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PhenoGO is a computed database designed for high throughput mining that provides phenotypic and experimental context - such as the cell type, disease, tissue, and organ - to existing annotations between gene products and Gene Ontology (GO) terms, as specified in the Gene Ontology Annotations (GOA) for multiple model organisms. Phenotypic and Experimental (P&E) contexts to identifiers are computationally mapped to general biological ontologies, including: the Cell Ontology (CO), phenotypes from the Unified Medical Language System (UMLS), species from Taxonomy of the National Center for Biotechnology Information (NCBI) taxonomy, and specialized ontologies such as Mammalian Phenotype Ontology (MP) and Mouse Anatomy (MA).

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• SciCrunch
• 17 years ago - by Anonymous

The goal of the mouse genome project is to determine the function of genes on mouse Chromosome 11 by saturating the chromosome with recessive mutations. The distal 40 cM of mouse Chr 11 exhibits linkage conservation with human Chromosome 17. We are using the chemical N-ethyl-N-nitrosourea (ENU) to saturate wild type chromosomes with point mutations. By determining the function of genes on a mouse chromosome, we can extrapolate to predict function on a human chromosome. We expect many of the new mutants to represent models of human diseases such as birth defects, patterning defects, growth and endocrine defects, neurological anomalies, and blood defects. Because many of the mutations we expect to isolate may be lethal or detrimental to the mice, we are using a unique approach to isolate mutations. This approach uses a balancer chromosome that is homozygous lethal and carries a dominant coat color marker to suppress recombination over a reasonable interval. On this site one can obtain a list of mutations on chromosome 11.

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• SciCrunch
• 17 years ago - by Anonymous

An Antibody supplier

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• 14 years ago - by Anonymous

An Antibody supplier

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• 14 years ago - by Anonymous

An Antibody supplier

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• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 16, 2013. This website endeavors to provide information on the Chronic Fatigue Syndrome Working Group (CFSWG) and its programs that is helpful to researchers, health care providers, people with CFS and their families, and the general public. :The mission of the Trans-NIH Working Group for Research on Chronic Fatigue Syndrome is to: :* Stimulate and support research on CFS within the context of the missions of all Institutes, Centers and Offices. :* Collaborate and coordinate the research agendas of all Institutes, Centers and Offices to issue on a regular basis joint Program Announcements or theme related Request for Applications to further interdisciplinary research in CFS. :* Present new knowledge to and facilitate novel theoretical approaches to CFS among NIH scientists. :* Plan and sponsor scientific symposia to foster awareness, provoke new scientific interest, and generate interdisciplinary collaboration on CFS among both the NIH and Academic medical community.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 18, 2015. Simbiome is a curated, online electronic resource that organizes and presents relevant resources for physics-based simulation of biomedical structures and related entities in biology and life sciences.

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• SciCrunch
• 17 years ago - by Anonymous

Clinicians can get a simultaneous consult about their patient''s diagnosis using SimulConsult''s diagnostic decision support software. After some patient findings are entered into the software, it provides an initial differential diagnosis and suggests other useful findings, including tests. The database used by the software has > 2,300 diagnoses, focused on genetic neurological and metabolic diseases, but is expanding with increasing content on non-neurological genetics and non-genetic neurology. The information about diseases is entered by clinicians, referenced to the literature and peer-reviewed by experts. The information includes many types of information ignored in other diagnostic approaches, allowing the software to take into account pertinent negatives, temporal information, and cost of tests. The approach is also flexible enough allow rapid addition of newly recognized diseases. SimulConsult enables both generalists and specialists to transform medical diagnosis, by lowering costs, reducing errors and eliminating the medical diagnostic odysseys experienced by far too many patients and their families. SimulConsult also enables researchers to find diseases with clinical presentations that are similar to other diseases or individual patients, assisting in identifying mechanisms of diseases. The software may be used only by medical professionals (doctors, nurse practitioners, genetic counselors, medical librarians and supervised trainees in these professions), who may register on the site or use the software through institutional access of their medical center. Keywords: diagnosis, diagnostic, software, neurology, genetic, neurological, metabolic, metabolism, human

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• SciCrunch
• 17 years ago - by Anonymous

G-Protein Coupled Receptor Oligomerization Knowledge Base (GPCR-OKB) ontology project offers an ontology that can be downloaded. :G Protein-Coupled Receptors (GPCRs) are a large and diverse family of membrane proteins whose members participate in the regulation of most cellular and physiological processes and therefore represent key pharmacological targets. Although several bioinformatics resources support research on GPCRs, most of them have been designed based on the traditional assumption that monomeric GPCRs constitute the functional receptor unit (Figure 1 below). The increase in the frequency and number of reports about GPCR dimerization/oligomerization and the implication of oligomerization in receptor function makes necessary the ability to store and access information about GPCR dimers/oligomers electronically. :We present here the design blueprint for an information system that can manage the elements of information required to describe comprehensively the phenomena of both homo- and hetero-oligomerization of GPCRs. Specifically, we present the ontology (Figures 2-4 below) that we plan to use for the development of an intuitive and user-friendly GPCR-Oligomerization Knowledge Base (GPCR-OKB). This information system is being designed in close collaboration with experimental colleagues working on GPCR oligomerization, and adopts the list of recommendations recently stipulated by the NC-IUPHAR subcommittee for the recognition and nomenclature of GPCR multimers. :Our long term goal is to disseminate to the scientific community organized, curated, and detailed information about GPCR dimerization/oligomerization, and its related structural context. :Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007 May 30;8:177. PMID 17537266 :The ontology files (developed in Protege) can be downloaded. :

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• SciCrunch
• 17 years ago - by Anonymous

An Antibody supplier

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• 14 years ago - by Anonymous

An Antibody supplier.

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• 14 years ago - by Anonymous

An Antibody supplier

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• 14 years ago - by Anonymous

Northern Eclipse 6.0 software is a Windows based full Image Analysis and Archiving System with a full suite of Image Processing techniques, Morphological and Densitometry measuring routines, digital and analogue camera control, SDK for custom camera driver solutions, 3D-Reconstruction, De-Convolution and programmable via 3 levels of automation plus access to hundreds of OLE applications and thousands of scripts.

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• SciCrunch
• 17 years ago - by Anonymous

The Internet Stroke Center at Washington University is pleased to offer this module for viewing CT, MR, and angiogram images of cerebrovascular and neurological diseases. While this project is still being perfected -- and many more cases have yet to be added -- we hope that you will find this collection useful in your education and practice. The images presented here are for educational use only. This information may not be used for diagnosis or treatment. All images are protected property of the Internet Stroke Center at Washington University and may not be reproduced without permission. Permission may be granted to students and professionals to borrow images from this site for educational purposes and/or presentations; we just ask that an email be sent detailing both the desired material and the intended use. Please direct all comments, questions, and requests to the Site Editor of the Internet Stroke Center.

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• SciCrunch
• 17 years ago - by Anonymous

Stroke Trials Registry is a continuously updated registry of randomized clinical trials in stroke and cerebrovascular disease. This project is a free public service from the Internet Stroke Center at Washington University School of Medicine; with support from the American Stroke Association and the National Institute of Neurological Disorders and Stroke. This registry will meet technical standards for inclusion in the International Clinical Trials Registry Platform of the World Health Organization. The information on this site is intended for health professionals. SPOTRIAS is an NIH-funded network of stroke research centers that perform early phase clinical projects, share data, and promote new approaches to therapy for acute stroke. clinical data, human, homo sapien, stroke, translational medicine

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• SciCrunch
• 14 years ago - by Anonymous

Hasenwinkel Research Group is interested in creating absorbable biopolymeric gels for the prevention of post-surgical tissue adhesions, novel two-solution bone cements fro fixation of total join replacements, nerve and soft tissue regeneration, surface modification of materials to enhanve and promote biological function and biocompatibility, studying effects of chemical, mechanical, and electrical environments on the development of three-dimensional tissue scaffolds in culture. :datum, lab web page :

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on December 10, 2012. With Cloverleaf Integration Services from Quovadx, Inc., the FDOH now provides managers and policy makers with access to critical data residing in various counties across the state. The Cloverleaf engine is used to map legacy electronic billing formats for Medicaid to HIPAA compliant formats for three of the largest patient care systems in the state without the need to make programming changes to the existing systems that bill Medicaid. The Cloverleaf solution also guarantees the delivery of messages, enables rapid development and deployment of application interfaces between systems and provides a means of maintaining compliance with any new HIPAA format changes. While making the data available to a larger audience, the privacy and security of sensitive health data is also maintained by the solution''s ability to manage security and business rules for each system.

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• SciCrunch
• 17 years ago - by Anonymous

i2b2 (Informatics for Integrating Biology and the Bedside) is an NIH-funded National Center for Biomedical Computing based at Partners HealthCare System. The i2b2 Center is developing a scalable informatics framework that will enable clinical researchers to use existing clinical data for discovery research and, when combined with IRB-approved genomic data, facilitate the design of targeted therapies for individual patients with diseases having genetic origin. For some resources (e.g. software) the use of the resource requires accepting a specific (e.g. OpenSource) license.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 2, 2023. A section of the Penn department of radiology, it is devoted to the development of computer-based image analysis methods and their application to clinical research studies. Image analysis methodologies include image registration, segmentation, population-based statistical analysis, biophysical modeling of anatomical deformations, and high-dimensional pattern classification. Clinical research studies spans a variety of clinical areas and organs, and they include brain diseases such as Alzheimer's disease and schizophrenia, evaluation of treatment effects in large clinical trials, diagnosis of cardiac diseases, and diagnosis prostate, breast and brain cancer. SBIA also performs small animal imaging research aiming to understand brain development in mouse models. It has multiple resources which can be accessed by researcher.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 16, 2013. Collection of Unix-based programs for pre-processing and analyzing neuroimaging datasets. This includes tools for mean-normalization of images, image registration, ANOVA, post-hoc contrast analysis, region-of-interest identification and examination (including time series). Includes a test data set.

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• SciCrunch
• 17 years ago - by Anonymous