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A patient led charity that funds research which will have an impact on the lives of people with Parkinson's, with the hope of an eventual cure for the condition. The Cure Parkinson's Trust has the clear goal of finding a cure for Parkinson's disease by investing in under resourced and underfunded projects that offer a possible cure in the future. This trust's primary role is identifying, funding and evaluating research projects, as well as hosting scientific forums to bring together relevant scientists within the field to discuss key areas of research and technology. Cure Parkinson's provides researchers with information on current research, research events, and the ability to apply for grants through the Cure Parkinson's Trust.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. This site has a dataset from the QE2 Study: Effects of CoEnzyme Q10 in Early Parkinson's Disease, was an NINDS funded pilot study of 80 subjects with early untreated Parkinson's disease (PD). The PI was Clifford Shults, MD at UCSD. It was a randomized, double-blind, parallel group comparison of three doses of coenzyme Q10 (CoQ10) (300, 600 and 1200 mg/day) versus placebo in patients and do not yet require treatment with levodopa. The QE2 Study: Effects of CoEnzyme Q10 in Early Parkinson's Disease, was an NINDS funded pilot study of 80 subjects with early untreated Parkinson's disease (PD). The PI was Clifford Shults, MD at UCSD. It was a randomized, double-blind, parallel group comparison of three doses of coenzyme Q10 (300, 600 and 1200 mg/day) versus placebo in patients and do not yet require treatment with levodopa or any other antiparkinsonian medication. Enrollment period May 1999 Feb. 2000; study participation ended June 2001.

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• SciCrunch
• 17 years ago - by Anonymous

American private research university in Los Angeles, California. Founded in 1880, it is the oldest private research university in California. USC has historically educated a large number of the nation's business leaders and professionals.

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• SciCrunch
• 12 years ago - submitted by Timothy Tsui

Resells antibodies incorporating quality control metrics for antibody reagents. Antibodies-online is based in Germany and provides valuable content in terms of information about antibodies, recent research news and specific news about current antibodies. All these informations are generated by antibodies-online staff or external databases like Pubmed, EMBL Harvester or from Google Scholar.

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• SciCrunch
• 17 years ago - by Anonymous

A portal to the Mouse Atlas of Gene Expression Project and Dissecting Gene Expression Networks in Mammalian Organogenesis Project. This Atlas will define the normal state for many tissues by determining, in a comprehensive and quantitative fashion, the number and identity of genes expressed throughout development. The resource will be comprehensive, quantitative, and publicly accessible, containing data on essentially all genes expressed throughout select stages of mouse development. Serial Analysis of Gene Expression (SAGE) is the gene expression methodology of choice for this work. Unlike expressed sequence tags (ESTs) and gene chip data, SAGE data are independent of prior gene discovery and are quantitative. Furthermore, SAGE data are digital, easily exchanged between laboratories for comparison and can be added to by scientists for years to come. Thus, this Atlas will include a data structure and data curation strategy that will facilitate the ongoing collection of gene expression data, even after the completion of this project. The Mouse Atlas project compromises 202 SAGE Libraries from 198 tissues. The list of libraries is available in a number of different groupings, including groups of libraries taken from specific tissue locations and libraries taken from specific developmental stages. Furthermore, this atlas will assemble gene expression profiles for a few focused experiments that will test hypotheses related to the techniques employed, tumor models and models of abnormal development. This will test the resource and provide quality control, validation and demonstrate applicability. Additionally, The Mammalian Organogenesis - Regulation by Gene Expression Networks (MORGEN) project will provide a complete, permanent, and accurate picture of mouse gene expression in the heart (atrioventricular canal and outflow tract), pancreas, and liver; new techniques to understand the interplay of proteins governing the expression of genes key to the development of these organ systems; and the identification of the master regulatory switches that control development of the tissues.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented May 10, 2017. A pilot effort that has developed a centralized, web-based biospecimen locator that presents biospecimens collected and stored at participating Arizona hospitals and biospecimen banks, which are available for acquisition and use by researchers. Researchers may use this site to browse, search and request biospecimens to use in qualified studies. The development of the ABL was guided by the Arizona Biospecimen Consortium (ABC), a consortium of hospitals and medical centers in the Phoenix area, and is now being piloted by this Consortium under the direction of ABRC. You may browse by type (cells, fluid, molecular, tissue) or disease. Common data elements decided by the ABC Standards Committee, based on data elements on the National Cancer Institute''s (NCI''s) Common Biorepository Model (CBM), are displayed. These describe the minimum set of data elements that the NCI determined were most important for a researcher to see about a biospecimen. The ABL currently does not display information on whether or not clinical data is available to accompany the biospecimens. However, a requester has the ability to solicit clinical data in the request. Once a request is approved, the biospecimen provider will contact the requester to discuss the request (and the requester''s questions) before finalizing the invoice and shipment. The ABL is available to the public to browse. In order to request biospecimens from the ABL, the researcher will be required to submit the requested required information. Upon submission of the information, shipment of the requested biospecimen(s) will be dependent on the scientific and institutional review approval. Account required. Registration is open to everyone.. Documented on October, 01, 2019.<br/>3D digital atlas of normal mouse development constructed from magnetic resonance image data. The download is a zipped file containing the six atlases Theiler Stages (ts) 13, 21,23, 24, 25 and 26 and MRI data for an unlabeled ts19 embryo. To view the atlases, download and install MBAT from: http://mbat.loni.ucla.edu Specimens were prepared in aqueous, isotonic solutions to avoid tissue shrinkage. Limited specimen handling minimized physical perturbation of the embryos to ensure accurate geometric representations of developing mouse anatomy. Currently, the atlas contains orthogonal sections through MRI volumes, three stages of embryos that have annotated anatomy, photographs of several stages of development, lineage trees for annotated embryos and a gallery of images and movies derived from the annotations. Anatomical annotations can be viewed by selecting a transverse section and selecting a pixel on the displayed slice.

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• SciCrunch
• 17 years ago - by Anonymous

This website allows visitors to search for genes of interest based on their spatial expression patterns in the Postnatal Day 7 mouse brain. Geneatlas provides two searching tools: A graphical interface for customized spatial queries; A textual interface for querying annotated structures. Geneatlas is the product of a collaboration between researchers at Baylor College of Medicine, Rice University, and University of Houston.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. This site aims to provide a discussion and source list for connectionist and neural network models of disorders associated with mental or brain conditions. Recent connectionist and neural network models of behavior, information processing patterns, and brain activity present in people with cognitive, affective, brain, and behavioral disorders are reviewed on this web site. Ways that assumptions regarding normal and disordered behavior may be represented in connectionist models are discussed for features of various disorders. Similarities and differences between the models and criteria for their evaluation are presented, and suggestions for inclusion of information which may help to make these models more directly comparable in the future are considered. References to Connectionist Models of Cognitive, Affective, Brain, and Behavioral Disorders include: General Neural Network Information Reviews, General Introductions, and Calls for More Connectionist Models of Mental Disorders Models of Psychopathologies and Psychiatric Disorders Models of Cognitive, Affective, Brain, and Behavioral Disorders Not Associated with Psychopathology Additionally, Web Sites for Neural Network Modelers of Disorder are provided.

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• SciCrunch
• 17 years ago - by Anonymous

A graphical simulation of a section of excitable neuronal membrane using the Hodgkin-Huxley equations. It provides full access to the Hodgkin-Huxley parameters, membrane parameters, stimulus parameters, and ion concentrations. In contrast with NEURON or GENESIS, which are vastly more sophisticated research tools, HHsim is simple educational software designed specifically for graduate or undergraduate neurophysiology courses. The user interface can be mastered in a couple of minutes and provides many ways for the student to experiment. Also included are sample exercises that use the simulator. HHsim is available as a Windows, Mac, or Unix executable file that does not require a Matlab license. Source code is included. It is also available in source-only form if you have Matlab R2007a or later. The latest release of HHsim is version 3.1, released February 16, 2008.

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• SciCrunch
• 17 years ago - by Anonymous

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• SciCrunch
• 17 years ago - submitted by Stephen Larson

THIS RESOURCE IS NO LONGER IN SERVICE, documented on February 07, 2013. A framework for understanding human cognition, grounded in principles specifying the character of human cognitive processes, and constrained by properties, of the underlying neural mechanisms. The Center will exploit this framework to guide formulation of explicit, testable models of normal and disordered cognition, including models of the development of cognitive functions and of their disintegration as a result of brain damage or disease. This site is intended as a public service and as a focal point for exchange of ideas among the participants in the Interdisciplinary Behavioral Science Center (IBSC). Public areas of the site provide information about the Center as a whole and about the various projects in the Center, as well as web-accessible documents and tools that we are making available as a public service. A fundamental tenet is that cognition is an emergent phenomenon, arising from the interactions of cooperating processing elements organized into specialized populations. One aim of the center will be to investigate the utility of explicit models that are formulated in terms of this approach, addressing many aspects of cognition including semantic knowledge, language processing, cognitive control, perception, learning and memory. A second aim will also investigate the principles that are embodied in the models, including principles of learning, processing and representation. Learning will be a central focus, since it plays a crucial role in cognitive development, acquisition of skills, formation of memories, and remediation of cognitive functions. A third aim of the Center will be to incorporate constraints from neuroscience. Findings from neuroscience will guide the specification of the principles and the formulation of domain-specific details of particular models, and will provide target experimental observations against which to assess the adequacy of the models. In addition, the Center will make use of neurophysiological methods in animals and functional brain imaging in humans to test predictions and generate additional data needed to constrain and inform model development. The Center will provide training funds for interdisciplinary research fellowships, to train junior scientists in the convergent use of behavioral, computational, and neuroscience methodologies. The outcome of the Centers efforts will be a fuller characterization of the nature of human cognitive processes, a clearer formulation of the underlying principles, and a more complete understanding of normal and disordered functions across many domains of cognition. This Center includes eight projects dedicated to various aspects of cognition and various general issues that arise in the effort to build explicit models that capture different aspects of cognition, and also includes an administrative core to help foster integration and provide computing resources. * Project 1: Functional and Neural Organization of Semantic Memory * Project 2: Interactive Processes in Language: Lexical Processing * Project 3: Interactive Processes in Language: Sentence Processing * Project 4: Mechanisms of Cognitive Control * Project 5: Interactive Processes in Perception: Neurophysiology of Figure-Ground Organization * Project 6: Basic Mechanisms and Cooperating Systems in Learning Memory * Project 7: Age and Experience Dependent Processes in Learning * Project 8: Theoretical Foundations * Core: Integration, Computational Resources, and Administration

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• SciCrunch
• 17 years ago - by Anonymous

A research center associated with the University of Pittsburgh that specializes in the diagnosis of Alzheimer's disease and related disorders. The overall objective of the ADRC is to study the pathophysiology of Alzheimer's disease, with the aim of improving the reliability of diagnosis of Alzheimer's and developing effective treatment strategies. Current research foci emphasize neuropsychiatry and neuropsychology, molecular genetics and epidemiology, basic neuroscience, and structural and functional imaging that aid in the diagnosis and treatment of Alzheimer's disease. Specific services at the ADRC include: comprehensive diagnostic evaluation of patients with suspected Alzheimer's disease and other forms of dementia; evaluation of memory, language, judgment, and other cognitive abilities; and education and counseling for patients and families.

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• SciCrunch
• 16 years ago - by Anonymous

Atlas of developing human brain for studying transcriptional mechanisms involved in human brain development. Consists of RNA sequencing and exon microarray data profiling up to sixteen cortical and subcortical structures across full course of human brain development, high resolution neuroanatomical transcriptional profiles of about 300 distinct structures spanning entire brain for four midgestional prenatal specimens, in situ hybridization image data covering selected genes and brain regions in developing and adult human brain, reference atlas in full color with high resolution anatomic reference atlases of prenatal (two stages) and adult human brain along with supporting histology, magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) data.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented May 12, 2016. A not-for-profit organization that utilizes creativity, innovation, and collaborative approaches to improve awareness, diagnosis, and management of movement disorders among people living with these conditions and the professionals who care for them. WE MOVE's mission is to facilitate the communication of emerging clinical advances and therapeutic approaches to the management and treatment of movement disorders. WE MOVE develops up-to-date training programs and comprehensive, interactive teaching materials to assist professionals in deepening their understanding of neurologic movement disorders and their associated pathophysiology, etiology, differential diagnosis and interventions. It also provides research news information on the latest developments in movement disorder research, comprehensive listings of other existing supportive nonprofit organizations dedicated to helping those with movement disorders, and information on movement disorder-related events. For those unfamiliar with different movement disorders, a glossary of terms is provided. WE MOVE is based in New York, New York. :NIF thanks the Parkinson's Disease Foundation for their referral of this resource to us., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 17 years ago - by Anonymous

Database of detailed protocols for single and double in situ hybridization (ISH) method, probes used by Yamamori lab and others useful for studies of brain, and many photos of mammalian (mostly mouse and monkey) brains stained with various gene probes. Also includes a brain atlas of gene expression. Currently, the atlas comprises a series of un-annotated images showing the localization of a particular probe or molecule, e.g., AChE.

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• SciCrunch
• 17 years ago - by Anonymous

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• SciCrunch
• 17 years ago - submitted by Eddy Kim

Genomic Object Net (GON) is a software platform for biological pathway modeling and simulation, based on two architectures hybrid functional Petri net (HFPN) and XML technology. This website provides pathway models of HFPN as well as the detailed explanation about these pathways.

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• SciCrunch
• 17 years ago - by Anonymous

A low-level specification for describing mathematics as a basis for machine to machine communication, developed by the W3C.

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• SciCrunch
• 17 years ago - by Anonymous

The VISN 6 MIRECC is organized as a translational medicine multi-site center focused on post deployment mental health issues. The overarching goals are improving clinical assessment and treatment and development of novel interventions through basic and clinical research. This MIRECC aims: (1) To determine whether early intervention in post-deployment mental health is effective in forestalling the development or decreasing the severity of post-deployment mental illness, (2) To determine what neuroimaging, genetic, neurocognitive, or other characteristics predict the development of post-deployment mental illness, and (3) To assess the longitudinal course of post-deployment mental illness.

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• SciCrunch
• 17 years ago - by Anonymous

This web site is an overview of the post-doctoral psychology training program at the VA Salt Lake City Health Care System (VA SLC HCS). Its purpose is to help prospective psychology post-docs learn about the training and professional growth opportunities that are available. The VA Salt Lake City Health Care System postdoctoral fellowship is a full-time, 12-month continuous appointment focused on specialty training in the evaluation and treatment of veterans with Post-Traumatic Stress Disorder. Postdoctoral Fellows will be active members of two interdisciplinary treatment teams: - The PTSD Clinical Team through the Mental Health Department - The Polytrauma Team through the Physical Medicine and Rehabilitation Department. Fellows will also provide community outreach to returning veterans from Afghanistan and Iraq. Especially relevant to the VA Mental Health Strategic Plan, psychological services are provided within the complementary areas of emotional trauma (e.g., military combat, military sexual trauma), physical trauma (e.g., TBI, orthopedic injuries), substance abuse, and couples/family discord, primarily within the OEF/OIF veteran population. Sponsors: This work is funded by the US Department of Veterans Affairs, Salt Lake City.

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• SciCrunch
• 17 years ago - by Anonymous