Curator Dashboard

A commercial search engine focusing on biologically relevant products.

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• SciCrunch
• 13 years ago - by Anonymous

A cross-platform software program for Bayesian MCMC analysis of molecular sequences. It is entirely orientated towards rooted, time-measured phylogenies inferred using strict or relaxed molecular clock models. It can be used as a method of reconstructing phylogenies but is also a framework for testing evolutionary hypotheses without conditioning on a single tree topology. BEAST uses MCMC to average over tree space, so that each tree is weighted proportional to its posterior probability. We include a simple to use user-interface program for setting up standard analyses and a suit of programs for analysing the results.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 26, 2019. Database of leaf senescence to collect SAGs, mutants, phenotypes and literature references. Leaf senescence has been recognized as the last phase of plant development, a highly ordered process regulated by genes called SAGs. By integrating the data from mutant studies and transgenic analysis, they collected many SAGs related to regulation of the leaf senescence in various species. Additionally, they have categorized SAGs according to their functions in regulation of leaf senescence and used standard criteria to describe senescence associated phenotypes for mutants. Users are welcome to submit the new SAGs.

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• SciCrunch
• 13 years ago - by Anonymous

A database that stores information on the biomolecules which are modulated during aging and by caloric restriction (CR). To enhance its usefulness, data collected from studies of CR''''s anti-oxidative action on gene expression, oxidative stress, and many chronic age-related diseases are included. AgingDB is organized into two sections A) apoptosis and the various mitochondrial biomolecules that play a role in aging; B) nuclear transcription factors known to be_sensitive to oxidative environment. AgingDB features an imagemap of biomolecular signal pathways and visualized information that includes protein-protein interactions of biomolecules. Authorized users can submit a new biomolecule or edit an existing biomolecule to reflect latest developments.

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• SciCrunch
• 13 years ago - by Anonymous

Database that gathers data on interactions in the mitochondrial proteome that has been used to construct a network for the aging process in humans and to identify interactions that influence this process, since mitochondria is a major source of cellular reactive oxygen species that accumulate during aging. It will: # aid in increasing our understanding of the molecular functions and interaction networks of mitochondrial proteins, # help in identifying new target proteins for experimental research using predicted protein-protein interaction information, and # help in identifying biomarkers for diagnosis and new molecular targets for drug development related to mitochondria. How is MitoInteractome different? * Provides protein-protein interaction information with graphical display. * Applies newly added new mitochondrial protein information by using BLAST incorporated in Mitointeractome * Shows correlation of mutation with their impact * Provides specific pathway information to aid study of their impact * Contains SNP Information

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• SciCrunch
• 13 years ago - by Anonymous

Database that contains gene sets and microRNA-regulated protein-protein interaction networks for longevity, age-related diseases and aging-associated processes.

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• SciCrunch
• 13 years ago - by Anonymous

Collection of annotated and manually curated data of genes related to aging divided into genes related to longevity and/or aging in model organisms (yeast, worms, flies, mice, etc.) and aging related human genes.

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• SciCrunch
• 13 years ago - by Anonymous

• Organization
• SciCrunch
• 17 years ago - submitted by Andrea Stagg

A discovery interface of digital objects, including documents, photographs, audio, video, and data sets, which reflect a range of materials collected, managed, and preserved by the UCSD Library to support teaching, learning and research. Content has been drawn from across the Library collections with strengths in the areas of Baja California, Melanesia, Oceanography, and UC San Diego history. Access to more content will increase over time. Items have been digitized from the original primary sources in our collections, and recently the Library began to partner with UC San Diego researchers on campus to make research data more readily available. The Digital Collections website gathers data into two broad categories of content: Library Digital Collections contains digitized versions of selected collections covering topics such as art, film, music, history and anthropology.

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• SciCrunch
• 13 years ago - by Anonymous

Radiation Oncology is a featured book on Wikibooks because it contains substantial content, it is well-formatted, and the Wikibooks community has decided to feature it. This wiki project is an open source, free access reference book. Anyone is welcome and encouraged to contribute anytime, anything (as long as it relates to Radiation Oncology). Feel free to edit it, update it, correct it, and otherwise increase its teaching potential. Full Table of Contents *Preface *Clinical Radiation Oncology *Treatment Toxicity and Supportive Care *Treatment Approaches *Cancer Biology *Appendices

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• SciCrunch
• 16 years ago - by Anonymous

Core facility that provides the following services: X-ray crystallography service. A Molecular Structure and Modeling Core laboratory has been established to provide technical services to support faculty researchers involved in cancer research and drug design at Xavier University. Drug design methods use molecular structure information and modeling methods to determine structure patterns among active and inactive compounds, identify and compare potential active sites, and screen databases to identify new leads. X-ray crystallography provides structure coordinates for druglike, organic compounds and small peptides. The goal of this core laboratory is to provide small molecule X-ray crystallographic services as well as to support ligand-based and structure-based drug design projects at any stage. The long term goal is to develop resources in order to enhance cancer related biomedical research capability at Xavier University. To achieve this goal, the Molecular Structure and Modeling Core Laboratory has set the following specific aims: 1. To provide salary support for a Core Scientist to provide molecular modeling services and training in support of Xavier faculty research projects 2. To establish new collaborations with faculty at other local and RCMI institutions who might benefit from molecular modeling services 3. To provide small molecule x-ray crystallography services 4. To provide support and maintenance costs for equipment in the MSM Core

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Bioassays service, Functional studies service, Gene expression service, Molecular biology service, Mass spectrometry based global scale protein profiling, 2D Gel Electrophoresis, Data analysis services. The RCMI Cell and Molecular Biology Core (CMB Core) provides focused services using cell and molecular biological techniques. It also provides access, upkeep and training on ?state of the art? equipment. Funding by the RMCI allows these services to be offered at minimal cost to users of the core. Technical services and necessary consumable supplies are provided to support cancer research projects at Xavier University. The long term goal of the Cell and Molecular Biology Core is to enhance the overall biomedical research capabilities at Xavier University.

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• SciCrunch
• 13 years ago - by Anonymous

A resource center that distributes important resources to the biogerontological community and facilitates interactions and collaborative efforts amongst researchers to aid biogerontologists and enhance research into the basic biology of aging. They aim to make SAGEWEB the premier aging-related website containing a variety of different content types including: * Databases related to the basic biology of aging * Software and bioinformatic tools for aging-related science * Educational tools for teachers and students interested in aging biology * Primers on important topics in aging-related science * Videos and podcasts of aging-related topics * Aging-related discussion forums and blogs * Links to additional aging-related labs, conferences, and resources

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• SciCrunch
• 13 years ago - by Anonymous

Government agency for Innovation by Science and Technology that helps Flemish companies and research centers in realizing their research and development projects by offering them financial funding, advice and a network of potential partners in Flanders and abroad. They also support the Flemish Government in its innovation policy.

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• SciCrunch
• 13 years ago - submitted by Andrea Stagg

Core facility that provides the following services: Drug Dosage Form Development. The center is focused on understanding and overcoming barriers to efficient oral, colonic, parenteral, pulmonary and vaginal delivery of drugs in the hopes of developing new treatments for chronic diseases such as cancer. Numerous new technologies are coming out of the Center as relationships have been formed with small, advanced technology businesses.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Animal husbandry. To provide the best husbandry and environment for housing, maintaining, and caring for research and laboratory animals used at Xavier University, with in all applicable guidelines, and to assist users by providing information and support for handling and care of animals.

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• SciCrunch
• 13 years ago - by Anonymous

The Wyss Institute Materials Characterization Core is dedicated to promoting leading edge biologically inspired research by providing users with a wide range of state-of-the-art materials characterization equipment and analysis software. These tools help support the characterization of a material?s unique physical, chemical, and mechanical properties. The Materials Characterization Core team provides exceptional hands on training, method development, and technical expertise. We also proactively stride to introduce the latest innovations in materials characterization to the Wyss Institute community and our affiliated partners. Our current techniques include chromatography, mass spectrometry, UV-Vis spectroscopy, particle sizing, quartz crystal microbalance, electrochemical testing, rheology, and nanoindentation.

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• SciCrunch
• 13 years ago - by Anonymous

The Core''s capabilities include six Computer Numerical Control (CNC) milling centers (one of which is a five-axis micro-milling machine), two 3D printers, a waterjet cutter, a laser cutter, and a sinker Electrical Discharge Machining (EDM) tool. The Core has three full time machinists with experience in both industrial and academic machine shops, creating prototypes for varied applications. In addition to fabrication, these experts help researchers during the design phase, enabling development from a simple concept into real prototypes.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: In-gel protease digestion service, LC-MS/MS protein identification service, Gel/LC-MS/MS Comprehensive analysis of a subproteome or proteome, MudPIT (LC/LC-MS/MS) analyis?comprehensive analysis of a subproteome or proteome, Reverse phase microbore HPLC peptide mapping service, MALDI mass spectrometry, ESI of intact proteins, Post-translational modification identifications, Custom proteomics database creation, Custom proteomics data analysis, Proteomics methods development. The Wistar Proteomics Facility provides mass spectrometry (MS) and sequence analysis of proteins and peptides at maximum sensitivity using state-of-the-art instruments and methods. The most commonly used services are identifications of either purified proteins or complex protein mixtures, such as sub-proteomes or complete proteomes, using electrospray ionization tandem mass spectrometry (ESI MS/MS). Typically, either individual bands are excised from 1-D SDS gels, or the entire gel lane is analyzed by slicing it into uniform fractions followed by trypsin digestion and nanocapillary HPLC interfaced directly with hybrid ion trap mass spectrometry (Gel/LC-MS/MS). Data is analyzed and filtered to produce low false-positive rates. Several options are available for quantitatively comparing protein changes in related samples, and additional options will be implemented in the future. Complementary services include reverse-phase microbore HPLC peptide mapping with UV detection and mass measurements of intact peptides and proteins using MALDI MS or ESI MS. Posttranslational modification (PTM) analyses including identifications of specific modified residues also are provided, although investigators should recognize that in most cases these studies are quite complex and require substantial effort. These studies, as well as analyses of complex protein mixtures, usually require preparation of custom sequence databases and/or custom data analyses, which can be provided by the facility as needed.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024.Core facility that provides the following services: Recombinant plasmid DNA engineering, Recombinant protein production via Baculovirus expression systems (BVES), Recombinant protein production in prokaryotic systems, Recombinant protein purification, Retrovirus production service. The Protein Expression Facility is a shared resource laboratory that provides Wistar Cancer Center Members and non-Wistar scientists technical assistance with viral vector preparation and the expression and purification of recombinant proteins. The Facility has greater than 20 years of experience in recombinant protein expression with special expertise in the use of baculovirus expression systems (BVES). The Facility offers the following services: 1. Recombinant plasmid DNA engineering 2. Viral vector production (i.e. baculovirus and retrovirus) 3. Analytical and preparative scale expression of nascent or epitope-tagged recombinant proteins 4. Protein purification These goals are accomplished by a centralized laboratory with dedicated, experienced staff, which enables high-throughput, economy of scale, virus preparation and protein expression services, including quality assurance and control procedures to ensure efficient, consistent production and purification of recombinant proteins and viral vectors. Many recombinant proteins produced by the facility have been used for crystallization efforts, analytical biochemistry studies designed to investigate enzymatic properties, structure-function relationships between protein-protein, protein-nucleic-acid, and protein-small molecule interactions, custom antibody production, experimental cancer vaccines, and development of miniaturized assays for small molecule screening. <i>The facility is supported in part by an NCI Cancer Center Support Grant and a grant from the NIH National Institute of Aging (PO1 AG031862).i>

• Resource
• SciCrunch
• 13 years ago - by Anonymous