Curator Dashboard

Software tools and databases for plant genomics.

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• SciCrunch
• 13 years ago - by Anonymous

The National Center for Medical Rehabilitation Research (NCMRR) established a multi-center network of sites that are working together to design clinical intervention protocols and measures of outcome for TBI. Through rigorous patient evaluation, using common protocols and interventions designed for multiple points of care����??including the accident scene, emergency room, intensive care unit, rehabilitation and long-term follow-up����??the NCMRR TBI Clinical Trials Network can study the required numbers of patients to provide answers more rapidly than individual centers acting alone. This interdisciplinary research Network is designed to evaluate the relationship among acute care practice, rehabilitation strategies, and the long-term functional outcome of TBI patients����??that is, to identify which intervention variables result in improvements in long-term outcomes. Taking advantage of the network model structure has allowed TBI research to progress toward a number of clinical research goals. Specifically, the NCMRR wants to highlight two major achievements to date. First, the TBI Network created a profile of its typical patient to determine the number of patients with different clinical features who might be eligible for future studies and to help estimate recruitment times necessary. Second, Network researchers are developing clinical treatment guidelines and procedures for all points in the continuum of care, including TBI Clinical Trials Network Guidelines for surgical care, systems-based protocol for severe and moderate TBI patients, deep-vein thrombosis prophylaxis procedures, and rehabilitation guidelines for physical therapy, speech-language pathology, occupational therapy, and neuropsychology.

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• SciCrunch
• 15 years ago - by Anonymous

The HTPSELEX database contains sets of in vitro selected transcription factor binding site sequences obtained via a high-throughput SELEX (HTPSELEX) method. In addition, the database also contains binding sites obtained with conventional SELEX method. The database hosts 12 individual Selex libraries for the transcription factors CTF/NF1 and LEF/TCF families totaling more than 40,000 sites. In addition we also have manually curated SELEX datasets from the literature for 25 different transcription factors.

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• SciCrunch
• 17 years ago - by Anonymous

Cancer and many other human diseases arise from gene defects, which are either inherited or occur - as in most cancers spontaneously in somatic cells. These defects cause aberrant activities of gene products and malfunctioning of molecular and cellular interactions, thereby inducing tumors and accompanying cancer progression. The central objective of our division is to understand the complex molecular processes of human health and disease. In particular, we are working on tools for improving diagnosis of malfunctioning and prognosis for patients as well as the identification and validation of novel targets for therapies. Main interest of the division is on cellular signaling networks and their roles in cancer drug resistance and metastasis. To this end, we apply high-throughput functional genomics and proteomics technologies, and analyze candidate genes using in vitro and in vivo systems. The division organizes the conference Systems Genomics 2010 (September 29 - October 1, 2010 at the DKFZ Heidelbeg) and aims at advancing the integration of high-throughput genomics, quantitative proteomics, computational biology, and clinics. Internationally outstanding speakers will discuss their latest results in molecular and translational disease research Sponsor. This work was supported in part by the National Genome Research Network (Contract No. 01GS0864) of the Federal Ministry of Education and Research (BMBF) and by Wilhelm-Sander Stiftung (Contract No. 2009.051.1). JDZ is supported by the DKFZ International PhD Program. We thank Moritz Kblbeck, Christian Schmidt and Ute Ernst for their excellent technical assistance.

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• SciCrunch
• 17 years ago - by Anonymous

It is an international research infrastructure for investigators interested in conducting population and clinic-based interdisciplinary studies on the genetic and molecular epidemiology of colon cancer and its behavioral implications. A central goal of the C-CFR is the translation of this research to the clinical and prevention setting for the benefit of Registry participants and the general public. The C-CFR has information and biospecimens contributed by greater than 11,300 families across the spectrum of risk for colon cancers and from population-based or relative controls. Of particular interest are: identification and characterization of cancer susceptibility genes definition of gene-gene and gene-environment interactions in cancer etiology translational, preventive, and behavioral implications of research findings Special features include: population-based and clinic-based ascertainment systematic collection of validated family history epidemiologic risk factor data clinical and follow-up data biospecimens (including tumor blocks and EBV transformed cell lines) ongoing molecular characterization of the participating families Goals: to contribute to the development of public health measures for the general population by increasing knowledge on genetic factors affecting cancer susceptibility and modification by environmental and lifestyle factors to protect those with increased susceptibility from developing cancer to provide life-prolonging treatment to genetically susceptible individuals Objectives: to establish a comprehensive research resource infrastructure to assist with the implementation of collaborative, interdisciplinary research protocols in the genetic epidemiology of cancer to identify, characterize, and follow-up a cohort of individuals and their family members, spanning the spectrum of cancer risk to identify diverse genetically susceptible populations that could benefit from enrollment in preventive and therapeutic interventions to develop an adaptive and evolving informatics model to support ongoing and future research consortia Sponsor. This study was supported by National Cancer Institute Grants R01 CA47147, R01 CA47305, and R01 CA69664.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 32,2023.

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• SciCrunch
• 16 years ago - by Anonymous

A set of Java-based command-line tools for detecting Copy Number Variants (CNVs) using next-generation sequencing data.

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• SciCrunch
• 13 years ago - by Anonymous

BRAT is an accurate and efficient tool for mapping short bisulfite-treated reads obtained from the Solexa-Illumina Genome Analyzer.

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• SciCrunch
• 13 years ago - by Anonymous

To explore the elephant shark genome, we have conducted a survey-sequencing and comparative analysis of the elephant shark genome in collaboration with J. Craig Venter Institute. The elephant shark sequences generated under this project have been deposited at GenBank under the project accession number AAVX01000000. The sequences can also be searched using BLAST and retrieved here. Cartilaginous fishes (Chondrichthyes) represented by sharks, rays, skates and chimaeras, are phylogenetically the oldest group of living jawed vertebrates. They constitute an important group for our understanding of the origins of the complex developmental and physiological systems of jawed vertebrates. They are also an useful outgroup for bony vertebrates such as tetrapods and teleost fishes and help in identifying specialized features that have led to the evolution of diverse groups of bony vertebrates. The elephant shark (Callorhinchus milii), also known as the elephant fish and ghost shark, is a chimaera belonging to the Order Chimaeriformes and Family Callorhynchidae. It has the smallest genome among the known cartilaginous fish genomes. Thus, it was proposed as a model cartilaginous fish genome for whole-genome sequencing and comparative analysis (Venkatesh et al. 2005. Curr. Biol. 15: R82-R83). The following resources of the elephant shark are available for the scientific community: *Elephant Shark 1.4x assembly fasta sequences zipped 227 megabytes *Genomic DNA *~8x coverage BAC library (average insert size, ~150 kb) *cDNA libraries (under construction) *cDNA (dated 11 April 2008) with orthologs in 5 vertebrates (human, opossum, chicken, frog, fugu)

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• SciCrunch
• 17 years ago - by Anonymous

Database of zebrafish genome.

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• SciCrunch
• 16 years ago - by Anonymous

StemCore Laboratories is a high-throughput genomics facility within the Ottawa Hospital Research Institute (OHRI). StemCore Laboratories is developing a world-class infrastructure for genomics, bioinformatics, and proteomics, and is capable of facilitating large-scale scientific research and biotechnology projects. Stemcore Laboratories seeks out projects that are challenging, cutting-edge, extend the boundaries of biological knowledge, and will positively impact the state of human health. Funded: Genome Canada, The Ontario Genomics Institute, The Canadian Foundation for Innovation, The Government of Ontario, The Stem Cell Network, Stantive Solutions

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 4th,2023. Listing of computer software for the gene mapping community on the following topics: genetic linkage analysis for human pedigree data, QTL analysis for animal/plant breeding data, genetic marker ordering, genetic association analysis, haplotype construction, pedigree drawing, and population genetics. The inclusion of a program should not be interpreted as an endorsement to that program from us. In the last few years, new technology produces new types of genetic data, and the scope of genetic analyses change dramatically. It is no longer obvious whether a program should be included or excluded from this list. Topics such as next-generation-sequencing (NGS), gene expression, genomics annotation, etc. can all be relevant to a genetic study, yet be specialized topics by themselves. Though programs on variance calling from NSG can be in, those can sequence alignment might be out; programs on eQTL can be in, those on differential expression might be out. This page was created by Dr. Wentian Li, when he was at Columbia University (1995-1996). It was later moved to Rockefeller University (1996-2002), and now takes its new home at North Shore LIJ Research Institute (2002-now). The present copy is maintained by Jurg Ott as a single file. More than 240 programs have been listed by December 2004, more than 350 programs by August 2005, close to 400 programs by December 2006, and close to 480 programs by November 2008, and over 600 programs by October 2012. A version of the searchable database was developed by Zhiliang Hu of Iowa State University, and a recent round of updating was assisted by Wei JIANG of Harbin Medical School. Some earlier software can be downloaded from EBI: ftp://ftp.ebi.ac.uk/pub/software/linkage_and_mapping/ (Linkage and Mapping Software Repository), and http://genamics.com/software/index.htm may contain archived copy of some programs.

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• SciCrunch
• 17 years ago - by Anonymous

The Ensembl Genomes project produces genome databases for important species from across the taxonomic range, using the Ensembl software system. Five sites are now available, one of which is Ensembl Protists, which houses protists species. Sponsors: EnsembProtists is a project run by EMBL - EBI to maintain annotation on selected genomes, based on the software developed in the Ensembl project developed jointly by the EBI and the Wellcome Trust Sanger Institute.

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• SciCrunch
• 17 years ago - by Anonymous

Web application to discover resources available at participating networked universities. This distributed platform for creating and sharing semantically rich data is built around semantic web technologies and follows linked open data principles.

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• SciCrunch
• 16 years ago - by Anonymous

Software tool developed for automatically reconstructing a set of major white matter pathways in the brain from diffusion weighted images using probabilistic tractography. This method utilizes prior information on the anatomy of the pathways from a set of training subjects. By incorporating this prior knowledge in the reconstruction procedure, our method obviates the need for manual intervention with the tract solutions at a later stage and thus facilitates the application of tractography to large studies. The trac-all script is used to preprocess raw diffusion data (correcting for eddy current distortion and B0 field inhomogenities), register them to common spaces, model and reconstruct major white matter pathways (included in the atlas) without any manual intervention. trac-all may be used to execute all the above steps or parts of it depending on the dataset and user''''s preference for analyzing diffusion data. Alternatively, scripts exist to execute chunks of each processing pipeline, and individual commands may be run to execute a single processing step. To explore all the options in running trac-all please refer to the trac-all wiki. In order to use this script to reconstruct tracts in Diffusion images, all the subjects in the dataset must have Freesurfer Recons.

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• SciCrunch
• 14 years ago - by Anonymous

Database and tool for finding and licensing unpatented research materials to for-profit entities. eRMa was developed by the NIH Office of Technology Transfer to expedite the process for transferring unpatented research materials to for-profit entities. NIH researchers make unpatented materials available to companies through internal use licenses executed by the OTT to support the continued advancement of scientific research. Examples of materials include mouse models used to develop new cancer therapies and cell lines used to test new therapies for chronic diseases, such as high blood pressure. An NIH internal use license is a contract that governs the transfer of tangible research materials from NIH to a company for commercial research use.

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• SciCrunch
• 15 years ago - by Anonymous

Software that performs ?decoding? of brain activity, by learning the difference between brain activity patterns among conditions and then classifying the brain activity based on the learning results. BDTB is a set of Matlab functions. BDTB is OS-independent.

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• SciCrunch
• 13 years ago - by Anonymous

Research facility for research on neurological and psychiatric disorders on the learning brain and the aging brain. The Centre utilizes a multidisciplinary approach to explore the causes and potential treatments of disorders like Alzheimer's disease, mental health and addiction, stroke and neurotrauma. The Centre focuses on translating research into patient care and therapies.

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• SciCrunch
• 15 years ago - by Anonymous

America''s longest-running scientific study of human aging, begun in 1958. BLSA scientists are learning what happens as people age and how to sort out changes due to aging from those due to disease or other causes. More than 1,400 men and women are study volunteers. They range in age from their 20s to their 90s. This study is currently recruiting healthy seniors over 70.

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• SciCrunch
• 15 years ago - by Anonymous

Tripod is a user-friendly chemical genomics browser that is currently being developed by the informatics group at the NIH Chemical Genomics Center. The main goal of Tripod is to facilitate easy access to chemical and biological data in an intuitive, user-friendly tool. To this end, the development of Tripod is inspired by the ubiquitous iTunes software, whereby browsing and managing of media contents are being adapted to chemical and biological data.

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• SciCrunch
• 15 years ago - by Anonymous