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DISABKIDS is a European project which aims at enhancing the quality of life and the independence of children with chronic health conditions and their families. The project proceeds according to three phases: 1. Development of an instrument (paper/pencil as well as a computer assisted version) to assess quality of life and patient needs in children/adolescents with chronic health conditions. 2. Psychometric testing of the developed instrument in the 7 pariticipating countries in a pilot study with 378 children/ adolescents and a subsequent field study with 1260 children/adolescents and their families (180 families in each country). 3. Implementation and Evaluation of the instrument in routine care The project expects to achieve progress in quality of life assessment in children and adolescents with disabilities a) by focussing on an European co-operation in construction of an assessment instrument for quality of life, in which the persons concerned (children/adolescents and their families) play a major role, b) by addressing needs for care as explicitly voiced by the persons concerned, c) by including psychosocial as well as clinical and socio-economic determinants of quality of life and d) by developing a mode of administration which is practicable for the patient group concerned, so that in using the instrument, current care can be evaluated and future care can be improved by corresponding to the patients'' needs. Sponsors: The DISABKIDS project funded by the European Commission within the Fifth Framework Programme (FP5)

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• SciCrunch
• 17 years ago - by Anonymous

Sponsor:<BR/> support is NIH grant R01 GM077122<BR/> National Institutes of Health, Claudia Adams Barr Program, and Friends of DFCI.<BR/> We are interested in how genomics changes promote cancer progression. Through collaboration with biomedical researchers, we analyze high-throughput microarray and sequencing data to study genomics, expression, and network changes in cancer cells. New methods are packaged into widely-used software such as dChip, which has been cited more than 1600 times.<BR/>

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• SciCrunch
• 17 years ago - by Anonymous

A simple program for finding nearly matched primers Sponsor: This material is based upon work supported by the National Science Foundation under Grant No. 0114726.

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• SciCrunch
• 17 years ago - by Anonymous

It is a collaboration between owners, breeders and scientists with the goal of studying the genetics of the Portuguese Water Dog. The Georgie project sends out periodic reports of our findings. These reports are generally sent to the participants along with detailed information on their dogs. Here we have reproduce the public versions of the report for your reference.

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• SciCrunch
• 14 years ago - by Anonymous

A database and analysis of the brainwaves of individuals with pronounced physical disabilities. BrainGate''s mission is to further the advancement of this life-changing technology to promote wider adoption to help impaired individuals communicate and interact with society. For instance, the Cyberkenetics BrainGate Neural Interface is currently the subject of a pilot clinical trial being conducted under an Investigational Device Exemption (IDE) from the FDA. The system is designed to restore functionality for a limited, immobile group of severely motor-impaired individuals. It is expected that people using the BrainGate System will employ a personal computer as the gateway to a range of self-directed activities. These activities may extend beyond typical computer functions (e.g., communication) to include the control of objects in the environment such as a telephone, a television and lights. BrainGate offers a systems approach which applies the language of neurons in both short and long-term settings. The platform technology is based on the results of several years of research and development at premier academic institutions such as Brown University, the Massachusetts Institute of Technology, Emory University, and the University of Utah.

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• SciCrunch
• 17 years ago - by Anonymous

The CpG island searcher screens for CpG islands which meet the criteria selected below in submitted DNA sequences. Abstract The unique variability in the 5'' region of the GR gene, with 9 alternative first exons and 13 splice variants plays a critical role in transcriptional control maintaining homeostasis of the glucocorticoid receptor (GR). This 5''mRNA heterogeneity, common to all species investigated, remains untranslated since the alternative first exons are spliced to exon 2 immediately upstream of the translation initiation codon. These alternative first exons are located either immediately upstream of the coding exons in the CpG island (exons B-H and J), or further upstream (exons 1A and 1I). The mechanisms regulating the differential usage of these first exons in different tissues and individuals, and the role of the 5''UTR in the splicing of the coding exons are still poorly understood. Here we review some of the mechanisms that have so far been identified. Data from our laboratory and others have shown that the multiple first exons represent only a first layer of complexity orchestrated probably by tissue-specific transcription factors. Modulation of alternative first exon activity by epigenetic methylation of their promoters represents a second layer of complexity at least partially controlled by perinatal programming. The alternative promoter usage also appears to affect the 3'' splicing generating the different GR coding variants, GRalpha, GRbeta, and GR-P. Aberrant GR levels are associated with stress-related disorders such as depression, and affect social behaviour, mood, learning and memory. Dissecting how tissue-specific GR levels are regulated, in particular in the brain, is a first step to understand the significance of aberrant GR levels in disease and behaviour. Copyright 2010. Published by Elsevier Inc.

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• SciCrunch
• 17 years ago - by Anonymous

Purpose of the Myc Hubsite The emergence of complex DNA microarray data on gene expression creates vast new opportunities but also poses serious challenges for information and library sciences. This complexity becomes more challenging as certain genes, such as MYC that encodes a transcription factor, switch on other genes. The purpose of this website is to provide a hub for the integration of information on Myc target genes, the role of Myc in human cancers, and proteins that interact with the Myc transcription factors. Links are provided that connect to PUBMED citations, Unigene database, and in specific cases to original data. Sponsor: Funded by a grant from the National Library of Medicine

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• SciCrunch
• 17 years ago - by Anonymous

The LVC64 accepts 64 microvolt-level buffered input signals from headstage preamps and serves as a 24-bit recording device. It is connected to a PC with an USB2.0 cable and provides a complete digital system to record broadband bioelectric signals. It has two parts such as a 64-channel ADC unit and a digital interface &amp; power supply unit. Between these units there is a slip ring commutator and a DC motor. The main features of the LVC system include: Up to 128 Analog inputs per system; Each Analog input is sampled with an individual 24 bit delta-sigma A/D converter Analog inputs are simultaneously sampled at 1750 to 32000 samples per second In addition to multiple unit activity - the EEG, field potentials and behavioral marker signals are recorded simultaneously in the same file Full scale analog input range is 5 millivolts RMS (14 mV peak-to-peak) Analog inputs are differential inputs Extremely low input referred noise levels of max. 8 uV peak-to-peak Direct headstage tether and tether extension cable inputs Slip ring commutator for un-twisting the twisted tether cable Headstage power supplies Up to 24 bit TTL compatible Parallel Input Port for monitoring external signals and external Timestamp Clock input and output for multiple system synchronization Totally electrically isolated system from AC Power and Ground ''Microvolts-to-harddisk dumper'' data acquisition program running in host PC (32-bit MS Window XP) Online display of records during data acquisition in Host PC''s monitor Offline spike sorting by Cooperative Linux software of the Host PC

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• SciCrunch
• 17 years ago - by Anonymous

Blender is the free open source 3D content creation suite, available for all major operating systems under the GNU General Public License. Because of the overwhelming success of the first open movie project, Ton Roosendaal, the Blender Foundation''s chairman, has established the Blender Institute. This now is the permanent office and studio to more efficiently organize the Blender Foundation goals, but especially to coordinate and facilitate Open Projects related to 3D movies, games or visual effects.

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• SciCrunch
• 17 years ago - by Anonymous

Welcome to the Anopheles gambiae Gene Expression Database at UC Irvine. Presented here is a relational database that combines data from microarray experiments, functional annotation, and the An. gambiae genome project to provide insight into gene expression and regulation in this mosquito vector of human malaria. Microarray analyses included in this site were based on the Affymetrix GeneChip Plasmodium/Anopheles Genome Array. Abundance of specific mRNAs represented in the array were determined for larvae (3rd and 4th instars), adult males (3 days post emergence), non-blood fed females (3 days post emergence) and females at 3, 24, 48, 72, and 96 hours following a blood meal, and females aged 18 days with or without a bloodmeal. Functional annotation integrated into the site for keyword searching combines keywords indexed in the ENSEMBL Mosquito Genome database, NCBI non-redundant databases and conserved motifs databases (GO, PFAM, SMART). Sequence data was captured from the ENSEMBL Mosquito Genome database.

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• SciCrunch
• 17 years ago - by Anonymous

Welcome to the Air Force Suicide Prevention Program (AFSPP) Website. This site is designed to provide information and tools to members of the Air Force community (Suicide Prevention Program Managers, commanders, gatekeepers, IDS members, etc.) in their efforts to help reduce Air Force suicides. Reducing suicide requires a community effort and we welcome your visit to our site.<BR/>

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• SciCrunch
• 17 years ago - by Anonymous

MMV, a not-for-profit public-private partnership, was established as a foundation in Switzerland in 1999. Our mission is to reduce the burden of malaria in disease-endemic countries by discovering, developing and facilitating delivery of new, effective and affordable antimalarial drugs. Our vision is a world in which these innovative medicines will cure and protect the vulnerable and under-served populations at risk of malaria, and help to ultimately eradicate this terrible disease. Sponsors/Donors: -Bill and Melinda Gates Foundation -CRIMALDDI -ExxonMobil -Irish Aid -National Institutes of Health -Netherlands Ministry of Foreign Affairs -Rockefeller Foundation (former donor) -Secretaria de Estado de Cooperacin Internacional (Spanish Agency for International Cooperation) -Swiss Agency for Development and Cooperation -UK Department for International Development -USAID -Wellcome Trust -World Bank -World Health Organization

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• SciCrunch
• 17 years ago - by Anonymous

Founded in 1981, ZymoGenetics is a biopharmaceutical company focused on the development and commercialization of therapeutic proteins. ZymoGenetics is publicly traded (NASDAQ: ZGEN) and headquartered in Seattle, Washington in the historic Seattle City Light Steam Plant building. Our mission is to create novel protein drugs that will significantly help patients fight their diseases. We have contributed to the discovery or development of six recombinant protein products now marketed by other companies. Current programs target viral infection, cancer, inflammatory diseases and bleeding. Our first internally developed product, RECOTHROM Thrombin, topical (Recombinant), was approved by the U.S. Food and Drug Administration (FDA) on January 17, 2008 for use as a topical hemostat to control moderate bleeding during surgical procedures and is now marketed in the United States. We have a promising pipeline of novel therapeutics, which we are developing on our own or in collaboration with partners.

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• SciCrunch
• 17 years ago - by Anonymous

Zoomify makes high-quality images zoom-and-pan for fast, interactive viewing on the web. Zoomify''s image viewing solutions use just HTML, JPEGs, and Flash - no large downloads, no special installs, and no server-side setup is required. And Zoomify''s innovative features provided added value including support for slideshows, hotspots, annotation, side-by-side comparison, and much more. Zoomifys products meet the high-quality, high-resolution imaging needs of creative professionals and image-centric applications. Zoomify is revolutionizing digital imaging in medicine and the sciences, image archiving and museum exhibits, defense and security, education, entertainment, and more.

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• SciCrunch
• 17 years ago - by Anonymous

A free web server for the analysis of short RNAs from high throughput sequencing data.

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• SciCrunch
• 13 years ago - by Anonymous

Computational tool developed to help identify cancer-associated ''driver'' mutations from ''passenger'' ones in a cancer genome.

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• 13 years ago - by Anonymous

This site provides several tools for selecting zinc finger protein (ZFP) target sites and for designing the proteins that will target them. These ZFPs can be fused with effector domains that confer transcriptional activation or repression activity as well as catalytic functions.

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• SciCrunch
• 17 years ago - by Anonymous

Aquatic Habitats (AHAB) is the worlds largest manufacturer of housing systems for aquatic research animals. We are biologists first and engineers second, so we understand the complexity of aquatic life and how to sustain it. Our turnkey systems are secure, efficient and as fail-safe as possible.<BR/>

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• SciCrunch
• 17 years ago - by Anonymous

Welcome to ZINC, a free database of commercially-available compounds for virtual screening. ZINC contains over 13 million purchasable compounds in ready-to-dock, 3D formats. ZINC is provided by the Shoichet Laboratory in the Department of Pharmaceutical Chemistry at the University of California, San Francisco (UCSF). To cite ZINC, please reference: Irwin and Shoichet, J. Chem. Inf. Model. 2005;45(1):177-82 PDF, DOI. We thank NIGMS for financial support (GM71896). There are release notes for ZINC 10. - We have a survey where you can give us feedback.

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• SciCrunch
• 17 years ago - by Anonymous

ZF-MODELS - Zebrafish Models for Human Development and Disease is an Integrated Project funded by the European Commission as part of its Sixth Framework Programme (EC Contract LSHG-CT-2003-503496). The project started on January 1, 2004 and is scheduled to run over a period of five years. The aim of this project is to exploit the advantages of the zebrafish to produce knowledge, technology and materials in the form of disease models, drug targets and insight into pathways of gene regulation applicable to human development and disease.

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• SciCrunch
• 17 years ago - by Anonymous