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The Cardiovascular Physiology Core Facility provides University of Wisconsin (UW) and non-UW researchers with a central resource for creating and studying animal models of disease on a fee-for-service basis. While the central focus of the facility is cardiovascular research, the techniques employed are often useful to investigators in other fields. Currently, the facility is conducting studies into diabetes, bone growth, drug toxicology, and gene therapy in liver and skeletal muscle, as well as cardiovascular disease. One of the most popular services provided by the facility is evaluation of the cardiovascular phenotype of transgenic mice.

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• 13 years ago - by Anonymous

An Portal, Core facility

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• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. GeneWake GmbH is a pharmacogenomics company with a sound scientific background in biomarker analysis in the field of oncology. Our mission is to realize a personalized and tailor-made cancer treatment by targeted analysis of relevant gene expression levels in tumour tissue and in circulating tumour cells in blood. By employing bioinformatical algorithms based on our knowledge in pathway structure and microarray data from public sources, biomarker screening can be limited to a low-density scale. The output of 10-20 potential genes can be used for ptient stratification or therapy tracking. In addition, GeneWake offers contract research like DNA and RNA sequencing and annotation, SNP genotyping, mutation detection, multiplex PCR, kit development, immune histology and genotyping for clinical studies.

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• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 22,2024. Therapeutic Validation core (TVC) assists clinical investigators to develop and perform correlative biological assays needed to validate mechanism(s) of action of candidate drugs/therapies and to develop and test new hypotheses. The TVC also provides technical and intellectual support in the development, implementation, and validation of predictive and pharmacodynamic biomarkers for novel, molecularly-targeted anticancer agents.

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• 14 years ago - by Anonymous

Serving 120+ investigators with a 5 laser high speed sorter and 3 benchtop analyzers with 13+ color capabilities, the Utah Flow Cytometry Core Facility has developed a paradigm to balance productivity with quality to minimize the cost per research project, keep overall costs contained, and provide the necessary scientific support. Central to this paradigm is a close working relationship with investigators to define their projects in the early stages of development to make optimal and efficient use of flow cytometry. In addition to high quality and well maintained instrumentation, success of this approach requires focused efforts in three major areas: 1) education of ALL users (faculty and staff) in the science and technology of flow cytometry, 2) active involvement in the scientific development of the project, 3) continuing education for core staff.

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• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. The Center for Drug Discovery and Innovation (CDDI) is a Florida Center of Excellence serving the research community at USF and south Florida. From concept to clinical trials there are significant challenges in the successful development of new pharmaceuticals. It is the mission of CDDI to assist research groups at USF in overcoming some of the critical bottlenecks in early phase drug discovery.

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• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented January 23, 2019. Core supports SBMRI investigators in exploring, understanding and analyzing complex biological data. Core is equipped with cutting-edge computational infrastructure and a selective collection of bioinformatics software. Core's services include consultation, data analysis and management, software development, and accessing to large computing resources. To meet various demands from the investigators, we provide services at multiple levels, from full service to cost-effective limited service as well as collaborative projects requiring longer-term commitment of time and effort.

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• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Affina Biotechnologies is dedicated to excellence in helping our customers develop measurements of activities, kinetics and affinities of interactions and concentrations of biomolecules. We offer a unique mix of label-free and label-dependent assay technologies supported by scientific and technical expertise and a wide range of instrumentation.

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• 13 years ago - by Anonymous

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960''''s. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. In the intervening years, laboratory and scientific personnel, from the US and abroad, have learned HLA typing through courses and workshops at the UCLA Immunogenetics laboratory. The center provides immunogenetics and histocompatibility testing services to a wide range of physicians, patients, pharmaceutical companies and other medical facilities. The laboratory is a World Health Organization reference laboratory for HLA, and is licensed by the State of California, New York, Maryland, Pennsylvania and Rhode Island, is CMS certified and accredited by the American Society for Histocompatibility and Immunogenetics.

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• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 6, 2016. The High-Throughput Clinical Proteomics (HTCP) core laboratory is a mass spectrometry core facility designed to profile large numbers of clinical samples for changes in protein content. We use small amounts (micrograms) of protein from samples such as urine, plasma, CSF, and cell lysates and incubate them with magnetic beads that bind different subsets of the total proteome. We then examine the different subsets of small proteins and peptides by high-resolution MALDI-TOF mass spectrometry. We measure the amounts and intact masses of the proteins in the samples and determine which have the greatest statistical relevance in defining clinical groupings before moving to physically isolate those peptides/proteins and identify them. The method works best for peptides and small proteins below 25 kDa and is an excellent complement to gel-based methods such as DIGE.

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• 14 years ago - by Anonymous

Core is a fully automated, high-throughput genomic Center equipped with next generation sequencing and microarray platforms. TCGB provides genomics technologies, comprehensive services, specialized expertise and a wide range of trainings, enabling these services to serve basic science and translational/clinical research. In addition, TCGB provides pre-experiment consultation and post-experiment support, including preparation of grant applications, publications, and strategic planning for additional research steps. TCGB also provides educational training to faculty, staff, and students to raise awareness of new directions and major discoveries in the areas of genomics and bioinformatics.

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• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 31,2025. The award-wining Keck Biophysics Facility at Northwestern University has a comprehensive set of state of the art instruments for biophysical and biochemical characterization of macromolecules and their interactions. We provide staff-service, technical expertise and assistance to investigators and companies in the continental US and Canada. The Facility has 15 years of experience with a broad array of biophysical techniques and has generated over 500 publications in top-tier journals.

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• 14 years ago - by Anonymous

The Clinical & Translational Research Laboratory (CTRL) offers a full range of cost-effective laboratory testing to support your research efforts. The laboratory performs routine chemistry tests (basic metabolic panel, comprehensive metabolic group, electrolyte panel, hepatic panel, lipid panel and individual tests), thyroid function tests, fertility tests, tumor marker tests, basic coagulation testing and routine urinalysis testing. These tests are performed in the CTRL lab; however, referral tests can be sent to the UCLA Clinical Laboratory or outside reference laboratories. New assays not on the test menu can be validated and performed to meet the needs of individual research investigators. The laboratory is California-licensed, CLIA-certified, and CAP-accredited. A copy of each certificate can be issued upon request. The lab is staffed by ten research scientists, two hospital laboratory technicians, and two clinical laboratory scientists. It occupies approximately 5,000 square feet of space located on the A-level of the Center for Health Sciences (CHS) building. The facility works with investigators both inside and outside the UCLA enterprise on a collaborative and fee-for-service basis.

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• 14 years ago - by Anonymous

Facility in the UCLA Department of Pathology and Laboratory Medicine and UCLA Jonsson Comprehensive Cancer Center Shared Facility. Provids pathology related services in support of basic, translational and clinical research at UCLA. Provides consultative services to investigators in pathology-related study design, tissue selection, microscopic interpretation, immunohistochemistry, laser capture microdissection, digital image analysis, and IRB-related tissue questions.

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• 14 years ago - by Anonymous

Acellera is company focused on developing high-throughput molecular dynamics techniques that deliver solutions for estimating common physico-chemical properties such as binding affinities, kinetics, poses and pathways with validated accuracy.Company mission is to accelerate transition to rational, computerized drug discovery via simulations and machine learning.

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• 13 years ago - by Anonymous

Provides biomarker service activity for both large pharma and biotech.

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• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 19,2024. Translational Research Laboratory at the Peter MacCallum Cancer Centre offers oncology focused, small animal PET imaging services to both academic and commercial investigators. Using the wide range of mouse models of cancer available at Peter Mac, experiments are tailored to investigators needs and performed in state of the art facilities. Infrastructure available includes 2 Philips Mosaic PET scanners, on-site radiotracer production, fully trained imaging staff and a dedicated animal facility. Digital autoradiography using the Biospace BetaImager and MicroImager allows high resolution ex-vivo imaging of labelled compounds in whole animal or tissue sections. The VisualSonics Vevo 770 small animal ultrasound is available for detection and monitoring of in vivo tumor growth. Ex-vivo correlative biomarker studies are also available.

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• 14 years ago - by Anonymous

The GCF provides second generation genome sequencing service to all members of the scientific community. Using the 454 Life Sciences/Roche Genome Sequencer FLX, we facilitate data collection and analysis.

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• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Portal, Core facility

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• 13 years ago - by Anonymous

Research organization offering R&D services to identify and develop vaccines and therapeutics for infectious diseases.

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• 13 years ago - by Anonymous