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Core provides LC-MS/MS analysis including Protein ID, Proteomics Profiling, Targeted Proteomics and Post Translational Modification analysis. Analytical proteomic services are provided with emphasis on label free quantitative proteomic profiling, analysis of macromolecular complexes, post-translational modification of their constituents and standard protein identification from complex protein mixtures.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 22, 2024. Queen''''s Medical Research Institute houses over 600 researchers and aims to tackle a wide range of diseases at the most fundamental cellular level.

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• SciCrunch
• 13 years ago - by Anonymous

The Gene Expression Core (GEC), part of the Advanced Genomics Technology Center at Mayo Clinic, provides comprehensive services and technical support for the measurement of gene expression in clinical and nonclinical samples. The GEC serves customers from both inside and outside Mayo Clinic. The GEC utilizes multiple state-of-the-art platforms _������������ including microarray-based technologies from Affymetrix, Illumina and Agilent, and quantitative polymerase chain reaction (qPCR) instrumentation from Fluidigm and Applied Biosystems _������������ for a variety of gene expression analyses. Services are also available for sample preparation for whole-genome messenger RNA (mRNA) and microRNA (miRNA) profiling by next-generation sequencing. The GEC currently provides whole-transcriptome and miRNA expression analyses of RNA derived from fresh-frozen tissues; formalin-fixed, paraffin-embedded tissues; laser-capture microdissected cells; and cell lines.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 19,2024. Portal, Core facility

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• SciCrunch
• 13 years ago - by Anonymous

Our laboratory applies a diverse array of biophysical techniques to study macromolecular interactions at hydrodynamic, thermodynamic, kinetic and structural level in the context of key signaling circuitry pertinent to cell growth and differentiation, cell survival and motility, cell cycle regulation, apoptosis and cancer. Our laboratory provides services in regards to the study of proteins, protein-protein and protein-ligand interactions using the following tools: - Isothermal Titration Calorimetry - Differential Scanning Calorimetry - Pressure Perturbation Calorimetry - Static Light Scattering - Dynamic Light Scattering - Stop-Flow Spectroscopy - Circular Dichroism - Molecular Modeling - Molecular Dynamics Please contact us for pricing and quotation.

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• SciCrunch
• 14 years ago - by Anonymous

An Portal, Core facility

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 16,2024. Portal, core facility.

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• SciCrunch
• 13 years ago - by Anonymous

Genome Center uses technologies to understand how heritable genetic information of diverse organisms functions in health and disease. Provides research facilities, service cores, and staff for genomics research and training. Core facilities for Bioinformatics,DNA Technologies and Expression Analysis, Metabolomics, Proteomics,TILLING Core,Yeast One Hybrid Services Core.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 19,2024. Portal, Core facility

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 16,2024. Portal, core facility.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 16,2024. Portal, Core facility

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that offers consultations on basic questions in research computing, bioinformatics and computational biology during the initial stages of study design and grant proposals as well as for ongoing, funded studies requiring external expertise. Core has experience in large-scale data management, database design and software development. Staff members can provide assistance in quality assurance and analysis of gene expression arrays, genome-wide SNP arrays, CNV studies and different aspects of second-generation sequencing technologies such as ChIP-seq, RNA-Seq or resequencing efforts. Services also include provision of external information generated from public database, data curation and assistance on choosing the right data format and annotation standard to ensure best practices in data management and submission are being maintained.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 22,2024. Portal, Core facility

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• SciCrunch
• 13 years ago - by Anonymous

Proteomics involves analysis and identification of protein structure and function. Through Proteomics Core, investigators at Mayo Clinic and elsewhere have access to a broad range of proteomics services, technologies and guidance to help them answer scientific questions. Toward a goal of improving patient care, the core offers services and conducts research in the areas of mass spectrometry-based differential proteomics, peptide synthesis, protein and peptide purification, and protein identification, characterization and expression.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 19,2024. Portal, Core facility

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• SciCrunch
• 13 years ago - by Anonymous

The Cell Culture and Cytogenetics Facility carries out classical and molecular cytogenetic analyses. These studies include karyotyping, special staining and banding procedures, and fluorescence in situ hybridization (FISH). This analysis can be performed on cells from blood or tissue specimens from humans or experimental animals, cultured cells, and/or fresh, frozen, or paraffin-embedded tumor biopsies. This approach can be used to characterize the karyotype of cells; map the location of new genes, virus, or transgene insertions; monitor established cell lines to rule out interspecies cell culture contamination or other changes during cell culture; ensure the fidelity of embryonic stem cells prior to production of knockout mice; determine the pattern of chromosomal gains and losses; and enumerate copy numbers of chromosomes or cancer-related genes. The Cell Culture and Cytogenetics Facility provides comprehensive state-of-the-art cytogenetics services ranging from assisting investigators with study design, performing cell culture, preparing probes, carrying out and interpreting classical and molecular cytogenetic analyses, and assisting in manuscript preparation. The laboratory includes equipment for cell culture, cryopreservation, cytogenetic harvests, cytogenetic analysis of human and other mammalian cells, FISH, molecular genetic procedures requisite for FISH, including polymerase chain reaction (PCR) amplification, fluorescence and light microscopy, darkroom for standard photomicrography and printing as well as digital imaging and printing to laser or dye sublimation printers.

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• SciCrunch
• 13 years ago - by Anonymous

Core sells sequencing data and bioinformatic analytics services to the scientific community. Core aims to permit the development of research on sequencing protocols and encourage collaboration with clinicians to develop the next generation genomic DNA testing.

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• SciCrunch
• 14 years ago - by Anonymous

Software for a general workbench for analyzing regulatory sequence regions and discovering transcription factor binding sites and cis-regulatory modules.

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• SciCrunch
• 13 years ago - by Anonymous

Research Histology Services is located in the Thomas E. Starzl Biomedical Science Tower at the University of Pittsburgh. RHS lab serves as the Core Liver and Kidney Laboratory for the Immune Tolerance Network (ITN) and the Core Heart Lab for the Clinical Trials in Organ Transplantation in Children (CTOTC04), providing histology services for ongoing clinical patient research studies throughout the United States and Canada. Provides range of histological research techniques that include decalcification, standard tissue processing, biopsy processing, paraffin embedding, OCT embedding of frozen tissues, serial sectioning, step/level sectioning, and cryostat sectioning. A wide spectrum of assays is available in addition to the routine hematoxylin and eosin (H&E) stain. Special histochemical stains routinely provided include; Masson Trichrome, PAS (periodic acid Schiff), Prussian Blue (Iron), Verhoff''''s Elastin Stain, Cresyl Violet, Toluidine Blue, and Luxol Fast Blue; additional histochemical staining is done upon request. Wide arrays of Immunoperoxidase and Immunofluorescent staining and apoptosis/ tunel stains are also available. Our goal is to return quality work in the shortest time possible.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 24,2024. Respiratory Disease Immunology Core Laboratory is to provide technical expertise and resources to investigators interested in the immunological evaluation of rhesus macaque models for lung disease. Studies are primarily carried out in conjunction with the Inhalation Exposure Core and the Computational Imaging Core at UCDavis, in order to provide a comprehensive evaluation of pathophysiological responses in the lung. Services provided by the RDICL include assistance with experimental design, allergen characterization and preparation (through Resource Services), evaluation of allergen-specific IgE and IgG, and quantitation of histamine. We also provide technical support for sample processing, including bronchoalveolar lavage, lung tissue, and blood. Flow cytometry and molecular analysis of lung and blood samples are coordinated with the Flow Cytometry Core Laboratory and the Infectious Disease Immunology Core Laboratory. In addition to immunological evaluation, the Respiratory Disease Immunology Core Laboratory can provide investigators with primary cell isolates and in vitro culture of rhesus lung epithelial cells and fibroblasts. The Core does not conduct studies with human lung cultures. Please inquire for additional assays that are in development. In the future, immunohistochemistry of lung samples will be offered in conjunction with the Computational Imaging Core at UCDavis.

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• SciCrunch
• 14 years ago - by Anonymous