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The Histology Core has all the requisite equipment and reagents to enable a variety of tissue processing, embedding and sectioning protocols, including epon/araldite, glycol and methyl methacrylate, polyethylene glycol (PEG), paraffin and cryosectioning. Users of the Histology Core can choose to submit full service jobs and allow core personnel to embed, section and counterstain fixed tissue samples or they can sign up to use a microtome and cut the tissue themselves. Training on any aspect of the histologic process is available on request. All core services are equally available to core members and non-members on a first-come first-served basis.

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• 14 years ago - by Anonymous

exeResearch is an independent research company providing computational chemistry and biochemistry research assistance to those in academia and industry. We help scientists without the resources, time, or knowledge to complete the needed computational aspects of their research projects.

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The CTC Core is devoted to the biology and enumeration of CTC in metastatic cancers. The Veridex CellSearch?? CTC Test is used to measure Circulating Tumor Cells (CTC) cells in blood samples from cancer patients. The technology can also be used to measure Circulating Endothelial Cells (CEC) in blood, as indicators of other vascular damage-associated diseases such as diabetes.

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Over the last 10 years the CRIC team has developed a set of software tools and applications to support the research activities of USC investigators. CRIC provides tools for data collection, migration, reporting, customized survey creation, and web-based data capture & reporting. CRIC has also developed and supported databases for laboratory data management, multi-center clinical trials coordination, epidemiologic & prevention studies as well as disease specific studies.

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Core facility that provides the following services: Sorting and analysis services. The facility houses two state-of-the-art BD analyzers with high-throughput capability, a Stratedigm benchtop analyzer, a high-speed BD cell sorter, and both Mac and PC workstations for data analysis. Sorting services are offered through the facility, as well as instrument and software training.

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Established in 2001 by Dr. Joseph Martin (Dean of Harvard Medical School, 1997-2007), the Harvard NeuroDiscovery Center is a pioneering biomedical research group focused on ending suffering from neurodegenerative diseases. By drawing on the intellectual strength and proven capability of the Harvard medical community and colleagues throughout the world, the NeuroDiscovery Center has developed a unique approach to understanding and treating these devastating diseases.

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An Portal, Core facility

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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 2,2024. ANFF provides leading-edge research capability and supports excellence in science. The capability provided by ANFF enables users to process hard materials (metals, composites and ceramics) and soft materials (polymers and polymer-biological moieties) and transform these into structures that have application in sensors, medical devices, nanophotonics and nanoelectronics. It has a strong emphasis on service provision to the research community. ANFF seeks to enhance national and international collaborations and enable world-class-research.

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Software package that detects statistically significant difference between read enrichment profiles in different ChIP-Seq samples.

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• 13 years ago - by Anonymous

The ANFF provides leading-edge research capability and supports excellence in science. The capability provided by ANFF enables users to process hard materials (metals, composites and ceramics) and soft materials (polymers and polymer-biological moieties) and transform these into structures that have application in sensors, medical devices, nanophotonics and nanoelectronics. It has a strong emphasis on service provision to the research community. ANFF seeks to enhance national and international collaborations and enable world-class-research.

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The ANFF provides leading-edge research capability and supports excellence in science. The capability provided by ANFF enables users to process hard materials (metals, composites and ceramics) and soft materials (polymers and polymer-biological moieties) and transform these into structures that have application in sensors, medical devices, nanophotonics and nanoelectronics. It has a strong emphasis on service provision to the research community. ANFF seeks to enhance national and international collaborations and enable world-class-research.

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THIS RESOURCE IS NO LONGER IN SERVCE, documented September 22, 2016. The ANFF provides leading-edge research capability and supports excellence in science. The capability provided by ANFF enables users to process hard materials (metals, composites and ceramics) and soft materials (polymers and polymer-biological moieties) and transform these into structures that have application in sensors, medical devices, nanophotonics and nanoelectronics. It has a strong emphasis on service provision to the research community. ANFF seeks to enhance national and international collaborations and enable world-class-research.

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Core facility that provides the following services: Microarray and other genomic data analysis, MiSeq. The Center provides broad-based support for the generation, analysis, and interpretation of genomic and other large-scale data in the context of basic, clinical and translational research. The CCCB has three primary elements. * The CCCB sequencing facility offers a wide range of services to assist in the design and execution of next-generation sequencing projects. Utilizing the Illumina (Solexa) sequencing technology, they currently support a number of applications inlcuding ChIP-Seq, RNA-Seq, whole genome, whole exome, and targeted re-sequencing. * The analytical services and support platform aims to provide state-of-the-art assistance in the collection, management, analysis, and interpretation of large-scale data with a focus on data generated using ''''omic technologies. In addition, they offer software, services, and training designed to assist investigators in advancing their research. * The CCCB research program is focused on development of new methods for improving analysis and interpretation of genomic data through integration of diverse data types with the goal of creating open-source software tools to be made freely-available to the research community.

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THIS RESOURCE IS NO LONGER IN SERVCE, documented September 22, 2016. Network of laboratories which provides leading-edge research capability and supports excellence in science. The capability provided by ANFF enables users to process hard materials (metals, composites and ceramics) and soft materials (polymers and polymer-biological materials) and transform these into structures that have various applications.

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Dedicated imaging facility for many aspects of brightfield and fluorescence microscopy, including low-light imaging, scanning confocal imaging, imaging of fixed and living tissues, deconvolution, multi-channel imaging, FRAP, FRET, time-lapse and z stack (3D and 4D) acquisition, and spectral analysis.

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3Scan uses the cutting edge technology of the KESM (Knife Edge Scanning Microscope) to automatically section and image samples. Knife-edge scanning, introduced in the KESM instrument, not only preserves image registration throughout the depth of the specimen block but also isolates the tissue above the knife from that below to eliminate undesirable events (back-scattering of light and bleaching of fluorescent-stained tissue below the knife). Using the KESM, 3Scan is able to scan a one cc^3 block of tissue (for example, a whole mouse brain) at submicron resolution in under 100 hours. With this resolution (a voxel size of 0.6 um x 0.7 um x 1.0 um) 3Scan is able to show cell scale phenomena in the context of a compete organ. In the example of a whole mouse brain this means that 3Scan is able to accurately model every neuron in the mouse brain sample.

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The CCIR provides a full range of biomedical imaging services to support clinical research projects. These services include: (1) Pre-study services that help investigators design, set up, and kick off the study; (2) Coordinating services, including Scanning, that provide assistance in executing, monitoring and evaluating the study; and, (3) Information Technology management services to handle, track, and process imaging data.

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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. Contract research organization that provides an architecture for text mining and semantic annotation. It provides facilities to link texts data to concepts of the Linked Open Data network through various sources like DBpedia, Geonames, CIA World Factbook or directly to Wikipedia or a search engine when there is no available resource.

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The main objective of the Joslin Diabetes Center Genomics Core is to facilitate research by laboratories by providing equipment, expertise, and services in nucleic acid analysis that would be too specialized or costly for individual laboratories to provide independently. Instruments include: ������������ Fluidics Station 400 ������������ GeneChip?������ Scanner 3000 ������������ Hybridization Oven 640 ������������ NanoDrop ND-1000 ������������ NanoDrop ND-3300

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Gnarus Systems is pleased to offer cat-SAR; a peer-reviewed in silico toxicity prediction expert system. The cat-SAR system associates 2-dimensional chemical fragments with active or inactive compounds in a learning set. Unlike many other approaches, cat-SAR is transparent and model parameter selection is controlled by the user. As such, the approach is sharable and allows unrestricted user scrutiny, intervention and model optimization throughout the SAR modeling process. This rationale negates any a priori requirements that a given set of data must fit the attributes of a predefined and often proprietary modeling process. The cat-SAR system essentially ??????????????????learns???????????? about the biological activity of chemicals by analyzing ??????????????????learning sets???????????? of data. These are endpoint specific databases of toxicological or pharmacological chemical activity (e.g., carcinogens and developmental toxicants) that are assembled by us or others. Currently, we have validated and usable learning sets for a variety of health endpoints including cancer, anticancer, genotoxicity, developmental toxicity, and chemical allergy. Currently, cat????????????SAR models are available for: Rats, mice, and rodents carcinogenesis including gender-specific submodels Mammary Cancer in Rodents Tissue/organ specific carcinogenesis for 12 tumor types Salmonella mutagenicity (i.e. the Ames Assay) Developmental Toxicity Allergic Contact Dermatitis Respiratory Hypersensitivity Mouse Local Lymph Node Assay Ocular toxicity Estrogen mimics based on the E-SCREEN assay Anticancer activity to several different breast cancer cell lines

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