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All new users must be trained by the facility manager over two orientation sessions and be approved to use the equipment in the facility. All users must obtain the financial approval from their PI and financial manager. Please submit a PO number or the Harvard billing code prior to the first use of the facility.

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• SciCrunch
• 13 years ago - by Anonymous

The Biological Analysis Service facility provides and/or facilitate access to digital imaging and biological analysis services in and out of Harvard campus. We aim to foster new research opportunity for HSPH investigator through providing initial support for pilot studies. Check out Bioanalysis Mini-Pilot Funding for description of the funding mechanism and an application form to request funds. Inside HSPH: * Biomedical Imaging * Flow Cytometry * Electron Microscopy * Proteomics Facility * Molecular Analysis Facility

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Cell sorting service, Cell analyzing service, Cell separation service, Cell cytometer service, Data services, Flow cytometry protocol development service, Benchtop flow cytometry analyzer training, Flow cytometry beta-testing service. Committed to meet all of the flow cytometry needs for the BIDMC and the external research community, the Flow Cytometry Core facility offers state of the art instrumentation for routine flow cytometry and cell sorting. It is continuously expanding with the newest software and machinery for both sort and analysis capabilities of up to 30 flourescent parameters. The Flow Cytometry Core facility is available to: answer technical questions; assist you in setting up flow cytometry experiments; assist you with acquiring, analyzing and interpreting your data; assist in data presentation and data storage; provide training on the four benchtop analyzers and on software. To schedule an appointment for regular flow cytometry (user operated), log onto our online web calendar at: http://bidflow.calendarhost.com/

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• SciCrunch
• 13 years ago - by Anonymous

There is a growing need for animal models to carry out in vivo developmental and regenerative medicine studies of human cells, tissues and organs. The Humanized Neonatal Mouse Center (HNMC) was created to accelerate research in the stem cell field by providing humanized mouse models to study human stem cell engraftment and differentiation in regenerative medicine. We have over 4 years of experience in constructing different types of humanized mouse models, including neonatal heart, lung and kidney injury models. We have extensive experience in hematopoietic stem cell reconstruction. It is our goal at HNMC to facilitate collaborative research in human stem cell biology, where physiologically relevant microenvironments (niches) may be created in vivo to study human stem cell fate and function under experimental settings where disease, damage or degenerative conditions can be controlled. We can provide customized humanized mouse models to the HSCI research community, to collaborate on research studies of common interest, and to advance the general use of these models for a broad range of translational and preclinical studies.

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• SciCrunch
• 13 years ago - by Anonymous

The West Quad Computing Group (WQCG) serves the research community of the BCMP and Cell Biology departments at Harvard Medical School. We provide support for your advanced computing needs, including design and maintenance of computational clusters, large data-set management, web and database backed applications, and workstation support, including workstations connected to research equipment. Please see Resources for more information, including a sample of some of our recent projects. We work in collaboration with the HMS Information Technology department. Please contact us using our support form for all of your computer support needs.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Protein identification from SDS-PAGE gel bands/spots (Coomassie stained level of protein), Protein phosphorylation service, TCA samples service. The Taplin Biological Mass Spectrometry Facility opened in February 2001 as a core facility for the analysis of proteins and peptides by mass spectrometry. The facility is focused on serving the needs of investigators at Harvard Medical School (HMS) and all the Harvard affiliated Institutions.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Project Consultation, CADD Design, and Fabrication. We have many years of experience designing and manufacturing custom tools for medical research. This has allowed us to compile a large collection of different solutions to a wide range of problems. We work on a daily basis with researchers working in these areas of medical science: * Cell Biology * Genetics * Anesthesiology Research * Surgical Research * Pathology Research * Respiratory Biology * Environmental Sciences

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• SciCrunch
• 13 years ago - by Anonymous

The SBGrid Core team provides research computing sysadmin support to structural biology laboratories in the Boston area.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: User-based microscopy service, Live Specimen Imaging, Widefield Fluorescence, Spinning Disk Confocal Microscopy, Laser Scanning Confocal, Color Imaging, Image Analysis, Microinjection, Phase Contrast and Differential Interference Contrast (DIC), Photo-bleaching, Photo-activation, & Laser Ablation, Microfluidic Perfusion, Imaging and microscopy training. The mission of the NIC@HMS is to: enhance basic research by providing access to state-of-the-art microscopy and imaging equipment, provide training courses on basic and advanced light microscopy techniques for the benefit of HMS and the greater Boston research community, introduce the latest innovations in light microscopy and imaging to the HMS community, serve as a learning center for our corporate partners and contributions, and provide a dedicated NIC@HMS director for ongoing technical consultation and support.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on 4/1/14. Software providing a framework to find isomiRNAs, templated and non-templated modifications in microRNAs.

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• SciCrunch
• 13 years ago - by Anonymous

Open access light microscopy and tissue core located within Neurobiology Department. Provides services in optical imaging, tissue clearing, in situ hybridization as well as introduces new equipment and cutting technology to the basic science community. Provides expertise, equipment, services and learning opportunities to researchers in the greater Boston area.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Enzyme-linked immunosorbent spot assay service, Fluorescence microscopy service, Real-time PCR Service. <BR/> <BR/>The NERCE Microbiology and Animal Resources Core maintains two laboratories, a BSL-2 and a BSL-3 laboratory, to support the research efforts of all New England investigators conducting research on NIAID priority pathogens. Each laboratory provides the physical environment, equipment, and support personnel required for scientists to work with these agents. The BSL-3 laboratory is an isolated suite that includes individual laboratory rooms and rooms for housing experimental animals, all within a single containment facility. The BSL-3 lab provides the extensive security and administrative support structure required for possession of CDC select agents. The laboratory acquires strains of viruses and bacteria, prepares seed stocks, and characterizes these seed stocks using phenotypic and molecular methods to ensure a well-characterized, pure biological reagent. Laboratory staff members assist investigators with experiments involving pathogen culture, fractionation of biological material, animal challenge, and vaccine and drug administration. The laboratory is equipped for commonly used analytical methods, including fluorescence microscopy, PCR, EIA, and ELISPOT. A single suite with both laboratory and experimental animal capability eliminates the need to transport infectious material between laboratories. The BSL-2 laboratory provides support required by the BLS-3 facility, access to attenuated strains exempt from select agent registration, and laboratory space for visiting investigators. Investigators interested in working with the Microbiology and Animal Resources core laboratory should complete the Core A Request Form and send it to Christine Anderson. See lab website for details. There are no charges for projects focused on NIAID priority pathogens and agents of emerging infectious disease.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Imaging system training, Live cell imaging. <BR/> <BR/>Live-cell imaging is a powerful method that enables investigators to observe cellular trafficking events with a high degree of spatial and temporal resolution, including visualization of individual bacteria or viral particles engaged in the process of infecting eukaryotic cells. A quantitative description of bacterial and viral invasion mechanisms can be obtained through such approaches. NERCE has provided funding to support the use of live-cell imaging for any New England investigator studying NIAID priority pathogens and agents of emerging infectious disease. Investigators interested in working with the Live-Cell Imaging core laboratory should complete the Imaging Core Request Form and send it to Gerald Beltz. There are no fees for use of the live-cell imaging core for research related to NIAID priority pathogens and agents of emerging infectious disease. <b>Please note that since the NERCE program will end in February 2014, our ability to support new requests for services is limited.b>

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Confocal microscopy. <BR/> <BR/>Confocal microscopy offers multiple benefits compared to conventional microscopy, particularly the ability to collect serial, high-resolution optical sections from thick specimens. Multicolor, three-dimensional images can be obtained, providing high-content information from single images. To assist NERCE investigators from throughout the region, NERCE has established a Confocal Microscope Facility at the University of Massachusetts Medical School. Funding through the NERCE has procured a state-of-the-art LEICA SP2 AOBS laser scanning confocal microscope, which combines spectrophotometric detection with confocal microscopy. The instrument is located at the BL2+ facility at the Lazare Research Building, at the University of Massachusetts Medical School, Worcester, MA. The use of live cell imaging combined with green fluorescent protein (GFP) technology is an exciting methodology with which to study the interactions between infectious agents and living cells. A variety of applications are amenable to confocal microscopy techniques and include: monitoring the localization of proteins in living or fixed cells, monitoring changes in the cellular distribution of proteins, and monitoring changes in the activation status and morphological changes in cells exposed to infectious agents.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Protein production, Bacterial fermentation for recombinant protein production, Baculovirus culture, Protein purification. <BR/> <BR/>The NERCE Biomolecule Production Core Laboratory is a core service laboratory with capability for expression and purification of recombinant proteins using bacterial and baculoviral expression systems, and preparation of bacterial carbohydrate components. It supports all New England investigators conducting research on NIAID priority pathogens that requires purified proteins or carbohydrates. Investigators are expected to provide data demonstrating efficacy of production and purification methods, as well as strains or purified recombinant plasmid preparations where applicable. See lab website for details. <b>Please note that since the NERCE program will end in February 2014, our ability to support new requests for services is limited.b>

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• SciCrunch
• 13 years ago - by Anonymous

Software package for high-performance read alignment, quantification and mutation discovery.General purpose read aligner which can be used to map both genomic DNA-seq reads and RNA-seq reads. Subread aligner as fast, accurate and scalable read mapping by seed-and-vote.These programs were also implemented in Bioconductor R package Rsubread.

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• SciCrunch
• 13 years ago - by Anonymous

The molecular electron microscopy facility at Harvard Medical School is predominantly used for our own research and can therefore not be considered a service facility. We are, however, committed to make our technology available to as many research groups in the community as possible. If you are interested to use molecular electron microscopy, please contact us by phone or email.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Soft-lithography service, Soft-lithography training and consultation. <BR/> <BR/>The HMS Microfluidics Facility aims to make the tools of Microfabrication and Microfluidics available to all HMS users.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Instrument operation and data analysis. <BR/> <BR/>Instrumentation for this facility includes an Agilent 6520 Accurate-Mass quadrupole time-of-flight (Q-TOF) LC/MS system with great mass accuracy, mass resolution, and sensitivity for small molecule mass identification/quantitation and metabolomics experiments. It is equipped with an Agilent 1200 series HPLC with DAD UV/V is detection for normal flow LC/MS and nitrogen CID for MS/MS. The Q-TOF LC/MS is located in laboratory of Dr. Suzanne Walker in the Department of Microbiology and Immunobiology.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Computational image data analysis. <BR/> <BR/>IDAC provides image data analysis services to individual labs and core facilities at Harvard Medical School, including the ICCB-Longwood Screening Facility (ICCB-L), the Drosophila RNAi Screening Center (DRSC), and the Nikon Imaging Center (NIC).

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• SciCrunch
• 13 years ago - by Anonymous