Curator Dashboard

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 7,2024. Core which provides services and hands-on training in the isolation and functional characterization of pancreatic islets from normal and diabetic humans and mice. It also maintains a repository of insulinoma cell lines for distribution. It puts emphasis on facilitating studies of primary islet cells and it has developed many unique tools and techniques for carrying such studies including novel animals models, biophysical methods and a library of adenovirus-based expression constructs for studying beta-cell function.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides the powerful tools of modern mass spectrometry and complex data set analysis to Diabetes Research Center investigators to permit structural identification and quantitation of proteins involved in diabetes and its complications.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides Diabetes Research Center affiliates with vectors necessary to overexpress, knockdown, knockout, or alter expression of RNAs and proteins of interest in cultured cells, isolated tissues, and animals.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 7,2024. Molecular biology and genetics core which helps independently funded investigators with an interest in diabetes mellitus and other metabolic disorders to clone, sequence and characterize cDNAs and genes of interest. It also provides research tools and expertise to enable investigators to discover how genetic variation in diabetes genes leads to hyperglycemia.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that supports the Diabetes Research Center affiliates by offering precise real time functional analysis of intact cells and primary tissue. The Cell Function Analysis Core also provides an islet isolation service, which gives affiliates easy access to primary tissue/cells ex vivo.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides specialized technical resources and expertise to enhance the efficiency, productivity and multidisciplinary nature of clinical research performed by Diabetes Research Center (DRC)-affiliated investigators.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

University-affiliated center to support both basic and clinical research in diabetes and related metabolic disorders with the ultimate purpose of translating findings into opportunities to prevent these diseases and to improve clinical care and outcomes.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides Diabetes Research Center affiliates with access to specialized expertise and equipment required for high quality histochemical and morphological analyses in a cost-effective manner.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that supports the Diabetes Research Center in its primary mission to enhance research, education and training in diabetes, obesity and related disorders at the University of Washington and in the Greater Seattle area. The Core coordinates and manages programs, evaluates Center activities, and performs other duties.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Diabetes research center created to address the prevalence of diabetes and obesity. The goal of the center is to support and develop successful approaches to the prevention, treatment, and cure of diabetes mellitus and obesity.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core which aims to develop and validate metabolomic methods and data analysis software and provide high quality routine metabolomic services. Its services include quantitation of selected water-soluble metabolites, fatty acids, and lipids, quantitation of metabolic fluxes using stable isotope tracers, and identification of novel metabolites involved in diabetes pathophysoiology.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core which offers experiment planning, sample preparation, quality assessment, library construction, DNA sequencing, and data analysis services to DRC members. Its services also include RNAseq, microRNAseq, GroSeq, CLIP-seq, nucleosome mapping, ATAC-Seq, ChIPseq, Exome sequencing, whole genome and targeted methylome analysis, hydroxymethyl DIP, and single cell RNAseq.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 6,2024. Core that maintains a centralized facility for the generation and propagation of reprogrammed iPS cells for use in molecular and cellular pathologies underlying diabetes and its complications.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides services related to the application of genetic methodologies to research related to diabetes. Services include generation of targeted genetic mouse models, using CRISPR/Cas9 system in mouse or rat embryos, generation of specialty viral vectors, specialty viral reagents, and specialty mouse models.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Provides MDRC researchers with expert consultation, training and support for routine and advanced microscopy and image analysis techniques. Services include Consultation and Advice on Microscopy and Immunohistochemistry, Cryosection Service, Confocal Microscopy, Image Analysis, Widefield Light Microscopy,Live Cell Microscopy,Training and Education.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 6,2024. Core that supports the use of the OMICS technologies by MDRC members (specifically on projects relevant to diabetes and related endocrine and metabolic disorders, including their complications) by supporting pilot studies that utilize these technologies.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 6,2024. Core that provides services in genotyping, sequencing, biobanks, and genetic epidemiology. It also offers access to the Amish exome variant database, basic molecular services, and viral vector construction and development.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Administration Core of the Michigan Diabetes Research Center (MDRC) provides leadership, infrastructure, and resources to support and enhance diabetes research, including the translation of scientific discoveries from bench to bedside. Establishes, promotes, and enhances multidisciplinary and collaborative basic biomedical and clinical research among member investigators studying diabetes, its complications, and related endocrine and metabolic disorders.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center which promotes multidisciplinary research in diabetes through raising awareness and interest in fundamental and clinical research, enhancing diabetes research, education and training opportunities, and providing core services that leverage funding and unique expertise.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core which promotes redox biology in diabetes-related research. It promotes research in areas common to the metabolic and vascular aspects of diabetes and cardiovascular disease. The core provides services in mitochondrial damage, function, proteomics, and oxidative stress assessment support for investigators carrying out diabetes mellitus (DM) and cardiometabolic disease (CMD) research at UAB.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen