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Founded in 1997 with the mission to provide a new source of microbial extracts for drug discovery, agrochemical, enzyme, and specialty chemical research. Discovery company pursuing untapped sources of chemical diversity and identifying lead candidates derived from microorganisms for development of new chemical entities.

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• SciCrunch
• 16 years ago - by Anonymous

When a patient suffering or thought to be suffering from cancer is cared for, samples are often taken to determine the precise diagnosis and to determine any treatment necessary. After this essential stage of the patient''s care, unused biological material is sometimes left over. This material is an essential and precious tool for research into cancer. For this reason, patients can decide to make the material available to researchers the world over who study either the development mechanism of cancer or the new treatments available. Residual samples are centralized and stored in the Tumor Bank at the Cliniques Universitaires Saint-Luc Cancer Centre. The research carried out on this material primarily benefits cancer patients. It can help improve existing treatments or discover new drugs, and also allows new diagnostic tools to be tested. Any financial profits obtained from assessing the results obtained are entirely reinvested in the work of the Cancer Centre''s Tumour Bank and in new research projects at the Catholic University of Louvain. Using and sharing material, and verification and retrospective analysis of clinical data, all comply with strict rules. As with donations of blood, marrow or organs, an Ethics Committee oversees the operations of the Tumour Bank and research projects. This committee is responsible for ensuring compliance with current Belgian and legal texts, especially those concerning the protection of patient privacy and rights.

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• SciCrunch
• 16 years ago - by Anonymous

A biomaterial supply resource containing over 600,000 samples of human tissue, serum, DNA, and RNA. Samples are handled consistently according to validated protocols and each tissue sample comes with detailed demographic information, gold standard clinical diagnostic information, complete drug history, full pathology reports, and complete phenotypic data.

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• SciCrunch
• 16 years ago - by Anonymous

Transcriptome database of acutely isolated purified astrocytes, neurons, and oligodendrocytes. Provides improved cell-type-specific markers for better understanding of neural development, function, and disease.

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• SciCrunch
• 16 years ago - by Anonymous

A suite of parallel bioinformatics applications based upon a popular open-source Java implementation of MapReduce, Hadoop.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 6, 2016. Biobehavioral blog on research and medicine as a continuum from biological mechanisms to behavioural phenomena., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 19, 2019. The Functional Catalogue is an annotation scheme for the functional description of proteins of prokaryotic and eukaryotic origin. Taking into account the broad and highly diverse spectrum of known protein functions, the FunCat consists of 28 main functional categories (or branches) that cover general fields like cellular transport, metabolism and cellular communication/signal transduction. The main branches exhibit a hierarchical, tree like structure with up to six levels of increasing specificity. In total, the FunCat version 2.1 includes 1362 functional categories. This general concept was retained since the annotation of the Saccharomyces cerevisiae genome with only 4 revisions and later on also proved to be well suited for the annotation of genomes from different domains of life (Ruepp et al. 2004). The present and previous versions as well as a version mapping file of the FunCat and annotation data of our core projects can be downloaded via FTP. The MIPS Functional Catalogue Database provides a search tool to browse and search the Functional Categories including the FunCat Number, description, EC number, GO number or keywords associated with the categories. All FunCat annotated proteins and the amount of Co-annotated-FunCats can be retrieved starting with a specific category in a selected organism. A statistical survey of the functional distribution of a given set of genes/entries, e. g. a set of genes with up-regulated expression under a certain condition can be retrieved.

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• SciCrunch
• 16 years ago - by Anonymous

Patent data resources at the EBI contain patent abstracts, patent chemical compounds, patent sequences and patent equivalents. There are various ways of accessing and searching the patent data.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 29, 2016. The need to use human neoplastic tissue under ideal conditions is currently of particular importance due to the development molecular pathology techniques that allow large-scale studies of genetic expression that are also of clinical significance. The Tumour Bank Network (TBN), instigated and coordinated by the Molecular Pathology Programme (MMP) aims to respond to this need by the promoting of Tumour Banks in Spanish hospitals. This will be achieved through the application of homogeneous procedures for the collection, processing and storage of neoplastic and normal tissue samples in such a way as to make molecular studies possible, avoiding that avoid the intrinsic bias of multi-centre studies possible. These Hospital Tumour Banks are based within the Pathology Departments of the collaborating Hospitals, that are interconnected through a computer-based network. In this way, each Centre''s tissue remains in the Hospital itself, thereby playing a key role in the development of the welfare, teaching and research activities within the Hospital. At the same time, it represents a tool to encourage of multi-hospital cancer research and of cooperation between basic and clinical researchers, constituting important collaboration between biomedical disciplines. The design does not correspond to a Central Tumour Bank, but that of a cooperative and coordinated Network of Hospital Banks, based on simple, homogeneous and optimal tissue treatment protocols. This Network is promoted by the Centro Nacional de Investigaciones Oncologicas (CNIO), which thereby undertakes the work of coordinating the network, using and maintaining the database, adhering to quality control. The aim of the CNIO's TBN is to acquire neoplastic and control non-neoplastic material of all types of malignant neoplasias, in the form of tissue fixed in formalin and paraffin embedded, of samples that are unfixed or frozen according to conventional methods as set out in Annexe 1 and even, exceptionally as fresh tissue. When other types of samples are required to carry out a specific project, the central office of the TBN will draw up a protocol with the group leading the project for the collection and maintenance of the tissue and clinicopathological data required for the proposed research. These protocols will be disseminated among the Associated Hospitals in order to gather the previously agreed number cases. Basic data surrounding the processing and preservation conditions for each case will be sent to the central office of the Bank, which under no circumstances will reveal the identity of the patient. Any Spanish cancer research team will be able to request tissue from the Tissue Bank Network. Absolute priority will be afforded to projects whose principal researcher belongs to one of the Associated Centres of the TNB, to other institutions with special agreements concerning the exchange of samples, and to the CNIO's researchers.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 18,2023.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 08, 2014. A multi-disciplinary institute providing specialized diagnostic evaluations, innovative treatments, education and research. It provides a collaborative, team-centered approach to provide innovative diagnostics to assist in developing cutting-edge brain based interventions and treatment strategies to best serve their patient's individual needs. Comprehensive Neuroscience Center is dedicated to working with children and adults who demonstrate neurodevelopmental disorders such as Autism Spectrum Disorders, Attention Deficits Hyperactivity Disorder, Learning Disabilities and Language-based deficits, as well as other neurological-based disorders including Traumatic brain injury, Disorders of Consciousness, Disorders of Aging, Alzheimer's and Dementia.

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• SciCrunch
• 17 years ago - by Anonymous

INI has developed a novel simulation tool, CX3D, for modeling the development of large realistic neural networks such as the neocortex, in a physical 3D space. The development of neural tissue is a complex organizing process, in which it is difficult to grasp how the various localized interactions between dividing cells leads relentlessly to global network organization. Simulation is a useful tool for exploring such complex processes because it permits rigorous analysis of observed global behavior in terms of the mechanistic axioms declared in the simulated model. In CX3D, as in biology, neurons arise by the replication and migration of precursors, which mature into cells able to extend axons and dendrites. Individual neurons are discretized into spherical soma and cylindrical neurite elements that have appropriate mechanical properties. The growth functions of each neuron are encapsulated in set of pre-defined modules that are automatically distributed across its segments during growth. The extracellular space is also discretized, and allows for the diffusion of extracellular signaling molecules, as well as the physical interactions of the many developing neurons. CX3D is a powerful tool for understanding neural development. Sponsors: CX3D has been developed with the support of the SECO EU Project (EU grant 216593). Keywords: Neuinformatics, Cortex, 3D, 3 Dimentional, Neocortex, Physicis, Neural, Tissue, Simulation, Neuron, Structure, Biology, Axon, Dentrite, Soma, Neurite, Development,

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• SciCrunch
• 17 years ago - by Anonymous

Software tool for testing and investigating methods in statistical genetics by generating samples of family data based on user specified models. (entry from Genetic Analysis Software), THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 14 years ago - by Anonymous

Large-scale archive of normalized digital spatial and functional data with an analytical query mechanism. One of its many applications is the elucidation of brain structure-function relationships. BRAID stores spatially defined data from digital brain images which have been mapped into normalized Cartesian coordinates, allowing image data from large populations of patients to be combined and compared. The database also contains neurological data from each patient and a query mechanism that can perform statistical structure-function correlations. The project is developing database technology for the manipulation and analysis of 3-dimensional brain images derived from MRI, PET, CT, etc. BRAID is based on the PostgreSQL server, an object/relational DBMS, which allows a standard relational DBMS to be augmented with application-specific datatypes and operators. The BRAID project is adding operations and datatypes to support querying, manipulation and analysis of 3D medical images, including: * Image Datatypes: BRAID supports a family of 3D image datatypes, each having an abstract type and an implementation type. Abstract types include boolean (for regions of interest), integer, float, vector (for representing morphological changes), tensor (for representing derivatives and standard deviations of vector images) and color. Implementation types at present include line-segment format and voxel array. * Image Operators: BRAID supports addition of images, multiplication (which is interpreted as intersection for boolean images), coercion of an image''s abstract or implementation type to another value, and determination of volumes of regions of interest. * Statistical Operators: A chi-squared test has been added to SQL as an aggregate operator on pairs of boolean values. * Web Interface: A general-purpose Web gateway allows the results of queries that return computed images to be displayed. You can download the BRAID source code 2.0. This version is developed under postgreSQL 7.3.4., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 16 years ago - by Anonymous

Ask a Biologist is designed as an educational resource for students preK-12, and their teachers and parents. Anyone is welcome to use Ask A Biologist. Keep in mind that it is intended primarily to serve grades preK-12, and to be available as a resource for teachers and parents. They also find that life-long learners enjoy many of the content areas on their web site and encourage anyone interested in biology to make use of the web content. As always, ASU faculty and staff will be accessible through email to their students. Sponsors: Ask A Biologist funded in part by the National Science Foundation and NSDL.

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• SciCrunch
• 17 years ago - by Anonymous

Non-profit organization dedicated to solving the author/contributor name ambiguity problem in scholarly communications by creating a central registry of unique identifiers for individual researchers and an open and transparent linking mechanism between ORCID and other current author ID schemes. These identifiers, and the relationships among them, can be linked to the researcher''s output to enhance the scientific discovery process and to improve the efficiency of research funding and collaboration within the research community. The ideal solution is to establish a registry that is adopted and embraced as the de facto standard by the whole of the community. A resolution to the systemic name ambiguity problem, by means of assigning unique identifiers linkable to an individual''s research output, will enhance the scientific discovery process and improve the efficiency of funding and collaboration. The organization brings together the leaders of the most influential universities, funding organizations, societies, publishers and corporations from around the globe and is managed by a fourteen member Board of Directors. A disambiguated set of authors will allow new services and benefits to be built for the research community by all stakeholders in scholarly communication: from commercial actors to non-profit organizations, from governments to universities.

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• SciCrunch
• 16 years ago - by Anonymous

OpenII (pronounced open-eye-eye) is a freely downloadable, open source information integration (II) tool suite. It includes 1) an extensible, plug-and-play platform for II tools and 2) several tools that assist with common integration tasks, including fully- or semi-automated support in the following scenarios: :- An integration engineer building a data warehouse must determine how diverse component data schemas map to the schema of the warehouse. :- An XML document that conforms to one schema needs to be converted into an equivalent document that conforms to a second (different) schema. :- To support data exchanges, a community needs to create a shared data model based on the models of its members. When a new member joins, the community needs to identify promising data exchange partners, and to what extent its shared model needs to be extended. Similarly, a chief information officer must identify data integration opportunities and make level-of-effort estimates after an acquisition or merger. To support these scenarios, OpenII provides a schema repository into which diverse data models can easily be imported. It also provides tools that 1) assist with identifying semantic correspondences across data models (Harmony), 2) compare a set of data models against a common reference model (Proximity), 3) visually organize a set of data models into clusters of related data models (Affinity), and 4) establish a common data model for a set of inter-related data models (Unity). Why should You use OpenII? Here are some reasons: :- OpenII is the only open-source platform for information integration tools. OpenII and its source code are freely available using the Apache 2.0 license, so you are free to borrow, extend or resell any portions of OpenII. :- The OpenII schema and mapping repository is based on a neutral modeling language. Thus, all of the OpenII tools can be used regardless of the underlying modeling language. For example, Harmony can identify correspondences among an XML schema, a relational database, and an OWL ontology. By comparison, most commercial tools are tied to a particular modeling language. :- OpenII is based on the Eclipse framework. As a result, the environment is already familiar to many programmers. Non-programmers can choose, instead, to use OpenII off-the-shelf without needing to first install Eclipse. :- OpenII is fully extensible. If needed components do not exist, they can be readily added. For example, adding a new importer or exporter is a straightforward task that can be completed in only a few hours. Moreover, each of the tools supports the introduction of new algorithms. And, programmers familiar with the Eclipse environment can add new views with moderate effort. Sponsors: This resource is supported by the MITRE Corporation.

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• SciCrunch
• 17 years ago - by Anonymous

This is a multiscale network diagram of aging pathways, from molecules to organism. The many observable signs of human senescence have been hypothesized by various researchers to result from several primary causes. Close inspection of the biochemical and physiological pathways associated with age-related changes and with the hypothesized causes reveals several parallel cascades of events that involve several important interactions and feedback loops. This network diagram is presented to aid in conceptualizing the many processes and interactions among them, including promising intervention points for therapy development. Environmental effects and proposed interventions are highlighted around the margins of the network. This diagram is maintained on the Web as a reference for researchers and students. Content is updated as new information comes to light. Sponsors: This work has been supported by Legendary Pharmaceuticals. Keywords: Network, Diagram, Human, Cell, Aging, Senescence, Biochemical, Pathway, Physiological, Therapy, Environmental, Researcher, Student,

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• SciCrunch
• 16 years ago - by Anonymous

Software tool for data sharing, incorporating blogs and spatial registration of data. Mainly used in geological data sets. A Virtual Research Environment (VRE) aims to combine the capabilities of two existing technologies that have already seen wide adoption among scientists: - The Godiva2 data visualization system provides a means for scientists to browse interactively in a ''Google Maps-like'' fashion through large environmental datasets, including numerical model outputs and high-resolution satellite imagery, using only a web browser. - The LabBlog is a web-based blogging tool specifically designed for the practising scientist to record, disseminate and evaluate their research. The Blog can also be used as a collaboration tool that allows secure discussion between colleagues. Although initially designed for the use of laboratory chemists, the LabBlog is being adapted in this project to meet the needs of environmental scientists. The BlogMyData VRE will allow scientists to explore data visually using Godiva2, then make comments about features in the data on a blog. Colleagues will discover these blog entries and offer further information, providing answers to research questions through comments. Through RSS and GeoRSS feeds, colleagues, investigators and other interested parties can be notified of research activity, and scientists can discover hitherto-unknown colleagues working with similar data in similar geographic regions. Sponsors: BlogMyData is a collaboration between the Reading e-Science Centre and the University of Southampton and is one of the JISC VRERI projects.

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• SciCrunch
• 17 years ago - by Anonymous

This is an online, interactive courseware for the study of neuroscience is provided by the Department of Neurobiology and Anatomy at The University of Texas Medical School at Houston. The project is being developed under the direction of the Department Chair and Editor, John H. Byrne. This content is intended to function as an online multimedia resource, and therefore is not supported as a downloadable or printable text.

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• SciCrunch
• 17 years ago - by Anonymous