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Facility is small molecule and functional genomics high-throughput screening laboratory. It is built around modular work stations and most assays are performed in 384-well plates. There are over 500,000 small molecules available for screening at ICCB-Longwood and compound collection is continuously growing. Whole human and mouse genome siRNA libraries, arrayed sgRNA libraries, lncRNA siRNA libraries, as well as miRNA mimic and inhibitor libraries, are also available for screening. These libraries can be screened at the genome level or in focused subsets.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Autoantibody determination, HLA typing and Genotyping for the best recognized susceptibility loci (INS, PTPN22, CTLA4). <BR/> <BR/>The Human Sample Procurement Core will support translational research endeavors within the JDRF Center by providing the Center''s laboratories access to well-characterized blood samples from patients with diabetes at different stages of the disease. This availability will greatly facilitate the translational exploration of concepts and targets emerging from the basic research projects. Individuals with T1D (recent onset, long-standing Type-1 diabetes) and matched controls (healthy or T2D) will be recruited from the patient population at the Joslin Diabetes Center and neighboring institutions. The Core will perform and record a basic characterization of patients and their samples. This analysis will include a thorough evaluation of clinical characteristics from a diabetes and autoimmune standpoint, and an immunogenetic workup (outsourced to Joslin or other cores): autoantibody determination, HLA typing and genotyping for the best recognized susceptibility loci (INS, PTPN22, CTLA4). A relational database will be adapted to record all patient information, copies of which will be provided in a de-identified manner to the investigators.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Maintainence and dissemination of transgenic and mutant mice. <BR/> <BR/>The Genetically Modified NOD Mouse Core provides Center investigators, as well as researchers elsewhere, with access to transgenic and mutant lines derived from the NOD mouse model: some will be generated within the Core; others are established lines of proven experimental value that are maintained in the Core. The Core will construct transgenic mice in strains that have a high susceptibility to diabetes (in particular in the NOD line). This includes trangenesis by conventional pronuclear injection or by delivery of RNAi cassettes on lentiviral vectors. The Core will also provide a panel of existing transgenic and mutant lines. These lines are chosen because of their established interest in allowing the dissection of immunological tolerance in Type 1 Diabetes, and in response to Center investigator needs.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Small molecule and peptide NMR spectrometry service. Formerly the NERCE NMR Resource. Nuclear magnetic resonance spectroscopy is a powerful tool for studying structural and conformational parameters of molecules. This tool is vital for the chemical analysis of both small molecules (like those discovered in small-molecule screens) and large molecules, such as carbohydrates and proteins found to have potential biologic importance.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Drosophila genome-wide and focused cell-based RNAi libraries, Custom synthesis of double-stranded RNAs for Drosophila cell-based RNAi. <BR/> <BR/>The DRSC facilitates genome-wide and related cell-based screening at our state-of-the-art facility. Since our beginnings in 2003, we have successfully guided screeners through the process, including help with assay development and optimization, data and image analysis, and planning of follow-up assays. Screens performed at the DRSC have resulted in an impressive number of publications on a wide range of topics in high-profile journals.

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• SciCrunch
• 13 years ago - by Anonymous

Core provides electron microscopy services, instrumentation and training. Services include consultation and experimental design for wide variety of biological samples for both Transmission Electron Microscopy and Scanning Electron Microscopy.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Flow cytometer equipment access, Flow cytometry consultation, Immunofluorescence analysis, Cellular sorting, Measurement of intracellular calcium signaling, DNA cell cycle analysis, Apoptosis assay service. <BR/> <BR/>The purpose of this Immunology Flow Cytometry Core of the Boston Area Diabetes Endocrinology Research Center (BADERC) is to provide flow cytometric techniques in a cost effective manner to the diabetes research community. The core is committed to providing to investigators both training and a diversity of state-of-the-art flow cytometric techniques. The Core will assist investigators in applying a variety of tough and cumbersome immunologic techniques and offers in-depth training of new methods.

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• SciCrunch
• 13 years ago - by Anonymous

Characterization of mineralized tissues, natural or synthetic, is a challenging task, since these materials are comprised of organic and mineral constituents, each with strikingly different physical and chemical properties. The function of the Forsyth Mineralized Tissue Analysis (MTA) Core is to provide a comprehensive structural, physical, and chemical analysis of wild type, mutant and engineered mineralized tissues, including teeth (enamel, dentin, cementum), cartilage and bone. The strengths of the MTA Core include a unique combination of specialized instrumentation, techniques, and expertise based on more than 30 years of experience in this field.

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• SciCrunch
• 13 years ago - by Anonymous

The Forsyth Institute established the micro computed tomography core in 2011. The Facility is located in the 4th floor of the Forsyth research building. The core now accepts samples from outside academic institutions and for-profit organizations.

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• SciCrunch
• 13 years ago - by Anonymous

Out of service. Documented on May,04,2021. This record has been removed from eagle-i search; this page is an archival copy only. Imaging Services offers high-quality poster printing.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: DNA screening from clinical samples, Comparison of bacterial associations in health vs. disease by microarray, Human microbial identification microarray service. <BR/> <BR/>The Microbial Identification Microarray Core (MIM) at The Forsyth Institute is a one-of-a-kind core service that enables the rapid determination of bacterial profiles of human clinical samples. The first MIM offering focuses on the detection of bacterial profiles from clinical samples from the oral cavity. Drs. Bruce Paster and Floyd Dewhirst, have used molecular analyses based on 16S rRNA sequencing to identify about 600 oral bacterial species, of which over half have not yet been cultivated. Using this information, they have developed the Human Oral Microbe Identification Microarray, or HOMIM, which allows the simultaneous detection of about 300 of the most prevalent oral bacterial species, including those that cannot yet be grown in vitro. Microarrays targeting bacterial species of the human and mouse intestines are presently under development. In addition, exploratory and pilot studies to identify bacteria within any human clinical sample by 16S rRNA cloning and sequencing are available. This service is available to researchers from all academic institutions and to industry. Researchers submit DNA isolated from clinical samples and receive an online comprehensive data analysis and easy-to-interpret readout. Depending upon the number of samples to be analyzed and position in the queue, results can usually be obtained within days. Note that results are presently for research purposes only.

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• SciCrunch
• 13 years ago - by Anonymous

Analysis of air pollution samples: including gravimetric determination of particle mass from filter samples; chemical analysis for passive and active samples of pollutant particles and gases; instrumental analysis of elemental and organic carbon collected on quartz fiber filters; trace elemental analysis of filter samples, and ; reflectance analysis of atmospheric black carbon.

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• SciCrunch
• 13 years ago - by Anonymous

Private university responsible for the medical speciality of surgery throughout Ireland.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Core offers consulting and support services for detection of different fluorescent parameters simultaneously, RBC contaminated samples, and high throughput analysis using 96 or 384-well plates. Cell sorter allows for collecting cells/particulates of interest, after screening for positively selected markers, downstream applications, and is capable of sorting four separate cell populations simultaneously.

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• SciCrunch
• 13 years ago - by Anonymous

The Biostatistics Core collaborates with clinical and laboratory investigators providing support for experimental design, statistical methods, data analysis and data management for epidemiologic studies, clinical trials and laboratory investigations. Collaborations have included Center grants, Program Projects and numerous individual investigator grants. These studies have largely focused on oral health research, particularly dental caries and periodontitis, with an emphasis on the microbial and immunologic aspects as well as diagnosis and treatment of these conditions and use of high throughput technologies in their evaluation.

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• SciCrunch
• 13 years ago - by Anonymous

Core specializes in oral microbial genomics, taxonomy, phylogenetics and the next generation sequence (NGS) data analysis with both in house and cloud high performance computational resource. In addition to supporting funded bioinformatics projects, Bioinformatics Core will also provide computational support to Forsyth and other researchers for processing, analyzing, and interpreting biological data.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Protein analysis, 2D gel electrophoresis service.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: HPLC service.

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• SciCrunch
• 13 years ago - by Anonymous

An Core facility

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Animal handling training service, Animal surgery.

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• SciCrunch
• 13 years ago - by Anonymous