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Core facility that provides the following services: X-ray crystallography service, X-ray crystallography reference database access service, X-ray crystallographic data analysis and processing service, Access to x-ray crystallography using synchrotron radiation, X-ray crystallography advising and consultation service. <BR/> <BR/>The X-ray Crystallography Facility located at 99 Brookline Ave. (Research North) was recently established as a core to serve the needs of investigators in the BIDMC and Harvard Medical School community interested in using structural biology as a tool in their research.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: DNA injection service, Embryonic stem cell injection service, Transgenic mouse line rescue service, Transgenic mouse embryo handling services, Mouse assisted reproductive services. <BR/> <BR/>The Beth Israel Deaconess Transgenic Core Facility opened in October of 1991.The Transgenic Core is a state-of-art facility that produces genetically altered animals.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Real-Time PCR service, Real-time PCR training service. <BR/> <BR/>Performs Real-Time-PCR and provides quantitative data on levels of gene expression. The Core comprises an ABI 7700 Sequence Detector System, equipped with all an investigator needs for experimental design/run and data processing.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Mouse breeding service, Mouse genotyping service, Tail vein injections service, Tissue service, Cancer mouse model service, Human tumor xenografts service. <BR/> <BR/>

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• SciCrunch
• 13 years ago - by Anonymous

Preclinical MRI Core at Beth Israel Deaconess Medical Center provides services including imaging of anatomy and function for small animals including mice, rats, and amphibians. Ex vivo samples from larger animals and patients can be imaged. Offers consultation on protocol design and pilot data for new projects. Analysis services are available as well.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Multi-Gene transcriptional profiling (MGTP) service. <BR/> <BR/>Multi-Gene Transcriptional Profiling (MGTP) is a real-time PCR based technique, developed in our lab, for quantifying mRNA copy numbers per cell with high reproducibility and accuracy. Primary Goals of the MGTP Core: * To make MGTP services available to investigators, and assist them in advancing their research and obtaining grants; * To assist studies of molecular signaling mechanisms and pathways, discovery of biomarkers, and development of clinical assays; and * To share the resources of our primer library, which currently includes about 2400 pre-validated human, and mouse genes. The MGTP Core makes these unique and powerful capabilities available to biomedical researchers. Thousands of pre-validated primers are available for use, and others can be designed on demand.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Mapping of post-translational modifications by LC/MS/MS, Protein (complex) identification by LC/MS/MS, Relative quantification of peptides by LC/MS/MS, SILAC, iTRAQ, and Isotope-free ratio quantification service, Metabolomics profiling service. <BR/> <BR/>The Mass Spectrometry Core Facility has been serving the BIDMC community since 2004. We specialize in a targeted mass spectrometry based proteomics approach for isolated proteins and protein complexes, especially phosphorylation and other post-translational modifications involved in cellular signaling using cutting edge instrumentation. Our trained staff offers the highest quality and reliable service with meticulous attention to detail for each sample. We routinely provide services including protein identification, post-translational modification mapping, and relative peptide/protein quantification by stable isotope labeling and label free methods using highly sensitive microcapillary LC/MS/MS techniques at nanoliter flow rates. Several different types of mass spectrometry are utilized depending upon the needs of the researcher including a fast scanning and highly sensitive 2D linear ion trap and a high resolution/high mass accuracy LTQ-Oribitrap mass spectrometer acquired in 2007. In 2005, in agreement with Harvard Medical School''s Pathology Dept., the BIDMC Mass Spectrometry Core became part of the NRB Mass Spectrometry and Proteomics Core, expanding its services and became part of the Cancer Proteomics Core for the Dana Farber Harvard Cancer Center. We serve all institutions regardless of affiliation and have an interest in samples related to many diseases such as cancer and diabetes.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: User-based microscopy service, Microscopy training service. The Imaging Core provides access to standard digital and laser scanning confocal microscopy, multiphoton microscopy, unbiased stereology, and automated confocal microscopy for large scale genome-wide screens. In addition, the Core has substantial capabilities in quantitative and three-dimensional volumetric image reconstruction.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: In Vivo Magnetic Resonance Imaging (MRI), Quantitative Image Analysis: Standard Uptake Value (SUV), 3D Volume Measurements, Animal Handling Techniques: Blood Collection, Injections (IV, IP), Oral Gavage, Tumor Inoculation, Transcardiac Perfusion, etc., Whole-body and Tissue Cryosectioning, Ex Vivo Tissue Radioactivity Measurement. <BR/> <BR/>Our goal is to provide state-of-the-art small animal imaging services to researchers in the Longwood Medical Area of Harvard Medical School. These services include multi-modality imaging, advanced data analysis, image fusion resources, and a satellite animal facility for longitudinal studies. A detailed description of our instruments and services are provided on our website, and we welcome questions and comments.

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• SciCrunch
• 13 years ago - by Anonymous

Core does routine paraffin and frozen sectioning on tissues for research purposes. We offer consultation services, and fee-for-service tissue grossing, processing, embedding, sectioning and staining. Special stains are also done routinely. Paraffin-embedded or frozen sections can be passed-on to a partner core, the BIDMC-Confocal and Immunostaining core, for DAB or fluorescence staining and analysis. No training or independent usage of Histology core or its equipment is possible.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27, 2023. Core provides services: RT PCR service, Gene expression profiling service, Proteomics analysis service, Bioinformatics and Systems Biology analyses, Next Generation Sequencing Service, Affymetrix Human and Mouse Gene 2.0 ST Arrays and 2.1 ST Arrayplates. Core proteomics facility for the Dana-Farber/Harvard Cancer Center. Workflows and algorithms for analysis of next-generation sequencing data including RNA-Seq, ChIP-Seq, Epigenetics-Seq and DNA seq, Comprehensive workflow for analysis of Microbiome sequencing data, Integrated systems biology analysis of transcriptome, miRNA, epigenome, metabolomics and proteomics data. Pipelines: MALDI Tissue imaging and targeted quantitative proteomics.

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• SciCrunch
• 13 years ago - by Anonymous

Core provides service for grossing, tissue processing, tissue embedding, thick and thin sectioning, staining grids, and taking images of samples in the electron microscope. Training is available to use the electron microscope independently. For tissue processing, we also have training or service for high pressure freezing, freeze substitution, and tissue embedding. The core also has the expertise to do Advanced 3-D Focused Ion Beam/Scanning Electron Microscopy and 3-D segmentation and analysis on cells or tissues.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Cell sorting service. <BR/> <BR/>The Department of Pathology Flow Cytometry Facility provides flow cytometric analysis and cell sorting services to investigators in the Harvard Medical School and in the Harvard affiliated hospitals and institutions. The facility currently has a FACSCalibur for assisted as well as unassisted flow cytometric acquisition and analysis, and a FACSAria for cell sorting (performed by an expert technician).

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• SciCrunch
• 13 years ago - by Anonymous

As the state''s only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.

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• SciCrunch
• 18 years ago - submitted by Andrea Stagg

Core facility that provides the following services: DNA sequencing service. <BR/> <BR/>The BIDMC DNA Sequencing Facility is equipped with an ABI 3130xl Automated DNA Sequencer. Turn around time is 24 hours: drop off samples by 10am (at CLS-426E or SL-232) and obtain results by 11am of the following day. Some results can be posted the same day of sample submission. Sample pick up is available in Longwood Medical Area - please send requests by email. Also available through the BIDMC DNA sequencing core to the Harvard Research community is the newest model of the Arcturus Laser Capture Microdissection System!

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• SciCrunch
• 13 years ago - by Anonymous

Partially funded through Harvard Catalyst, the Clinical Research Coordinator Core is available to support and collaborate with investigators and their research teams in all phases of clinical research, providing services that include assisting with the organization, implementation and completion of clinical research studies.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Adult cardiac myocyte isolation service, Adult rat cardiac myocyte cultures service, Animal maintenance service, Aortic banding surgery service, Echocardiography service, Hind limb ischemia surgery service, I/R surgery service, Invasive cardiac output measurement service, Laser Doppler service, MI surgery service, Special animal care maintenance service, Tail vein blood collection service, Telemetric BP monitoring service. <BR/> <BR/>The goal of Cardiac Physiology Core is to provide expertise in evaluation of cardiac pathology for non-cardiovascular and cardiovascular researchers who are not equipped for such analysis. The core provides non-invasive and invasive evaluation of cardiac physiology that may be difficult or time-consuming for those investigators without proper expertise, experience and equipments.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Fluorescence activated cell sorting, Data analysis and interpretation. <BR/> <BR/>Cytometry and cell sorting core at the Center for Virology and Vaccine Research. The facility has a BD FACSAria II housed in a sterile biosafety cabinet in a BSL2+ facility, allowing sorting of unfixed, live cells into a variety of tubes and plates. Equipment, consultation, dedicated operator, and data analysis available to outside researchers. To schedule an appointment, please fill out and submit the Investigator Sort Form available on our website or contact us below.

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• SciCrunch
• 13 years ago - by Anonymous

The mission of the Biomedical Research Informatics Core (BRIC) is to utilize the expertise of BIDMC ''informaticians'' with backgrounds in medicine, biology, engineering, biostatistics, and computer science to facilitate research at our institution by (a) providing a high level of service and experience in informatics that is difficult for individual laboratories to achieve and maintain, (b) developing the infrastructure required to address common informatics needs of all researchers, and (c) identifying areas in which there can be closer collaboration among life scientists and quantitative scientists. View our portfolio for examples of BRIC projects. To arrange for a free consultation, please contact Griffin Weber. If you choose to use BRIC services, hourly fees vary depending on the types of services needed. You will be given an estimate of the number of hours before any work begins.

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• SciCrunch
• 13 years ago - by Anonymous

Provides education and training on the use of noninvasive brain stimulation for both clinical practice and research. Uses techniques like TMS and tDCS for diagnosing, treating, and researching neuropsychiatric conditions, aiding neurorehabilitation after brain injuries, and educating professionals, focusing on disorders like depression, schizophrenia, epilepsy, chronic pain, and stroke recovery to improve brain function and quality of life

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• SciCrunch
• 13 years ago - by Anonymous