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Core that offers support for data-driven projects related to basic, clinical and translational research, with a particular emphasis on diabetes. The core aims to ensure that researchers take advantage of the most modern and robust methods available in the field of Bioinformatics and Biostatistics.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 9,2024. Core that provides services in Gene Editing Expertise Using CRISPR/CAS9, Conventional Transgenic Mouse Generation, Conventional Knockout, Knock-In Mouse Generation, and Cryopereservation of Sperm, Oocytes and Embryos.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 9,2024. Core that provides services in tissue analysis and imaging, islet biology, liver biology, and adipocyte biology. It includes the indepedent cores Derivation of IPSC and Bioenergetics as well as the Specialty Animal Surgery Subcore and Bone Biology Subcore.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 14,2024. Core which utilizes a breeding colony of Ossabaw swine with metabolic syndrome and long-term complications, most notably cardiovascular disease. It provides swine maintenance (glucose tolerance tests, body composition, glucose clamp studies, and imaging studies), characterization of cardiovascular disease (intravascular ultrasound, blood flow velocity, microvascular studies), and tissues (both banked and fresh) for analysis ex vivo.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 24,2024. Core consisting of several subcores: Ligand Assay and Biomarker Subcore (offers services in Multiplex Assay Detection Systems, Comprehensive Laboratory Animal Monitoring System (CLAMS), and Body Composition), Rodent Physiology and Behavioral Analysis Subcore, and Glucose Metabolism Analysis Subcore (provides services in Dynamic Physiologic Testing).

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 24,2024. Core that typically organizes a meeting with the investigator/user and relevant core directors to discuss the different services and tests that the Diabetes Research Center would recommend to the investigator. It also provides support letters for grant proposals submitted by investigators.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center whose goal is to understand the causes of both type 1 and 2 diabetes and promotes translational research that is aimed at reducing the burden of these diseases in the U.S. It has a specific focus on childhood diabetes and diabetes that affects minority populations.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides spectrum of advanced cellular and tissue pathology and imaging services for diabetes researchers at Columbia University. It also has microscopy equipment and services such as confocal, live 2-photon and scanning and transmission electron microscopy.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core within Indiana Center for Diabetes and Metabolic Diseases that offers services that facilitate conduct of research involving human subjects, including providing low-cost, high quality analyte measurements for variety of hormones, cytokines, lipids and other analytes. Its human studies services include metabolic phenotyping (e.g. GTT, clamp studies, tracer studies), and access to a biobank of human tissues and serum.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides consultation and specialized services for intravital microscopy of pancreas and transplanted islets, FRET assays, and fluorescent biosensors for analysis of intracellular signaling cascades to serve the area diabetes investigators.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides services that facilitate the efficient characterization of mouse models of diabetes and its complications: NMR Body Composition Analysis, Whole Body Metabolic Assessment (chamber calorimetry with motion detection), Metabolic Clamps, Gastric Infusion/Feeding and Thermogenic Phenotyping.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Services include islet isolation services from mice and rats and access to porcine and human islets. The core is equipped with BioRep Perifusion Apparatus for measurement of insulin secretion and offers services for islet and beta cell calcium imaging. Provides services for islet transplantation and assists investigators who wish to perform immunohistochemistry, immunofluorescence and/or analysis of endocrine or beta cell mass on whole pancreata from mouse and rat models.Offers services for rodent metabolic characterization, including performance of insulin and glucose tolerance testing, analysis of body composition, and metabolic cage analysis using the TSE System cages. Recently added services include zebrafish characterization to screen genes and small molecules for their effects on islet development and function.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that includes over seventy investigators engaged in basic and translational research in diabetes and related metabolic disorders, and their complications. It contains four Research Cores that serve for innovative and translational research.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 24,2024. Core that provides services for DNA sequencing and oligonucleotide synthesis, as well as support for projects that require research laboratory automation, such as siRNA screens and transcript abundance profiling. It also offers experimental design and advice for automation and high throughput screening of siRNA collections based on the Ambion siRNA collection.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core which assists investigators to quantify and phenotypically characterize cell populations that contribute to the metabolic, immunologic and developmental programs of diabetes and its complications; and to purify populations of cells of relevance to diabetes and its complications.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core makes available to Diabetes Research Center investigators variety of high quality radio-immunoassay, ELISA, and other analytical methods, and facilitates access of DRC investigators to measurement of small molecules by targeted and untargeted metabolomics/lipidomics with the Irving Institute Biomarkers Core. TBAC also provides consultations and services for in vivo methods to measure insulin secretion and sensitivity.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core which assists with the in vivo assessment of glucose and fatty acid metabolism, insulin sensitivity and energy homeostasis in mice and rats. It provides tools to understand the behavior and physiology mediating the relationships among diabetes, nutrient sensing, obesity and diabetic cardiovascular complications in rodents.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center which provides research support for investigators pursuing research on diabetes and metabolic disorders.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 23,2024.Transgenic core which generates transgenic and gene knockout mouse models relevant to obesity, diabetes and nutrition research. It also provides consultation on all aspects of making transgenic and gene knockout mice.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 23,2024.Core which provides islets to the local diabetes research community in the Boston area. They collaborate with researchers nationally to provide nonhuman primate (NHP) islets for research.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen