Curator Dashboard

Facility provides customized solutions for complex single cell profiling with up to 45 markers simultaneously. Offers full service and established workflows from panel design, antibody labelling and sample processing to high-dimensional data analysis. Offers expertise in antibody conjugation, sample staining, and data analysis.

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• 1 year ago - by Anonymous

Core offers advanced services to detect, quantify, and characterize pathogens, as well as assess host immune responses. Supports both standardized and custom assay developments. MVSC is composed of three integrated units: Virology Unit which provides viral stocks for variety of viruses at BSL2 and BSL3, as well as assay services including virus expansion and characterization, viral titer by plaque and TCID50 assays, live virus neutralization and inhibition assays at both BSL-2 and –3. Viruses currently in use by the core include SIV, HIV, Zika, Dengue, SARS-CoV-2, Mayaro, Eastern Equine Encephalitis Virus, Poliovirus, Enterovirus D68, and others. Luminex and Serology Unit Services include antibody detection in serum or plasma by Luminex-based assays and/or ELISA for SPF-agents such as SIV, SRV, STLV, B virus, SFV, CMV, RRV, SVV, SV40, and LCV, and non-SPF infectious agents like measles, Burkholderia pseudomallei, Trypanosoma cruzi, Mycobacterium tuberculosis, and SARS-CoV-2. This unit also offers services for cytokine quantification in body fluids including serum and CSF, as well as tissue culture supernatant. Sequencing Unit provides services related to quantitative PCR and RT PCR detection of viruses such as SIV, Zika, and SARS-CoV-2, as well as next generation sequencing services including whole genome (pathogen or host), epigenetics, targeted amplicons, and 16S and ITS metagenomics. Sequencing unit also performs single cell RNA-seq (10x and Parse) assays as well as NGS based genotyping of NHP, including for major histocompatibility complex (MHC) allelic genotyping.

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• 1 year ago - by Anonymous

Light microscopy imaging core facility located in the Life Sciences Center at Dartmouth College (Hanover, NH). Facility personnel provide training and imaging guidance. Imaging instruments available to trained users include: laser scanning and spinning disk confocal systems (with super-resolution capability), a TIRF system, and a multiphoton microscope. Image analysis software (e.g. Nikon Elements, ZEN, Arivis Vision 4D, and Imaris Quant) is also available through the facility.

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• 1 year ago - submitted by Jessica Warren

Software R package to perform fixed and random-effects multivariate and univariate meta-analysis and meta-regression.

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• 1 year ago - by Anonymous

Software R package designed to streamline collection and use of cancer transcriptional signatures across bulk, single-cell, and spatial transcriptomics data. Used for collection and implementation of public transcriptional cancer signatures.

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• 1 year ago - by Anonymous

Software R package used in survival analysis that evaluates predictive accuracy of survival model. Measures how well model can distinguish between pairs of individuals with different survival times. Calculates proportion of all pairs of individuals whose predicted survival times are correctly ordered.

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• 1 year ago - by Anonymous

Software package for analysis of RNA expresison data. Used to make pythoneer bioinformatician workflow less colluded with R.

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• 1 year ago - by Anonymous

Software R package to quantify allelic imbalances associated with homologous recombination deficiency in ovarian cancer.

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• 1 year ago - by Anonymous

Software R package for analysis and visualization of macroevolutionary dynamics on phylogenetic trees.

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• 1 year ago - by Anonymous

Software statistical framework that allows simultaneous extraction of tumor sample composition and cell type and sample specific whole-transcriptome profiles from individual bulk RNA-seq samples.

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• 1 year ago - by Anonymous

Software integrated library and plugins for mathematical morphology with ImageJ.Collection of generic tools based on Mathematical Morphology to process binary and grey-level 2D and 3D images, integrated into user-friendly plugins.

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• 1 year ago - by Anonymous

Software tool to infer junction-balanced genome graphs with high fidelity. Builds genome graph based on junctions and read depth from whole genome sequencing, inferring optimal copy numbers for both vertices (DNA segments) and edges (bonds between segments).

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• 1 year ago - by Anonymous

Software annotation, interpretation and visualisation tool for structural variants. Used to aid interpretation of structural variant and copy number data derived from short-read, whole-genome sequencing. Classifies raw structural variant calls into distinct events and predicts their effect on local structure of derivative chromosome and functional impact on affected genes.

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• 1 year ago - by Anonymous

Software tool to determine read depth ratios of supplied tumor and reference genomes.

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• 1 year ago - by Anonymous

Software tool to generate tumor BAF file for use in PURPLE from provided VCF of likely heterozygous SNP sites.

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• 1 year ago - by Anonymous

Software suite containing tools for detection of genomic rearrangements. Multithreaded structural variant (SV) caller that performs efficient genome-wide break-end assembly prior to variant calling using novel positional de Bruijn graph-based assembler. GRIDSS2 is structural variant caller to explicitly report single breakends-breakpoints in which only one side can be unambiguously determined.

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• 1 year ago - by Anonymous

Fixation pump for anatomy laboratories. DUOTRONIC III features extra light 1/8 HP motor pump, ensuring considerable outflow without preliminary pressure. The pump is magnetic transmission, centrifugal device equipped with mixing system (based on the principle of the water fountain) allowing homogeneous mixing. Specifications: Stainless steel base with handles; 11 litre tank, graduation in litre; 15 Psi pressure; 220 mono 50 Hz/60 Hz.

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• 1 year ago - by Anonymous

Core has maintained CAP (College of American Pathologists) and CLIA (Clinical Laboratory Improvement Act) accreditations since 2001 and has maintained the required standards for the past 20 years. Core offers automated clinical chemistry, immunology and hematology assays. Tests range from commercially available FDA approved methods to research grade ELISA’s.

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• 1 year ago - submitted by Matthew Rudy

Software R package to infer biological activities from omics data using collection of methods.

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• 1 year ago - by Anonymous

Software R package for storing the regulons. Gene regulatory network containing signed transcription factor (TF) - target gene interactions. DoRothEA regulons, the collection of TF and its transcriptional targets, were curated and collected from different types of evidence for both human and mouse. Confidence level was assigned to each TF-target interaction based on number of supporting evidence.

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• 1 year ago - by Anonymous