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Core facility that provides the following services: Analysis of gene function by RNA interference, MicroRNA profiling, Chromatin immunoprecipitation (ChIP) assay, Flow cytometry, Conventional and real time PCR assays.
The goal of the center is to address training, research problems, and technology transfer issues as they relate to the environment; by increasing the number of under-represented minority graduates in science, mathematics, engineering, and technology. ERT2C projects focus on analysis of toxic elements and compounds in a closed environment, trace metals in soil, soil sediments, air and wastewater processes, wastewater contaminants, and environmental policy and law. The Core Analytical Facility is an important component of the center. The Core?s mission is to achieve regional, community, and national recognition as a quality environmental analytical laboratory and environmental research program. This Mission will be achieved through the characterization of environmental toxicants in the ambient environment (air, soil, and/or water) and the investigation of the mechanisms involved in the toxicity effect.
The Biosensor and Biomarker Technology (BBT) Core Facility is a research support facility at Texas Southern University (TSU) that provides technical and resources support as well as hands-on training in molecular and biochemical techniques for environmental and biomedical research investigators. The main objective of the BBT is to provide essential research infrastructure to improve and facilitate the research capabilities of faculty investigators and graduate students at TSU. To accomplish this goal, the BBT core facility provides assistance to research investigators in the following molecular, environmental and toxicological techniques through RCMI-sponsored research resources.
Core facility that provides the following services: Coulter XL flow analysis, Cytomation MoFlo cell sorting, LaserScan Cytometry, BD Biosciences LSR II flow cytometry analysis, Flow cytometry data analysis. The Flow Cytometry Facility is a core facility of Schepens Eye Research Institute that provides fluorescent-based cell analysis and sorting to Boston area biomedical researchers.
Core facility that provides the following services: Microscopy Instrumentation Access, Training in Microscopy/Imaging, Assisted Microscopy. The mission of Ragon Institute Imaging Core, Microscopy Division is to bring the latest imaging modalities and technology to bear on fundamental molecular and cell biological questions pertaining to infectious diseases. As an MGH Core Facility, the Ragon Institute Imaging Core also serves the MGH greater MGH community. Since the Ragon Institute is also a collaboration between MGH, Harvard, and MIT, so too does the facility welcome members of the MIT and Harvard communities as we are now located in Cambridge at MIT. The facility encompasses five imaging systems, including a Zeiss LSM510 laser scanning confocal microscope and a fully automated Zeiss Axio Observer microscope, both housed in BL2+ compliant facilities. These imaging systems are therefore fully equipped for both fixed and live cell imaging. In addition, the facility has two slide scanning systems (MIRAX MIDI and TissueFAXS) for high speed automated imaging and cellular screening of tissue sections and cultured cells on glass slides. In the Flow Cytometry section of the Imaging Core, we also have an ImageStream X Mark II by Amnis. The core also serves as a resource for addressing a variety of imaging needs including consultation on a topics related to imaging applications, experimental design, and sample preparation.
Core facility that provides the following services: Research equipment design and fabrication service, Sample collection service, Animal transporting/shipping service, Animal handling and husbandry service, Breeding colony management service. Animal Quarters (AQ) provides safe and sanitary facilities for animal research projects in accordance with the Animal Welfare Act, Public Health Service Policy, National Institutes of Health Guidelines for the Care and Use of Laboratory Animals and the UAF Institutional Animal Care and Use Committee. Housed animals include arctic ground squirrels, laboratory mice, red-backed voles, syrian hamsters, American widgeon, northern shovelers, lesser scaup, greater scaup, northern pintail, green-winged teal, zebrafish, sticklebacks, bettas, and black bears.
Core facility that provides the following services: Flow Cytometric Cell Sorting. The mission of Ragon Institute Imaging Core, Flow Cytometry Division is to provide training and access to flow cytometers with up to 18 parameters, as well as cell sorting of biohazardous samples. As an MGH Core Facility, the Ragon Institute Imaging Core serves the greater MGH community. Since the Ragon Institute is also a collaboration between MGH, Harvard, and MIT, so too does the facility welcome members of the MIT and Harvard communities. The facility is equipped with three LSR2?s, an LSR Fortessa, a FACSCalibur, and a FACSAria IIu cell sorter in a biosafety cabinet. The core also serves as a resource for addressing a variety of flow cytometry needs including consultation on topics related to experimental design and sample preparation.
The Biostatistics Core serves the needs of the HIV/AIDS researchers within the Ragon Institute and its affiliates. In particular, members of the Biostatistics Core provide expertise in the planning, conduct and analysis of research with the goal of enhancing the scientific quality of HIV-related research at the institute. The primary objective of the core is to ensure that studies are well designed, correctly analyzed, clearly presented, and correctly interpreted.
The Research Subject Advocate''s main responsibility is to assure that all steps are taken throughout any clinical research activity to protect the participating subjects and to ensure that their safety is given the highest priority. Also it is her responsibility to assure that all investigators/collaborators and CRC personnel are managing patient health information according to the Health Information Portability and Accountability Act.
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The goal of the Biostatistical Support Service is to provide investigators expert advice on proper study design and data analysis. The support includes consults with the center biostatistician, faculty consultants from the School of Public Health, Department of Biostatistics and Epidemiology, Medical Sciences Campus, University of Puerto Rico, and use of statistical software.
Core facility that provides the following services: Protein identification from Coommassie stained gel, Protein identification from silver stained gel, Protein identification from complex mixtures (in solution) service, Running SDS-PAGE service, SILAC (Data Acquisition and Analysis), ICAT (Data Acquisition and Analysis), ITRAQ (Data Acquisition and Analysis). The Proteomics Center at Children''s Hospital Boston offers the most up-to-date proteomics equipment currently available. This includes the latest equipment for protein separation and several state-of-the-art mass spectrometers, which detect and quantify proteins in a sample and measure them to determine their structure and characteristics.
The Microscopy and Imaging Core at the University of Hawaii Cancer Center (CC) provides access to a wide range of imaging instruments to UHCC member, and will soon extend the service to non-members. The facility also offers access to a licensed MetaMorph software package for the processing and analysis of microscopy images. Currently, the core houses four major instruments and three microscopes for routine fluorescence and brightfield use. The core is also in charge of maintenance and service of an IVIS Lumina (Caliper Life Sciences). This is a highly sensitive system to image fluorescent and/or bioluminescent reporters both in vivo and in vitro.
Molecular biology is a field with a tremendous capacity for advancing our scientific understanding of disease and human health. Our Core facility provides its users with a centralized source of expertise as well as access to sophisticated instrumentation. This strong combination of knowledge and equipment helps to increase the productivity of the scientists at PSM so that they may more quickly make discoveries that can be translated to the clinical level and thus have a measureable impact on improving health in the US and worldwide.
Core facility that provides the following services: Pavlovian fear conditioning, Freezing response analysis, Insertion of cannula. The goals of this core are to enhance the neuroscience-related projects currently being undertaken by PSM investigators and to stimulate further neuroscience research through enhanced scientific interactions between basic scientists at PSM. In addition, this neuroscience core facility will also serve as a tool for attracting strong new recruits.
Core facility that provides the following services: HIV viral load test, Immunoprofile assay, HIV genotype by sequencing assay, Virtual phenotyping assay, RNA and DNA tropism, HCV genotyping, HCV qualitative and quantitative test, HIV ELISA. The Ponce School of Medicine (PSM) RCMI AIDS Research Infrastructure Program (ARIP) proposes to further upgrade its core laboratory units in order to best meet the needs of current and prospective ARIP faculty members. It also proposes to facilitate the institution of career development programs specifically designed to meet the identified requirements of the ARIP faculty members; the current mentoring and partnership program will be strengthened to support their careers. The proposed ARIP Phase V activities will revolve around three specific aims. Specific Aim #1: To further improve and expand the research capabilities of the AIDS research core laboratories in viral genetics, immunology, and drugs of abuse. ARIP cores will be made accessible to the AIDS/HIV investigators from other institutions and countries in order to facilitate the development of high caliber collaborative research that will share the same technologies. The advanced technologies and instrumentation offered by ARIP will enable investigators to study the characteristics of the AIDS/HIV infection in the Caribbean region. Sophisticated instruments and equipment will be made available in real time to investigators from other institutions (via an Internet-2 connection) in an ongoing effort to foster collaboration. By accessing the institution website (www.psm.edu), interested investigators can take part in online training sessions as well as reserve instruments. Specific Aim #2: To implement a career development program (tailor-made for individual ARIP faculty members) that will include research & career mentoring, research consultation, and partnership development. A concerted effort will be made to develop a viable institutional faculty retention plan, which will include faculty incentives through research enterprise activities; in the past, lack of effective faculty development and retention programs has caused the loss of key members. Critical self-analyses were performed to identify the needs of current faculty members so that specific plans might be designed around the requirements of each individual. Specific Aim #3: To implement additional AIDS/HIV-related research programs at PSM as well as at the island?s other three RCMI-sponsored institutions. PSM currently has eight faculty members with actively funded AIDS-related independent research projects (representing the greatest number among the PR RCMI institutions). ARIP members have been active in pursuing the possibility of developing CFAR and CTSA proposals via the program?s ongoing partnership with the consortium of U-FL, USF, FCU, and FSU.
Core facility that provides the following services: Clinical study support services. The Office of Human Subject Recruitment and Protection (OHSRP) provides consultation and guidance to the Penn research community on all issues related to adult and pediatric human subjects being seen through the CTRC facilities, including recruitment and protection. The role of the OHSRP is to champion the mission of the feasible, safe and ethical conduct of human subject research within the CTRC. The original Research Subject Advocate (RSA) was a position mandated by the National Center for Research Resources under the NIH and was defined in order to ensure that research was being conducted in ways that did not increase the risk associated with conducting studies. In April 2008, the CTSA Consortium Steering Committee approved and endorsed best practices, which serve to define the mission, scope, and model for research advocacy within the CTSA consortium. The OHSRP has advanced the role of the Research Subject Advocate (RSA) by adopting the 2008 best practices defined by the CTSA Consortium. The OHSRP operations are complementary to and integrative with existing entities at the institution to promote and facilitate safe and ethical conduct of human research. The OHSRA complements the University of Pennsylvania Office of Human Research (OHR) and Institutional Review Board (IRB) in support of ensuring the safety of individuals participating in health research. The OHSRP serves as a resource to the research community and to participants; has a voice in policy regarding research ethics, participants? rights, and research safety; and plays a role in the protection of human subjects and responsible conduct of research educational programs of the institution. The OHSRP has direct access to, an authority that can temporarily suspend a research activity based on ethical and safety concerns so that problems can be explored or resolved through proper procedures. This capacity enables preliminary intervention into problems that might not necessarily invoke an institutional review board (IRB) suspension. The OHSRP has a reporting pathway to institutional officials of appropriate authority and is free of conflict of interest.
Patient Coordinator Services is responsible for scheduling the subjects for the research-related appointments; her goal is to facilitate the participation of the subjects in the clinical studies in collaboration with the research staff and the investigators.
Core facility that provides the following services: Cell culture and tissue services, DNA isolation service, Cell culture and tissue services, Epstein Barr Virus (EBV) lymphocyte transformation service, Cell culture and tissue services, Fibroblast culture and cryopreservation service, Cell culture and tissue services, Specialized cell isolation service, Molecular biology services, microsatellite haplotyping service, Molecular biology services, mutation analysis service, Molecular biology services, Restriction fragment analysis service, Molecular biology services, RNA services, Molecular biology services, SNP genotyping service, Specimen Collection, Processing, and Point-of-Care services, Bedside tests by Bayer Rapid Point 400, Specimen Collection, Processing, and Point-of-Care services; Collection, processing and storage of specimens, Specimen Collection, Processing, and Point-of-Care services, Packaging and shipping of samples. The Translational Core Laboratory consists of the Specimen Collection, Processing and Point of Care, Biochemistry, Cell Culture/DNA Isolation, and Molecular Biology core laboratories. Laboratory testing is integrated across Penn and CHOP, and TCL services are provided at multiple physical locations at both Penn and CHOP. Penn location: first floor Smilow Center for Translational Research CHOP location: 804 Abramson Research Center (ARC)
Core facility that provides the following services: Data management assistance, Biostatistical analysis assistance. The Study Design and Biostatistics (SDAB) Core works closely with existing resources to provide targeted study design and biostatistics support to ITMAT/CTSA investigators. The Core serves as a direct provider of services, including protocol review, study design, proposal development, and performance of simple to potentially substantial complex analyses. SDAB integrates the support available with the HUP and CHOP Clinical and Translational Research Centers (CTRCs), the expertise and resources of faculty in the Center for Clinical Epidemiology and Biostatistics / Department of Biostatistics and Epidemiology (CCEB/DBE), the Biostatistics Analysis Center (BAC), and the Biostatistics and Data Management Core (BDMC) at CHOP.