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Core facility that provides the following services: Clinical diagnosis services, Genomic sequencing service, ABI capillary sequencing service, Illumina next generation sequencing service, shRNA library sequencing service, High throughput genome sequencing, PCR to detection service, Plasmid sequencing service, Sequencing, Chip-Seq service, Digital Gene Expression Service, Nucleic acid library construction service, Next gen seq bioinformatics support service, Transcriptome and RNA-Seq service.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Imaging training, Imaging equipment access. The Molecular Imaging Laboratory?s research focuses on small animal in vivo imaging using MRI, and optical fluorescent and bioluminescent imaging. In particular, we are interested in using molecular imaging techniques to study mechanisms of image contrast enhancement, improvement of sensitivity and specificity of tumor detection, and applications of diagnostics using small animal disease models.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: DNA extraction from whole blood, saliva, isolated cell pellet, RNA extraction from whole blood with PaxGene tubes, Lymphoblast transformation, Isolation and cryo-preservation of white blood cells. The BioSample Services Facility (BSF) provides sample handling and preparation resources to investigators in the Partners research community. Our goal is to efficiently and effectively process specimens enabling the generation of high quality data via down stream processes. All projects containing subject samples and submitted to the BSF for handling must be IRB approved in advance. All specimens must be entered into our Laboratory Information Management System (GIGPAD) prior to delivery to the BSF. Our staff will work with you to design an implementation plan that would best fit your research needs.

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• SciCrunch
• 13 years ago - by Anonymous

The Partners Biorepository for Medical Discovery (PBMD), operated by the Partners HealthCare Center for Personalized Genetic Medicine, aims to foster collaborations among investigators, physicians and patients seen at Partners HealthCare institutions. This Partners-wide project is at the forefront of developing the tools needed to expedite the discovery and introduction of new ways to fight disease. As we advance the age of personalized medicine, it is critical that physicians and scientists work with large numbers of patients to advance the delivery of healthcare. The Biorepository provides an opportunity for patients to interact with investigative studies ? safely, securely and privately ? in ways that could have an enormous benefit for us all. The Biorepository continues in a development phase, and is actively working with a number of groups at BWH and MGH who are consenting patients for clinical and translational research studies. Samples are maintained in an institution-wide repository which is a growing resource available to Partners investigators and research groups.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Microscope access service, Microscope training service. Confocal and multiphoton are modern fluorescence techniques in microscopy for generating optical sections from live or fixed biological specimens. In general, both techniques employ a point scanning and point detecting design. The confocal microscope achieves point detection by using a confocal pinhole to block off out-of-focus emission from the specimen. The multiphoton microscope, on the other hand, generates intrinsic point emission directly from the in-focus spot, thereby eliminating the need for a confocal pinhole. Subsequent scanning of the entire field of view results in an optical section. Computer reconstruction of serial optical sections, collected at consecutive axial (z) positions, can reveal the spatial localization of cells and tissues (sometime subcellular molecules) in 3D. The ability to see biochemical processes in live cells, in real time, sheds light on the vastly complex molecular world of cells and may allow IDI scientists to identify new targets for drugs that will treat exposure to dangerous toxins and bacteria as well as fight a wide variety of diseases.

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• SciCrunch
• 13 years ago - by Anonymous

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• SciCrunch
• 15 years ago - submitted by Eddy Kim

Core facility that provides the following services: Introduction to the GE In Cell Analyzer 1000 for High Content Analysis (HCA). In collaboration with GE Healthcare Bio-sciences, the NeuroDiscovery Center has established a program centered around the IN Cell Analyzer 1000 - a flexible and easy to use sub-cellular analysis system suitable for medium-throughput screening, assay development and basic research. Based in the NeuroDiscovery Laboratory for Drug Discovery in Neurodegeneration, the IN Cell Analyzer 1000 is available for use by NeuroDiscovery members. (While priority is given to members investigating neurodegenerative diseases and the central nervous system, we welcome enquiries from all investigators.)

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Equipment support, Research software design. Is a core area housing major equipment such as ultracentrifuges, freezers, spectrophotometers, gamma counters, etc, as well as the centralized cell culture facility. The unit fosters equipment sharing, centralizes maintenance of equipment and provides repair for the equipment of all the projects.

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• SciCrunch
• 13 years ago - by Anonymous

High quality statistical support is important in the preparation of grant applications or study protocols for clinical trials. Such support typically is not readily available to investigators who are new to clinical trials. To address this weakness, the NeuroDiscovery Center provides consulting and collaborative services to its members who are engaged in clinical research applicable to neurodegenerative disease.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Transgene microinjection service, Embryonic stem cell gene targeting service, Blastocyst injection service, Cryopreservation of embryos and sperm, Genotyping service, Mouse consulting service. The Genome Modification Facility (GMF) provides transgenic, gene targeting, and other services to investigators of Harvard University and its affiliated institutions, as well as to investigators within the US and abroad. The GMF performs microinjections of DNA into fertilized embryos to generate transgenic mice, DNA transfection into ES cells for the creation of recombinant ES cell clones, injection of gene-targeted ES cells into host blastocysts to generate gene knock-out or knock-in mice, teratoma formation studies, and other related ES cell-based services. Other services include cryopreservation of mouse sperm and embryos, in vitro fertilization (IVF), recovery of cryopreserved mouse sperm and embryos, rederivation of pathogen free mouse lines, and derivation ES cell lines from wild type and mutant mice with a variety of genetic backgrounds. Our staff provides general consultations on experimental designs and vectors for gene modification-related projects, DNA preparation, recombinant ES clones, mouse genotyping, colony breeding and husbandry. We can also customize services as requested to support development of animal models of human diseases.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: MLV plasmid construction service, HIV plasmid construction service, Adenovirus plasmid construction service. The Harvard Gene Therapy Initiative was founded with the objective of promoting the use of gene therapy in both research and therapeutic applications and to conduct research developing new gene delivery vector technologies.

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• SciCrunch
• 13 years ago - by Anonymous

The Forsyth Center for Clinical and Translational Research (CCTR) is a unique clinical facility with 6 fully-equipped dental units and associated laboratories that are specifically dedicated to conduct clinical research in oral and related systemic diseases. Clinical trials following FDA guidelines are performed at all levels, from early phase 1 trials to large, multicenter definitive clinical trials, with the goal of improving outcomes and the long-term health of patients. We routinely conduct studies in the oral environment, that include standard clinical measurement protocols for dental caries, dental calculus, gingivitis, periodontal diseases, intraoral local anesthetic evaluation, tooth restoration and tooth whitening evaluation. In addition, the clinic is equipped for obtaining and processing microbiological samples, gingival crevice fluid samples, blood and saliva samples for analysis of bacteria, inflammatory mediators, as well as for genomic and proteomic analyses. Under the new leadership of Dr. Thomas Van Dyke, Vice President of Clinical Research at The Forsyth Institute, the Center proposes new goals/efforts in discovering new techniques, testing new ideas and searching for valuable biomarkers for preventing and treating periodontal diseases and associated systemic inflammatory conditions. The CCTR is actively involved with the design and conduct of clinical research under Good Clinical Practices for submission to regulatory agencies. It has a published international reputation in evaluating intraoral local drug delivery devices, oral diagnostic systems, local anesthesia, restorative materials, tooth whitening systems and the association of oral diseases with systemic conditions. Forsyth''s Institutional Review Board is a member of the Harvard Catalyst Regulatory Group and meets on a monthly basis providing complete review of clinical protocols.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: ABI Prism Taqman Allelic Discrimination Assay, OpenArray SNP genotyping, Illumina genotyping, Custom Illumina GoldenGate genotyping, Illumina Infinium genotyping analysis, Illumina methylation analysis. The Partners Genotyping Facility, part of the Partners HealthCare Center for Personalized Genetic Medicine (PCPGM), provides flexible, high quality, high-throughput SNP genotyping to the Harvard-Partners research community, including Harvard Medical School, hospitals in the Partners HealthCare network, investigators in the Dana-Farber-/ Harvard Cancer Center, and the Harvard School of Public Health. The portfolio of Genotyping methods at PCPGM now includes Illumina, TaqMan and TaqMan OpenArrays. <html><b>Note: DF/HCC members will receive the DF/HCC discount on both genotyping and sequencing services from our facilityb>html>

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• SciCrunch
• 13 years ago - by Anonymous

The Small Molecule Mass Spectrometry Facility at the FAS Center for Systems Biology offers support for the analysis of a wide variety of analytes using mass spectrometry based techniques. We are located in the second basement (B2) level of the Northwest Laboratory building at 52 Oxford Street, Cambridge, MA 02138. We provide services for molecular formula confirmation (accurate mass measurement), structural elucidation (MS/MS) and quantitation of small molecules. In addition, we can assist you in the mass analysis of a wide variety of non-proteomics samples including metabolites, medium sized proteins and oligonucleotides. Please contact us and tell us about your samples prior to submission or use of our Open Access laboratory.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Progamming and sequencing classes and training. Research Computing (RC) facilitates the advancement of complex research by providing leading edge computing services across the Faculty of Arts & Sciences (FAS). RC staff maintain expertise in constantly changing computing technologies, while ''speaking the language'' of the FAS researchers, to help them use computing more effectively.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Macromolecular X-ray diffraction service, Charge density analysis, Single-Crystal service, Crystal mounting service, Cambridge structural database access, Inorganic crystal structure database access. The X-ray diffraction facility in Harvard University offers single crystal X-ray data collection, structure solution and refinement of small molecule structures.

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• SciCrunch
• 13 years ago - by Anonymous

The Neuroimaging facility has a 3-Tesla magnetic resonance imaging scanner for non-invasive human brain imaging. Our aim is to: * Provide functional and anatomic magnetic resonance imaging (MRI) to scientists studying human cognition, brain development and aging, and individual differences * Provide training for undergraduate and graduate students destined to become the next generation of neuroscientists * Pioneer innovative ways of imaging the human brain and is a first adopter of new neuroimaging technology, tools and applications * Develop and make available the data processing and visualization tools demanded by advancing neuroimaging technologies.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Access to fabrication lab. Technological advances hold a key to greater understanding of the structure and function of complex neural circuits. Neuroengineering is a core facility that provides customized engineering solutions to neuroscience problems faced by our members. Assistance with experimental design, electronics, machining, and software development, are all services provided.

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• SciCrunch
• 13 years ago - by Anonymous

CBS hosts an optical imaging facility that houses advanced devices for widespread use by neuroscientists and is developing the next generation of optical techniques. The optical imaging is intended to be an extension of individual labs, housed in shared space. By pooling equipment, highly skilled technical management of the tools is available, allowing for routine technological upgrades, quicker troubleshooting, and expert advice. In addition, the joint space leads to camaraderie amongst users, and allows new technical advances in one lab to spread rapidly to other labs. This core facility also frees up space in individual labs that can be used in other ways. Finally, the shared equipment lowers barriers to adoption of the latest technology. This core facility provides: * Laser scanning microscopes with motorized stages for high throughput reconstructions of the nervous system * A histology suite for brain sectioning and tissue preparation * Stereo fluorescence macroscopes * The newest tools for high-resolution optical microscopy * Ultra-fast optical scanning microscopes

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• SciCrunch
• 13 years ago - by Anonymous

The Flow and Imaging Cytometry Resource provides research flow and imaging cytometry services to all investigators in the PCIMM at Children''s Hospital, Boston and Immune Disease Institute, HMS and the local scientific community on a case-by-case basis. With state of the art instrumentation, such as the standard configuration 3-lasers FACSAria located in BL2+-facility, 20-parameters 4-lasers FACSAria SORP and DIVA FACSVantage SE TurboSort?, the facility offers high speed cell sorting and complex analytical services, development of collaborative projects as well as consulting on design and development of new protocols and methods.

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• SciCrunch
• 13 years ago - by Anonymous