Curator Dashboard

It serves as a gateway for clinicians, families and researchers who have an interest in or are affected by Batten disease or who wish to find out more. Information can be accessed via four main routes - Clinicians, Families, Researchers, Professional Support. The Clinical route describes Batten disease and includes details on diagnosis and diagnostic services. The Family route also describes Batten disease and lists support groups. The Research route includes the NCL Mutation Database, established in 1998, and other useful information. The Professional Support route includes details of coordinated initiatives to support those affected by Batten disease. A fifth route, Research Consortia, serves to meet research needs and currently act as a focus for collaborative efforts to identify the remaining human and animal NCL genes and facilitate functional approaches. An additional route, Creativity, has been launched to display creative items from families with Batten disease, and to celebrate life, in both its fullness and fragility.

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• SciCrunch
• 17 years ago - by Anonymous

The NASC International Affymetrix Service is a commercial website that provides transcripomics services for a fee. This data is available for any available species, any consortium chip, and any kind of experiment. The website also provides open source and free Xspecies software and techniques that can be (examples) used to perform GeneChip transcriptomics experiments on species for which no current Affymetrix chip exists.

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• SciCrunch
• 16 years ago - by Anonymous

MBGD is a database for comparative analysis of completely sequenced microbial genomes, the number of which is now growing rapidly. The aim of MBGD is to facilitate comparative genomics from various points of view such as ortholog identification, paralog clustering, motif analysis and gene order comparison. The heart of MBGD function is to create orthologous or homologous gene cluster table. For this purpose, similarities between all genes are precomputed and stored into the database, in addition to the annotations of genes such as function categories that were assigned by the original authors and motifs that were found in the translated sequence. Using these homology data, MBGD dynamically creates orthologous gene cluster table. Users can change a set of organisms or cutoff parameters to create their own orthologous grouping. Based on this cluster table, users can further analyze multiple genomes from various points of view with the functions such as global map comparison, local map comparison, multiple sequence alignment and phylogenetic tree construction.

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• SciCrunch
• 17 years ago - by Anonymous

Software package focused on finding differential exon usage using RNA-seq exon counts between samples with different experimental designs. It provides functions that allows the user to make the necessary statistical tests based on a model that uses the negative binomial distribution to estimate the variance between biological replicates and generalized linear models for testing. The package also provides functions for the visualization and exploration of the results.

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• SciCrunch
• 13 years ago - by Anonymous

MATCONT is a graphical MATLAB package for the interactive numerical study of parameterized dynamical systems. It is developed in parallel with the command line continuation toolbox CL_MATCONT and with the command line continuation toolbox CL_MATCONTM for the interactive numerical study of parameterized maps and iterates of maps. MATCONT and CL_MATCONT allow the numerical continuation of equilibria, limit cycles and homoclinic orbits, detection of codimension 1 and 2 bifurcations, continuation of the codimension 1 bifurcations and computation of their normal forms. For equilibria normal form coefficients of codimension 2 bifurcations are also computed, as well as switching to the codimension 1 curves in codimension 2 points. CL_MATCONTM provides similar facilities for maps and iterates of maps, including normal form coefficients of codimension 2 bifurcations and continuation of homoclinic and heteroclinic connections and tangencies of such connections.

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• SciCrunch
• 17 years ago - by Anonymous

An efficient software tool to utilize update-to-date information to functionally annotate genetic variants detected from diverse genomes (including human genome hg18, hg19, as well as mouse, worm, fly, yeast and many others). Given a list of variants with chromosome, start position, end position, reference nucleotide and observed nucleotides, ANNOVAR can perform: 1. gene-based annotation. 2. region-based annotation. 3. filter-based annotation. 4. other functionalities. (entry from Genetic Analysis Software)

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• SciCrunch
• 14 years ago - by Anonymous

Collection of structural data of biological macromolecules. Database of information about 3D structures of large biological molecules, including proteins and nucleic acids. Users can perform queries on data and analyze and visualize results.

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• SciCrunch
• 16 years ago - by Anonymous

A R package that enables the identification of protein binding footprints in DNase I hypersensitive sites sequencing (DNase-seq) data.

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• 13 years ago - by Anonymous

A web-based compendium of molecular alterations in primary immunodeficiency diseases. Detailed information about genes and proteins that are affected in primary deficiency diseases is presented along with other pertinent information about protein-protein interactions, microarray gene expression profiles in various organs and cells of the immune system and mouse studies. RAPID also hosts a tool, the mutation viewer, to predict deleterious and novel mutations and also to visualize the mutation positions on the DNA sequence, protein sequence and three-dimensional structure for PID genes. The information in this database should be useful to researchers as well as clinicians.

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• SciCrunch
• 17 years ago - by Anonymous

Neuroscience for Kids has been created for all students and teachers who would like to learn about the nervous system. Discover the exciting world of the brain, spinal cord, neurons and the senses. Use the experiments, activities and games to help you learn about the nervous system. There are plenty of links to other web sites for you to explore. Can''t find what you are looking for? Search the web site and the questions/answers page. Keep up-to-date on new discoveries in brain research with Neuroscience in the News, request the Neuroscience for Kids Newsletter or watch BrainWorks, a 30-minute TV show about the brain hosted by Dr. Eric H. Chudler. Portions of Neuroscience for Kids are available in Spanish, Slovene, Chinese, Portuguese, Italian, Korean, Dutch, Japanese and Turkish. Neuroscience for Kids is maintained by Eric H. Chudler, Ph.D. and was supported by a Science Education Partnership Award (R25 RR12312) from the National Center for Research Resources (NCRR). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH. Support: NCRR

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• 17 years ago - by Anonymous

An academic, non-profit foundation recognized of public utility that coordinates research and education in bioinformatics throughout Switzerland and provides high quality bioinformatics services to the national and international research community. * The first and primary SIB mission consists of providing services, i.e. the bioinformatics research infrastructure for life science research. It is carried through in a top-down approach, with objectives set by the SIB Board of Directors and an implementation plan agreed with the concerned groups. Federal funds are almost exclusively used to fulfill this mission. * Within the second mission the SIB plays a federating role, linking the Swiss bioinformatics community and promoting and coordinating research and education. This activity is mainly performed in a bottom-up way with funding from the universities and other partners and from research grants.

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• 16 years ago - by Anonymous

Biobank provides data collected at Assessment Center and via online questionnaires on participants aged 40-69 years recruited throughout United Kingdom and provides summary information to improve prevention, diagnosis and treatment of serious and life threatening illnesses.

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• 16 years ago - by Anonymous

The Okinawa Institute of Science and Technology Promotion Corporation (OIST PC) was established in September 2005 to conduct best in the world research and education in science and technology, and to prepare the ground for the creation of a new graduate University in Okinawa. Our concept was to grow the project out of interdisciplinary research in areas that integrate components from biology, physics, chemistry, mathematics and computation science. We have done so by recruiting researchers in Neurosciences, Molecular Sciences and Mathematical and Computational Biology, and we have recently added Environmental Science as a new focus. OIST P.C. is unique in that we are a Japanese government-funded agency, but maintain independence in developing and conducting our research and academic programs. We drive towards excellence, and we are committed to developing programs to enable outstanding researchers to be given the opportunity to conduct independent research and to excel in their chosen research topics, as well as extending to talented students the chance to access a world-class education program in Okinawa. At a time when worldwide support for research is increasingly risk-averse and obtaining funding places an ever-growing burden on faculty, OIST promotes innovative research in a highly facilitating and supportive environment. In addition to seminars and workshops, Okinawa Institute of Science and Technology Promotion Corporation (OIST) provides students from Japanese and overseas universities with education and research opportunities through a system of collaborative graduate programs and placements. Prior to the opening of the graduate university in FY 2012, these allow students to receive research guidance in a broad range of topics from Principal Investigators of research laboratories at OIST (units) through two different student research assistantships.

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• SciCrunch
• 16 years ago - by Anonymous

Data analysis service to predict whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids. SIFT can be applied to naturally occurring nonsynonymous polymorphisms and laboratory-induced missense mutations. (entry from Genetic Analysis Software) Web service is also available.

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• SciCrunch
• 14 years ago - by Anonymous

Blog intended for grantees of the National Institute on Aging (NIA) at the NIH, as well as applicants for funding, those with an application in mind, application reviewers, and students pursuing careers in research on aging and Alzheimer's disease.

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• SciCrunch
• 14 years ago - by Anonymous

The mission of the Indiana Alzheimer Disease Center is to serve as a shared research resource in order to facilitate research in Alzheimer disease and related disorders and to distinguish them from normal aging. Within this mission, one objective is to provide an environment and core resources to enhance ongoing research and foster new lines by bringing together basic and clinical scientists to study the etiology, pathogenesis, diagnosis, and treatment of Alzheimer disease and related dementias, with an emphasis on hereditary dementias. The Center is composed of 6 cores: Administrative, Clinical, Neuropathology, Data Management, Education and Information Transfer, and Imaging. The Neuropathology Core functions as brain-bank facility, which stores samples from hundreds of autopsied cases and supplies them to research investigators around the world. The focus of the IADC is on behavioral neurology, clinicopathological correlations, biochemistry, and genetics of AD, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), Gerstmann-Str��������ussler-Scheinker disease (GSS), Parkinson disease and other hereditary diseases associated with abnormal protein accumulation. The Neuropathology Core carries out state-of-the-art neuropathological examination of brain, spinal cord and other tissue samples obtained from individuals affected by neurodegenerative dementia and/or other related neurodegenerative diseases. The Core is composed of five different laboratories: histology and immunohistochemistry, electron microscopy, molecular biology, biochemistry, as well as a small-animal laboratory dedicated to the study of murine models of human diseases. In the past 15 years, we have been among the first to discover mutations in genes implicated in the etiology and pathogenesis of early-onset dementia. Specifically we have identified novel mutations in the Amyloid Precursor Protein gene (APP) and Presenilin 1 (PSEN1) that are responsible for hereditary forms of early-onset AD. We have also found several novel mutations responsible for Gerstmann-Str��������ussler-Scheinker (GSS) disease, a hereditary degenerative disease causing ataxia, parkinsonism and dementia secondary to the accumulation of mutated prion protein (PrP). We have reported mutations in the MAPT gene in FTDP-17, a tauopathy which causes personality changes, cognitive dysfunction, rigidity and dementia. Other areas of research in neurodegeneration are related to the study of genetic mutations of Neuroserpin (SCNA) and Light Ferritin Polypeptide genes.

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• SciCrunch
• 16 years ago - by Anonymous

Detection of differentially expressed genes (DEGs) from the comparison of two biological conditions among different levels of gene expression, using several statistical methods: Rank Product, t-test, SAM, Limma, ANOTA, DESeq, edgeR.

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• SciCrunch
• 13 years ago - by Anonymous

Web-based repository and analysis site for connectivity matrices that have been derived from neuroimaging data including different imaging modalities, subject groups, and studies. Users can analyze connectivity matrices that have been shared publicly and upload their own matrices to share or analyze privately.

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• SciCrunch
• 13 years ago - by Anonymous

Engine and database to search the three-dimensional fragments within 3D RNA structures using as an input the sequence(s) and / or secondary structure(s) given in the dot-bracket notation. The database contains RNA sequences and secondary structures, described in the dot-bracket notation, derived from PDB-deposited RNA structures and their complexes. It also contains atom coordinates of the unmodified and modified nucleotide and nucleoside residues extracted from the PDB-deposited RNA structures, as well as torsion and pseudotorsion angle values, sugar pucker parameters and classification of base pair types given for the PBD-deposited RNA structures. Knowledge of the three dimensional RNA structure is crucial for all fields of biomolecular research. In contrast to the protein field, only about 1.300 experimentally derived structures of RNAs are deposited in the Protein Data Bank (PDB). To complement the results of experimental studies, new approaches based on bioinformatics and calculation are pursued in several laboratories to make tertiary RNA structure prediction possible. RNA FRABASE version 2.0 should greatly facilitate various RNA structure modelling approaches, RNA structure analysis and motif searching. If one compares the three dimensional RNA structure to a spatial puzzle, the RNA FRABASE allows to pull out a defined piece of this puzzle - the 3D RNA fragment. The architecture of the web-accessible RNA FRABASE engine and database is based on the following information path: PDB-deposited RNA structures �� RNA sequences and secondary structures described in the dot-bracket notation �� secondary structures of RNA fragments �� 3D RNA fragments. RNA FRABASE 2.0 also stores data and conformational parameters in order to provide on the spot structural filters to explore the three-dimensional RNA structures. An instant visualization of the 3D RNA structures is provided.

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• SciCrunch
• 16 years ago - by Anonymous

The ALS Therapy Development Institute is a nonprofit biotechnology company discovering treatments for patients alive today. Our approach combines the power of a nonprofit mission with the best practices of a for-profit biotechnology company: rigorous, open-minded research and proven drug development techniques. ALS TDI combines the passion and dedication of a nonprofit organization with the entrepreneurial and scientific spirit of a biotechnology company * Our laboratory, the leading drug discovery program for ALS, bridges a critical research gap * Our in-house expertise translates research into potential drug candidates by screening drugs in the SOD1 mouse model of ALS. * Our scientific collaborations are designed to bring the most promising leads closer to patient use. * We share emerging knowledge on the disease with patients, physicians, and researchers as quickly and comprehensively as possible. * Every decision is made in the interest of finding effective treatments for people living with ALS. * Our unique approach accelerates drug development for ALS.

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• SciCrunch
• 17 years ago - by Anonymous