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Biomarker Commons aggregates news and research on disease biomarkers, and includes links to biomarker journals, resources and commercial services. There are a number of biomarkers in use today, not only in experimental research but in the clinical setting. * Translation biomarkers are used in both a preclinical (i.e. animal models) and clinical setting * Early detection biomarkers are used to identify the earliest stages of disease onset * Diagnostic biomarkers are used to identify the presence or absence of a specific disease state * Staging biomarkers are used to distinguish between different stages of a chronic disorder * Prognostic biomarkers are used to determine patient survival probability * Disease biomarkers are related to a clinical outcome or measure of disease * Predictive or efficacy biomarkers are used to predict the efficacy of a specific drug therapy * Target biomarkers are used to determine the interaction of a drug or small molecule with its target * Mechanism biomarkers are used to report on the downstream effects of a drug * Toxicity biomarkers are used to determine the toxicological effects of drugs on an in vitro or in vivo system * Surrogate biomarkers are regarded as valid substitutes for measuring clinical outcomes Users may search biomarker news (search by tags, news archive. or insights), sign up for biomarker news email alerts, follow biomarker commons and view biomarker news top tags

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• SciCrunch
• 16 years ago - by Anonymous

A relational database with dynamic querying and data integration that can be used by researchers to identify genetic sequences with a high probability of being associated with aflatoxin accumulation resistance, according to multiple lines of evidence. CFRAS-DB integrates genomic, proteomic, and genetic data from multiple studies in maize dealing with aflatoxin accumulation or Aspergillus flavus resistance., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 16 years ago - by Anonymous

In the Born Lab the goal is to seek to understand the circuitry of the mammalian cerebral cortex and how it endows us with the ability to see . . . and hear and think and talk. The approach is to study visual cortex of alert monkeys trained to report specific aspects of their visual experience. This allows us to define the neural correlates of specific percepts and then study their underlying mechanisms by activating or inactivating components of the circuit. Our primary tools are extracellular electrophysiologyboth with single electrodes and multi-electrode arraysand psychophysics. They are complemented by techniques that allow us to dissect and probe cortical circuitry: �� circuit tracing with genetically modified rabies viruses �� microstimulation to insert specific signals into cortical circuits �� cortical cooling (cryoloops) to reversibly inactivate circuit elements �� microarrays to identify molecular markers of neuronal subtypes �� optogenetics to improve the spatial and temporal specificity with which we can manipulate circuits Current Projects: *Dissecting parallel pathways. *Probing cortico-cortical feedback.

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• SciCrunch
• 16 years ago - by Anonymous

A platform for semantic data integration through RDF warehousing and efficient reasoning that helps to resolve conflicts in the data. Search and explore over 5 billion RDF statements from various sources including UniProt, PubMed, EntrezGene and 20 more... Perform complex SPARQL queries and retrieve more than one billion RDF resources. One of the major problems that biotechnology and pharmaceutical industries face today is how to combine data from multiple sources and make their research more productive. Data integration takes much time and often leads to errors and redundancies that require more time and resources to resolve. LinkedLifeData is a data warehouse that syndicates tons of heterogeneous biomedical knowledge in a common data model. The platform uses an extension of the RDF model that is able to track the provenance of each individual fact in the repository and thus update the information. Data Sources include: Disease Ontology, LinkedCT, Reactome, HPRD, DBPedia, UniProt, CellMap, NCBI Entrez-Gene, UMLS, IMID, MINT, DrugBank, LHGDN, Gene Ontology, HumanCYC, PubMed, NCI Nature, Human Phenotype Ontology, BioGRID, IntAct, HapMap, Symptom Ontology, DailyMed, ChEBI, Diseasome, Freebase, SIDER

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• SciCrunch
• 16 years ago - by Anonymous

Formerly a topical portal studying the brain which collected and imaged 1000 human brains, the Brain Observatory has partnered with the Institute for Brain and Society to build virtual laboratories that will feed directly into the database of images and knowledge created in the context of the Human Brain Library. The Brain Observatory will also host exhibits, conferences, and events aimed at promoting a heightened awareness of brain research and how its results can benefit personal brain fitness and mental health.

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• SciCrunch
• 16 years ago - by Anonymous

Microbiology news and views to help the busy scientist keep up-to-date on current research, forthcoming conferences, hot research topics, high impact publications, and much more.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE documented June 6, 2013 Database of all S. pombe (fission yeast) known and predicted protein coding genes, pseudogenes, transposons, tRNAs, rRNAs, snRNAs, snoRNAs and other known and predicted non-coding RNAs. Curation of new and existing literature is ongoing and changes are incorporated weekly. User feedback is welcome. The genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824, has been sequenced and annotated. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. Some 43% of the genes contain introns, of which there are 4,730. Fifty genes have significant similarity with human disease genes; half of these are cancer related. We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. These genes may have originated with the appearance of eukaryotic life. Few similarly conserved genes that are important for multicellular organization were identified, suggesting that the transition from prokaryotes to eukaryotes required more new genes than did the transition from unicellular to multicellular organization.

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• SciCrunch
• 16 years ago - by Anonymous

The Museum of Comparative Anthropogeny (MOCA) is a collection of comparative information regarding humans and our closest evolutionary cousins (chimpanzees, bonobos, gorillas and orangutans i.e, great apes), with an emphasis on uniquely human features. MOCA is organized by Domains, each grouping Topics by areas of interest and scientific discipline. Each topic entry will eventually cover existing information about a particular difference (alleged or documented) between humans and non-human hominids. Comparisons of these non-human hominids with humans are difficult, as so little is known about their phenotypic features (phenomes), in contrast to humans. Ethical, fiscal and practical issues also limit collection of further information about great apes. MOCA attempts to collect existing information about human-specific differences from great apes, currently scattered in the literature. Having such information in one location could lead to new insights and multi-disciplinary interactions, and to ethically-sound studies to explain differences, and uniquely human specializations. MOCA is not targeted at experts in specific disciplines, but rather aims to communicate basic information to a broad audience of scientists from many backgrounds, and to the interested lay public. MOCA includes not only aspects wherein there are known or apparent differences between humans and great apes, but additionally, topics for which popular wisdom about claimed or assumed differences is not entirely correct. It is for all these reasons that MOCA is called a Museum, and not an Encyclopedia or Database.

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• SciCrunch
• 16 years ago - by Anonymous

A commercial organization which provides construction, architecture, engineering, and ecological services to private and public sector clients in Malaysia and overseas. The main focus of the Renexus Group is to incorporate sustainability in the projects they service. The Group provides services for both small and large scale projects, from project inception and development to commissioning and support services.

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• SciCrunch
• 16 years ago - by Anonymous

PrabiG is the Grenoble portal of the Prabi (Rhone-Alpes Bioinformatics Center) platform. It aims at providing the scientific community with tools and data related to proteomics and metabolomics. PrabiG is currently hosting the following projects : * UniPathway * ProteHome * OBIWarehouse * AT_Chloro

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• SciCrunch
• 16 years ago - by Anonymous

The NCBCs are a set of networked computation core facilities for biomedical infrastructure funded under the NIH Common Fund, the National Program of Excellence in Biomedical Computing (NPEBC). There are seven funded Centers that cover systems biology, image processing, biophysical modeling, biomedical ontologies, information integration, and tools for gene-phenotype and disease analysis. The centers will create innovative software programs and other tools that enable the biomedical community to integrate, analyze, model, simulate, and share data on human health and disease. Each Center has Cores that are focused on (1) computational science, (2) biomedical computational science and (3) driving biological projects whose intent is to drive the interaction between computational and biomedical computational science. In addition to the Centers, the NIH has a number of active program announcements to develop collaborations with the biomedical research community��this includes announcements from the Biomedical Information Science and Technology Initiative (BISTI) and the Program for Collaborations with National Centers for Biomedical Computing. There are numerous efforts in education and training that emanate from the Centers and there is an annual all hands meeting.

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• SciCrunch
• 16 years ago - by Anonymous

Graduate medical school of University of California, San Diego. It was the third medical school in the University of California system, after those established at UCSF and UCLA, and is the only medical school in the San Diego metropolitan area.

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• SciCrunch
• 16 years ago - submitted by Andrea Stagg

Not yet vetted by NIF curator

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• SciCrunch
• 16 years ago - by Anonymous

Not yet vetted by NIF curator

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• SciCrunch
• 16 years ago - by Anonymous

A commercial orthobiologics company whose main goal is to improve patient quality of life using the science of human biology to advance solutions for spine, orthopedics, and sports medicine.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on February 2nd, 2022. Manufacturer of Dermagraft, a bio-engineered skin substitute that assists in restoring damaged tissue and supports the body's natural healing process.

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• SciCrunch
• 16 years ago - by Anonymous

Not yet vetted by NIF curator

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• SciCrunch
• 16 years ago - by Anonymous

Molecular Biology Gateway is the gateway to Web resources for molecular biology, genomics, PCR, protocols, microbiology, and biochemistry. Major categories include: Current Molecular Biology News, Microbiology, Virology, Genomics and Bioinformatics, PCR, Journals, Books, and other Publications, Protocols, Technology, Books, and Recommended Reading.

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• SciCrunch
• 16 years ago - by Anonymous

The Down Syndrome Center for Research and Treatment (DSCRT) is one of the first programs in the country to connect academic research with treatment of adults and children with Down syndrome. Our goal is to apply cutting edge basic research to develop treatments that will help people with Down syndrome improve their cognition and forestall the onset of Alzheimer''s disease. Members of this special population continue to live fuller, healthier lives. We hope to build on this progress and advance their potential even further. About 400,000 people with Down syndrome live in the U.S. today, and one in every 733 babies is born with the condition. Children with Down syndrome are at risk for congenital heart defects, respiratory and hearing problems, childhood leukemia, and thyroid conditions. They typically also have mild to moderate cognitive impairment that affects learning, memory and speech. This is an important topic for research. With increased health care, education, and societal support, people with Down syndrome are living longer, fuller lives. But as they age we are discovering an increased occurrence of the symptoms associated with Alzheimer''s disease. In fact, about 25 percent of individuals with Down syndrome over age 35 increasingly show clinical signs and symptoms of Alzheimer''s type dementia. By age 60, more than half show cognitive decline.

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• SciCrunch
• 16 years ago - by Anonymous

International biobank storing whole blood and DNA from 200,000 individuals, serum and plasma samples from more than 100,000 individuals as well as urine, RNA tubes, cells, buffy coat and Na-heparin tubes for environmental analysis for as many as 50,000 individuals. All bio-specimens from the HUNT surveys are collected, processed and stored at the HUNT Biobank in Levanger. The National CONOR Biobank is located on the same site, where it serves as a central research repository for DNA samples from all the largest Norwegian health surveys. These make up the Cohorts of Norway (CONOR), which include samples from more than 200,000 individuals. * HUNT 1 was carried out in 1984-1986 to establish the health history of 75,000 people. * HUNT 2, carried out in 1995-1997, focused on the evolution of the health history of 74,000 people. This included blood sample collection from 65,000 people. The data that accompany biospecimens in the biobank are stored in secured computer systems that run complex database management and analysis software. * HUNT 3 was completed in June 2008. 93,210 people were invited to participate in the study, and as of the 6th of June, 2008, 48,289 people participated (52% participation rate). The data, collected by means of questionnaires, interviews, clinical examinations and collection of blood and urine samples, will be ready for analysis in January 2009. * Young-HUNT is the adolescent part of HUNT including participants aged 13-19 years. Young-HUNT1 (1995-97) was conducted as part of HUNT2, 9141 adolescents participated (90% response rate). Young-HUNT2 (2000-01) was a follow-up study of Young-HUNT1, 2400 students participated in both studies (77% of the invited). Young-HUNT3 (2006-08) was a new cross-sectional study as part of HUNT3. This time 8677 adolescents participated (87% response rate). Data collection included self-reported questionnaires, structured interviews, clinical measurements and, in Young-HUNT3, buccal smears. All institutions with research expertise can apply for access to analyze HUNT data. Projects must have recommendations from The Regional Committee for Medical Research in Norway (REK) and be registered with The Norwegian Social Science Data Services (NSD).

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• SciCrunch
• 16 years ago - by Anonymous