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The Major Instrumentation Core has been established to provide technical services and consumable supplies necessary for the operation and maintenance of a variety of major instruments that support biomedical research at Xavier University. The long term goal of the Major Instrumentation Core is to enhance the overall biomedical research capabilities at Xavier University by making available essential instrument-based platforms for various research projects. To achieve this goal the Major Instrumentation Core has set the following specific aims: 1). support biomedical research projects on campus by providing essential analytical instrumentation, 2). maintain and operate existing instruments, 3). acquire new instruments, and 4). provide technical support for user community of the core.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024.Core facility that provides the following services: Tissue culture suite access, Biological assay development for screening experiments, High-throughput-screening service, Post-screening studies. The Wistar Molecular Screening Facility is a shared resource facility open to Wistar and non-Wistar scientists. The laboratory operates on a fee-for-service basis, providing expertise in bridging automated technology with the development of innovative, robust biochemical or cell-based assays for high-throughput chemical and functional genomic screens. The laboratory strives to possess the flexibility to accommodate diverse biological systems and a variety of investigator-developed assay types. While service is the primary role of the laboratory, the staff will also develop and implement new technology as needed to fulfill the needs of its users. Education and training is also part of the laboratory''s mission, as trainees apply high-throughput screening experiments to their investigations. The ultimate goal of the laboratory is to enable scientists to apply cutting edge technology and unique resources to discover agents (i.e. small molecules, siRNA) to further study the functions of poorly understood proteins, signaling pathways, and cells in complex biological process relevant to human physiology and disease. The combinations of these activities will provide scientists opportunities to develop new innovative basic and translational research, preliminary data for hypothesis driven research grant applications, and public-private partnerships. The Wistar Molecular Screening Facility was developed with support from the Lankenau Institute for Medical Research, the Commonwealth of Pennsylvania Department of Community and Economic Development Keystone Innovation Zone initiative, The F. M. Kirby Foundation, The CLAWS Foundation, The Florence & Daniel Green Foundation, The McClean Contributionship, From The Heart Foundation, and the Noreen O?Neill Foundation for Melanoma Research.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Live-cell time-lapse microscopy, Low magnification and photomacrography? service, Confocal microscopy service, Two-photon microscopy, Small animal whole body luminescence and fluorescence imaging?, 2, 3, 4, and 5D image analysis, Imaging consultation service, Imaging equipment, image processing, and image analysis training, In-lab microscopy assistance and maintenance service, Imaging Facility instrument access. The Imaging Facility is a shared resource with the primary goal of providing exceptional microscopy and imaging services, as well as individual access to a variety of state-of-the-art imaging resources for members of the Wistar research community. The imaging systems have been designed to be extremely flexible to reflect a broad range of challenging scientific questions and specimens. Each system provides a combination of illumination, optics and image capture options. Diverse subjects ranging from fluorescently tagged live cell cultures and stained tissue sections, to 3D tumor spheroids and low magnification explanted tissues, can be accommodated with available systems. Current equipment includes standard upright and inverted fluorescence microscopes, a customized live-cell time lapse microscope capable of 6D imaging, a laser scanning confocal microscope, a 2-photon microscope designed for in vivo imaging, a small animal, whole body luminescence and fluorescence imager, special low magnification (photomacrography) systems as well as a variety of traditional photographic cameras, lenses and lighting equipment. Users of the facility may be trained for unassisted use of all core assets, or they may elect assisted service with the facility staff performing the imaging. The Imaging staff also provides assistance to researchers with additional aspects of their imaging requirements. Ideal approaches to specimen documentation are often unique to the experiment and the staff can help design the most effective imaging protocols to answer a particular question. On-site assistance is available to help investigators get the most out of their own systems. Image analysis and specialized Photoshop training, creative imaging for journal covers, and guidance on digital imaging ethics help to round out the services available from the facility.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Paraffin sectioning service, Frozen sectioning service, Histology staining services. This facility provides basic histology services. These include fixing, processing and paraffin embedding of all types of tissues for light microscopy (i.e. routine stains, immunohistochemistry or in situ hybridization). Routine hematoxylin and eosin staining as well as special staining is done in the lab. Slides are prepared for immunohistochemistry and in situ and immunohistochemistry. Frozen sectioning is also available. It is advisable to contact the facility about freezing techniques so the best sections can be obtained.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Microarray services, RNA amplification service, ABI 7900 Real-time qPCR service, Capillary DNA sequencing and microsatellite analysis, Illumina HiSeq 2000 sequencing service, Illumina Genome Analyzer services. The Wistar Genomics Facility serves as a hub for consultation and scientific interactions relating to nucleic-acid based methods and provides expertise and support to insure the best possible use of emerging nucleic-acid technologies. In addition to consultation and collaboration with Wistar Cancer Center members, the Facility provides services to the greater scientific community. The establishment of this facility was supported in part by an NCI Cancer Center Support Grant and equipment grants from the Commonwealth of Pennsylvania, The Pew Charitable Trusts and the National Cancer Institute.

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• SciCrunch
• 13 years ago - by Anonymous

An ontology of biodiversity of INPA

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• SciCrunch
• 13 years ago - by Anonymous

Core provides High Throughput Data Analysis, Customized Bioinformatics Services, Custom Programming, High Performance Computing, Data management. Located in the Center for Systems and Computational Biology. Provides Cancer Center investigators with database management, software application support, expertise in statistical analyses and computational modeling of biomedical research data.

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• SciCrunch
• 13 years ago - by Anonymous

The current zebrafish facility is composed of approximately 100 research tanks available for short and long-term studies, and a significant expansion project is underway. The facility enables investigator access to the unique advantages of the zebrafish model, which provides hundreds of mutant and transgenic zebrafish with unique properties suited for specific experiments. This core?s essential mission is to provide a reliable mechanism for incorporation and propagation of new and existing zebrafish lines into the core.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Hematology Services, Parasitology Services, Chemistry Analysis Services, Cell Line Testing, Customizable Chemistry Analysis, Phenotyping Services, Infertility evaluation in male mice, Veterinary Pathologist Consultation. Access to consented and de-identified human tissue specimens; Comprehensive, state of the art diagnostic, necropsy and comparative pathology services for animal model systems with specific expertise and focus on mouse models; Research histology including advanced techniques, immunohistochemistry, immunofluorescence, laser capture micro-dissection and tissue micro-array preparation; Access to experts in veterinary and human pathology.

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• SciCrunch
• 13 years ago - by Anonymous

Vanderbilt Transgenic Mouse/Embryonic Stem Cell Shared Resource (TMESCSR) provides services that facilitate the generation, storage and regeneration of genetically altered mice.

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• SciCrunch
• 13 years ago - by Anonymous

The Tissue Core laboratory provides direct proteome profiling and protein imaging of intact tissues by MALDI-MS. The Core also provides proteome profiling of biofluids by MALDI-MS as they pertain to a specific disease.

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• SciCrunch
• 13 years ago - by Anonymous

Provides support for phone interview-based collection of information from study subjects. The Survey Research Shared Resource provides services to investigators related to development and implementation of mail, telephone, web and mixed mode surveys.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Polysomnography, Titrations with continuous positive airway pressure, Multiple sleep latency testing, Wrist actigraphy, Video polysomnography. The Vanderbilt Sleep Research Core offers two hard-wired sleep systems with synchronized video-polysomnography and 21 channels of EEG, with dedicated registered sleep technologists. A sleep core/sleep reading center manager and the core director (Dr. Beth Malow) assist investigators with protocol development. It offers polysomnography, titrations with continuous positive airway pressure, multiple sleep latency testing, and wrist actigraphy (wireless devices that measure sleep-wake patterns non-intrusively based on accelerometers that measure activity vs. rest). The core provides for centralized scoring of polysomnography and actigraphy data for multicenter trials. In addition to the scoring component, emphasis is placed on the quality of the sleep recordings at the individual sites with close communication among the individual site technologists and the sleep core manager.

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• SciCrunch
• 13 years ago - by Anonymous

The Rat Neurobehavioral Core provides equipment, training and consulting for Vanderbilt personnel who are interested in studying rat models of both neurological and psychiatric disorders. Examples of assays available for research in rats include models of anxiety, depression, drug abuse, learning and memory, cognition, attention, social interaction, pain, motor activity and coordination. Investigators can employ the latest technology in video capture and software-based analysis of behavior. Additionally, the facility offers a 24 hr/day home cage monitoring system that includes measurement of sleep EEG and core body temperature. A surgical suite is available, outfitted with a wide variety of equipment such as standard rat stereotaxic frames and a stereo-microscope, as well as various perfusion tables. Housing takes place inside the facility?s vivarium, which is Virus-Antibody free.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Immunophenotyping, Fluorescent protein expression analysis, Cell-cycle analysis, Functional assay service, Non-infectious cell sorting, BSL2+ biohazardous cell sorting, Flow cytometry consultation service, Flow cytometry training and ongoing advice, Flow cytometry data management service, Flow cytometry collaboration facilitation, Flow cytometer access. The Wistar Institute Flow Cytometry Shared Resource provides flow cytometric services, training, advice, and support for the use of flow cytometric techniques by Wistar Cancer Center investigators, as well as the greater basic research community.

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• SciCrunch
• 13 years ago - by Anonymous

The Neurochemistry Core Lab performs assays of neurotransmitter concentrations in brain tissue, designs custom assays as well as provides training in HPLC methods.

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• SciCrunch
• 13 years ago - by Anonymous

The objectives of the physiology core are to establish average values and normal ranges for physiologic parameters of renal function in mice, and to develop novel assays of mouse kidney structure and function. Our goal is to provide valuable institutional and national shared resources to facilitate better understanding of kidney diseases and treatments.

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• SciCrunch
• 13 years ago - by Anonymous

The overall goal of the Histology and Morphometry Core is 1) to provide a common facility and expertise for the broad spectrum of morphologic studies that may be required for interpretation of studies of various models of kidney disease and their response to interventions; 2) to provide tissue samples from existing archival specimens from various mouse and rat kidney disease models that may be used for exploration and characterization of expression patterns of various novel target molecules; and 3) to develop and enhance existing morphologic techniques to improve the ability of center investigators to localize specific molecules and tissue sections, and to interpret their significance based on the spatial localization and relationship to patterns of injury.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core facility that provides training and expertise in nutrition/diet methodology to obtain valid and reliable assessment and analyses of dietary intakes, nutritional status, body composition and metabolism.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Simple Protein Identification, Multidimensional Protein Identification Technology, 2D Difference Gel Electrophoresis (2D-DIGE). The Proteomics Laboratory provides state-of the-art MS instrumentation and analytical methods to analyze proteins and proteomes.

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• SciCrunch
• 13 years ago - by Anonymous