Curator Dashboard

A command-line program for the statistical analysis of SNP-disease association in case-control/cohort/cross-sectional studies with potentially missing genotype data. SNPMStat allows the user to estimate or test SNP effects and SNP-environment interactions by maximizing the (observed-data) likelihood that properly accounts for phase uncertainty, study design and gene-environment dependence. For SNPs without missing data, the program performs the standard association analysis. For typed SNPs with missing data or untyped SNPs, the program performs the maximum-likelihood analysis. (entry from Genetic Analysis Software)

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• SciCrunch
• 14 years ago - by Anonymous

A command-line program for the imputation of untyped SNPs. tagIMPUTE is based on a few flanking SNPs that can optimally predict the SNP under imputation. (entry from Genetic Analysis Software)

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• SciCrunch
• 14 years ago - by Anonymous

This Gateway is a collaboration between the Consortium for Functional Glycomics (CFG) and Nature Publishing Group (NPG), providing a comprehensive resource for functional glycomics research. Use this site to stay up-to-date on glycomics news, request CFG resources, and search databases of glycan-binding proteins, glycan structures, and glycosyltransferases. The Functional Glycomics Update provides a one-stop overview of the latest research in glycobiology for specialists and non-specialists alike. It is updated monthly to bring you the latest news and selected highlights from Nature journals. In addition, it will provide two featured articles a month on the most relevant advances in the field published in NPG and other top journals. By collating new articles into a key worded research library, we hope to provide a continuously updated and broad overview of the field. Sponsor. The CFG is a large international research initiative funded by NIGMS to elucidate the roles of carbohydrate-protein interactions in cell communication at the cell surface.

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• SciCrunch
• 17 years ago - by Anonymous

This database contains links to 600+ Alcohol, Tobacco, and Other Drugs (ATOD) organizations and resources on the web. It can be viewed by name in the A-to-Z list, by category or you can type any keyword or phrase into the search box to find links that match your search term. The categorical list includes ATOD Research Centers, Information Resources, Treatment, Training, U.S. Gov''t Agencies, Internat''l Gov''t Agencies, Recovery, Washington State, Organizations/Advocacy, Professional Societies, Journals/Newsletters, Other Sites

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• SciCrunch
• 17 years ago - by Anonymous

The goal of the Institute is to explore the interfaces of fundamental biological science, clinical science, and clinical care with a special emphasis on targeted cancer therapy. The current focus centers on signaling by protein kinases. These enzymes (protein kinases) play a key regulatory role in nearly every aspect of cell biology. Owing to the myriad actions of protein kinases, it is imperative that they be stringently regulated because aberrant activity of these enzymes can lead to a variety of diseases including, inter alia, cancer, diabetes and autoimmune, cardiovascular, degenerative, inflammatory, and nervous disorders. Because mutations and dysregulation of protein kinases play causal roles in human disease, these enzymes represent attractive drug targets. Our research focuses on the epidermal growth factor receptor protein-tyrosine kinase, Raf/Mek/Erk protein kinases, and on the regulation of tyrosine hydroxylase activity by protein phosphorylation. The Blue Ridge Institute for Medical Research is a Federal tax exempt 501(c)(3) non-profit organization incorporated in the State of North Carolina on 24 March 2006 (EIN 20-4665742; DLN 17053144012016).

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• SciCrunch
• 16 years ago - submitted by Andrea Stagg

CnidBase, the Cnidarian Evolutionary Genomics Database, is a tool for investigating the evolutionary, developmental and ecological factors that affect gene expression and gene function in cnidarians. In turn, CnidBase will help to illuminate the role of specific genes in shaping cnidarian biodiversity in the present day and in the distant past. CnidBase highlights evolutionary changes between species within the phylum Cnidaria and structures genomic and expression data to facilitate comparisons to non-cnidarian metazoans. CnidBase aims to further the progress that has already been made in the realm of cnidarian evolutionary genomics by creating a central community resource which will help drive future research and facilitate more accurate classification and comparison of new experimental data with existing data.

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• SciCrunch
• 17 years ago - by Anonymous

It is an independent nonprofit organization established to provide meaningful trans-disciplinary experiential education to students by making the most cutting-edge instructional methods and technologies available to them to bring new inventions to the marketplace and to encourage knowledge sharing and collaboration among its numerous constituencies. The Center provides a comprehensive program in which its students learn and acquire real-world experience by assisting universities, private and public research institutions, companies, and entrepreneurs to evaluate new technologies and facilitate the creation and development of new ventures. By offering a virtual venue for students and other constituencies worldwide, our stakeholders and collaborators can connect and share knowledge, expertise, resources, best practices, and other important information. Employers, investors and others searching for talent place a premium on relevant experience. However, students, individuals seeking a change in their careers, and prospective entrepreneurs often find it difficult to obtain positions that can provide needed experience, even if they are willing to work without compensation. This conundrum often leads to people taking or staying in positions for which they have no passion and which do not make the best use of their abilities. The Centers program is designed to provide extensive, intensive and relevant experience to its participants, with particular emphasis on teaching them to adapt to and thrive in our lightning fast, rapidly changing and increasingly flat world. As an independent organization, the Centers program and activities are not restricted to any particular institution or jurisdiction. Thus the Center can attract students, clients, professionals and other stakeholders, establish collaborations, and pursue other opportunities appropriate to its mission almost anywhere. eductional resource.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software that uses partition function posterior probability estimates to compute maximum expected accuracy multiple sequence alignments. Computes maximal expected accuracy multiple sequence alignments from partition function posterior probabilities.Produces accurate alignments on long and heterogeneous length datasets containing protein repeats.

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• SciCrunch
• 13 years ago - by Anonymous

Functional genomic database for malaria parasites. Database for Plasmodium spp. Provides resource for data analysis and visualization in gene-by-gene or genome-wide scale. PlasmoDB 5.5 contains annotated genomes, evidence of transcription, proteomics evidence, protein function evidence, population biology and evolution data. Data can be queried by selecting from query grid or drop down menus. Results can be combined with each other on query history page. Search results can be downloaded with associated functional data and registered users can store their query history for future retrieval or analysis.Key community database for malaria researchers, intersecting many types of laboratory and computational data, aggregated by gene.

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• SciCrunch
• 16 years ago - by Anonymous

It presents accurate pig gene annotations in all sequenced genomic regions. It integrates various available pig sequence data, including 3.84 million whole-genome-shortgun (WGS) reads and 0.7 million Expressed Sequence Tags (ESTs) generated by Sino-Danish Pig Genome Project, and 1 million miscellaneous GenBank records. The Pig Analysis Database has covered nearly 50% of the whole pig genome and over 70% of the coding sequences (CDS), and aims to provide the most complete pig gene set to date. In addition to gene annotations, the PigGIS also presents expressional information from 98 EST libraries, SNPs detected from both WGS reads and ESTs, oligos that can be used in microarray design and relevant evolutionary data. SIFT analysis of deleterious mutations will come in future.

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• SciCrunch
• 17 years ago - by Anonymous

A modular framework for finding gene fusions by analyzing Paired-End RNA-Sequencing data.

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• SciCrunch
• 13 years ago - by Anonymous

Operon DB is a method to detect and analyze conserved gene pairs - pairs of genes that are located close on the same DNA strand in two or more bacterial genomes. For each conserved gene pair, we calculate an estimate of probability that the genes belong to the same operon. The algorithm takes into account several alternative possibilities. One is that functionally unrelated genes may have the same order due simply because they were adjacent in a common ancestor. Other possibilities are that genes may be adjacent in two genomes by chance alone, or due to horizontal transfer of the gene pair.

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• SciCrunch
• 17 years ago - by Anonymous

NSERC aims to make Canada a country of discoverers and innovators for the benefit of all Canadians. The agency supports university students in their advanced studies, promotes and supports discovery research, and fosters innovation by encouraging Canadian companies to participate and invest in postsecondary research projects. NSERC researchers are on the vanguard of science, building on Canada''s long tradition of scientific excellence.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

A catalog of antibodies important for zebrafish research, maintained by ZFIN. ZFIN Antibody Wiki is where zebrafish researchers can help each other by sharing antibody information - new antibodies, protocols, tips - anything that might be helpful.

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• SciCrunch
• 16 years ago - by Anonymous

A blog on transcriptomics, bioinformatics and computational biology.

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• SciCrunch
• 13 years ago - by Anonymous

Software for estimating mRNA abundances from the whole transcriptome shotgun sequencing (RNA-Seq) data based on effective length normalization using uniquely mappable areas of gene and mRNA isoform models. Using the known transcriptome sequence model such as RefSeq, NEUMA pre-computes the numbers of all possible gene-wise and isoform-wise informative reads: the former being sequences mapped to all mRNA isoforms of a single gene exclusively and the latter uniquely mapped to a single mRNA isoform. The results are used to estimate the effective length of genes and transcripts, taking experimental distributions of fragment size into consideration. NEUMA covers a large proportion of genes and mRNA isoforms and offers a measure of consistency (''consistency coefficient'') for each gene between an independently measured gene-wise level and the sum of the isoform levels. NEUMA is applicable to both paired-end and single-end RNA-Seq data.

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• SciCrunch
• 13 years ago - by Anonymous

A database of genes that give a seed phenotype when disrupted by mutation. The long-term goal of this project is to establish a comprehensive dataset of essential genes. The updated project database (December, 2007) presents information on 358 genes and 605 mutants. More than 60% of these mutants have been analyzed in the Meinke laboratory (Stillwater, OK).

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• SciCrunch
• 17 years ago - by Anonymous

A software pipeline for analyzing ABySS-assembled contigs from shotgun transcriptome data.

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• SciCrunch
• 13 years ago - by Anonymous

A plant small RNA target analysis server which features two important analysis functions: 1) reverse complementary matching between miRNA and target transcript using a proven scoring schema, and 2) target site accessibility evaluation by calculating unpaired energy (UPE) required to ?open? secondary structure around miRNA?s target site on mRNA. PsRNATarget incorporates recent discoveries in plant miRNA target recognition, e.g. it distinguishes translational and post-transcriptional inhibition, and it reports the number of miRNA/target site pairs that may affect miRNA binding activity to target transcript. PsRNATarget is designed for high-throughput analysis of next-generation data with an efficient distributed computing back-end pipeline that runs on a Linux cluster. The server front-end integrates three simplified user-friendly interfaces to accept user-submitted or preloaded miRNAs and transcript sequences; and outputs a comprehensive list of miRNA / target pairs along with the online tools for batch downloading, key word searching and results sorting., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 13 years ago - by Anonymous

Data set of extensive information on the changing circumstances of aged and disabled beneficiaries - Living, noninstitutionalized population of the continental United States from the Social Security Administration''''s Master Benefit Record who were new recipients of Social Security benefits (first payment in mid-1980 through mid-1981) or who had established entitlement to Medicare and were eligible for, but had not received, Social Security benefits as of July 1982. Based initially on a national cross-sectional survey of new beneficiaries in 1982, the original data base was expanded with information from administrative records and a second round of interviews in 1991. Variables measured in the original New Beneficiary Survey (NBS) include demographic characteristics; employment, marital, and childbearing histories; household composition; health; income and assets; program knowledge; and information about the spouses of married respondents. The 1991 New Beneficiary Follow-up (NBF) updated marital status, household composition, and the economic profile and contains additional sections on family contacts, postretirement employment, effects of widowhood and divorce, major reasons for changes in economic status, a more extensive section on health, and information on household moves and reasons for moving. Disabled-worker beneficiaries were also asked about their efforts to return to work, experiences with rehabilitation services, and knowledge of SSA work incentive provisions. The NBDS also links to administrative files of yearly covered earnings from 1951 to 1992, Medicare expenditures from 1984 to 1999, whether an SSI application has ever been made and payment status at five points in time, and dates of death as of spring 2001. For studies of health, the Medicare expenditure variables include inpatient hospital costs, outpatient hospital costs, home health care costs, and physicians'''' charges. The survey data cover functional capacity including ADLs and IADLs. For studies of work in retirement, the survey includes yearly information on extent of work, characteristics of the current or last job, and reasons for working or not working. No other data set has such detailed baseline survey data of a population immediately after retirement or disability, enhanced with subsequent measures over an extended period of time. The data are publicly available through NACDA and the Social Security Administration Website. * Dates of Study: 1982-1991 * Study Features: Longitudinal * Sample Size: ** 18,136 (NBS 1981) ** 12,677 (NBF 1991) Links: * 1982 (ICPSR): http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/08510 * 1991 (ICPSR): http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/06118

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• SciCrunch
• 14 years ago - by Anonymous