exome (WES), expression, RNA Seq, and CHIP Seq analyses. Data for the Alzheimer’s Disease Sequencing Project (ADSP) are available through a partnership with dbGaP (ADSP at dbGaP). Repository for many types of data generated from NIA supported grants and/or NIA funded biological samples. Data are deposited at NIAGADS or NIA-approved sites. Genetic Data and associated Phenotypic Data are available to qualified investigators in scientific community for secondary analysis.

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• SciCrunch
• 15 years ago - by Anonymous

Cell repository for Alzheimer's disease that collects and maintains biological specimens and associated data. Its data is derived from large numbers of genetically informative, phenotypically well-characterized families with multiple individuals affected with Alzheimer's disease, as well as individuals for case-control studies.

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• SciCrunch
• 16 years ago - by Anonymous

Repository of knockout mice that have been extensively characterized. For each mouse line, the contractors will provide not only the mouse line itself, but also detailed, objective data on the impact of the specific gene deletion on the mouse''s phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data. Such comprehensive information on such a large group of mice has never been available to public sector researchers, and is expected to greatly accelerate efforts to explore gene functions in health and disease. This resource will give researchers unprecedented access to two private collections of knockout mice, providing valuable models for the study of human disease and laying the groundwork for a public, genome-wide library of knockout mice. The contracts also provide for the opportunity for NIH to obtain up to 1500 additional mouse lines and phenotypic data over the next three years, pending available funds. The new contracts provide NIH with irrevocable, perpetual, worldwide, royalty-free licenses to use and distribute to academic and non-profit researchers these lines of knockout mice. The mouse lines, which will be stored in the form of frozen embryos, frozen sperm and frozen embryonic stem (ES) cells, will be delivered to NIH-funded mouse repositories that supply mice to universities, medical schools and research labs all over the world. When researchers express interest in obtaining a certain knockout mouse line, the repositories will send them live mice, frozen embryos, sperm, and/or ES cells, so they can study the mice in their own labs. All data on the mice will be made available to researchers worldwide without restriction in publicly available databases on the Web. This resource will be available for a nominal fee which will be used to cover the cost of handling, shipping and replenishing the stock. Under the license agreements with Deltagen and Lexicon, researchers who receive the knockout mice lines through NIH are free to publish any results from research involving the line and also to seek patent or other intellectual property protection for any of the inventions or discoveries resulting from such research. List of Available Knockout Mice: http://www.informatics.jax.org/external/ko/

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• SciCrunch
• 17 years ago - by Anonymous

Focus is the generation of a reference expression database for the C57BL/6J mouse. The current dataset will consist of 90 samples, primarily from adult tissue, and was analyzed using a technique known as Massively Parallel Signature Sequencing (MPSS). The data are stored in the Gene Expression Omnibus (GEO).The focus of this project is the generation of a reference RNA transcriptome expression database for the C57BL/6J mouse. The current dataset will consist of 90 samples, primarily from adult tissue, and was analyzed using a technique known as Massively Parallel Signature Sequencing (MPSS)

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• SciCrunch
• 14 years ago - by Anonymous

It records bibliographic, chemical and crystallographic information for organic molecules and metal-organic compounds whose 3D structures have been determined using X-ray diffraction and neutron diffraction.<BR/> The CSD records results of single crystal studies and powder diffraction studies which yield 3D atomic coordinate data for at least all non-H atoms. In some cases the CCDC is unable to obtain coordinates, and incomplete entries are archived to the CSD.<BR/> The CSD includes crystal structure data arising from:<BR/> * publications in the open literature<BR/> * Private Communications to the CSD (via direct data deposition)<BR/> The Cambridge Structural Database System (CSDS) is a single product that comprises the following components: The Cambridge Structural Database (CSD); CSDS Software: search and information retrieval (ConQuest), structure visualization (Mercury), statistical analysis of retrieved data (VISTA), and software for database creation (PreQuest); Knowledge bases derived from the CSD: Mogul (intramolecular geometry) and IsoStar (intermolecular interactions, including data from the PDB).<BR/> Cambridge Structural Database (CSD) is the world repository of small-molecule crystal structures. For example, the crystal structures supported by the National Institute on Drug Abuse are deposited here.<BR/>

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. The main site for the Medical Shool of Georgia's Alzheimer's research.

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• SciCrunch
• 16 years ago - by Anonymous

NSL, Neural Simulation Language, is a simulation system for large-scale general neural networks. NSL provides a simulation environment simplifying the task of modeling neural networks. In particular, NSL supports neural models having as basic data structure neural layers with similar properties and similar connection patterns, where neurons are modeled as leaky integrators with connections subject to diverse learning rules. Development of NSL has gone hand in hand with modeling of neural mechanisms underlying visuomotor coordination, with special emphasis on the analysis of data from anurans, monkeys, and humans. NSL follows an object-oriented design, providing higher level programming abstraction corresponding to neural elements. NSL provides system development tools, such as visualization capabilities and a run-time interpreter, which give the user powerful tools in developing and analyzing models. NSL has been widely used throughout the world for both teaching and research. simulation; software

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• SciCrunch
• 17 years ago - by Anonymous

Software modeling tool for realistic simulation of cellular signaling in complex 3-D subcellular microenvironment in and around living cells. Program that uses spatially realistic 3D cellular models and specialized Monte Carlo algorithms to simulate movements and reactions of molecules within and between cells.

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• SciCrunch
• 17 years ago - by Anonymous

FlexProt detects the optimal flexible structural alignment of a pair of protein structures. The first structure is assumed to be rigid, while in the second structure potential flexible regions are automatically detected.

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• SciCrunch
• 17 years ago - by Anonymous

Imagebank consists of freely available images contributed by academics, researchers, Learned Societies, industry and individuals with rights cleared for educational purposes. :Users are able to search for images based on keywords or browse within a wide range of bioscience subject areas. Images are then downloadable along with informative descriptive text provided by the contributor. All images undergo a validation process by Centre for Bioscience staff with good subject knowledge. ImageBank also offers reviews of, and links to existing bioscience image databases.

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• SciCrunch
• 17 years ago - by Anonymous

An open international project under the patronage of the Human Proteome Organisation (HUPO) that aims: To analyze the brain proteome of human as well as mouse models in healthy, neurodiseased and aged status with focus on Alzheimer's and Parkinson's Disease; To perform quantitative proteomics as well as complementary gene expression profiling on disease-related brain areas and bodily fluids; To advance knowledge of neurodiseases and aging in order to push new diagnostic approaches and medications; To exchange knowledge and data with other HUPO projects and national / international initiatives in the neuroproteomic field; To make neuroproteomic research and its results available in the scientific community and society. Recent work has shown that standards in proteomics and especially in bioinformatics are mandatory to allow comparable analyses, but still missing. To address this challenge, the HUPO BPP is closely working together with the HUPO Proteome Standards Initiative (HUPO PSI).

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• SciCrunch
• 17 years ago - by Anonymous

A web tool that allows you to use large reference epigenome datasets for your own analysis without complex scripting or laborious preprocessing.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 16, 2013. The 7 database (or a7db) provides physiological, pharmacological and structural data pertaining to the 7 subunit of the nicotinic acetylcholine receptor. As well as the simple boolean-based query, there are several other ways to help you interrogate the database; * One page query builder * Query builder based on the category of data * Upload a prebuilt/previous query * Browse the database To gain insight into what sort of data can be queried, the one page or categorized query builders are recommended. Or you can just browse the database. The best way to navigate is to use the links on the left. Please be aware that we are presenting the raw data and that it is up to the user on how best to interpret that data. You can read more about the database in the recent article in BMC Neuroscience

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on June 08, 2011. This database contains gene expression data for various physiological and pathological processes in mouse brain. All the data have been obtained by adaptor-tagged competitive PCR, an advanced version of quantitative PCR. Brain Gene Expression Database (BGED) contains gene expression data for various physiological and pathological processes in mouse brain. All the data have been obtained by adaptor-tagged competitive PCR, an advanced version of quantitative PCR. Manual Download 1. Data retrieval Gene expression data can be retrieved either by ID numbers or by keywords representing functional annotations from this page. The ID numbers include GenBank, RefSeq, SwissProt, Gene Ontology, and BED (our own ID). The keyword search is based either on definition in GenBank, SwissProt and RefSeq, functional annotation of SwissProt database, or Gene Ontology terms. 2. Gene expression pattern display * Display of multiple gene expression patterns. Expression patterns of multiple genes selected by the keyword search can be displayed from the result page of the keyword search. * Gene expression pattern similarity search This function is available on the information page of each gene accessed through BED ID (in-house ID).

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• SciCrunch
• 17 years ago - by Anonymous