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Core facility that provides the following services: Assisted support, Equipment access, Cell sorting. <BR/> <BR/>Laboratory performs fluorescence cytometry services related to Immunology, Infectious Disease, and Immunostimulatory Compounds.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27, 2023. Core for Microarray analysis, Database development, Systems biology analysis, Genome assembly, Pathway data analysis, Expression data analysis, Metagenomics analysis. To maintain equipment and software for bioinformatic research, promote bioinformatics education on the MSU campus, and provide training and support to biologists implementing bioinformatics tools in their research.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Lab animal technician services, Animal husbandry service. <BR/> <BR/>The Mission of the Animal Resources Center is to provide healthy animals for use in IACUC-approved research, educational and testing protocols at Montana State University,ensure that University research animals are cared for in a humane and appropriate manner by the provision of modern, well maintained facilities, trained personnel, technical support, veterinary care and monitoring of animal care and use, provide resources, technical assistance, and information for University researchers and educators in meeting the requirements of animal-related protocols, and ensure observance of ethical standards and federal regulations pertaining to the care and use of animals for research, education and testing at Montana State University.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Basic animal care service, Clinical and health monitoring service, Humane euthanasia service, Animal disposal service, Animal quarantine service, Necropsy and diagnostics service, Animal vaccination service, Animal use consultation service, Breeding service, Animal sample collection service, Assistance with minor surgery, Animal tattooing service. <BR/> <BR/>Access to CLAR facilities is restricted to authorized investigators with CLAR and IACUC approval. No individuals may enter the facilities without this CLAR/IACUC authorization. Since its inception, the Center for Laboratory Animal Resources (CLAR) has centralized most research and teaching animal care for the Atlanta University Center consortium. Our purpose is to provide total animal care services as needed to all academic and/or research faculty and staff affiliated with any one of the member institutions of the Atlanta University Center (AUC).

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVCE, documented January 25, 2019. Core focuses on integration of MSM and affiliated health information systems into an interoperable repository. The long-term goal is to establish an integrated standards-based informatics platform to support MSM clinical and translational research investigators in their own work and in sharing research information with collaborators and other investigators in parallel fields.

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• SciCrunch
• 13 years ago - by Anonymous

The Analytical Chemistry and Protein Profiling Core is comprised of three primary labs: * Analytical Chemistry * Protein Profiling/2D Gel * 2D Gel Electrophoresis Lab

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Sperm Cryoperservation - Standard Mouse Backgrounds; including quality test (QC), 129 or Hybrid ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, C57BL/6 (JM8A) ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, Microinjection of one targeted 129, JM8A, or hybrid ES Cell clone, Microinjection of one targeted C57BL/6 (JM8 & others) ES Cell clone, Transgenic / DNA pronuclear Microinjection, Transgenic/ BAC DNA pronuclear Microinjection to hybrid mouse strain, Mice colony breeding, Mice ID tag & tail biopsy, Mice tail DNA preparation, Sperm Cryoperservation - Non-Standard Mouse Backgrounds; including quality test(QC), Recovery live born pups for testing following QC, IVF recovery of one mouse line from cryopreserved sperm for most strains (~10 pups provided), Recovery of cryopreserved mice embryos (up to 80 embryos), Special DNA Prep. <BR/> <BR/>The MGH Transgenic and Gene Targeting Facility generates transgenic and knockout or knock-in mice to study gene function in embryonic stem cell and somatic cell systems. Services include: microinjection of DNA into fertilized embryos for the creation of transgenic mice, transfection of DNA into ES cells for the generation of recombinant ES cell clones, injection of gene-targeted ES cell clones into host blastocysts for the generation of gene knockout or knock-in mice, and other related ES cell based services. The facility is also equipped to perform in vitro fertilization projects, cryopreservation of mouse sperm and embryos, recovery of cryopreserved mouse sperm and embryos, and derivation of ES cell lines from a variety of genetic backgrounds. The facility provides consultation within reason on experimental design and vectors for gene targeting-related projects. The facility can also provide advice for the preparation of DNA, recombinant ES clones, mouse genotyping, handling and husbandry. The facility supports innovative and experimental approaches involving transgenic and knockout or knock-in mice to better help investigators study gene regulation and function, and develop appropriate animal models to study human genetic disorders.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Recombinant protein expression and purification in yeast Pichia pastoris, Large-scale production of immunotoxins for cell depletion studies, Large scale production of recombinant cytokines, Cost effective small-scale production using E.coli system. <BR/> <BR/>The Recombinant Protein Expression and Purification (RPrEP) Core was established in 2009 to provide a cost-effective resource to the MGH and DF/ HCC community for expression and purification of recombinant proteins necessary for pre-clinical studies as well as for basic mechanistic studies by immunologists and cancer biologists. Recombinant Proteins can be manufactured by this Core for a variety of applications according to MGH-DF/ HCC investigator needs. In addition to large-scale production of recombinant proteins in yeast Pichia pastoris, a cost effective small-scale production service will be provided using E.coli or yeast Pichia pastoris expression system (e.g. for small animal studies, use as immunogens, ELISAs, or high throughput microarray platforms).

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Gene variations analysis, Genotyping service. <BR/> <BR/>The Human Genotyping Lab assists investigators to apply the genomic technologies to population-based research. The strategic plan is to create a link between basic science, clinical investigation and population-based research by integrating genomic sciences into our research program. The central hypothesis is that health disparities are related in part to ethnicity-specific DNA variants in critical genes that influence the susceptibility to common diseases. Morehouse School of Medicine has a longstanding interest on the studies of ethnic disparities and a longstanding strength on community outreach to underserved minority populations. Accordingly, the major objective of the MSM Human Genome Core Laboratory is to enhance the research capacity on these sample cohorts and upgrade our research to the molecular genetic level based on cutting-edge genomic technologies.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Fragment (microsatellite) analysis service, Enumeration of polymorphisms (SNPs), DNA sequencing. <BR/> <BR/>The DNA Sequencing Lab is the longest-established lab in the Gene Profiling Core, providing DNA sequence analysis to investigators involved in research utilizing molecular biology techniques. The lab uses capillary electrophoresis sequencing technology and is built around the ABI 3130xl Gene Analyzer (16-capillary) and associated software for DNA sequence analysis.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 30, 2023. Core facility that provides the following services: Microscopy consultation services, Technical microscopy service, Microscopy training services, Conventional immunofluorescence microscopy service, Confocal microscopy service, Live-cell imaging service, Conventional electron microscopy service, EM immunogold labeling service, Tissue sectioning service, Tissue fixation, Computer based image analysis and quantification.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Synthesis of Radiopharmaceuticals for PET, PET scanning/imaging service. <BR/> <BR/>The PET Core Laboratory provides a full range of technical and professional services for the design and execution of programs using Positron Emission Tomography (PET). The PET Core Facility provides the required facilities and personnel on a per study basis to allow investigators to use PET without requiring them to acquire the needed special expertise and equipment.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Magnetic Resonance Spectroscopy Service, Magnetic Resonance Imaging Service. <BR/> <BR/>The Musculoskeletal Imaging Research Core (MIRC) offers specialized imaging techniques including quantitative computed tomography (QCT), magnetic resonance (MR) spectroscopy of muscle and high-resolution soft tissue MR imaging. QCT is a technique widely employed for studies evaluating body composition and bone mineral density. MR spectroscopy is a technique that allows non-invasive quantification of metabolites in human tissues.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: 4.7T/7T MRI, PET-CT, SPECT, FMT, BLI, Animal housing service, Multimodality imaging and image fusion, Quantitative image analysis and processing, Animal surgical services, Radiochemistry, Histopathology, Data Management, In vivo confocal microscopy. <BR/> <BR/>The Mouse Imaging Program (MIP) at the Center for Systems Biology is a uniquely integrated imaging resource providing the larger Harvard/MIT research community with access to state-of-the-art in vivo imaging technologies. The program offers magnetic resonance imaging (MRI), positron emission tomography (PET-CT), single photon emission computed tomography (SPECT-CT), computed tomography (CT), bioluminescence (BLI), fluorescence mediated tomography (FMT), and various other fluorescence imaging technologies. The fully integrated program also provides mouse holding facilities for serial imaging, surgery, anesthesia and veterinary care. Image reconstruction, 3D display, fusion, quantitative image analysis and online data access are also available. The program performs its own research, aimed at continuously improving existing imaging technologies and has deep knowledge of cardiovascular, oncology and neurological mouse models of disease. A list of publications made possible by utilizing MIP resources is available on the <a href=https://csb.mgh.harvard.edu/mouse_imaging/publications>Program web sitea>. Imaging requests may be submitted through the <a href=https://csb.mgh.harvard.edu/mouse_imaging>MIP websitea>.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: 3D Imaging, Normative data comparison, Scan review. The High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) Core Facility offers measurements of the microscopic internal structure of cortical and trabecular bone in the distal radius and tibia. Additionally, the HR-pQCT Core Facility offers Finite Element Analysis to estimate key biomechanical properties of the bone including failure load and stiffness. By scanning the distal radius and tibia, the HR-pQCT Core can measure a variety of important parameters reflecting the integrity or cortical and trabecular bone. This information cannot be determined using standard clinical imaging techniques such as dual-energy x-ray absorptiometry (DXA). A scanning appointment is a 30 minute addition to a clinical research visit and involves less radiation exposure than traditional bone densitometry. With applications for both cross-sectional and longitudinal research, investigators have employed our facilities and expertise to study a variety of bone-related diseases with participants ranging in age from children to the elderly. The goal of the HR-pQCT Core is to provide facilities and personnel on a per study basis, allowing investigators access to important information about bone structure and function without requiring special expertise and equipment. Getting Started: To begin organizing a cohort for HR-pQCT studies or to inquire further, please contact the Core Director, Dr. Joel Finkelstein.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Offline assisted or self-performed analysis. <BR/> <BR/>The HSCI-CRM Flow Cytometry Core Facility seeks to provide high quality, accessible cytometry sorting and analysis services to laboratories in the Center for Regenerative Medicine, Harvard Stem Cell Institute, and MGH research communities at an affordable rate. The Core''s equipment and highly trained operators provide an advanced level of sorting and analysis services to its investigators. Additionally, the Core is dedicated to training users on all aspects of flow cytometry, including practical issues, information about specific applications, and critical interpretation of sorting results. The Core''s three full-time staff members strive to ensure that each investigator''s visit benefits their individual experiments to the greatest extent possible. To ensure the best availability to all users, the Core offers an online scheduling system, and provides extended sorting hours until late evening. HSCI faculty have reduced pricing for use of the Core''s services.

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• SciCrunch
• 13 years ago - by Anonymous

The core laboratory facility has the necessary equipment to provide each study with the initial specimen processing and handling required for shipping to a reference laboratory and for storage and maintenance at a sample repository. Laboratory procedures provided by the core laboratory are intended for research use only,and not for diagnostic; it may provide other specialized services for specific protocols on a case by case basis.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Double- and triple-labeling experiments, Acquisition of high-resolution images: 2048 x 2048 pixels, Single molecule visualization, allowing dynamic observation and functional analyses of both in vivo and living cells, Total internal reflection fluorescence experiments (TIRF). <BR/> <BR/>This Core consists of a Zeiss LSM 5 Pascal laser confocal microscope with a Zeiss RGB vario laser module and Nikon C1 Confocal/TIRF System with 3 PMT. A Zeiss Axiovert 200 fully motorized light microscope is available with fluorescence, bright-field, phase-contrast and Nomarski (DIC) capabilities. Image acquisition and analyses are performed using Zeiss LSM 5 Pascal Confocal Microscopy Software (Release 3.2) on 2 workstations. Zeiss Physiology software is available also. Live cell imaging is available using a Zeiss temperature controller with custom chamber and heating stage. The Nikon C1 Confocal/TIRF System fully motorized Nikon Eclipse Ti microscope is available with fluorescence, bright-field and TIRF capabilities. Imaging acquisition and analyses are performed using EZ-C1 and NIC-Elements Software.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Fresh hepatocytes in suspension, Plated hepatocytes, Cryopreserved hepatocytes, Custom hepatocyte isolations, Decellularized whole rat livers. The mission of the Cell Resource Core (CRC) is to provide high quality primary cells and tissues to researchers reliably and affordably. Leveraging a new MGH technology that significantly increases the viable yield of high quality hepatocytes from human and animal donor livers, we are initially offering hepatocytes to the research community.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Custom mutation detection and DNA sequencing services, Custom genotyping service. <BR/> <BR/>This resource provides custom genotyping (microsatellite, SNP, other) in human and mouse, mutation detection/DNA sequencing, dosage analysis and related services to further the CHGR mission of promoting the use of genetic strategies in basic and clinical research.

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• SciCrunch
• 13 years ago - by Anonymous