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The Royal Ontario Museum is among the worlds leading museums of natural history, and of world cultures. Indeed, in combining a universal museum of cultures with that of natural history, the ROM offers an unusual breadth of experience to visitors and scholars from around the world. We realize more acutely now that nature and humanity are intertwined, and the ROM offers many examples in its collections and programs of these fundamental relationships. It is the ROMs mission to engage the public in exploration of cultural change and to serve as an advocate for science in the study of nature. Our collections and research serve as the basis for programs ranging from formal student education courses to public debates, lectures, symposia, films, tours, publications, travel and family activities. The museum aims to host and produce programs of intellectual depth and social relevance on both sides of its mandate, including unique ROM exhibitions and works of a collaborative nature. Through the ROMs Institute for Contemporary Culture, the museum also explores current issues through works of art and programs in many media. The ROM is near completion of a major capital project (Renaissance ROM) that will see the building of 27 new galleries, the liberation of many stranded collections, the addition of valuable public amenities, and the creation of dramatic new architecture in the Michael Lee-Chin Crystal, designed by Daniel Libeskind. This is among the largest capital projects in the history of Canadian cultural institutions, and brings the assets of the museum fully to the public again even as the ROM prepares to celebrate its centenary in 2014. On this website, you have access to thousands of photographs and summaries from the ROMs collections, results of its research activities around the world, information on current programs and exhibitions, and means to download information, watch podcasts and purchase tickets to the museum and its events. You will also find information about its restaurants, the ROM Museum Store and rental services for ROM facilities after hours. The Royal Ontario Museum offers a unique platform to the engage the worlds of culture and the environment at the centre of one of North Americas great cities. We look forward to meeting you here, and to sharing the adventures of this place, with all its treasures.

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• SciCrunch
• 17 years ago - by Anonymous

The Centre for Automotive Safety Research at the University of Adelaide, is internationally recognised as a leading research organisation in its field. The Centre conducts high quality independent research that enables rational decision making, leading to a reduction in the human and economic losses from road crashes. The Centre is focused on: * Conducting multidisciplinary research to understand how road crashes and the resulting injuries are caused * Proposing and evaluating ways to prevent crashes and injuries * Providing independent professional advice on road safety matters to government and non-government organisations in Australia and overseas The Centre began life in 1973 as the Road Accident Research Unit (RARU) with the planning and undertaking of an in-depth study of road accidents in the Adelaide metropolitan area. From 1981 through 1998, the Unit''s work was supported by a grant from the National Health And Medical Research Council. During that grant period RARU''s research program was concentrated in two areas: the study of brain injury mechanisms in fatally injured road users and the epidemiology of drink driving and alcohol related crashes. Notably, an investigation of the influence of vehicle speed in fatal pedestrian accidents led on to case control studies of the relationship between a driver''s travelling speed and risk of involvement in a casualty crash in both urban and rural areas. RARU''s analysis of the occurrence of brain injury in road crashes called into question the then prevailing paradigm of brain injury mechanisms. This prompted the development of an experimental study of axonal injury that, in turn, led to the Japan Automobile Research Institute initiating a formal collaborative research agreement with RARU, and now with CASR, in the area of crash injury biomechanics. Also a part of our legacy is that over 40 years ago the Centre''s previous Director, Professor Jack McLean, co-authored the first paper in the world to show that car design played a major role in pedestrian protection, revealing that pedestrians are run under, not over, by the striking car.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. Rosetta Inpharmatics in Seattle, WA Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co. Inc., develops and implements technologies that will improve drug discovery. The company''s leading-edge genomic research and data analysis efforts focus on how medical compounds affect biology, enabling more accurate selection of drug targets and more efficient drug development. Rosetta Inpharmatics was founded in 1996 to design and implement DNA microarray gene expression technologies.

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• SciCrunch
• 17 years ago - by Anonymous

Roche NimbleGen, Inc. is a leading innovator, manufacturer and supplier of a proprietary suite of DNA microarrays, consumables, instruments and services. Roche NimbleGen uniquely produces high-density arrays of long oligo probes that provide greater information content and higher data quality necessary for studying the full diversity of genomic and epigenomic variation. Roche NimbleGen is enabling a new era of High-Definition Genomics by providing scientists with cost-effective, high-throughput tools for extracting and integrating complex data on important forms of genomic and epigenomic variation not previously accessible on a genome-wide scale. Scientists can thus obtain a clearer understanding of genomic and epigenomic structure and function and how they impact biology and medicine. This improved performance is made possible by Roche NimbleGen''s proprietary Maskless Array Synthesis (MAS) technology, which uses digital light processing and rapid, high-yield photochemistry to synthesize long oligo, high-density DNA microarrays with extreme flexibility. NimbleGen Systems was established in 1999. The MAS technology is the result of research collaborations between the departments of biotechnology, genetics, physics, and semiconductor engineering at the University of Wisconsin - Madison. Roche NimbleGen has the exclusive worldwide license to the MAS technology from the Wisconsin Alumni Research Foundation (WARF).

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• SciCrunch
• 17 years ago - by Anonymous

Organization that facilitates spinal cord injury research and care. By accelerating the translation of discoveries and best practices into improved treatments, it aims to improve the lives of people living with SCI.

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• SciCrunch
• 14 years ago - by Anonymous

Resources for macromolecular X-ray crystallography from the Richardson Laboratory, including kinemages (a scientific illustration presented as an interactive computer display), databases, software, training materials and images

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• SciCrunch
• 17 years ago - by Anonymous

Software platform to explore, analyze and visualize data. SAS 9.4 is part of SAS Platform. Standardized data governance and management from statistical software company SAS.

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• SciCrunch
• 17 years ago - by Anonymous

Headquartered in Redwood City California, WideTag is a pioneer in architecting computing systems that integrate sensors, positioning devices and memory with social, Web 2.0-style services in applications that revolutionize business and push consumer technology.<BR/>

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• SciCrunch
• 17 years ago - by Anonymous

Wheaton Industries Inc. is a leading marketer, manufacturer and re-packager of containers, laboratory ware, instrumentation and associated products and services sold principally to customers in the general laboratory, life sciences, and diagnostics and reagent / chemicals packaging markets. Our products and services are marketed and sold globally through two divisions. The laboratory research products are sold through Wheaton Science Products, and the packaging products are sold through Wheaton Science Packaging.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. Tools were developed by the Critical Appraisal Skills Programme (CASP) to help with the process of critically appraising articles of the following types of research. These are available and free to download for personal use.

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• SciCrunch
• 17 years ago - by Anonymous

This site is designed for researchers and students who want a quick way to generate random numbers or assign participants to experimental conditions. Research Randomizer can be used in a wide variety of situations, including psychology experiments, medical trials, and survey research. The program uses a JavaScript random number generator to produce customized sets of random numbers. Since its release in 1997, Research Randomizer has been used to generate number sets over 10.7 million times. This service is part of Social Psychology Network and is fast, free, and runs with any recent web browser as long as JavaScript isn''t disabled. Research Randomizer is a free service offered to students and researchers interested in conducting random assignment and random sampling. By using this service, you agree to abide by the SPN User Policy and to hold Research Randomizer and its staff harmless in the event that you experience a problem with the program or its results. Although every effort has been made to develop a useful means of generating random numbers, Research Randomizer and its staff do not guarantee the quality or randomness of numbers generated. Any use to which these numbers are put remains the sole responsibility of the user who generated them. What are the system requirements needed to run Research Randomizer? This program works best with Firefox and other recent web browsers. If you''re using a browser that came with America Online, or older browsers made prior to 2003, you may experience some difficulties with Research Randomizer. You may also not be able to use Research Randomizer with some limited-function browsers that do not fully support JavaScript, such as the Opera broswer used on certain game consoles. We would suggest that you update to a fairly recent, fully- functional stand-alone browser. How do I know what browser I am using? The easiest way to find this out is to click Help on the pulldown menu at the top of the screen. One of the options should be About Mozilla Firefox, About Internet Explorer, About Netscape, or something similar. Selecting this option will open a window that displays the name, version number, and copyright date of your browser. How does Research Randomizer generate its numbers? Research Randomizer uses the Math.random method within the JavaScript programming language to generate its random numbers for all modern web browsers. If you are using an older version of Microsoft Internet Explorer or Netscape Navigator (that is prior to version 4.0 of either), Research Randomizer uses an adaptation of the Central Randomizer by Paul Houle. Note that Research Randomizer no longer supports much-older browsers by other vendors (e.g., Mosaic). Who designed Research Randomizer? The original idea and programming for Research Randomizer came from Geoffrey C. Urbaniak in 1997. Research Randomizer was then jointly developed with Scott Plous, webmaster of Social Psychology Network, and online tutorials were added to the main program. In 1999 the site was redesigned with the assistance of Mike Lestik, in 2003 Mike Lestik added the download function, and in 2007 Mike Lestik and Scott Plous redesigned the site and added new content.

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• SciCrunch
• 17 years ago - by Anonymous

Welcome to the Department of Genome Sciences, which began in September 2001 by the fusion of the Departments of Genetics and Molecular Biotechnology. Our goal is to address leading edge questions in biology and medicine by developing and applying genetic, genomic and computational approaches that take advantage of genomic information now available for humans, model organisms and a host of other species. Our faculty study a broad range of topics, including the genetics of E. coli, yeast, C. elegans, Drosophila, and mouse; human and medical genetics; mathematical, statistical and computer methods for analyzing genomes, and theoretical and evolutionary genetics; and genome-wide studies by such approaches as sequencing, transcriptional and translational analysis, polymorphism detection and identification of protein interactions. Our chair, Dr. Robert Waterston, joined the department in January 2003. Our department includes both faculty with primary appointments in Genome Sciences, as well as adjuncts in other departments and Seattle institutions. Nine faculty are members of the National Academy of Sciences, including 2001 Nobel Prize winner Dr. Lee Hartwell, who conducted much of his groundbreaking work in the Department of Genetics. Five training faculty are Howard Hughes Medical Institute Investigators. Graduate research in the Department leads to a Ph.D. in Genome Sciences and students may also choose to participate in the Computational Molecular Biology or Molecular Medicine programs. Our department has around 55 - 60 graduate students at any given time and has moved into the new William H. Foege Building.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 20, 2019. Development and implementation of algorithms to predict nucleic acid folding and hybridization by free energy minimization using empirically derived thermodynamic parameters. Modeling and algorithm development have been closely coupled with the derivation of nearest neighbor and related energy rules. Current work is focused on the computation of partition functions for systems containing two molecules in solution that can fold as well as hybridize with each other. Ensemble free energies, mole fractions of different monomer and dimer species and base pair probabilities are computed over a range of temperatures. These computations lead to the prediction of UV absorbance (optical density) and heat capacity (Cp) melting profiles that can be directly compared with experimental data. A related project is the development of an algorithm named FASTH that searches RNA or DNA sequence databases for optimal hybridization sites for nucleic acid query sequences. Unlike traditional search algorithms, such as BLASTN and FASTA, FASTH uses hybridization free energy as the criterion for selection

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Retrieve-ensembl-seq is included in the software suite regulatory sequence analysis tools (RSAT), allowing instant submission of retrieved sequences to further analysis tools. AVAILABILITY: retrieve-ensembl-seq is integrated in the RSAT suite: http://rsat.ulb.ac.be/rsat. Web site: http://rsat.ulb.ac.be/rsat/retrieve-ensembl-seq_form.cgi. Web services: http://rsat.ulb.ac.be/rsat/web_services/RSATWS.wsdl. Stand-alone distribution: freely available under an academic licence to download from the RSAT web site. The complete manual, a convenient tutorial and demos are available from the RSAT website. Additional help can be found on the RSAT public forum.

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• SciCrunch
• 17 years ago - by Anonymous

Cambridge, Massachusetts-based biotechnology company focused on cancer. Focus areas are blood cancers and solid tumors. Compounds: ponatinib, AP26113, ridaforolimus and AP1903., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 17 years ago - by Anonymous

About the LAGAN Toolkit The LAGAN Tookit consists of four components: CHAOS CHAOS is a pairwise local aligner optimized for non-coding, and other poorly conserved regions of the genome. It uses both exact matching and degenerate seeds, and is able to find homology in the presence of gaps. LAGAN LAGAN is our highly parametrizable pairwise global alignment program. It takes local alignments generated by CHAOS as anchors, and limits the search area of the Needleman-Wunsch algorithm around these anchors; Multi-LAGAN Multi-LAGAN is a generalization of the pairwise algorithm to multiple sequence alignment. M-LAGAN performs progressive pairwise alignments, guided by a user-specified phylogenetic tree. Alignments are aligned to other alignments using the sum-of-pairs metric. Shuffle-LAGAN Shuffle-LAGAN is a novel glocal alignment algorithm that is able to find rearrangements (inversions, transpositions and some duplications) in a global alignment framework. It uses CHAOS local alignments to build a map of the rearrangements between the sequences, and LAGAN to align the regions of conserved synteny. The website uses scripts written by Alex Poliakov. The website was designed by Marina Sirota.

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• SciCrunch
• 17 years ago - by Anonymous

Our vision a world where regular physical activity, good nutrition, and healthy weight are part of everyone''s life. Our mission to lead strategic public health efforts to prevent and control obesity, chronic disease, and other health conditions though regular physical activity and good nutrition. Our goals: * Increase health-related physical activity through population-based approaches. * Improve those aspects of dietary quality most related to the population burden of chronic disease and unhealthy child development. * Decrease prevalence of obesity through preventing excess weight gain and maintenance of healthy weight loss. Our Work With fiscal year (FY) 2008 funding of 38 million, CDC''s DNPAO is working to reduce obesity and obesity-related diseases. This is done through state programs, research, surveillance, training, intervention development and evaluation, leadership, policy and environmental change, communication and social marketing, and partnership development. See At A Glance 2009 for more. Supporting State Programs The Nutrition, Physical Activity and Obesity Program (NPAO) is a cooperative agreement between the Centers for Disease Control and Prevention''s Division of Nutrition, Physical Activity and Obesity (DNPAO) and 23 state health departments. The program goal is to prevent and control obesity and other chronic diseases through healthful eating and physical activity. The state program will develop strategies to leverage resources and coordinate statewide efforts with multiple partners to address all of the following DNPAO principal target areas: 1. Increase physical activity. 2. Increase the consumption of fruits and vegetables. 3. Decrease the consumption of sugar sweetened beverages. 4. Increase breastfeeding initiation, duration and exclusivity. 5. Reduce the consumption of high energy dense foods. 6. Decrease television viewing. Our Research DNPAO supports research to enhance the effectiveness of physical activity and nutrition programs. Topics of these research activities include: * the effectiveness of parent-focused strategies to reduce the time children spend watching television * the influences of the home environment on sugar-sweetened beverage consumption * the use of policy interventions to promote physical activity * the effectiveness of breastfeeding interventions in various settings. Publications: http://www.cdc.gov/nccdphp/DNPAO/aboutus/manuscripts/index.html

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• SciCrunch
• 17 years ago - by Anonymous

Recombineering (recombination-mediated genetic engineering) is a powerful method for fast and efficient construction of vectors for subsequent manipulation of the mouse genome or for use in cell culture experiments. It is also an efficient way of manipulating the bacterial genome directly. Recombineering is a method based on homologous recombination in E. Coli using recombination proteins provided from ? phage. Our bacterial strains contain a defective ? prophage inserted into the bacterial genome. The phage genes of interest, exo, bet, and gam, are transcribed from the ?PL promoter. This promoter is repressed by the temperature-sensitive repressor cI857 at 32C and derepressed (the repressor is inactive) at 42C. When bacteria containing this prophage are kept at 32C no recombination proteins are produced. However, after a brief (15 minutes) heat-shock at 42C a sufficient amount of recombination proteins are produced. exo is a 5''-3'' exonuclease that creates single-stranded overhangs on introduced linear DNA. bet protects these overhangs and assists in the subsequent recombination process. gam prevents degradation of linear DNA by inhibiting E. Coli RecBCD protein. Linear DNA (PCR product, oligo, etc.) with sufficient homology in the 5'' and 3'' ends to a target DNA molecule already present in the bacteria (plasmid, BAC, or the bacterial genome itself) can be introduced into heat-shocked and electrocompetent bacteria using electroporation. The introduced DNA will now be modified by exo and bet and undergo homologous recombination with the target molecule. The method is so efficient that co-electroporation of a supercoiled plasmid and a linear piece of DNA into heat-shocked, electrocompetent bacteria will work as well.

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• SciCrunch
• 17 years ago - by Anonymous

Software application for a fast exact Hardy-Weinberg Equilibrium test for SNPs (entry from Genetic Analysis Software)

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. A business division of Sigma-Aldrich Corporation, focusing on providing custom manufactured products and specialized services used in the industrial development and manufacturing, including processes, that bring new drugs and new electronic products to market., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 17 years ago - by Anonymous