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Dedicated imaging facility for many aspects of brightfield and fluorescence microscopy, including low-light imaging, scanning confocal imaging, imaging of fixed and living tissues, deconvolution, multi-channel imaging, FRAP, FRET, time-lapse and z stack (3D and 4D) acquisition, and spectral analysis.

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• SciCrunch
• 13 years ago - by Anonymous

3Scan uses the cutting edge technology of the KESM (Knife Edge Scanning Microscope) to automatically section and image samples. Knife-edge scanning, introduced in the KESM instrument, not only preserves image registration throughout the depth of the specimen block but also isolates the tissue above the knife from that below to eliminate undesirable events (back-scattering of light and bleaching of fluorescent-stained tissue below the knife). Using the KESM, 3Scan is able to scan a one cc^3 block of tissue (for example, a whole mouse brain) at submicron resolution in under 100 hours. With this resolution (a voxel size of 0.6 um x 0.7 um x 1.0 um) 3Scan is able to show cell scale phenomena in the context of a compete organ. In the example of a whole mouse brain this means that 3Scan is able to accurately model every neuron in the mouse brain sample.

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• SciCrunch
• 13 years ago - by Anonymous

The CCIR provides a full range of biomedical imaging services to support clinical research projects. These services include: (1) Pre-study services that help investigators design, set up, and kick off the study; (2) Coordinating services, including Scanning, that provide assistance in executing, monitoring and evaluating the study; and, (3) Information Technology management services to handle, track, and process imaging data.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. Contract research organization that provides an architecture for text mining and semantic annotation. It provides facilities to link texts data to concepts of the Linked Open Data network through various sources like DBpedia, Geonames, CIA World Factbook or directly to Wikipedia or a search engine when there is no available resource.

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• SciCrunch
• 13 years ago - by Anonymous

The main objective of the Joslin Diabetes Center Genomics Core is to facilitate research by laboratories by providing equipment, expertise, and services in nucleic acid analysis that would be too specialized or costly for individual laboratories to provide independently. Instruments include: ������������ Fluidics Station 400 ������������ GeneChip?������ Scanner 3000 ������������ Hybridization Oven 640 ������������ NanoDrop ND-1000 ������������ NanoDrop ND-3300

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• SciCrunch
• 13 years ago - by Anonymous

Gnarus Systems is pleased to offer cat-SAR; a peer-reviewed in silico toxicity prediction expert system. The cat-SAR system associates 2-dimensional chemical fragments with active or inactive compounds in a learning set. Unlike many other approaches, cat-SAR is transparent and model parameter selection is controlled by the user. As such, the approach is sharable and allows unrestricted user scrutiny, intervention and model optimization throughout the SAR modeling process. This rationale negates any a priori requirements that a given set of data must fit the attributes of a predefined and often proprietary modeling process. The cat-SAR system essentially ??????????????????learns???????????? about the biological activity of chemicals by analyzing ??????????????????learning sets???????????? of data. These are endpoint specific databases of toxicological or pharmacological chemical activity (e.g., carcinogens and developmental toxicants) that are assembled by us or others. Currently, we have validated and usable learning sets for a variety of health endpoints including cancer, anticancer, genotoxicity, developmental toxicity, and chemical allergy. Currently, cat????????????SAR models are available for: Rats, mice, and rodents carcinogenesis including gender-specific submodels Mammary Cancer in Rodents Tissue/organ specific carcinogenesis for 12 tumor types Salmonella mutagenicity (i.e. the Ames Assay) Developmental Toxicity Allergic Contact Dermatitis Respiratory Hypersensitivity Mouse Local Lymph Node Assay Ocular toxicity Estrogen mimics based on the E-SCREEN assay Anticancer activity to several different breast cancer cell lines

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Assay design and development service. The NeuroDiscovery Center''''s Laboratory for Drug Discovery in Neurodegeneration (LDDN) was established to discover chemical agents from which we and others will develop a new generation of drugs to treat neurodegenerative diseases (including degenerative diseases of the eye and ear). To accomplish this goal, LDDN has recruited a permanent staff of industry-seasoned scientists with expertise in assay development, laboratory automation, informatics, and medicinal chemistry, to work in close collaboration with principal investigators from the academic neuroscience community. In this way, LDDN helps transform discoveries in the basic biology of neurodegeneration into opportunities for drug discovery. (While priority is given to members investigating neurodegenerative diseases and the central nervous system, we welcome inquiries from all investigators.)

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• SciCrunch
• 14 years ago - by Anonymous

Our facility provides equipment and training for researchers interested in using widefield & confocal microscopy, photobleaching, and live cell imaging studies.

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• SciCrunch
• 14 years ago - by Anonymous

The cell sorting and analysis lab provides access to the most sophisticated flow cytometers presently available. The core is able to analyze and physically separate cells based upon features detectable with fluorescently labeled monoclonal antibodies. The Simches site is located in the newly constructed space located in room 3.434 in the Simches Building. Major Equipment (Simches): Analytic Seven Laser LSR configured with 355 nm, 407 nm, 488 nm, 532 nm, 594 nm, 633 nm, and 780 nm air cooled lasers providing a wide range of excitation possibilities. Modified Digital Vantage cell sorter with 2 water-cooled argon, 2 krypton and one air cooled 633 nm laser. The CNY site is located in the newly constructed space located in room 6.307 in Building 149, 13th Street, Charlestown Navy Yard. Major Equipment (CNY): Analytic three Laser LSR II configured with 405 nm, 488 nm, and 633 nm air cooled lasers providing a wide range of excitation possibilities. A four laser FACS Aria II cell sorter configured with 405 nm, 488 nm, 594 nm and 633 nm air cooled lasers providing a wide range of excitation and sorting possibilities.

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• SciCrunch
• 14 years ago - by Anonymous

The Duke Clinical Research Unit is a state-of-the-art research facility located within the Duke University Medical Center campus that provides infrastructure support to sponsors and investigators who are: - Testing new drug candidates and other cutting-edge therapies - Seeking to identify and validate novel biomarkers Building on the strength of Duke''s thought leadership, therapeutic expertise, patient base, and access to the latest technologies, the DCRU is a critical component of the Duke Translational Medicine Institute''s efforts to speedily translate new laboratory discoveries into treatments for patients DCRU is a Duke resource available to investigators for the conduct of clinical trials in either adult or pediatric populations. For non-commercial clinical trials funded by the NIH, foundations, investigators������������������������ departments, and similar funding mechanisms, the DCRU provides: - Space - Nursing support - Core laboratory support - Statistical support for study design and analysis - Metabolic kitchen support DCRU can also be your partner for industry-sponsored studies, offering either full-service execution of your studies or fee for service in the above areas.

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• SciCrunch
• 13 years ago - by Anonymous

A centralized laboratory that provides DNA sequencing and plasmid clone storage and distribution services to researchers in the DF/HCC community and around the world. It provides the following services: Large-scale DNA sequencing service, Small-scale DNA sequencing service, Same-day sequencing service, Automated, high-throughput plasmid DNA preparations, Chain termination sequencing service, DNA extraction service. The DNA Resource Core was started to meet a growing need for DNA sequencing services at a cost that is affordable for academic labs. Our services now include DNA sequencing for large- and small-scale projects and a plasmid repository & distribution service. Our highest priorities are quality assurance, user support and timely request fulfillment. Questions about the plasmid repository can also be directed to plasmidhelp(at)hms.harvard.edu.

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• SciCrunch
• 14 years ago - by Anonymous

Bio Basic Inc. is a privately owned dynamic biotechnology company. The company was founded in 1990 in Toronto, Canada. From 1990 to 1995, Bio Basic Inc.''s primary focus has been in the field of biochemicals. Starting in 1995, Bio Basic Inc. has begun manufacturing various Life Science Products. Throughout the past years, the company has developed rapidly and served as a one-stop-shop to our customers in the life sciences field. To date, Bio Basic Inc. has approximately 600 employees, seven laboratories, three factory buildings, 40 international distributors and over 10,000 customers worldwide. Bio Basic Inc. is committed to innovation and excellence. In an effort to achieve this, Bio Basic Inc. has continuously directed efforts in R & D and improving the quality of our products. Bio Basic Inc. is proud to offer a breath of products and services to customers worldwide. Several of our product lines such as, Molecular Biology Kits, Biochemicals, Synthetic Genes and Synthetic Oligos have already shown dominant market presence and have been widely recognized by customers worldwide.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 15,2024. Nano Research Facility (NRF) at Washington University in St. Louis is a NNIN nodal facility supported by the National Science Foundation. It cultivates an open, shared research, and education environment that brings researchers across disciplines together, particularly in the emerging area of nanomaterials with applications in the energy, environment, and biomedical fields. The mission is to be a resource to the scientific and technical community for the advancement of nanoscience and nanotechnology in a safe and environmentally benign manner. NRF includes a micro- and nano-fabrication lab (clean room), surface characterization lab, particle technology lab, and imaging lab with a focus on bio-imaging. NRF provides unique technical expertise in: Knowledge-based synthesis of nanostructured materials Particle instrumentation tools for toxicity studies Non-invasive imaging modalities for biological applications Clean Energy Applications Energy and Environmental nanotechology Environmental Health and Safety As a member of the National Nanotechnology Infrastructure Network (NNIN), supported by the National Science Foundation, NRF is available to both academic and industrial users nation-wide and across the globe.

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• SciCrunch
• 13 years ago - by Anonymous

Core that was established in 1998 and currently provides approximately 3,000 surgical, imaging and functional cardiovascular physiology services annually to its academic and industry partners throughout the world. With an experienced staff of 4 dedicated investigators, each with over 10 years of animal physiology experience, the MCPC provides a focused, systematic approach to the study of the basal physiology and pathophysiology of the mouse cardiovascular system.

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• SciCrunch
• 13 years ago - by Anonymous

The mission of the USC Arnold and Mabel Beckman Center for Immune Monitoring is to provide the USC community and external customers with the highest quality support for clinical trials for immunotherapy of human cancers; facilitate basic, translational, and clinical research with an immunological monitoring component; and provide immunological assay training and education. The IM core provides quality assessments of immunological function necessary for the study of pathogenesis, treatment, and prevention of cancer and other human diseases. Supporting clinical trials for immunotherapy of human cancer: For physicians involved in clinical trials for immunotherapy of human cancer, the Beckman Center for Immune Monitoring Core offers several assays to assess patient immune responses. Such assays provide a highly sensitive and quantitative means of measuring the efficacy of an experimental treatment as a surrogate endpoint or as a correlative to clinical responses. It can help establish proof of principle that a treatment works, and suggest changes to adapt a standard treatment protocol to individual patient needs. Besides the Gold Standard of Immune monitoring: the ELISPOT assay for detection of cytokines released by activated T cells, we also perform intracellular cytokine staining and can detect tumor specific T cells by MHC tetramer analysis. Helper and killer T cells can be separated, and proliferative and cytotoxic responses are quantified in radioactive assays. The monitoring protocol of choice is tailor made to fit the needs and the possibilities of each treatment protocol. The core offers freezing and storage capacity for clinical samples and full analytical support for monitoring assays. It is also possible to send in samples for post-assay analysis using our state-of-the-art ELISPOT reader. Facilitating research with an immune monitoring component: For researchers within travel distance of our facility, we offer equipment and technical assistance for performance and/or analysis of ELISPOT assays, flow cytometry-based assays, radioisotope-based proliferation and cytotoxicity assays, multiplexing ELISA assays, and molecular-based quantitative PCR assays. Our lab has equipment for controlled rate freezing and storage of cryopreserved peripheral blood cells, tissue culture facilities and an ELISPOT reader to analyze your 96 well plates. Assays and technical support are also available to support translational projects that utilize in-vitro systems and in vivo animal models.

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• SciCrunch
• 14 years ago - by Anonymous

IDRC aims to improve the detection and prevention of infectious diseases, by developing new diagnostic laboratory methods for use in evidence-based research and clinical practice

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• SciCrunch
• 14 years ago - by Anonymous

Core facility that provides provides state-of-the-art molecular pathology resources to the Harvard community including laser capture microscopy, DNA/RNA/miRNA quality/expression analysis, Luminex FlexMap 3D multiplex bead cytometry, and real-time PCR. The ATRC is a fee-for-use facility. For NeuroDiscovery members, the first 10 hours of training, consultation and instrument use is free. This initial period is intended to provide a first time user with preliminary data/proof of concept regarding their project, and is generally sufficient when investigators work under the aegis of ATRC staff. Thereafter, the base fee varies depending on activity and the extent of your proposed work. Project-based charge-back agreements for large projects can be negotiated with the ATRC Director, Dr. Charles Vanderburg. Although priority is given to NeuroDiscovery members investigating neurodegenerative diseases and the CNS, the facility is also available to any academic investigators within the Harvard medical community and the greater-Boston research community. Under special arrangements the facility may also be made available to the commercial sector. Please contact ATRC Director, Dr. Charles Vanderburg, for details.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 22, 2024. Analyte Center provides analytical services to the research community within Baylor College of Medicine and to investigators at other institutions. We provide access to state-of-the-art gas chromatography/mass spectroscopy, tandem mass spectroscopy, and high pressure liquid chromatography for the purpose of quantitative analysis of small organic molecules. In addition to a broad spectrum of routinely offered services we can also provide specialty services on demand provided our instrumentation will provide the sensitivity and specificity required for the investigator.

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• SciCrunch
• 14 years ago - by Anonymous

Laboratory facility has two Isoprime Isotope Ratio mass spectrometers. One capable of measuring oxygen and hydrogen isotope ratios of water and the other capable of measuring carbon and nitrogen isotope ratios of organic matter.

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• SciCrunch
• 14 years ago - by Anonymous

An Portal, Core facility

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• SciCrunch
• 13 years ago - by Anonymous